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Purified anti-mouse CD11c Antibody Purified anti-mouse CD11c Antibody

Pricing & Availability
Clone
N418 (See other available formats)
Regulatory Status
RUO
Other Names
αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype
Armenian Hamster IgG
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Product Citations
publications
N418_A_Purified_Pos_071006.jpg
C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_A_Purified_Pos_071006.jpg
    C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_B_Purified_Neg_071006.jpg
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Cat # Size Price Quantity Check Availability Save
117301 50 µg DKK214
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117302 500 µg DKK838
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Description

CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IP, IHC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References
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  226. Fu H, et al. 2019. Front Immunol. 10:271. PubMed
  227. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  228. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
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  230. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  231. Molica F,et al. 2017. Sci Rep.. 10.1038/s41598-017-14130-4. PubMed
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  237. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  238. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
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  248. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  249. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  250. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  251. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  252. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  253. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  254. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
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  259. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
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  263. Cepeda JR, et al. 2020. MAbs. 12:1836714. PubMed
  264. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  265. Rebouças A, et al. 2021. Microorganisms. 9:. PubMed
  266. Rigo MM, et al. 2020. FEBS J. :. PubMed
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  268. Wikstrom M, et al. 2006. J Immunol. 177:913. PubMed
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  270. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  271. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  272. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  273. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  274. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  275. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  276. von Roemeling CA, et al. 2020. Nat Commun. 11:1508. PubMed
  277. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  278. Eisenach P, et al. 2010. J Cell Sci. 123:4182. PubMed
  279. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  280. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  281. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  282. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  283. Benson M, et al. 2007. J Exp Med. 204:1765. PubMed
  284. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  285. García G, et al. 2020. Am J Pathol. 844:190. PubMed
  286. Leppin K, et al. 2014. Invest Ophthalmol Vis Sci . 55:3603. PubMed
  287. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  288. Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed
  289. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
  290. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  291. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  292. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  293. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  294. Chen B, et al. 2021. Cell. 184:6262. PubMed
  295. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  296. Hung LY, et al. 2019. J Immunol. 203:511. PubMed
  297. Rios–Doria J, et al. 2017. Cancer Res. 77:2686. PubMed
  298. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  299. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  300. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  301. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  302. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  303. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  304. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
RRID
AB_313770 (BioLegend Cat. No. 117301)
AB_313771 (BioLegend Cat. No. 117302)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD11c Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse CD11c N418 FC
Biotin anti-mouse CD11c N418 FC,IHC-F
FITC anti-mouse CD11c N418 FC
PE anti-mouse CD11c N418 FC
Purified anti-mouse CD11c N418 FC,CyTOF®,IP,IHC
Brilliant Violet 711™ anti-mouse CD11c N418 FC
APC/Fire™ 750 anti-mouse CD11c N418 FC
TotalSeq™-A0106 anti-mouse CD11c N418 PG
Brilliant Violet 750™ anti-mouse CD11c N418 FC
TotalSeq™-C0106 anti-mouse CD11c N418 PG
TotalSeq™-B0106 anti-mouse CD11c N418 PG
KIRAVIA Blue 520™ anti-mouse CD11c N418 FC
Spark Blue™ 550 anti-mouse CD11c N418 FC
Alexa Fluor® 488 anti-mouse CD11c N418 FC
Alexa Fluor® 647 anti-mouse CD11c N418 FC,IHC,ICC,3D IHC
PE/Cyanine5 anti-mouse CD11c N418 FC
PE/Cyanine7 anti-mouse CD11c N418 FC
Brilliant Violet 605™ anti-mouse CD11c N418 FC
Alexa Fluor® 700 anti-mouse CD11c N418 FC
Pacific Blue™ anti-mouse CD11c N418 FC
APC/Cyanine7 anti-mouse CD11c N418 FC
PerCP/Cyanine5.5 anti-mouse CD11c N418 FC
PerCP anti-mouse CD11c N418 FC
Brilliant Violet 421™ anti-mouse CD11c N418 FC,IHC
Brilliant Violet 570™ anti-mouse CD11c N418 FC
Brilliant Violet 785™ anti-mouse CD11c N418 FC
Brilliant Violet 510™ anti-mouse CD11c N418 FC
Brilliant Violet 650™ anti-mouse CD11c N418 FC
PE/Dazzle™ 594 anti-mouse CD11c N418 FC
Alexa Fluor® 594 anti-mouse CD11c N418 IHC-F,3D IHC
Purified anti-mouse CD11c (Maxpar® Ready) N418 FC,CyTOF®
Spark NIR™ 685 anti-mouse CD11c N418 FC
Spark UV™ 387 anti-mouse CD11c N418 FC
Spark Red™ 718 anti-mouse CD11c N418 FC
Spark Blue™ 515 anti-mouse CD11c N418 FC
PerCP/Fire™ 806 anti-mouse CD11c N418 FC
Spark PLUS UV395™ anti-mouse CD11c N418 FC
Spark Blue™ 574 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark PLUS B550™ anti-mouse CD11c N418 FC
APC/Fire™ 810 anti-mouse CD11c Antibody N418 FC
PE/Fire™ 640 anti-mouse CD11c Antibody N418 FC
Spark YG™ 581 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark YG™ 593 anti-mouse CD11c (Flexi-Fluor™) Antibody N418 FC
Spark PLUS V475™ anti-mouse CD11c Antibody N418 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
N418 (See other available formats)
Regulatory Status
RUO
Other Names
αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
N418_A_Purified_Pos_071006.jpg
C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_A_Purified_Pos_071006.jpg
    C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_B_Purified_Neg_071006.jpg
Compare all formats
Cat # Size Price Quantity Check Availability Save
117301 50 µg DKK214
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117302 500 µg DKK838
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Description

CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IP, IHC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References
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  4. Ma XT, et al. 2006. Cancer Research 66:1169.
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  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
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  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
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  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  24. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
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  12. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  13. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  14. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  15. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  16. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
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  146. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  147. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  148. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  149. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  150. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  151. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  152. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  153. Dallari S, et al. 2017. Nat Commun. 8:14830. PubMed
  154. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  155. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  156. Martinez LE, et al. 2020. J Virol. 94:00:00. PubMed
  157. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  158. Aguilar EG, et al. 2021. Blood Adv. 5:4219. PubMed
  159. Owen KL, et al. 2020. EMBO Rep. 21:e50162. PubMed
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  163. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  164. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  165. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  166. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  167. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
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  170. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  171. Liedmann S, et al. 2022. Mol Cell. 82:2401. PubMed
  172. Campisi L, et al. 2022. Nature. 606:945. PubMed
  173. Chi H, et al. 2022. Cells. 11: . PubMed
  174. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
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RRID
AB_313770 (BioLegend Cat. No. 117301)
AB_313771 (BioLegend Cat. No. 117302)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Other Formats

View All CD11c Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse CD11c N418 FC
Biotin anti-mouse CD11c N418 FC,IHC-F
FITC anti-mouse CD11c N418 FC
PE anti-mouse CD11c N418 FC
Purified anti-mouse CD11c N418 FC,CyTOF®,IP,IHC
Brilliant Violet 711™ anti-mouse CD11c N418 FC
APC/Fire™ 750 anti-mouse CD11c N418 FC
TotalSeq™-A0106 anti-mouse CD11c N418 PG
Brilliant Violet 750™ anti-mouse CD11c N418 FC
TotalSeq™-C0106 anti-mouse CD11c N418 PG
TotalSeq™-B0106 anti-mouse CD11c N418 PG
KIRAVIA Blue 520™ anti-mouse CD11c N418 FC
Spark Blue™ 550 anti-mouse CD11c N418 FC
Alexa Fluor® 488 anti-mouse CD11c N418 FC
Alexa Fluor® 647 anti-mouse CD11c N418 FC,IHC,ICC,3D IHC
PE/Cyanine5 anti-mouse CD11c N418 FC
PE/Cyanine7 anti-mouse CD11c N418 FC
Brilliant Violet 605™ anti-mouse CD11c N418 FC
Alexa Fluor® 700 anti-mouse CD11c N418 FC
Pacific Blue™ anti-mouse CD11c N418 FC
APC/Cyanine7 anti-mouse CD11c N418 FC
PerCP/Cyanine5.5 anti-mouse CD11c N418 FC
PerCP anti-mouse CD11c N418 FC
Brilliant Violet 421™ anti-mouse CD11c N418 FC,IHC
Brilliant Violet 570™ anti-mouse CD11c N418 FC
Brilliant Violet 785™ anti-mouse CD11c N418 FC
Brilliant Violet 510™ anti-mouse CD11c N418 FC
Brilliant Violet 650™ anti-mouse CD11c N418 FC
PE/Dazzle™ 594 anti-mouse CD11c N418 FC
Alexa Fluor® 594 anti-mouse CD11c N418 IHC-F,3D IHC
Purified anti-mouse CD11c (Maxpar® Ready) N418 FC,CyTOF®
Spark NIR™ 685 anti-mouse CD11c N418 FC
Spark UV™ 387 anti-mouse CD11c N418 FC
Spark Red™ 718 anti-mouse CD11c N418 FC
Spark Blue™ 515 anti-mouse CD11c N418 FC
PerCP/Fire™ 806 anti-mouse CD11c N418 FC
Spark PLUS UV395™ anti-mouse CD11c N418 FC
Spark Blue™ 574 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark PLUS B550™ anti-mouse CD11c N418 FC
APC/Fire™ 810 anti-mouse CD11c Antibody N418 FC
PE/Fire™ 640 anti-mouse CD11c Antibody N418 FC
Spark YG™ 581 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark YG™ 593 anti-mouse CD11c (Flexi-Fluor™) Antibody N418 FC
Spark PLUS V475™ anti-mouse CD11c Antibody N418 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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