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Alexa Fluor® 700 anti-mouse/human CD11b Antibody Alexa Fluor® 700 anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
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Product Citations
publications
M1slash70_ALX700_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) Alexa Fluor® 700 (filled histogram) or rat IgG2b, κ Alexa Fluor® 700 isotype control (open histogram) (gated on total cells).
  • M1slash70_ALX700_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) Alexa Fluor® 700 (filled histogram) or rat IgG2b, κ Alexa Fluor® 700 isotype control (open histogram) (gated on total cells).
Compare all formats See Alexa Fluor® 700 spectral data
Cat # Size Price Quantity Check Availability Save
101222 100 µg NOK1774
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is highly recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633nm / 635nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser
Red Laser (633 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References
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  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
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  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Jebbawi F, et al. 2021. Parasite Immunol. 43:e12834. PubMed
  2. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  3. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  4. Du Y, et al. 2022. FASEB J. 36:e22248. PubMed
  5. Lees-Shepard JB, et al. 2022. J Clin Invest. 132: . PubMed
  6. Liu F, et al. 2022. Adv Sci (Weinh). 9:e2104823. PubMed
  7. Kiani Shabestari S, et al. 2022. Cell Rep. 39:110961. PubMed
  8. Campisi L, et al. 2022. Nature. 606:945. PubMed
  9. Silva Pereira S, et al. 2022. Elife. 11: . PubMed
  10. Gupta S, et al. 2022. Sci Adv. 8:eabn4886. PubMed
  11. Akalu YT, et al. 2022. Elife. 11: . PubMed
  12. Huseni MA, et al. 2023. Cell Rep Med. 4:100878. PubMed
  13. Rohwedder I, et al. 2023. JCI Insight. 8: . PubMed
  14. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  15. Feng J, et al. 2022. Immunity. 55:405. PubMed
  16. Li DD, et al. 2022. Cell Host Microbe. 30:530. PubMed
  17. Arruda DC, et al. 2022. J Control Release. 350:228. PubMed
  18. Bermea KC, et al. 2022. J Vis Exp. . PubMed
  19. Lopes N, et al. 2022. Cell Rep Med. 3:100812. PubMed
  20. Pagni RL, et al. 2022. Front Immunol. 13:1005937. PubMed
  21. Li J, et al. 2022. Elife. 11:. PubMed
  22. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  23. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  24. Griffin GK, et al. 2023. Nature. 618:834. PubMed
  25. Miranda K, et al. 2022. iScience. 25:104994. PubMed
  26. Bergot AS, et al. 2020. J Immunol. 204:1787. PubMed
  27. Quinn K, et al. 2013. J Immunol. 191:5085. PubMed
  28. Domingues AF, et al. 2020. Elife. 9:e51754. PubMed
  29. Roco JA et al. 2019. Immunity. 51(2):337-350 . PubMed
  30. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  31. Gawish R, et al. 2022. Elife. 11:. PubMed
  32. Groenen AG, et al. 2022. J Lipid Res. 63:100167. PubMed
  33. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  34. Israelow B, et al. 2020. bioRxiv. . PubMed
  35. Metushi I, et al. 2014. Drug Metab Dispos. 42:963. PubMed
  36. Hahn J, et al. 2020. Brain Behav Immun. 87:329. PubMed
  37. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  38. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  39. Sykes DB et al. 2016. Cell. 167(1):171-186 . PubMed
  40. Cluny NL, et al. 2022. J Neuroinflammation. 19:73. PubMed
  41. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  42. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  43. Reyes RM, et al. 2021. Oncoimmunology. 10:2006529. PubMed
  44. Mukherjee D, et al. 2022. Nat Commun. 13:3747. PubMed
  45. Renga G, et al. 2020. Life Sci Alliance. 3:. PubMed
  46. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  47. Li B, et al. 2017. Am J Physiol Renal Physiol. 312(1):F43-F53. PubMed
  48. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  49. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  50. Francian A, et al. 2021. J Drug Target. 29:754. PubMed
  51. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  52. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  53. Perelman SS, et al. 2021. Nat Microbiol. 6:731. PubMed
  54. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  55. Al Mamun A, et al. 2019. Neurochem Int. 127:148. PubMed
  56. Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed
  57. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  58. Ruf B, et al. 2021. Cancer Immunol Res. 9:1024. PubMed
  59. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  60. Chen D, et al. 2020. Cancer Immunol Res. 8:883. PubMed
  61. Kim P, et al. 2015. J Exp Med. 212:633. PubMed
  62. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  63. Searles S, et al. 2013. J Immunol. 191:3884. PubMed
  64. Lasso P, et al. 2020. Front Immunol. 584959:11. PubMed
  65. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  66. Boehm DT, et al. 2018. Infect Immun. 86:. PubMed
  67. Baier FA, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:745. PubMed
  68. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  69. Matundan H, et al. 2019. J Virol. 93. PubMed
  70. Hu Q, et al. 2020. Cell Death Dis. 1.100694444. PubMed
  71. Devaraj A, et al. 2021. J Clin Invest. 131:. PubMed
  72. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  73. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  74. Becker W, et al. 2021. J Crohns Colitis. 15:1032. PubMed
  75. Fournier M, Bijl C 2015. Stem Cells Dev. 24: 2413-2422. PubMed
  76. Boehm DT, et al. 2019. NPJ Vaccines. 4:40. PubMed
  77. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  78. Taylor D, et al. 2022. Front Immunol. 13:936129. PubMed
  79. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  80. Pizzolla A, et al. 2016. PLoS One. 11: 0160407. PubMed
  81. Zhao Y et al. 2018. Cell reports. 24(2):379-390 . PubMed
  82. Wingert S, et al. 2021. MAbs. 13:1950264. PubMed
  83. Hoyt T, et al. 2015. Infect Immun . 83:743. PubMed
  84. Soberanes S et al. 2018. Cell metabolism. 29(2):335-347 . PubMed
  85. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  86. NULL, et al. 2022. Cell. 185:916. PubMed
  87. Ni X, et al. 2022. Front Immunol. 13:773291. PubMed
  88. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  89. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  90. Yun H, et al. 2020. Immunity. 53(5):1050-1062.e5. PubMed
  91. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  92. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  93. Genoud V, et al. 2018. Oncoimmunology. 7:e1501137. PubMed
  94. Zhang Z, et al. 2020. Nature. 579:415. PubMed
  95. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  96. Fransén Pettersson N, et al. 2018. PLoS One. 13:e0203228. PubMed
  97. Gundra UM, et al. 2017. Nat Immunol. 1.195833333. PubMed
  98. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  99. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  100. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  101. Rossnagl S, et al. 2016. PLoS Biol. 14: 1002562. PubMed
  102. Prigge J, et al. 2015. J Immunol. 195: 5347 - 5357. PubMed
  103. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  104. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  105. Gawish R, et al. 2022. Elife. 11:. PubMed
  106. Ehrens A, et al. 2021. Cell Reports. 34(2):108621. PubMed
  107. Goldberg EL, et al. 2021. Cell Metabolism. :. PubMed
  108. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  109. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  110. Zhu Q, et al. 2021. J Am Heart Assoc. 10:e023491. PubMed
  111. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
  112. Spanier J, et al. 2016. Nat Commun. 7:11804. PubMed
  113. Jebbawi F, et al. 2021. Parasite Immunol. 43:e12834. PubMed
  114. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  115. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  116. Du Y, et al. 2022. FASEB J. 36:e22248. PubMed
  117. Lees-Shepard JB, et al. 2022. J Clin Invest. 132: . PubMed
  118. Liu F, et al. 2022. Adv Sci (Weinh). 9:e2104823. PubMed
  119. Kiani Shabestari S, et al. 2022. Cell Rep. 39:110961. PubMed
  120. Campisi L, et al. 2022. Nature. 606:945. PubMed
  121. Silva Pereira S, et al. 2022. Elife. 11: . PubMed
  122. Gupta S, et al. 2022. Sci Adv. 8:eabn4886. PubMed
  123. Akalu YT, et al. 2022. Elife. 11: . PubMed
  124. Huseni MA, et al. 2023. Cell Rep Med. 4:100878. PubMed
  125. Rohwedder I, et al. 2023. JCI Insight. 8: . PubMed
  126. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  127. Feng J, et al. 2022. Immunity. 55:405. PubMed
  128. Li DD, et al. 2022. Cell Host Microbe. 30:530. PubMed
  129. Arruda DC, et al. 2022. J Control Release. 350:228. PubMed
  130. Bermea KC, et al. 2022. J Vis Exp. . PubMed
  131. Lopes N, et al. 2022. Cell Rep Med. 3:100812. PubMed
  132. Pagni RL, et al. 2022. Front Immunol. 13:1005937. PubMed
  133. Li J, et al. 2022. Elife. 11:. PubMed
  134. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  135. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  136. Griffin GK, et al. 2023. Nature. 618:834. PubMed
  137. Miranda K, et al. 2022. iScience. 25:104994. PubMed
  138. Bergot AS, et al. 2020. J Immunol. 204:1787. PubMed
  139. Quinn K, et al. 2013. J Immunol. 191:5085. PubMed
  140. Domingues AF, et al. 2020. Elife. 9:e51754. PubMed
  141. Roco JA et al. 2019. Immunity. 51(2):337-350 . PubMed
  142. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  143. Gawish R, et al. 2022. Elife. 11:. PubMed
  144. Groenen AG, et al. 2022. J Lipid Res. 63:100167. PubMed
  145. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  146. Israelow B, et al. 2020. bioRxiv. . PubMed
  147. Metushi I, et al. 2014. Drug Metab Dispos. 42:963. PubMed
  148. Hahn J, et al. 2020. Brain Behav Immun. 87:329. PubMed
  149. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  150. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  151. Sykes DB et al. 2016. Cell. 167(1):171-186 . PubMed
  152. Cluny NL, et al. 2022. J Neuroinflammation. 19:73. PubMed
  153. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  154. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  155. Reyes RM, et al. 2021. Oncoimmunology. 10:2006529. PubMed
  156. Mukherjee D, et al. 2022. Nat Commun. 13:3747. PubMed
  157. Renga G, et al. 2020. Life Sci Alliance. 3:. PubMed
  158. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  159. Li B, et al. 2017. Am J Physiol Renal Physiol. 312(1):F43-F53. PubMed
  160. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  161. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  162. Francian A, et al. 2021. J Drug Target. 29:754. PubMed
  163. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  164. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  165. Perelman SS, et al. 2021. Nat Microbiol. 6:731. PubMed
  166. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  167. Al Mamun A, et al. 2019. Neurochem Int. 127:148. PubMed
  168. Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed
  169. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  170. Ruf B, et al. 2021. Cancer Immunol Res. 9:1024. PubMed
  171. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  172. Chen D, et al. 2020. Cancer Immunol Res. 8:883. PubMed
  173. Kim P, et al. 2015. J Exp Med. 212:633. PubMed
  174. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  175. Searles S, et al. 2013. J Immunol. 191:3884. PubMed
  176. Lasso P, et al. 2020. Front Immunol. 584959:11. PubMed
  177. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  178. Boehm DT, et al. 2018. Infect Immun. 86:. PubMed
  179. Baier FA, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:745. PubMed
  180. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  181. Matundan H, et al. 2019. J Virol. 93. PubMed
  182. Hu Q, et al. 2020. Cell Death Dis. 1.100694444. PubMed
  183. Devaraj A, et al. 2021. J Clin Invest. 131:. PubMed
  184. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  185. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  186. Becker W, et al. 2021. J Crohns Colitis. 15:1032. PubMed
  187. Fournier M, Bijl C 2015. Stem Cells Dev. 24: 2413-2422. PubMed
  188. Boehm DT, et al. 2019. NPJ Vaccines. 4:40. PubMed
  189. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  190. Taylor D, et al. 2022. Front Immunol. 13:936129. PubMed
  191. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  192. Pizzolla A, et al. 2016. PLoS One. 11: 0160407. PubMed
  193. Zhao Y et al. 2018. Cell reports. 24(2):379-390 . PubMed
  194. Wingert S, et al. 2021. MAbs. 13:1950264. PubMed
  195. Hoyt T, et al. 2015. Infect Immun . 83:743. PubMed
  196. Soberanes S et al. 2018. Cell metabolism. 29(2):335-347 . PubMed
  197. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  198. NULL, et al. 2022. Cell. 185:916. PubMed
  199. Ni X, et al. 2022. Front Immunol. 13:773291. PubMed
  200. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  201. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  202. Yun H, et al. 2020. Immunity. 53(5):1050-1062.e5. PubMed
  203. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  204. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  205. Genoud V, et al. 2018. Oncoimmunology. 7:e1501137. PubMed
  206. Zhang Z, et al. 2020. Nature. 579:415. PubMed
  207. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  208. Fransén Pettersson N, et al. 2018. PLoS One. 13:e0203228. PubMed
  209. Gundra UM, et al. 2017. Nat Immunol. 1.195833333. PubMed
  210. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  211. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  212. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  213. Rossnagl S, et al. 2016. PLoS Biol. 14: 1002562. PubMed
  214. Prigge J, et al. 2015. J Immunol. 195: 5347 - 5357. PubMed
  215. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  216. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  217. Gawish R, et al. 2022. Elife. 11:. PubMed
  218. Ehrens A, et al. 2021. Cell Reports. 34(2):108621. PubMed
  219. Goldberg EL, et al. 2021. Cell Metabolism. :. PubMed
  220. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  221. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  222. Zhu Q, et al. 2021. J Am Heart Assoc. 10:e023491. PubMed
  223. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
  224. Spanier J, et al. 2016. Nat Commun. 7:11804. PubMed
RRID
AB_493705 (BioLegend Cat. No. 101222)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

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Description Clone Applications
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
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TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
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TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Spark YG™ 581 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
StarBright UltraViolet 575 anti-mouse/human CD11b M1/70 FC
StarBright UltraViolet 740 anti-mouse/human CD11b M1/70 FC
Spark PLUS V475™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 06.27.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
M1slash70_ALX700_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) Alexa Fluor® 700 (filled histogram) or rat IgG2b, κ Alexa Fluor® 700 isotype control (open histogram) (gated on total cells).
  • M1slash70_ALX700_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) Alexa Fluor® 700 (filled histogram) or rat IgG2b, κ Alexa Fluor® 700 isotype control (open histogram) (gated on total cells).
Compare all formats See Alexa Fluor® 700 spectral data
Cat # Size Price Quantity Check Availability Save
101222 100 µg NOK1774
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is highly recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633nm / 635nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Red Laser (633 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References
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  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
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  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
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  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
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  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
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  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
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  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
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  129. Arruda DC, et al. 2022. J Control Release. 350:228. PubMed
  130. Bermea KC, et al. 2022. J Vis Exp. . PubMed
  131. Lopes N, et al. 2022. Cell Rep Med. 3:100812. PubMed
  132. Pagni RL, et al. 2022. Front Immunol. 13:1005937. PubMed
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  134. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
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  137. Miranda K, et al. 2022. iScience. 25:104994. PubMed
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  139. Quinn K, et al. 2013. J Immunol. 191:5085. PubMed
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  142. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  143. Gawish R, et al. 2022. Elife. 11:. PubMed
  144. Groenen AG, et al. 2022. J Lipid Res. 63:100167. PubMed
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  146. Israelow B, et al. 2020. bioRxiv. . PubMed
  147. Metushi I, et al. 2014. Drug Metab Dispos. 42:963. PubMed
  148. Hahn J, et al. 2020. Brain Behav Immun. 87:329. PubMed
  149. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  150. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  151. Sykes DB et al. 2016. Cell. 167(1):171-186 . PubMed
  152. Cluny NL, et al. 2022. J Neuroinflammation. 19:73. PubMed
  153. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  154. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  155. Reyes RM, et al. 2021. Oncoimmunology. 10:2006529. PubMed
  156. Mukherjee D, et al. 2022. Nat Commun. 13:3747. PubMed
  157. Renga G, et al. 2020. Life Sci Alliance. 3:. PubMed
  158. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  159. Li B, et al. 2017. Am J Physiol Renal Physiol. 312(1):F43-F53. PubMed
  160. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  161. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  162. Francian A, et al. 2021. J Drug Target. 29:754. PubMed
  163. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  164. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  165. Perelman SS, et al. 2021. Nat Microbiol. 6:731. PubMed
  166. Enriquez AB, et al. 2022. iScience. 25:104305. PubMed
  167. Al Mamun A, et al. 2019. Neurochem Int. 127:148. PubMed
  168. Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed
  169. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  170. Ruf B, et al. 2021. Cancer Immunol Res. 9:1024. PubMed
  171. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  172. Chen D, et al. 2020. Cancer Immunol Res. 8:883. PubMed
  173. Kim P, et al. 2015. J Exp Med. 212:633. PubMed
  174. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  175. Searles S, et al. 2013. J Immunol. 191:3884. PubMed
  176. Lasso P, et al. 2020. Front Immunol. 584959:11. PubMed
  177. Mirando AC, et al. 2020. Oncoimmunology. 9:1760685. PubMed
  178. Boehm DT, et al. 2018. Infect Immun. 86:. PubMed
  179. Baier FA, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:745. PubMed
  180. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  181. Matundan H, et al. 2019. J Virol. 93. PubMed
  182. Hu Q, et al. 2020. Cell Death Dis. 1.100694444. PubMed
  183. Devaraj A, et al. 2021. J Clin Invest. 131:. PubMed
  184. Yamada KJ, et al. 2020. PLoS Pathog. 16:e1008354. PubMed
  185. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  186. Becker W, et al. 2021. J Crohns Colitis. 15:1032. PubMed
  187. Fournier M, Bijl C 2015. Stem Cells Dev. 24: 2413-2422. PubMed
  188. Boehm DT, et al. 2019. NPJ Vaccines. 4:40. PubMed
  189. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  190. Taylor D, et al. 2022. Front Immunol. 13:936129. PubMed
  191. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  192. Pizzolla A, et al. 2016. PLoS One. 11: 0160407. PubMed
  193. Zhao Y et al. 2018. Cell reports. 24(2):379-390 . PubMed
  194. Wingert S, et al. 2021. MAbs. 13:1950264. PubMed
  195. Hoyt T, et al. 2015. Infect Immun . 83:743. PubMed
  196. Soberanes S et al. 2018. Cell metabolism. 29(2):335-347 . PubMed
  197. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  198. NULL, et al. 2022. Cell. 185:916. PubMed
  199. Ni X, et al. 2022. Front Immunol. 13:773291. PubMed
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RRID
AB_493705 (BioLegend Cat. No. 101222)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Spark YG™ 581 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
StarBright UltraViolet 575 anti-mouse/human CD11b M1/70 FC
StarBright UltraViolet 740 anti-mouse/human CD11b M1/70 FC
Spark PLUS V475™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 06.27.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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