Loading...

APC anti-mouse CD117 (c-Kit) Antibody APC anti-mouse CD117 (c-Kit) Antibody

Pricing & Availability
Clone
2B8 (See other available formats)
Regulatory Status
RUO
Other Names
c-KIT, Stem Cell Factor Receptor (SCFR)
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
2B8_APC_1_072611
  • 2B8_APC_1_072611
  • 2B8_APC_2_072611
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
105811 25 µg DKK499
Check Availability


Need larger quantities of this item?
Request Bulk Quote
105812 100 µg DKK1242
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow mast cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone fixed frozen sections2, and spatial biology (IBEX)5,6. The 2B8 antibody does not block c-Kit activity.

Application References
  1. Ikuta K, et al. 1992. P. Natl. Acad. Sci. USA 89:1502. (FC)
  2. Podd BS, et al. 2006. J. Immunol. 176:6532. PubMed (IHC)
  3. Bachelet I, et al. 2008. J. Immunol. 180:6064. PubMed (FC)
  4. Charles N, et al. 2010. Nat. Med. 16:701. PubMed (FC)
  5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  2. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  3. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  4. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  5. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  6. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  7. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  8. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  9. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  10. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  11. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  12. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  13. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  14. Wang X, et al. 2023. Nature. 618:808. PubMed
  15. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  16. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  17. Barkaway A, et al. 2021. Immunity. . PubMed
  18. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  19. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  20. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  21. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  22. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  23. Zhu H, et al. 2018. Elife. 7:. PubMed
  24. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  25. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  26. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  27. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  28. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  29. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  30. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  31. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  32. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  33. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  34. Gao B, et al. 2018. Aging Cell. 3. PubMed
  35. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  36. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  37. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  38. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  39. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  40. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  41. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  42. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  43. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  44. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  45. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  46. Plein A, et al. 2018. Nature. 562:223. PubMed
  47. Eisele AS, et al. 2022. Elife. 11:. PubMed
  48. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  49. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  50. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  51. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  52. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  53. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  54. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  55. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  56. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  57. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  58. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  59. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  60. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  61. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  62. Dong S, et al. 2021. Nature. 591:117. PubMed
  63. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  64. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  65. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  66. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  67. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  68. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  69. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  70. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  71. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  72. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  73. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  74. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  75. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  76. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  77. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  78. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  79. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  80. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  81. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  82. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  83. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  84. Engblom C, et al. 2017. Science. 358:6367. PubMed
  85. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  86. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  87. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  88. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  89. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  90. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  91. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  92. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  93. Koide S, et al. 2022. iScience. 25:103603. PubMed
  94. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  95. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  96. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  97. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  98. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  99. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  100. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  101. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  102. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  103. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  104. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  105. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  106. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  107. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  108. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  109. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  110. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  111. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  112. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  113. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  114. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  115. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  116. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  117. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  118. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  119. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  120. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  121. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  122. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  123. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  124. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  125. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  126. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  127. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  128. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  129. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  130. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  131. Wang X, et al. 2023. Nature. 618:808. PubMed
  132. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  133. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  134. Barkaway A, et al. 2021. Immunity. . PubMed
  135. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  136. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  137. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  138. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  139. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  140. Zhu H, et al. 2018. Elife. 7:. PubMed
  141. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  142. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  143. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  144. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  145. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  146. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  147. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  148. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  149. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  150. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  151. Gao B, et al. 2018. Aging Cell. 3. PubMed
  152. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  153. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  154. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  155. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  156. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  157. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  158. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  159. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  160. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  161. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  162. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  163. Plein A, et al. 2018. Nature. 562:223. PubMed
  164. Eisele AS, et al. 2022. Elife. 11:. PubMed
  165. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  166. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  167. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  168. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  169. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  170. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  171. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  172. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  173. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  174. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  175. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  176. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  177. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  178. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  179. Dong S, et al. 2021. Nature. 591:117. PubMed
  180. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  181. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  182. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  183. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  184. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  185. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  186. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  187. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  188. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  189. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  190. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  191. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  192. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  193. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  194. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  195. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  196. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  197. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  198. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  199. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  200. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  201. Engblom C, et al. 2017. Science. 358:6367. PubMed
  202. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  203. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  204. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  205. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  206. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  207. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  208. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  209. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  210. Koide S, et al. 2022. iScience. 25:103603. PubMed
  211. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  212. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  213. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  214. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  215. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  216. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  217. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  218. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  219. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  220. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  221. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  222. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  223. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  224. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  225. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  226. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  227. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  228. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  229. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  230. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  231. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  232. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  233. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  234. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
RRID
AB_313220 (BioLegend Cat. No. 105811)
AB_313221 (BioLegend Cat. No. 105812)

Antigen Details

Structure
Ig superfamily, 145 kD
Distribution

Hematopoietic stem cells, AML, mast cells

Function
Growth factor receptor, tyrosine kinase
Ligand/Receptor
Stem Cell Factor (SCF)
Cell Type
Embryonic Stem Cells, Hematopoietic stem and progenitors, Leukemia, Mast cells, Mesenchymal Stem Cells
Biology Area
Immunology, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Galli SJ, et al. 1994. Adv. Immunol. 55:1.
3. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
4. Besmer P, et al. 1986. Nature 320:415.
5. Witte ON. 1990. Cell 63:5.

Gene ID
16590 View all products for this Gene ID
UniProt
View information about CD117 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD117 Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse CD117 (c-Kit) 2B8 FC
PE/Dazzle™ 594 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) (Maxpar® Ready) 2B8 FC,CyTOF®
Brilliant Violet 711™ anti-mouse CD117 (c-Kit) 2B8 FC
APC/Fire™ 750 anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 510™ anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 785™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 594 anti-mouse CD117 (c-Kit) 2B8 IHC-F,3D IHC
TotalSeq™-A0012 anti-mouse CD117 (c-kit) 2B8 PG
Brilliant Violet 605™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 700 anti-mouse CD117 (c-Kit) 2B8 FC
TotalSeq™-C0012 anti-mouse CD117 (c-Kit) 2B8 PG
TotalSeq™-B0012 anti-mouse CD117 (c-Kit) 2B8 PG
Brilliant Violet 650™ anti-mouse CD117 (c-kit) 2B8 FC
APC anti-mouse CD117 (c-Kit) 2B8 FC
Biotin anti-mouse CD117 (c-Kit) 2B8 FC
FITC anti-mouse CD117 (c-Kit) 2B8 FC
PE anti-mouse CD117 (c-Kit) 2B8 FC
PE/Cyanine5 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Spark NIR™ 685 anti-mouse CD117 (c-kit) 2B8 FC
Alexa Fluor® 488 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 647 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Pacific Blue™ anti-mouse CD117 (c-Kit) 2B8 FC
PerCP/Cyanine5.5 anti-mouse CD117 (c-kit) 2B8 FC
PerCP anti-mouse CD117 (c-kit) 2B8 FC
APC/Cyanine7 anti-mouse CD117 (c-kit) 2B8 FC
Brilliant Violet 421™ anti-mouse CD117 (c-Kit) 2B8 FC,SB
Spark Red™ 718 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 574 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 550 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark UV™ 387 anti-mouse CD117 (c-Kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 581 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 593 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Go To Top Version: 2    Revision Date: 06/28/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
2B8 (See other available formats)
Regulatory Status
RUO
Other Names
c-KIT, Stem Cell Factor Receptor (SCFR)
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
2B8_APC_1_072611
  • 2B8_APC_1_072611
  • 2B8_APC_2_072611
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
105811 25 µg DKK499
Check Availability


Need larger quantities of this item?
Request Bulk Quote
105812 100 µg DKK1242
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow mast cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone fixed frozen sections2, and spatial biology (IBEX)5,6. The 2B8 antibody does not block c-Kit activity.

Application References
  1. Ikuta K, et al. 1992. P. Natl. Acad. Sci. USA 89:1502. (FC)
  2. Podd BS, et al. 2006. J. Immunol. 176:6532. PubMed (IHC)
  3. Bachelet I, et al. 2008. J. Immunol. 180:6064. PubMed (FC)
  4. Charles N, et al. 2010. Nat. Med. 16:701. PubMed (FC)
  5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  2. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  3. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  4. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  5. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  6. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  7. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  8. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  9. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  10. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  11. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  12. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  13. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  14. Wang X, et al. 2023. Nature. 618:808. PubMed
  15. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  16. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  17. Barkaway A, et al. 2021. Immunity. . PubMed
  18. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  19. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  20. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  21. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  22. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  23. Zhu H, et al. 2018. Elife. 7:. PubMed
  24. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  25. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  26. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  27. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  28. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  29. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  30. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  31. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  32. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  33. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  34. Gao B, et al. 2018. Aging Cell. 3. PubMed
  35. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  36. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  37. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  38. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  39. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  40. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  41. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  42. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  43. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  44. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  45. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  46. Plein A, et al. 2018. Nature. 562:223. PubMed
  47. Eisele AS, et al. 2022. Elife. 11:. PubMed
  48. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  49. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  50. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  51. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  52. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  53. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  54. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  55. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  56. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  57. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  58. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  59. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  60. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  61. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  62. Dong S, et al. 2021. Nature. 591:117. PubMed
  63. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  64. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  65. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  66. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  67. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  68. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  69. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  70. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  71. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  72. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  73. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  74. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  75. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  76. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  77. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  78. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  79. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  80. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  81. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  82. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  83. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  84. Engblom C, et al. 2017. Science. 358:6367. PubMed
  85. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  86. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  87. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  88. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  89. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  90. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  91. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  92. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  93. Koide S, et al. 2022. iScience. 25:103603. PubMed
  94. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  95. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  96. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  97. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  98. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  99. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  100. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  101. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  102. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  103. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  104. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  105. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  106. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  107. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  108. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  109. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  110. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  111. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  112. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  113. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  114. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  115. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  116. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  117. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  118. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  119. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  120. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  121. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  122. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  123. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  124. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  125. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  126. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  127. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  128. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  129. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  130. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  131. Wang X, et al. 2023. Nature. 618:808. PubMed
  132. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  133. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  134. Barkaway A, et al. 2021. Immunity. . PubMed
  135. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  136. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  137. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  138. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  139. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  140. Zhu H, et al. 2018. Elife. 7:. PubMed
  141. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  142. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  143. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  144. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  145. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  146. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  147. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  148. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  149. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  150. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  151. Gao B, et al. 2018. Aging Cell. 3. PubMed
  152. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  153. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  154. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  155. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  156. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  157. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  158. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  159. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  160. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  161. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  162. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  163. Plein A, et al. 2018. Nature. 562:223. PubMed
  164. Eisele AS, et al. 2022. Elife. 11:. PubMed
  165. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  166. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  167. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  168. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  169. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  170. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  171. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  172. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  173. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  174. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  175. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  176. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  177. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  178. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  179. Dong S, et al. 2021. Nature. 591:117. PubMed
  180. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  181. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  182. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  183. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  184. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  185. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  186. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  187. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  188. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  189. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  190. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  191. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  192. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  193. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  194. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  195. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  196. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  197. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  198. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  199. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  200. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  201. Engblom C, et al. 2017. Science. 358:6367. PubMed
  202. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  203. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  204. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  205. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  206. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  207. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  208. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  209. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  210. Koide S, et al. 2022. iScience. 25:103603. PubMed
  211. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  212. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  213. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  214. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  215. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  216. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  217. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  218. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  219. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  220. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  221. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  222. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  223. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  224. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  225. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  226. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  227. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  228. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  229. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  230. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  231. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  232. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  233. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  234. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
RRID
AB_313220 (BioLegend Cat. No. 105811)
AB_313221 (BioLegend Cat. No. 105812)

Antigen Details

Structure
Ig superfamily, 145 kD
Distribution

Hematopoietic stem cells, AML, mast cells

Function
Growth factor receptor, tyrosine kinase
Ligand/Receptor
Stem Cell Factor (SCF)
Cell Type
Embryonic Stem Cells, Hematopoietic stem and progenitors, Leukemia, Mast cells, Mesenchymal Stem Cells
Biology Area
Immunology, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Galli SJ, et al. 1994. Adv. Immunol. 55:1.
3. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
4. Besmer P, et al. 1986. Nature 320:415.
5. Witte ON. 1990. Cell 63:5.

Gene ID
16590 View all products for this Gene ID
UniProt
View information about CD117 on UniProt.org

Other Formats

View All CD117 Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse CD117 (c-Kit) 2B8 FC
PE/Dazzle™ 594 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) (Maxpar® Ready) 2B8 FC,CyTOF®
Brilliant Violet 711™ anti-mouse CD117 (c-Kit) 2B8 FC
APC/Fire™ 750 anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 510™ anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 785™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 594 anti-mouse CD117 (c-Kit) 2B8 IHC-F,3D IHC
TotalSeq™-A0012 anti-mouse CD117 (c-kit) 2B8 PG
Brilliant Violet 605™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 700 anti-mouse CD117 (c-Kit) 2B8 FC
TotalSeq™-C0012 anti-mouse CD117 (c-Kit) 2B8 PG
TotalSeq™-B0012 anti-mouse CD117 (c-Kit) 2B8 PG
Brilliant Violet 650™ anti-mouse CD117 (c-kit) 2B8 FC
APC anti-mouse CD117 (c-Kit) 2B8 FC
Biotin anti-mouse CD117 (c-Kit) 2B8 FC
FITC anti-mouse CD117 (c-Kit) 2B8 FC
PE anti-mouse CD117 (c-Kit) 2B8 FC
PE/Cyanine5 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Spark NIR™ 685 anti-mouse CD117 (c-kit) 2B8 FC
Alexa Fluor® 488 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 647 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Pacific Blue™ anti-mouse CD117 (c-Kit) 2B8 FC
PerCP/Cyanine5.5 anti-mouse CD117 (c-kit) 2B8 FC
PerCP anti-mouse CD117 (c-kit) 2B8 FC
APC/Cyanine7 anti-mouse CD117 (c-kit) 2B8 FC
Brilliant Violet 421™ anti-mouse CD117 (c-Kit) 2B8 FC,SB
Spark Red™ 718 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 574 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 550 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark UV™ 387 anti-mouse CD117 (c-Kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 581 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 593 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Go To Top Version: 2    Revision Date: 06/28/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account