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APC anti-mouse CD140a Antibody APC anti-mouse CD140a Antibody

Pricing & Availability
Clone
APA5 (See other available formats)
Regulatory Status
RUO
Other Names
PDGF receptor-α, PDGFR-α
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
APA5_APC_030510
Mouse fibroblast NIH/3T3 cells stained with APA5 APC
  • APA5_APC_030510
    Mouse fibroblast NIH/3T3 cells stained with APA5 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
135907 25 µg DKK535
Check Availability


Need larger quantities of this item?
Request Bulk Quote
135908 100 µg DKK1586
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Platelet-derived growth factor receptor-α (PDGFR-α), CD140a, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs: PDGF-AA, PDGF-AB, and PDGF-BB. PDGFRa is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140a is expressed on embryonic tissues and mesenchymal-derived cells of adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse PDGFR-α-hIgG1 recombinant fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported (for relevant formats) applications include: Western Blot, blocking function2, and immunohistochemical staining of paraffin and frozen sections. The LEAF™ purified antibody is recommended for functional assays.

Application References
  1. Takakura N, et al. 1996. J. Invest. Dermatol. 107:770.
  2. Liao C, et al. 2010. J. Clin. Invest. 120:242. (Block)
  3. Chen H, et al. 2015. ASN Neuro 8:7. PubMed.
  4. Miyawaki T, et al. 2004. J Neurosci. 24(37): 8124-34. (IHC-F)
Product Citations
  1. Vasanthakumar A, et al. 2020. Nature. 579:581. PubMed
  2. Hattori Y, et al. 2022. J Neurosci. 42:362. PubMed
  3. Wei Y, et al. 2021. Elife. 10: . PubMed
  4. Jadhav U et al. 2017. Cell stem cell. 21(1):65-77 . PubMed
  5. Agarwalla P, et al. 2022. Nat Biotechnol. 40:1250. PubMed
  6. Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed
  7. Korsunsky I, et al. 2022. Med. 3:481. PubMed
  8. Akasaka H, et al. 2023. JCI Insight. 8:. PubMed
  9. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  10. Corna G, et al. 2016. J Immunol. 197: 1914 - 1925. PubMed
  11. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  12. Wang W, et al. 2019. Cell Metab. 30:174. PubMed
  13. Zhang X, et al. 2020. Cell Reports. 28(3):792-803.e4.. PubMed
  14. Vazquez-Armendariz AI, et al. 2021. STAR Protocols. 2(2):100594. PubMed
  15. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  16. Nawaz A, et al. 2022. Nat Commun. 13:7058. PubMed
  17. Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
  18. Paris AJ, et al. 2020. Nat Cell Biol. 1.747916667. PubMed
  19. Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
  20. Ghelman J, et al. 2021. Glia. 69(11):2699-2716. PubMed
  21. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  22. Wang B,et al. 2017. Cell Discov.. 10.1038/celldisc.2017.36. PubMed
  23. Bahar Halpern K, et al. 2020. Nat Commun. 11:1936. PubMed
  24. Reddy A, et al. 2020. Cell. 183:62. PubMed
  25. Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
  26. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  27. Ko T, et al. 2022. Nat Commun. 13:3275. PubMed
  28. Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
  29. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  30. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  31. Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
  32. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  33. Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
  34. Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
  35. Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
  36. Shi X, et al. 2022. Clin Transl Med. 12:e711. PubMed
  37. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  38. Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
  39. Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
  40. Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
  41. Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
  42. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  43. Hu Y, et al. 2021. EMBO Rep. 22:e52481. PubMed
  44. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  45. Lu Z, et al. 2021. J Clin Invest. 131:. PubMed
  46. Moiseenko A, et al. 2020. Cell Rep. 33:108549. PubMed
  47. Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
  48. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  49. Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
  50. Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
  51. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  52. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  53. Chandrakanthan V, et al. 2016. Proc Natl Acad Sci U S A. 113: 2306-2315. PubMed
  54. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  55. Pinho AV, et al. 2018. Nat Commun. 9:5083. PubMed
  56. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  57. Vasanthakumar A, et al. 2020. Nature. 579:581. PubMed
  58. Hattori Y, et al. 2022. J Neurosci. 42:362. PubMed
  59. Wei Y, et al. 2021. Elife. 10: . PubMed
  60. Jadhav U et al. 2017. Cell stem cell. 21(1):65-77 . PubMed
  61. Agarwalla P, et al. 2022. Nat Biotechnol. 40:1250. PubMed
  62. Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed
  63. Korsunsky I, et al. 2022. Med. 3:481. PubMed
  64. Akasaka H, et al. 2023. JCI Insight. 8:. PubMed
  65. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  66. Corna G, et al. 2016. J Immunol. 197: 1914 - 1925. PubMed
  67. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  68. Wang W, et al. 2019. Cell Metab. 30:174. PubMed
  69. Zhang X, et al. 2020. Cell Reports. 28(3):792-803.e4.. PubMed
  70. Vazquez-Armendariz AI, et al. 2021. STAR Protocols. 2(2):100594. PubMed
  71. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  72. Nawaz A, et al. 2022. Nat Commun. 13:7058. PubMed
  73. Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
  74. Paris AJ, et al. 2020. Nat Cell Biol. 1.747916667. PubMed
  75. Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
  76. Ghelman J, et al. 2021. Glia. 69(11):2699-2716. PubMed
  77. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  78. Wang B,et al. 2017. Cell Discov.. 10.1038/celldisc.2017.36. PubMed
  79. Bahar Halpern K, et al. 2020. Nat Commun. 11:1936. PubMed
  80. Reddy A, et al. 2020. Cell. 183:62. PubMed
  81. Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
  82. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  83. Ko T, et al. 2022. Nat Commun. 13:3275. PubMed
  84. Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
  85. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  86. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  87. Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
  88. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  89. Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
  90. Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
  91. Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
  92. Shi X, et al. 2022. Clin Transl Med. 12:e711. PubMed
  93. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  94. Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
  95. Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
  96. Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
  97. Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
  98. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  99. Hu Y, et al. 2021. EMBO Rep. 22:e52481. PubMed
  100. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  101. Lu Z, et al. 2021. J Clin Invest. 131:. PubMed
  102. Moiseenko A, et al. 2020. Cell Rep. 33:108549. PubMed
  103. Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
  104. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  105. Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
  106. Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
  107. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  108. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  109. Chandrakanthan V, et al. 2016. Proc Natl Acad Sci U S A. 113: 2306-2315. PubMed
  110. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  111. Pinho AV, et al. 2018. Nat Commun. 9:5083. PubMed
  112. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
RRID
AB_2043969 (BioLegend Cat. No. 135907)
AB_2043970 (BioLegend Cat. No. 135908)

Antigen Details

Structure
Alpha chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that forms homo- or hetero-dimers on the surface after ligand binding.
Distribution

Expressed on embryonic tissues and mesenchymal-derived cells of adult mouse.

Function
Play a role in wound healing and act as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils.
Ligand/Receptor
PDGFs
Cell Type
Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Mukouyama YS, et al. 2006. Proc Natl Acad Sci USA. 103(5):1551
2. Miyawaki T, et al. 2004. J Neurosci. 24(37):8124
3. Takakura N, et al. 1997. J Histochem Cytochem. 45(6):883

Gene ID
18595 View all products for this Gene ID
UniProt
View information about CD140a on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
APA5 (See other available formats)
Regulatory Status
RUO
Other Names
PDGF receptor-α, PDGFR-α
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
APA5_APC_030510
Mouse fibroblast NIH/3T3 cells stained with APA5 APC
  • APA5_APC_030510
    Mouse fibroblast NIH/3T3 cells stained with APA5 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
135907 25 µg DKK535
Check Availability


Need larger quantities of this item?
Request Bulk Quote
135908 100 µg DKK1586
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Platelet-derived growth factor receptor-α (PDGFR-α), CD140a, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs: PDGF-AA, PDGF-AB, and PDGF-BB. PDGFRa is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140a is expressed on embryonic tissues and mesenchymal-derived cells of adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse PDGFR-α-hIgG1 recombinant fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported (for relevant formats) applications include: Western Blot, blocking function2, and immunohistochemical staining of paraffin and frozen sections. The LEAF™ purified antibody is recommended for functional assays.

Application References
  1. Takakura N, et al. 1996. J. Invest. Dermatol. 107:770.
  2. Liao C, et al. 2010. J. Clin. Invest. 120:242. (Block)
  3. Chen H, et al. 2015. ASN Neuro 8:7. PubMed.
  4. Miyawaki T, et al. 2004. J Neurosci. 24(37): 8124-34. (IHC-F)
Product Citations
  1. Vasanthakumar A, et al. 2020. Nature. 579:581. PubMed
  2. Hattori Y, et al. 2022. J Neurosci. 42:362. PubMed
  3. Wei Y, et al. 2021. Elife. 10: . PubMed
  4. Jadhav U et al. 2017. Cell stem cell. 21(1):65-77 . PubMed
  5. Agarwalla P, et al. 2022. Nat Biotechnol. 40:1250. PubMed
  6. Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed
  7. Korsunsky I, et al. 2022. Med. 3:481. PubMed
  8. Akasaka H, et al. 2023. JCI Insight. 8:. PubMed
  9. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  10. Corna G, et al. 2016. J Immunol. 197: 1914 - 1925. PubMed
  11. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  12. Wang W, et al. 2019. Cell Metab. 30:174. PubMed
  13. Zhang X, et al. 2020. Cell Reports. 28(3):792-803.e4.. PubMed
  14. Vazquez-Armendariz AI, et al. 2021. STAR Protocols. 2(2):100594. PubMed
  15. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  16. Nawaz A, et al. 2022. Nat Commun. 13:7058. PubMed
  17. Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
  18. Paris AJ, et al. 2020. Nat Cell Biol. 1.747916667. PubMed
  19. Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
  20. Ghelman J, et al. 2021. Glia. 69(11):2699-2716. PubMed
  21. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  22. Wang B,et al. 2017. Cell Discov.. 10.1038/celldisc.2017.36. PubMed
  23. Bahar Halpern K, et al. 2020. Nat Commun. 11:1936. PubMed
  24. Reddy A, et al. 2020. Cell. 183:62. PubMed
  25. Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
  26. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  27. Ko T, et al. 2022. Nat Commun. 13:3275. PubMed
  28. Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
  29. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  30. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  31. Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
  32. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  33. Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
  34. Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
  35. Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
  36. Shi X, et al. 2022. Clin Transl Med. 12:e711. PubMed
  37. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  38. Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
  39. Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
  40. Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
  41. Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
  42. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  43. Hu Y, et al. 2021. EMBO Rep. 22:e52481. PubMed
  44. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  45. Lu Z, et al. 2021. J Clin Invest. 131:. PubMed
  46. Moiseenko A, et al. 2020. Cell Rep. 33:108549. PubMed
  47. Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
  48. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  49. Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
  50. Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
  51. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  52. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  53. Chandrakanthan V, et al. 2016. Proc Natl Acad Sci U S A. 113: 2306-2315. PubMed
  54. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  55. Pinho AV, et al. 2018. Nat Commun. 9:5083. PubMed
  56. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  57. Vasanthakumar A, et al. 2020. Nature. 579:581. PubMed
  58. Hattori Y, et al. 2022. J Neurosci. 42:362. PubMed
  59. Wei Y, et al. 2021. Elife. 10: . PubMed
  60. Jadhav U et al. 2017. Cell stem cell. 21(1):65-77 . PubMed
  61. Agarwalla P, et al. 2022. Nat Biotechnol. 40:1250. PubMed
  62. Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed
  63. Korsunsky I, et al. 2022. Med. 3:481. PubMed
  64. Akasaka H, et al. 2023. JCI Insight. 8:. PubMed
  65. Wietecha MS, et al. 2020. Nat Commun. 2.266666667. PubMed
  66. Corna G, et al. 2016. J Immunol. 197: 1914 - 1925. PubMed
  67. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  68. Wang W, et al. 2019. Cell Metab. 30:174. PubMed
  69. Zhang X, et al. 2020. Cell Reports. 28(3):792-803.e4.. PubMed
  70. Vazquez-Armendariz AI, et al. 2021. STAR Protocols. 2(2):100594. PubMed
  71. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  72. Nawaz A, et al. 2022. Nat Commun. 13:7058. PubMed
  73. Chen YT, et al. 2021. Nat Commun. 12:6845. PubMed
  74. Paris AJ, et al. 2020. Nat Cell Biol. 1.747916667. PubMed
  75. Kinsella S, et al. 2021. Cell Rep. 37:109789. PubMed
  76. Ghelman J, et al. 2021. Glia. 69(11):2699-2716. PubMed
  77. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  78. Wang B,et al. 2017. Cell Discov.. 10.1038/celldisc.2017.36. PubMed
  79. Bahar Halpern K, et al. 2020. Nat Commun. 11:1936. PubMed
  80. Reddy A, et al. 2020. Cell. 183:62. PubMed
  81. Shook BA, et al. 2020. Cell Stem Cell. 26(6):880-895. PubMed
  82. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  83. Ko T, et al. 2022. Nat Commun. 13:3275. PubMed
  84. Taguchi A, et al. 2017. Cell Stem Cell. 21:730. PubMed
  85. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  86. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  87. Rebekka K Schneider et al. 2017. Cell stem cell. 20(6):785-800 . PubMed
  88. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  89. Murakami Y, et al. 2019. Sci Rep. 1.188888889. PubMed
  90. Hiebert P et al. 2018. Developmental cell. 46(2):145-161 . PubMed
  91. Zhao T et al. 2018. Cell stem cell. 23(1):31-45 . PubMed
  92. Shi X, et al. 2022. Clin Transl Med. 12:e711. PubMed
  93. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  94. Jing Y, et al. 2020. Cancer Gene Ther. 27:910. PubMed
  95. Hogarth MW, et al. 2019. Nat Commun. 10:2430. PubMed
  96. Avraham S, et al. 2019. Oncogene. 38:3812. PubMed
  97. Wang QA et al. 2018. Cell metabolism. 28(2):282-288 . PubMed
  98. Nowlan B, et al. 2019. Haematologica. 105:71. PubMed
  99. Hu Y, et al. 2021. EMBO Rep. 22:e52481. PubMed
  100. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  101. Lu Z, et al. 2021. J Clin Invest. 131:. PubMed
  102. Moiseenko A, et al. 2020. Cell Rep. 33:108549. PubMed
  103. Wang W, et al. 2014. Proc Natl Acad Sci U S A. 111:14466. PubMed
  104. Kurowska-Stolarska M, et al. 2016. J Allergy Clin Immunol. S0091-6749(16)31132-0. PubMed
  105. Cangkrama M, et al. 2020. EMBO Mol Med. 12:e11466. PubMed
  106. Grainger N, et al. 2020. J Physiol. 598:3283. PubMed
  107. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  108. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  109. Chandrakanthan V, et al. 2016. Proc Natl Acad Sci U S A. 113: 2306-2315. PubMed
  110. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  111. Pinho AV, et al. 2018. Nat Commun. 9:5083. PubMed
  112. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
RRID
AB_2043969 (BioLegend Cat. No. 135907)
AB_2043970 (BioLegend Cat. No. 135908)

Antigen Details

Structure
Alpha chain of the platelet-derived growth factor receptor, a receptor tyrosine kinase that forms homo- or hetero-dimers on the surface after ligand binding.
Distribution

Expressed on embryonic tissues and mesenchymal-derived cells of adult mouse.

Function
Play a role in wound healing and act as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils.
Ligand/Receptor
PDGFs
Cell Type
Embryonic Stem Cells, Mesenchymal cells, Mesenchymal Stem Cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Mukouyama YS, et al. 2006. Proc Natl Acad Sci USA. 103(5):1551
2. Miyawaki T, et al. 2004. J Neurosci. 24(37):8124
3. Takakura N, et al. 1997. J Histochem Cytochem. 45(6):883

Gene ID
18595 View all products for this Gene ID
UniProt
View information about CD140a on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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