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APC anti-mouse CD117 (c-Kit) Antibody APC anti-mouse CD117 (c-Kit) Antibody

Pricing & Availability
Clone
2B8 (See other available formats)
Regulatory Status
RUO
Other Names
c-KIT, Stem Cell Factor Receptor (SCFR)
Isotype
Rat IgG2b, κ
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Product Citations
publications
2B8_APC_1_072611
  • 2B8_APC_1_072611
  • 2B8_APC_2_072611
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
105812 100 µg NOK1725
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105811 25 µg NOK693
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Description

CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow mast cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone fixed frozen sections2, and spatial biology (IBEX)5,6. The 2B8 antibody does not block c-Kit activity.

Application References
  1. Ikuta K, et al. 1992. P. Natl. Acad. Sci. USA 89:1502. (FC)
  2. Podd BS, et al. 2006. J. Immunol. 176:6532. PubMed (IHC)
  3. Bachelet I, et al. 2008. J. Immunol. 180:6064. PubMed (FC)
  4. Charles N, et al. 2010. Nat. Med. 16:701. PubMed (FC)
  5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  2. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  3. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  4. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  5. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  6. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  7. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  8. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  9. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  10. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  11. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  12. Wang X, et al. 2023. Nature. 618:808. PubMed
  13. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  14. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  15. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  16. Barkaway A, et al. 2021. Immunity. . PubMed
  17. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  18. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  19. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  20. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  21. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  22. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  23. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  24. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  25. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  26. Zhu H, et al. 2018. Elife. 7:. PubMed
  27. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  28. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  29. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  30. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  31. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  32. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  33. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  34. Gao B, et al. 2018. Aging Cell. 3. PubMed
  35. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  36. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  37. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  38. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  39. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  40. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  41. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  42. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  43. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  44. Eisele AS, et al. 2022. Elife. 11:. PubMed
  45. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  46. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  47. Plein A, et al. 2018. Nature. 562:223. PubMed
  48. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  49. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  50. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  51. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  52. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  53. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  54. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  55. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  56. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  57. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  58. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  59. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  60. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  61. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  62. Dong S, et al. 2021. Nature. 591:117. PubMed
  63. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  64. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  65. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  66. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  67. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  68. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  69. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  70. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  71. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  72. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  73. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  74. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  75. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  76. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  77. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  78. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  79. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  80. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  81. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  82. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  83. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  84. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  85. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  86. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  87. Engblom C, et al. 2017. Science. 358:6367. PubMed
  88. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  89. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  90. Koide S, et al. 2022. iScience. 25:103603. PubMed
  91. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  92. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  93. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  94. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  95. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  96. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  97. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  98. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  99. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  100. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  101. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  102. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  103. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  104. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  105. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  106. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  107. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  108. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  109. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  110. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  111. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  112. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  113. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  114. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  115. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  116. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  117. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  118. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  119. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  120. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  121. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  122. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  123. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  124. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  125. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  126. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  127. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  128. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  129. Wang X, et al. 2023. Nature. 618:808. PubMed
  130. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  131. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  132. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  133. Barkaway A, et al. 2021. Immunity. . PubMed
  134. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  135. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  136. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  137. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  138. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  139. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  140. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  141. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  142. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  143. Zhu H, et al. 2018. Elife. 7:. PubMed
  144. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  145. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  146. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  147. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  148. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  149. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  150. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  151. Gao B, et al. 2018. Aging Cell. 3. PubMed
  152. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  153. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  154. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  155. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  156. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  157. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  158. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  159. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  160. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  161. Eisele AS, et al. 2022. Elife. 11:. PubMed
  162. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  163. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  164. Plein A, et al. 2018. Nature. 562:223. PubMed
  165. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  166. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  167. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  168. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  169. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  170. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  171. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  172. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  173. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  174. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  175. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  176. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  177. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  178. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  179. Dong S, et al. 2021. Nature. 591:117. PubMed
  180. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  181. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  182. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  183. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  184. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  185. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  186. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  187. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  188. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  189. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  190. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  191. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  192. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  193. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  194. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  195. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  196. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  197. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  198. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  199. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  200. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  201. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  202. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  203. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  204. Engblom C, et al. 2017. Science. 358:6367. PubMed
  205. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  206. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  207. Koide S, et al. 2022. iScience. 25:103603. PubMed
  208. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  209. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  210. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  211. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  212. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  213. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  214. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  215. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  216. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  217. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  218. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  219. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  220. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  221. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  222. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  223. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  224. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  225. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  226. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  227. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  228. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  229. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  230. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  231. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  232. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  233. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  234. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
RRID
AB_313221 (BioLegend Cat. No. 105812)
AB_313220 (BioLegend Cat. No. 105811)

Antigen Details

Structure
Ig superfamily, 145 kD
Distribution

Hematopoietic stem cells, AML, mast cells

Function
Growth factor receptor, tyrosine kinase
Ligand/Receptor
Stem Cell Factor (SCF)
Cell Type
Embryonic Stem Cells, Hematopoietic stem and progenitors, Leukemia, Mast cells, Mesenchymal Stem Cells
Biology Area
Immunology, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Galli SJ, et al. 1994. Adv. Immunol. 55:1.
3. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
4. Besmer P, et al. 1986. Nature 320:415.
5. Witte ON. 1990. Cell 63:5.

Gene ID
16590 View all products for this Gene ID
UniProt
View information about CD117 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

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Description Clone Applications
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TotalSeq™-A0012 anti-mouse CD117 (c-kit) 2B8 PG
Brilliant Violet 605™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 700 anti-mouse CD117 (c-Kit) 2B8 FC
TotalSeq™-B0012 anti-mouse CD117 (c-Kit) 2B8 PG
TotalSeq™-C0012 anti-mouse CD117 (c-Kit) 2B8 PG
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Brilliant Violet 650™ anti-mouse CD117 (c-kit) 2B8 FC
APC anti-mouse CD117 (c-Kit) 2B8 FC
Biotin anti-mouse CD117 (c-Kit) 2B8 FC
FITC anti-mouse CD117 (c-Kit) 2B8 FC
PE anti-mouse CD117 (c-Kit) 2B8 FC
PE/Cyanine5 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 488 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 647 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Pacific Blue™ anti-mouse CD117 (c-Kit) 2B8 FC
PerCP/Cyanine5.5 anti-mouse CD117 (c-kit) 2B8 FC
PerCP anti-mouse CD117 (c-kit) 2B8 FC
APC/Cyanine7 anti-mouse CD117 (c-kit) 2B8 FC
Brilliant Violet 421™ anti-mouse CD117 (c-Kit) 2B8 FC,SB
Spark Red™ 718 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 574 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 550 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark UV™ 387 anti-mouse CD117 (c-Kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 581 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 593 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Go To Top Version: 2    Revision Date: 06.28.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
2B8 (See other available formats)
Regulatory Status
RUO
Other Names
c-KIT, Stem Cell Factor Receptor (SCFR)
Isotype
Rat IgG2b, κ
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Product Citations
publications
2B8_APC_1_072611
  • 2B8_APC_1_072611
  • 2B8_APC_2_072611
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
105812 100 µg NOK1725
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105811 25 µg NOK693
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Description

CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse bone marrow mast cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemistry of acetone fixed frozen sections2, and spatial biology (IBEX)5,6. The 2B8 antibody does not block c-Kit activity.

Application References
  1. Ikuta K, et al. 1992. P. Natl. Acad. Sci. USA 89:1502. (FC)
  2. Podd BS, et al. 2006. J. Immunol. 176:6532. PubMed (IHC)
  3. Bachelet I, et al. 2008. J. Immunol. 180:6064. PubMed (FC)
  4. Charles N, et al. 2010. Nat. Med. 16:701. PubMed (FC)
  5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  2. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  3. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  4. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  5. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  6. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  7. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  8. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  9. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  10. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  11. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  12. Wang X, et al. 2023. Nature. 618:808. PubMed
  13. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  14. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  15. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  16. Barkaway A, et al. 2021. Immunity. . PubMed
  17. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  18. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  19. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  20. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  21. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  22. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  23. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  24. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  25. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  26. Zhu H, et al. 2018. Elife. 7:. PubMed
  27. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  28. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  29. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  30. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  31. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  32. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  33. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  34. Gao B, et al. 2018. Aging Cell. 3. PubMed
  35. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  36. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  37. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  38. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  39. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  40. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  41. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  42. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  43. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  44. Eisele AS, et al. 2022. Elife. 11:. PubMed
  45. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  46. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  47. Plein A, et al. 2018. Nature. 562:223. PubMed
  48. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  49. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  50. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  51. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  52. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  53. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  54. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  55. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  56. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  57. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  58. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  59. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  60. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  61. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  62. Dong S, et al. 2021. Nature. 591:117. PubMed
  63. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  64. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  65. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  66. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  67. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  68. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  69. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  70. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  71. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  72. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  73. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  74. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  75. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  76. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  77. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  78. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  79. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  80. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  81. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  82. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  83. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  84. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  85. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  86. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  87. Engblom C, et al. 2017. Science. 358:6367. PubMed
  88. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  89. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  90. Koide S, et al. 2022. iScience. 25:103603. PubMed
  91. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  92. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  93. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  94. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  95. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  96. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  97. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  98. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  99. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  100. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  101. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  102. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  103. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  104. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  105. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  106. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  107. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  108. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  109. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  110. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  111. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  112. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  113. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  114. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  115. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  116. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  117. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  118. Julien E, et al. 2021. Stem Cells. 39:636. PubMed
  119. Mirchandani AS, et al. 2022. Nat Immunol. 23:927. PubMed
  120. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  121. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  122. Xin DQ, et al. 2022. Neural Regen Res. 17:2238. PubMed
  123. Yuan O, et al. 2022. Sci Adv. 8:eabm9987. PubMed
  124. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  125. Rahman SMT, et al. 2022. Cell Rep. 41:111682. PubMed
  126. Guan H, et al. 2023. Int J Mol Sci. 24:. PubMed
  127. Elbasiony E, et al. 2023. NPJ Aging. 9:2. PubMed
  128. Ma S, et al. 2023. Front Cell Dev Biol. 11:1140554. PubMed
  129. Wang X, et al. 2023. Nature. 618:808. PubMed
  130. Lengefeld J, et al. 2021. Sci Adv. 7:eabk0271. PubMed
  131. Jabbar S, et al. 2022. Exp Hematol Oncol. 11:83. PubMed
  132. Tran NT, et al. 2019. Cell Rep. 28:3510. PubMed
  133. Barkaway A, et al. 2021. Immunity. . PubMed
  134. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  135. Wu J, et al. 2022. Nat Commun. 13:7321. PubMed
  136. Davis FM, et al. 2020. J Immunol. 2503:204. PubMed
  137. Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
  138. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  139. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  140. Gutiérrez-Gutiérrez Ó, et al. 2021. EMBO Rep. 22:e52905. PubMed
  141. Pessoa Rodrigues C, et al. 2021. Sci Adv. 7:. PubMed
  142. Sasse C, et al. 2022. Pathogens. 11:. PubMed
  143. Zhu H, et al. 2018. Elife. 7:. PubMed
  144. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  145. Yu K, et al. 2021. Cell Reports. 35(12):109273. PubMed
  146. Chen J, et al. 2021. Sci Adv. 7:. PubMed
  147. Al-Rifai R, et al. 2022. Nat Commun. 13:6592. PubMed
  148. Ludin A, et al. 2012. Nat Immunol. 13:1072. PubMed
  149. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  150. Guo B, et al. 2018. Nat Med. 24:360. PubMed
  151. Gao B, et al. 2018. Aging Cell. 3. PubMed
  152. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  153. Davis FM, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2353. PubMed
  154. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  155. Markov SD, et al. 2021. Mol Cancer Ther. 20:2457. PubMed
  156. Beauchamp EM, et al. 2021. Blood Cancer Discov. 6:. PubMed
  157. Nguyen DH, et al. 2020. Nat Cell Biol. 22:1423. PubMed
  158. Paiva RS, et al. 2021. Eur J Immunol. 51:1968. PubMed
  159. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  160. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  161. Eisele AS, et al. 2022. Elife. 11:. PubMed
  162. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  163. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  164. Plein A, et al. 2018. Nature. 562:223. PubMed
  165. Morshed M, et al. 2014. J Immunol. 192:5314. PubMed
  166. Koh F, et al. 2015. Proc Natl Acad Sci U S A. 112:1734. PubMed
  167. Ritter M, et al. 2020. Ann Hematol. 99:2329. PubMed
  168. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  169. Paiva RA, et al. 2021. Cell Reports. 35(2):108967. PubMed
  170. Wang L, et al. 2021. Cancer Immunol Res. 9:348. PubMed
  171. Widner DB, et al. 2021. J Cachexia Sarcopenia Muscle. 12:1079. PubMed
  172. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  173. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  174. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  175. Srivastava S, et al. 2019. Cancer Cell. 35:489. PubMed
  176. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  177. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  178. Bahal R, et al. 2016. Nat Commun. 7:13304. PubMed
  179. Dong S, et al. 2021. Nature. 591:117. PubMed
  180. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  181. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  182. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  183. Umemoto T, et al. 2008. Biochem Biophys Res Commun. 365:176. PubMed
  184. Convente MR, et al. 2018. J Bone Miner Res. 33:269. PubMed
  185. Tran NT, et al. 2020. STAR Protocols. 1(1):100028. PubMed
  186. Zhu M, et al. 2015. J Immunol. 195: 4492 - 4502. PubMed
  187. Lebert-Ghali C, et al. 2016. Blood. 127: 87-90. PubMed
  188. Wang X, et al. 2020. Cell Res. 30:1109. PubMed
  189. Oka Y, et al. 2020. Sci Adv. 6:. PubMed
  190. Sibon D et al. 2019. Cell reports. 26(12):3246-3256 . PubMed
  191. Tsuchiya K, et al. 2019. Nat Commun. 10:2091. PubMed
  192. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  193. Chen Z, et al. 2019. J Exp Med. 216:152. PubMed
  194. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  195. Li W, et al. 2021. PLoS Pathog. 17:e1009462. PubMed
  196. N. H, et al. 2017. Journal of Vascular Research. 10.1159/000464287. PubMed
  197. Gandhapudi S, et al. 2015. J Immunol. 194:3820. PubMed
  198. Gao Y, et al. 2020. Immunity. 52(6):1007-1021.e8. PubMed
  199. Inverso D, et al. 2021. Developmental Cell. 56(11):1677-1693.e10. PubMed
  200. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  201. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  202. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  203. Legrand JMD, et al. 2019. Nat Commun. 10:2278. PubMed
  204. Engblom C, et al. 2017. Science. 358:6367. PubMed
  205. Suzuki S, et al. 2021. Cell Reports. 34(7):108752. PubMed
  206. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  207. Koide S, et al. 2022. iScience. 25:103603. PubMed
  208. Zhuo X, et al. 2021. Biomed Rep. 15:64. PubMed
  209. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  210. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  211. Christoforou N, et al. 2013. PLoS One. 8:65963. PubMed
  212. Artinger E, et al. 2013. Proc Natl Acad Sci U S A. 110:12000. PubMed
  213. Wang E, et al. 2013. Proc Natl Acad Sci U S A. 110:3901. PubMed
  214. Sabnis A, et al. 2009. PLoS One. 7:e59. PubMed
  215. He M, et al. 2020. Cell Metabolism. 31(3):580-591. PubMed
  216. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  217. Brian BF 4th et al. 2019. Elife. 8 pii: e46043. PubMed
  218. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  219. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  220. Matsuzaki Y, et al. 2015. Biomed Rep. 1: 91 - 97. PubMed
  221. Li K, et al. 2020. Nat Commun. 0.795138889. PubMed
  222. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  223. Halvarsson C, et al. 2019. Antioxid Redox Signal. 31:211. PubMed
  224. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  225. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  226. Gozdecka M, et al. 2018. Nat Genet. 50:883. PubMed
  227. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  228. Liu J, et al. 2012. Proc Natl Acad Sci U S A. 109:10018. PubMed
  229. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  230. Li ZG, et al. 2020. Chin Med J (Engl). 1943:133. PubMed
  231. Cui Y, et al. 2020. Eur J Pharmacol. 881:173233. PubMed
  232. Gu Z, et al. 2021. Nat Genet. 53:672. PubMed
  233. Lei F, et al. 2012. J Vis Exp. 63: 3986. PubMed
  234. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
RRID
AB_313221 (BioLegend Cat. No. 105812)
AB_313220 (BioLegend Cat. No. 105811)

Antigen Details

Structure
Ig superfamily, 145 kD
Distribution

Hematopoietic stem cells, AML, mast cells

Function
Growth factor receptor, tyrosine kinase
Ligand/Receptor
Stem Cell Factor (SCF)
Cell Type
Embryonic Stem Cells, Hematopoietic stem and progenitors, Leukemia, Mast cells, Mesenchymal Stem Cells
Biology Area
Immunology, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Galli SJ, et al. 1994. Adv. Immunol. 55:1.
3. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
4. Besmer P, et al. 1986. Nature 320:415.
5. Witte ON. 1990. Cell 63:5.

Gene ID
16590 View all products for this Gene ID
UniProt
View information about CD117 on UniProt.org

Other Formats

View All CD117 Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse CD117 (c-Kit) 2B8 FC
PE/Dazzle™ 594 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) (Maxpar® Ready) 2B8 FC,CyTOF®
Brilliant Violet 711™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 594 anti-mouse CD117 (c-Kit) 2B8 IHC-F,3D IHC
APC/Fire™ 750 anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 510™ anti-mouse CD117 (c-Kit) 2B8 FC
Brilliant Violet 785™ anti-mouse CD117 (c-Kit) 2B8 FC
TotalSeq™-A0012 anti-mouse CD117 (c-kit) 2B8 PG
Brilliant Violet 605™ anti-mouse CD117 (c-Kit) 2B8 FC
Alexa Fluor® 700 anti-mouse CD117 (c-Kit) 2B8 FC
TotalSeq™-B0012 anti-mouse CD117 (c-Kit) 2B8 PG
TotalSeq™-C0012 anti-mouse CD117 (c-Kit) 2B8 PG
Spark NIR™ 685 anti-mouse CD117 (c-kit) 2B8 FC
Brilliant Violet 650™ anti-mouse CD117 (c-kit) 2B8 FC
APC anti-mouse CD117 (c-Kit) 2B8 FC
Biotin anti-mouse CD117 (c-Kit) 2B8 FC
FITC anti-mouse CD117 (c-Kit) 2B8 FC
PE anti-mouse CD117 (c-Kit) 2B8 FC
PE/Cyanine5 anti-mouse CD117 (c-Kit) 2B8 FC
Purified anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 488 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Alexa Fluor® 647 anti-mouse CD117 (c-Kit) 2B8 FC,IHC-F
Pacific Blue™ anti-mouse CD117 (c-Kit) 2B8 FC
PerCP/Cyanine5.5 anti-mouse CD117 (c-kit) 2B8 FC
PerCP anti-mouse CD117 (c-kit) 2B8 FC
APC/Cyanine7 anti-mouse CD117 (c-kit) 2B8 FC
Brilliant Violet 421™ anti-mouse CD117 (c-Kit) 2B8 FC,SB
Spark Red™ 718 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 574 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark Blue™ 550 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark UV™ 387 anti-mouse CD117 (c-Kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 581 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Spark YG™ 593 anti-mouse CD117 (c-kit) (Flexi-Fluor™) 2B8 FC
Go To Top Version: 2    Revision Date: 06.28.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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