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Purified anti-human LRRK2 Antibody

Pricing & Availability
Clone
Poly23A19 (See other available formats)
Regulatory Status
RUO
Other Names
Leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Isotype
Goat Polyclonal IgG
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Product Citations
publications
Poly23A19_PURE_LRRK-2_ELISA_092425
Direct ELISA showing purified anti-human LRRK2 (clone Poly23A19) bound plate immobilized recombinant human LRRK2. The wells were incubated with serially diluted primary antibody at room temperature for 2 hours in 1% BSA-PBS, followed by incubation with HRP Doney anti-goat. TMB High Sensitivity Substrate Solution (Cat No. 421501) was used for detection. Absorbance was measured at 450nm.
  • Poly23A19_PURE_LRRK-2_ELISA_092425
    Direct ELISA showing purified anti-human LRRK2 (clone Poly23A19) bound plate immobilized recombinant human LRRK2. The wells were incubated with serially diluted primary antibody at room temperature for 2 hours in 1% BSA-PBS, followed by incubation with HRP Doney anti-goat. TMB High Sensitivity Substrate Solution (Cat No. 421501) was used for detection. Absorbance was measured at 450nm.
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612162 100 µg 360 CHF
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Description

Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Polyclonal
Host Species
Goat
Immunogen
Recombinant Human Lrrk2 (carrier-free)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

Direct ELISA - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.

Additional Product Notes

This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone Poly23A19) could function as a capture and detection antibody as a self-pairing antibody and using Recombinant Human LRRK2 (carrier-free) protein as the assay standard. For assay development flexibility purposes, this product is provided as a purified format.

Antigen Details

Structure
Dimer
Distribution

Tissue distribution: Lung, Kidney, parathyroid gland, CNS
Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome

Function
LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.
Biology Area
Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family
Mitochondrial Markers
Antigen References
  1. Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600.
  2. Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34.
  3. Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511–25.
  4. Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394–406.
  5. Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474–84.
Gene ID
120892 View all products for this Gene ID
UniProt
View information about LRRK-2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09.24.2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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