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APC anti-mouse CD62L Antibody APC anti-mouse CD62L Antibody

Pricing & Availability
Clone
MEL-14 (See other available formats)
Regulatory Status
RUO
Other Names
L-selectin, LECAM-1, Ly-22, LAM-1, MEL-14
Isotype
Rat IgG2a, κ
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Product Citations
publications
MEL-14_APC_090707
C57BL/6 mouse splenocytes were stained with CD62L (clone MEL-14) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • MEL-14_APC_090707
    C57BL/6 mouse splenocytes were stained with CD62L (clone MEL-14) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
104411 25 µg DKK393
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104412 100 µg DKK1147
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Description

CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C3H/eb mouse B lymphoma 38C-13
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1-3, complement-dependent cytotoxicity4, in vivo and in vitro blocking of adhesion1-3,5, and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections6. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104457-104462).

Application References
  1. Gallatin WM, et al. 1983. Nature 304:30. (IP, Block)
  2. Siegelman MH, et al. 1990. Cell 61:611. (IP, Block)
  3. Lewinsohn DM, et al. 1987. J. Immunol. 138:4313. (IP, Block)
  4. Iwabuchi K, et al. 1991. Immunobiology 182:161. (CMCD)
  5. Pizcueta P, et al. 1994. Am. J. Pathol. 145:461.
  6. Reichert RA, et al. 1986. J. Immunol. 136:3535. (IHC, FC)
  7. Olver S, et al. 2006. Cancer Res. 66:571.
  8. Fukushima A, et al. 2006. Invest. Ophthalmol. Vis. Sci. 47:657. PubMed
  9. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Lee JW, et al. 2006. Nature Immunol. 8:181.
  12. Shigeta A, et al. 2008. Blood 112:4915 (FC) PubMed
  13. de Vries VC, et al. 2009. Am. J. Transplant. 9:2270 PubMed
Product Citations
  1. Jayachandran R, et al. 2019. Immunity. 50:152. PubMed
  2. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  3. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  4. Ferrao Blanco MN, et al. 2022. Br J Pharmacol. 179:2771. PubMed
  5. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  6. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  7. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  8. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  9. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  10. Du J, et al. 2022. Sci Immunol. 7:eabo5407. PubMed
  11. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  12. Battistello E, et al. 2023. Mol Cell. 83:1216. PubMed
  13. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  14. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  15. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  16. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  17. Scieszka DP, et al. 2023. Respir Res. 24:138. PubMed
  18. Milighetti M, et al. 2023. iScience. 26:106937. PubMed
  19. Cowan J, et al. 2013. J Exp Med. 210:675. PubMed
  20. Ender F, et al. 2017. PLoS One. 12(2):e0172446. PubMed
  21. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  22. Wang J, et al. 2012. Blood. 120:1489. PubMed
  23. Martens R, et al. 2020. Nat Commun. 11:1114. PubMed
  24. Thi VAD, et al. 2019. Mol Cells. 42:869. PubMed
  25. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  26. Shibata K, et al. 2022. Nat Commun. 13:6948. PubMed
  27. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  28. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  29. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  30. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  31. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  32. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  33. Ren S, et al. 2019. Oncol Rep. 41:1509. PubMed
  34. Baptista AP et al. 2019. Immunity. 50(5):1188-1201 . PubMed
  35. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  36. Gilleron J et al. 2018. Cell reports. 25(12):3329-3341 . PubMed
  37. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  38. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  39. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  40. Wei H, et al. 2021. Malar J. 20:89. PubMed
  41. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  42. Zhao Y, et al. 2021. J Biol Chem. 297:101166. PubMed
  43. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  44. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  45. Roy S, et al. 2020. Sci Rep. 10:10992. PubMed
  46. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  47. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  48. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  49. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  50. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  51. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  52. Li Y, et al. 2020. Nat Commun. 11:2781. PubMed
  53. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  54. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  55. Guo Z, et al. 2016. Nat Commun. 7:10307. PubMed
  56. Ma X et al. 2019. Cell Metab. 30(1):143-156 . PubMed
  57. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  58. Phiwpan K, et al. 2015. PLoS One. 10:128198. PubMed
  59. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  60. Deng B, et al. 2022. J Immunother Cancer. 10:. PubMed
  61. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  62. Sinclair LV et al. 2019. Elife. 8 pii: e44210. PubMed
  63. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  64. Kondratieva T, et al. 2020. PLoS One. 15:e0239668. PubMed
  65. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  66. Darragh LB, et al. 2022. Nat Commun. 13:7015. PubMed
  67. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  68. Ruer-Laventie J, et al. 2020. Bio Protoc. e3531:10. PubMed
  69. Lu Y, et al. 2021. Gastroenterology. 161:575. PubMed
  70. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  71. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  72. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  73. Glassman CR, et al. 2021. eLife. 10:00. PubMed
  74. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  75. Su X, et al. 2022. J Transl Med. 20:378. PubMed
  76. Coquery C, et al. 2014. PLoS One. 9:102284. PubMed
  77. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
  78. White C, et al. 2015. J Immunol. 194:697. PubMed
  79. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  80. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  81. Morimoto Y, et al. 2018. Immunity. 49:134. PubMed
  82. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  83. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  84. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  85. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  86. Kretschmer L, et al. 2020. Nat Commun. 0.536805556. PubMed
  87. Ma K, et al. 2022. iScience. 25:104347. PubMed
  88. Borges da Silva H, et al. 2020. Immunity. 53(1):158-171.e6. PubMed
  89. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  90. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  91. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  92. Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
  93. Jenkinson W, et al. 2012. PLoS One. 7:e53416. PubMed
  94. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  95. Daneshmandi S, et al. 2021. Cell Reports. 34(10):108831. PubMed
  96. Roy S, et al. 2021. Nat Commun. 12:3182. PubMed
  97. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  98. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  99. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  100. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
  101. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  102. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  103. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  104. Schaffert S, et al. 2015. J Immunol. 195: 1470-1479. PubMed
  105. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  106. Xu Y, et al. 2016. Nat Commun. 7:12073. PubMed
  107. Webb LM, et al. 2020. J Clin Invest. 130:1683. PubMed
  108. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  109. Lin JD, et al. 2020. Cell Host & Microbe. 27(5):830-840. PubMed
  110. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  111. Parks CA, et al. 2019. Proc Natl Acad Sci U S A. 116:3136. PubMed
  112. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  113. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  114. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  115. Kooijman S, et al. 2015. Am J Physiol Heart Circ Physiol. 309: H646-H654. PubMed
  116. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  117. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  118. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
  119. Louise V Webb et al. 2019. Immunity. 50(2):348-361 . PubMed
  120. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  121. Hodgson R, et al. 2022. Commun Biol. 5:1216. PubMed
  122. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  123. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  124. Yu Z, et al. 2021. Biomed Res Int. 2021:9958745. PubMed
  125. Bae S, et al. 2021. Cell Reports. 35(11):109264. PubMed
  126. Jayachandran R, et al. 2019. Immunity. 50:152. PubMed
  127. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  128. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  129. Ferrao Blanco MN, et al. 2022. Br J Pharmacol. 179:2771. PubMed
  130. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  131. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  132. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  133. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  134. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  135. Du J, et al. 2022. Sci Immunol. 7:eabo5407. PubMed
  136. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  137. Battistello E, et al. 2023. Mol Cell. 83:1216. PubMed
  138. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  139. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  140. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  141. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  142. Scieszka DP, et al. 2023. Respir Res. 24:138. PubMed
  143. Milighetti M, et al. 2023. iScience. 26:106937. PubMed
  144. Cowan J, et al. 2013. J Exp Med. 210:675. PubMed
  145. Ender F, et al. 2017. PLoS One. 12(2):e0172446. PubMed
  146. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  147. Wang J, et al. 2012. Blood. 120:1489. PubMed
  148. Martens R, et al. 2020. Nat Commun. 11:1114. PubMed
  149. Thi VAD, et al. 2019. Mol Cells. 42:869. PubMed
  150. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  151. Shibata K, et al. 2022. Nat Commun. 13:6948. PubMed
  152. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  153. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  154. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  155. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  156. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  157. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  158. Ren S, et al. 2019. Oncol Rep. 41:1509. PubMed
  159. Baptista AP et al. 2019. Immunity. 50(5):1188-1201 . PubMed
  160. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  161. Gilleron J et al. 2018. Cell reports. 25(12):3329-3341 . PubMed
  162. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  163. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  164. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  165. Wei H, et al. 2021. Malar J. 20:89. PubMed
  166. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  167. Zhao Y, et al. 2021. J Biol Chem. 297:101166. PubMed
  168. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  169. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  170. Roy S, et al. 2020. Sci Rep. 10:10992. PubMed
  171. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  172. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  173. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  174. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  175. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  176. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  177. Li Y, et al. 2020. Nat Commun. 11:2781. PubMed
  178. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  179. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  180. Guo Z, et al. 2016. Nat Commun. 7:10307. PubMed
  181. Ma X et al. 2019. Cell Metab. 30(1):143-156 . PubMed
  182. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  183. Phiwpan K, et al. 2015. PLoS One. 10:128198. PubMed
  184. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  185. Deng B, et al. 2022. J Immunother Cancer. 10:. PubMed
  186. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  187. Sinclair LV et al. 2019. Elife. 8 pii: e44210. PubMed
  188. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  189. Kondratieva T, et al. 2020. PLoS One. 15:e0239668. PubMed
  190. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  191. Darragh LB, et al. 2022. Nat Commun. 13:7015. PubMed
  192. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  193. Ruer-Laventie J, et al. 2020. Bio Protoc. e3531:10. PubMed
  194. Lu Y, et al. 2021. Gastroenterology. 161:575. PubMed
  195. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  196. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  197. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  198. Glassman CR, et al. 2021. eLife. 10:00. PubMed
  199. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  200. Su X, et al. 2022. J Transl Med. 20:378. PubMed
  201. Coquery C, et al. 2014. PLoS One. 9:102284. PubMed
  202. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
  203. White C, et al. 2015. J Immunol. 194:697. PubMed
  204. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  205. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  206. Morimoto Y, et al. 2018. Immunity. 49:134. PubMed
  207. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  208. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  209. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  210. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  211. Kretschmer L, et al. 2020. Nat Commun. 0.536805556. PubMed
  212. Ma K, et al. 2022. iScience. 25:104347. PubMed
  213. Borges da Silva H, et al. 2020. Immunity. 53(1):158-171.e6. PubMed
  214. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  215. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  216. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  217. Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
  218. Jenkinson W, et al. 2012. PLoS One. 7:e53416. PubMed
  219. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  220. Daneshmandi S, et al. 2021. Cell Reports. 34(10):108831. PubMed
  221. Roy S, et al. 2021. Nat Commun. 12:3182. PubMed
  222. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  223. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  224. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  225. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
  226. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  227. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  228. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  229. Schaffert S, et al. 2015. J Immunol. 195: 1470-1479. PubMed
  230. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  231. Xu Y, et al. 2016. Nat Commun. 7:12073. PubMed
  232. Webb LM, et al. 2020. J Clin Invest. 130:1683. PubMed
  233. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  234. Lin JD, et al. 2020. Cell Host & Microbe. 27(5):830-840. PubMed
  235. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  236. Parks CA, et al. 2019. Proc Natl Acad Sci U S A. 116:3136. PubMed
  237. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  238. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  239. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  240. Kooijman S, et al. 2015. Am J Physiol Heart Circ Physiol. 309: H646-H654. PubMed
  241. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  242. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  243. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
  244. Louise V Webb et al. 2019. Immunity. 50(2):348-361 . PubMed
  245. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  246. Hodgson R, et al. 2022. Commun Biol. 5:1216. PubMed
  247. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  248. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  249. Yu Z, et al. 2021. Biomed Res Int. 2021:9958745. PubMed
  250. Bae S, et al. 2021. Cell Reports. 35(11):109264. PubMed
RRID
AB_313098 (BioLegend Cat. No. 104411)
AB_313099 (BioLegend Cat. No. 104412)

Antigen Details

Structure
Selectin, 95 kD (neutrophils) or 74 kD (lymphocytes)
Distribution

Subsets of B and T cells, monocytes, granulocytes, subset of NK cells

Function
Lymphocyte homing to HEV, rolling on activated endothelium
Ligand/Receptor
CD34, GlyCAM-1, MAdCAM-1
Cell Type
B cells, Granulocytes, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Kishimoto TK, et al. 1990. P. Natl. Acad. Sci. USA 87:2244.
3. Tedder TF, et al. 1995. J. Exp. Med. 181:2259.

Gene ID
20343 View all products for this Gene ID
UniProt
View information about CD62L on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD62L Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse CD62L MEL-14 FC
Brilliant Violet 711™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 785™ anti-mouse CD62L MEL-14 FC
PE/Dazzle™ 594 anti-mouse CD62L MEL-14 FC
APC/Fire™ 750 anti-mouse CD62L MEL-14 FC
TotalSeq™-A0112 anti-mouse CD62L MEL-14 PG
Brilliant Violet 650™ anti-mouse CD62L MEL-14 FC
TotalSeq™-C0112 anti-mouse CD62L MEL-14 PG
Ultra-LEAF™ Purified anti-mouse CD62L MEL-14 FC,CyTOF®,IHC-F,IP,CMCD,Block
KIRAVIA Blue 520™ anti-mouse CD62L MEL-14 FC
TotalSeq™-B0112 anti-mouse CD62L MEL-14 PG
APC anti-mouse CD62L MEL-14 FC
Biotin anti-mouse CD62L MEL-14 FC
FITC anti-mouse CD62L MEL-14 FC
PE anti-mouse CD62L MEL-14 FC
PE/Cyanine5 anti-mouse CD62L MEL-14 FC
Purified anti-mouse CD62L MEL-14 FC,CyTOF®,IHC-F,IP
Alexa Fluor® 488 anti-mouse CD62L MEL-14 FC
Alexa Fluor® 647 anti-mouse CD62L MEL-14 FC
Pacific Blue™ anti-mouse CD62L MEL-14 FC
Alexa Fluor® 700 anti-mouse CD62L MEL-14 FC
APC/Cyanine7 anti-mouse CD62L MEL-14 FC
PerCP/Cyanine5.5 anti-mouse CD62L MEL-14 FC
PerCP anti-mouse CD62L MEL-14 FC
Brilliant Violet 421™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 570™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 605™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 510™ anti-mouse CD62L MEL-14 FC
Purified anti-mouse CD62L (Maxpar® Ready) MEL-14 FC,CyTOF®
Spark Red™ 718 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Spark PLUS B550™ anti-mouse CD62L MEL-14 FC
Spark YG™ 581 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Spark YG™ 593 anti-mouse CD62L (Flexi-Fluor™) Antibody MEL-14 FC
Spark NIR™ 685 anti-mouse CD62L (Flexi-Fluor™) Antibody MEL-14 FC
Spark UV™ 387 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
MEL-14 (See other available formats)
Regulatory Status
RUO
Other Names
L-selectin, LECAM-1, Ly-22, LAM-1, MEL-14
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
MEL-14_APC_090707
C57BL/6 mouse splenocytes were stained with CD62L (clone MEL-14) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • MEL-14_APC_090707
    C57BL/6 mouse splenocytes were stained with CD62L (clone MEL-14) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
104411 25 µg DKK393
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104412 100 µg DKK1147
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Description

CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C3H/eb mouse B lymphoma 38C-13
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1-3, complement-dependent cytotoxicity4, in vivo and in vitro blocking of adhesion1-3,5, and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections6. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104457-104462).

Application References
  1. Gallatin WM, et al. 1983. Nature 304:30. (IP, Block)
  2. Siegelman MH, et al. 1990. Cell 61:611. (IP, Block)
  3. Lewinsohn DM, et al. 1987. J. Immunol. 138:4313. (IP, Block)
  4. Iwabuchi K, et al. 1991. Immunobiology 182:161. (CMCD)
  5. Pizcueta P, et al. 1994. Am. J. Pathol. 145:461.
  6. Reichert RA, et al. 1986. J. Immunol. 136:3535. (IHC, FC)
  7. Olver S, et al. 2006. Cancer Res. 66:571.
  8. Fukushima A, et al. 2006. Invest. Ophthalmol. Vis. Sci. 47:657. PubMed
  9. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  10. Chappaz S, et al. 2007. Blood doi:10.1182/blood-2007-02-074245. (FC) PubMed
  11. Lee JW, et al. 2006. Nature Immunol. 8:181.
  12. Shigeta A, et al. 2008. Blood 112:4915 (FC) PubMed
  13. de Vries VC, et al. 2009. Am. J. Transplant. 9:2270 PubMed
Product Citations
  1. Jayachandran R, et al. 2019. Immunity. 50:152. PubMed
  2. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  3. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  4. Ferrao Blanco MN, et al. 2022. Br J Pharmacol. 179:2771. PubMed
  5. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  6. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  7. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  8. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  9. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  10. Du J, et al. 2022. Sci Immunol. 7:eabo5407. PubMed
  11. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  12. Battistello E, et al. 2023. Mol Cell. 83:1216. PubMed
  13. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  14. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  15. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  16. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  17. Scieszka DP, et al. 2023. Respir Res. 24:138. PubMed
  18. Milighetti M, et al. 2023. iScience. 26:106937. PubMed
  19. Cowan J, et al. 2013. J Exp Med. 210:675. PubMed
  20. Ender F, et al. 2017. PLoS One. 12(2):e0172446. PubMed
  21. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  22. Wang J, et al. 2012. Blood. 120:1489. PubMed
  23. Martens R, et al. 2020. Nat Commun. 11:1114. PubMed
  24. Thi VAD, et al. 2019. Mol Cells. 42:869. PubMed
  25. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  26. Shibata K, et al. 2022. Nat Commun. 13:6948. PubMed
  27. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  28. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  29. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  30. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  31. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  32. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  33. Ren S, et al. 2019. Oncol Rep. 41:1509. PubMed
  34. Baptista AP et al. 2019. Immunity. 50(5):1188-1201 . PubMed
  35. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  36. Gilleron J et al. 2018. Cell reports. 25(12):3329-3341 . PubMed
  37. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  38. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  39. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  40. Wei H, et al. 2021. Malar J. 20:89. PubMed
  41. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  42. Zhao Y, et al. 2021. J Biol Chem. 297:101166. PubMed
  43. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  44. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  45. Roy S, et al. 2020. Sci Rep. 10:10992. PubMed
  46. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  47. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  48. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  49. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  50. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  51. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  52. Li Y, et al. 2020. Nat Commun. 11:2781. PubMed
  53. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  54. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  55. Guo Z, et al. 2016. Nat Commun. 7:10307. PubMed
  56. Ma X et al. 2019. Cell Metab. 30(1):143-156 . PubMed
  57. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  58. Phiwpan K, et al. 2015. PLoS One. 10:128198. PubMed
  59. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  60. Deng B, et al. 2022. J Immunother Cancer. 10:. PubMed
  61. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  62. Sinclair LV et al. 2019. Elife. 8 pii: e44210. PubMed
  63. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  64. Kondratieva T, et al. 2020. PLoS One. 15:e0239668. PubMed
  65. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  66. Darragh LB, et al. 2022. Nat Commun. 13:7015. PubMed
  67. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  68. Ruer-Laventie J, et al. 2020. Bio Protoc. e3531:10. PubMed
  69. Lu Y, et al. 2021. Gastroenterology. 161:575. PubMed
  70. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  71. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  72. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  73. Glassman CR, et al. 2021. eLife. 10:00. PubMed
  74. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  75. Su X, et al. 2022. J Transl Med. 20:378. PubMed
  76. Coquery C, et al. 2014. PLoS One. 9:102284. PubMed
  77. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
  78. White C, et al. 2015. J Immunol. 194:697. PubMed
  79. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  80. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  81. Morimoto Y, et al. 2018. Immunity. 49:134. PubMed
  82. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  83. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  84. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  85. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  86. Kretschmer L, et al. 2020. Nat Commun. 0.536805556. PubMed
  87. Ma K, et al. 2022. iScience. 25:104347. PubMed
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  89. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  90. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  91. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  92. Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
  93. Jenkinson W, et al. 2012. PLoS One. 7:e53416. PubMed
  94. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  95. Daneshmandi S, et al. 2021. Cell Reports. 34(10):108831. PubMed
  96. Roy S, et al. 2021. Nat Commun. 12:3182. PubMed
  97. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  98. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  99. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  100. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
  101. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  102. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  103. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  104. Schaffert S, et al. 2015. J Immunol. 195: 1470-1479. PubMed
  105. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  106. Xu Y, et al. 2016. Nat Commun. 7:12073. PubMed
  107. Webb LM, et al. 2020. J Clin Invest. 130:1683. PubMed
  108. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  109. Lin JD, et al. 2020. Cell Host & Microbe. 27(5):830-840. PubMed
  110. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  111. Parks CA, et al. 2019. Proc Natl Acad Sci U S A. 116:3136. PubMed
  112. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  113. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  114. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  115. Kooijman S, et al. 2015. Am J Physiol Heart Circ Physiol. 309: H646-H654. PubMed
  116. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  117. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  118. Katsuyama T, et al. 2021. Cell Reports. 36(1):109339. PubMed
  119. Louise V Webb et al. 2019. Immunity. 50(2):348-361 . PubMed
  120. Chen S, et al. 2018. Nat Commun. 9:5298. PubMed
  121. Hodgson R, et al. 2022. Commun Biol. 5:1216. PubMed
  122. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  123. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  124. Yu Z, et al. 2021. Biomed Res Int. 2021:9958745. PubMed
  125. Bae S, et al. 2021. Cell Reports. 35(11):109264. PubMed
  126. Jayachandran R, et al. 2019. Immunity. 50:152. PubMed
  127. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  128. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  129. Ferrao Blanco MN, et al. 2022. Br J Pharmacol. 179:2771. PubMed
  130. Chakraborty P, et al. 2022. Cancer Res. 82:1969. PubMed
  131. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  132. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  133. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  134. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  135. Du J, et al. 2022. Sci Immunol. 7:eabo5407. PubMed
  136. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  137. Battistello E, et al. 2023. Mol Cell. 83:1216. PubMed
  138. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  139. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  140. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  141. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  142. Scieszka DP, et al. 2023. Respir Res. 24:138. PubMed
  143. Milighetti M, et al. 2023. iScience. 26:106937. PubMed
  144. Cowan J, et al. 2013. J Exp Med. 210:675. PubMed
  145. Ender F, et al. 2017. PLoS One. 12(2):e0172446. PubMed
  146. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  147. Wang J, et al. 2012. Blood. 120:1489. PubMed
  148. Martens R, et al. 2020. Nat Commun. 11:1114. PubMed
  149. Thi VAD, et al. 2019. Mol Cells. 42:869. PubMed
  150. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  151. Shibata K, et al. 2022. Nat Commun. 13:6948. PubMed
  152. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  153. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  154. Di Martile M, et al. 2020. J Immunother Cancer. 8:. PubMed
  155. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  156. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  157. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  158. Ren S, et al. 2019. Oncol Rep. 41:1509. PubMed
  159. Baptista AP et al. 2019. Immunity. 50(5):1188-1201 . PubMed
  160. Kim CJ, et al. 2018. Immunity. 49:1034. PubMed
  161. Gilleron J et al. 2018. Cell reports. 25(12):3329-3341 . PubMed
  162. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  163. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  164. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  165. Wei H, et al. 2021. Malar J. 20:89. PubMed
  166. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  167. Zhao Y, et al. 2021. J Biol Chem. 297:101166. PubMed
  168. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  169. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  170. Roy S, et al. 2020. Sci Rep. 10:10992. PubMed
  171. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  172. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  173. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  174. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  175. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  176. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  177. Li Y, et al. 2020. Nat Commun. 11:2781. PubMed
  178. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  179. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  180. Guo Z, et al. 2016. Nat Commun. 7:10307. PubMed
  181. Ma X et al. 2019. Cell Metab. 30(1):143-156 . PubMed
  182. Yu Y, et al. 2022. Nat Commun. 13:6357. PubMed
  183. Phiwpan K, et al. 2015. PLoS One. 10:128198. PubMed
  184. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  185. Deng B, et al. 2022. J Immunother Cancer. 10:. PubMed
  186. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  187. Sinclair LV et al. 2019. Elife. 8 pii: e44210. PubMed
  188. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  189. Kondratieva T, et al. 2020. PLoS One. 15:e0239668. PubMed
  190. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  191. Darragh LB, et al. 2022. Nat Commun. 13:7015. PubMed
  192. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  193. Ruer-Laventie J, et al. 2020. Bio Protoc. e3531:10. PubMed
  194. Lu Y, et al. 2021. Gastroenterology. 161:575. PubMed
  195. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  196. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  197. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  198. Glassman CR, et al. 2021. eLife. 10:00. PubMed
  199. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  200. Su X, et al. 2022. J Transl Med. 20:378. PubMed
  201. Coquery C, et al. 2014. PLoS One. 9:102284. PubMed
  202. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
  203. White C, et al. 2015. J Immunol. 194:697. PubMed
  204. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  205. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  206. Morimoto Y, et al. 2018. Immunity. 49:134. PubMed
  207. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  208. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  209. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  210. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  211. Kretschmer L, et al. 2020. Nat Commun. 0.536805556. PubMed
  212. Ma K, et al. 2022. iScience. 25:104347. PubMed
  213. Borges da Silva H, et al. 2020. Immunity. 53(1):158-171.e6. PubMed
  214. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  215. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  216. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  217. Resch TK, et al. 2018. Sci Rep. 0.722916667. PubMed
  218. Jenkinson W, et al. 2012. PLoS One. 7:e53416. PubMed
  219. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  220. Daneshmandi S, et al. 2021. Cell Reports. 34(10):108831. PubMed
  221. Roy S, et al. 2021. Nat Commun. 12:3182. PubMed
  222. Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed
  223. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  224. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  225. Shimba A et al. 2018. Immunity. 48(2):286-298 . PubMed
  226. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  227. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  228. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  229. Schaffert S, et al. 2015. J Immunol. 195: 1470-1479. PubMed
  230. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  231. Xu Y, et al. 2016. Nat Commun. 7:12073. PubMed
  232. Webb LM, et al. 2020. J Clin Invest. 130:1683. PubMed
  233. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  234. Lin JD, et al. 2020. Cell Host & Microbe. 27(5):830-840. PubMed
  235. Chakraborty P, et al. 2020. Cell Reports. 28(7):1879-1893.e7.. PubMed
  236. Parks CA, et al. 2019. Proc Natl Acad Sci U S A. 116:3136. PubMed
  237. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  238. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  239. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  240. Kooijman S, et al. 2015. Am J Physiol Heart Circ Physiol. 309: H646-H654. PubMed
  241. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  242. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
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RRID
AB_313098 (BioLegend Cat. No. 104411)
AB_313099 (BioLegend Cat. No. 104412)

Antigen Details

Structure
Selectin, 95 kD (neutrophils) or 74 kD (lymphocytes)
Distribution

Subsets of B and T cells, monocytes, granulocytes, subset of NK cells

Function
Lymphocyte homing to HEV, rolling on activated endothelium
Ligand/Receptor
CD34, GlyCAM-1, MAdCAM-1
Cell Type
B cells, Granulocytes, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Kishimoto TK, et al. 1990. P. Natl. Acad. Sci. USA 87:2244.
3. Tedder TF, et al. 1995. J. Exp. Med. 181:2259.

Gene ID
20343 View all products for this Gene ID
UniProt
View information about CD62L on UniProt.org

Other Formats

View All CD62L Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse CD62L MEL-14 FC
Brilliant Violet 711™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 785™ anti-mouse CD62L MEL-14 FC
PE/Dazzle™ 594 anti-mouse CD62L MEL-14 FC
APC/Fire™ 750 anti-mouse CD62L MEL-14 FC
TotalSeq™-A0112 anti-mouse CD62L MEL-14 PG
Brilliant Violet 650™ anti-mouse CD62L MEL-14 FC
TotalSeq™-C0112 anti-mouse CD62L MEL-14 PG
Ultra-LEAF™ Purified anti-mouse CD62L MEL-14 FC,CyTOF®,IHC-F,IP,CMCD,Block
KIRAVIA Blue 520™ anti-mouse CD62L MEL-14 FC
TotalSeq™-B0112 anti-mouse CD62L MEL-14 PG
APC anti-mouse CD62L MEL-14 FC
Biotin anti-mouse CD62L MEL-14 FC
FITC anti-mouse CD62L MEL-14 FC
PE anti-mouse CD62L MEL-14 FC
PE/Cyanine5 anti-mouse CD62L MEL-14 FC
Purified anti-mouse CD62L MEL-14 FC,CyTOF®,IHC-F,IP
Alexa Fluor® 488 anti-mouse CD62L MEL-14 FC
Alexa Fluor® 647 anti-mouse CD62L MEL-14 FC
Pacific Blue™ anti-mouse CD62L MEL-14 FC
Alexa Fluor® 700 anti-mouse CD62L MEL-14 FC
APC/Cyanine7 anti-mouse CD62L MEL-14 FC
PerCP/Cyanine5.5 anti-mouse CD62L MEL-14 FC
PerCP anti-mouse CD62L MEL-14 FC
Brilliant Violet 421™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 570™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 605™ anti-mouse CD62L MEL-14 FC
Brilliant Violet 510™ anti-mouse CD62L MEL-14 FC
Purified anti-mouse CD62L (Maxpar® Ready) MEL-14 FC,CyTOF®
Spark Red™ 718 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Spark PLUS B550™ anti-mouse CD62L MEL-14 FC
Spark YG™ 581 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Spark YG™ 593 anti-mouse CD62L (Flexi-Fluor™) Antibody MEL-14 FC
Spark NIR™ 685 anti-mouse CD62L (Flexi-Fluor™) Antibody MEL-14 FC
Spark UV™ 387 anti-mouse CD62L (Flexi-Fluor™) MEL-14 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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