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- Clone
- S22005D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- OSMRβ, IL-31R
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
U-87 MG cells (human glioblastoma cell line) were stained with purified anti-human OSMR (clone S22005D) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 321809 | 100 µg | 340€ | ||||
Oncostatin M receptor (OSMR), also known as IL-31 receptor subunit beta, is a member of the IL-6 receptor family. It is expressed in bone marrow, endothelium, liver, lung and skin tissues. OSMR forms the type II OSM receptor complex when paired with interleukin 6 signal transducer (gp130) and forms the IL-31 receptor when complexed with interleukin 31 receptor A (IL31RA). The binding of OSM to either of these receptors triggers activation of the JAK-STAT signaling pathway.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human OSMR protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S22005D does not affect the binding of clone S22005H on target cells.
Antigen Details
- Structure
- Transmembrane immunoglobulin-like glycoprotein, 130 kD
- Distribution
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Hepatocytes, mesothelial cells, glial cells and epithelial cells
- Function
- Ligand binding, signal transduction
- Interaction
- gp130, IL-31RA
- Ligand/Receptor
- IL-31, OSM
- Cell Type
- Epithelial cells, Macrophages, Mesenchymal cells, Monocytes
- Biology Area
- Immunology
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
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- Mosley B, et al. 1996. J Biol Chem. 271:32635.
- Auguste P, et al. 1997. J Biol Chem. 272:15760.
- Hermanns HM, et al. 1999. J. Immunol. 163:6651.
- Gene ID
- 9180 View all products for this Gene ID
- UniProt
- View information about OSMR on UniProt.org
Related FAQs
Other Formats
View All OSMR Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human OSMR | S22005D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human OSMR
U-87 MG cells (human glioblastoma cell line) were stained wi...
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