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Brefeldin A Solution (1,000X) Brefeldin A Solution (1,000X)

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Regulatory Status
RUO
Other Names
BFA
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420601 1 mL NOK537
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  2. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  3. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  4. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  5. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  6. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  7. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  8. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  9. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  10. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  11. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  12. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  13. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  14. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  15. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  16. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  17. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  18. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  19. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  20. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  21. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  22. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  23. Chan L, et al. 2022. Cells. 12: . PubMed
  24. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  25. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  26. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  27. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  28. Zander R, et al. 2022. Immunity. 55:475. PubMed
  29. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  30. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  31. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  32. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  33. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  34. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  35. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  36. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  37. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  38. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  39. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  40. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  41. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  42. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  43. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  44. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  45. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  46. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  47. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  48. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  49. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  50. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  51. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  52. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  53. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  54. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  55. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  56. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  57. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  58. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  59. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  60. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  61. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  62. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  63. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  64. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  65. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  66. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  67. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  68. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  69. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  70. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  71. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  72. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  73. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  74. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  75. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  76. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  77. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  78. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  79. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  80. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  81. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  82. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  83. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  84. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  85. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  86. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  87. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  88. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  89. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  90. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  91. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  92. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  93. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  94. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  95. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  96. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  97. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  98. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  99. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  100. Jondle CN, et al. 2021. MBio. 12:. PubMed
  101. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  102. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  103. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  104. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  105. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  106. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  107. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  108. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  109. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  110. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  111. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  112. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  113. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  114. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  115. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  116. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  117. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  118. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  119. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  120. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  121. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  122. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  123. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  124. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  125. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  126. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  127. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  128. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  129. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  130. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  131. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  132. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  133. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  134. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  135. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  136. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  137. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  138. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  139. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  140. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  141. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  142. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  143. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  144. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  145. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  146. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  147. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  148. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  149. Harty N 2011. J Immunol. 186:3836. PubMed
  150. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  151. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  152. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  153. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  154. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  155. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  156. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  157. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  158. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  159. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  160. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  161. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  162. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  163. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  164. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  165. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  166. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  167. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  168. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  169. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  170. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  171. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  172. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  173. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  174. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  175. Ma K, et al. 2022. iScience. 25:104347. PubMed
  176. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  177. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  178. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  179. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  180. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  181. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  182. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  183. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  184. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  185. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  186. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  187. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  188. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  189. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  190. Sekine T, et al. 2020. Cell. 183:158. PubMed
  191. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  192. Guo C, et al. 2018. Immunity. 49:842. PubMed
  193. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  194. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  195. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  196. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  197. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  198. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  199. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  200. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  201. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  202. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  203. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  204. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  205. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  206. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  207. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  208. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  209. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  210. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  211. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  212. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  213. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  214. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  215. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  216. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  217. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  218. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  219. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  220. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  221. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  222. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  223. Markey K, et al. 2009. Blood. 113:5644. PubMed
  224. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  225. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  226. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  227. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  228. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  229. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  230. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  231. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  232. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  233. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  234. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  235. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  236. Rist M, et al. 2015. J Virol. 89:703. PubMed
  237. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  238. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  239. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  240. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  241. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  242. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  243. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  244. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  245. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  246. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  247. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  248. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  249. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  250. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  251. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  252. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  253. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  254. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  255. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  256. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  257. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  258. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  259. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  260. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  261. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  262. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  263. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  264. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  265. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  266. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  267. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  268. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  269. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  270. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  271. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  272. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  273. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  274. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  275. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  276. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  277. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  278. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  279. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  280. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  281. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  282. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  283. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  284. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  285. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  286. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  287. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  288. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  289. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  290. Chan L, et al. 2022. Cells. 12: . PubMed
  291. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  292. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  293. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  294. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  295. Zander R, et al. 2022. Immunity. 55:475. PubMed
  296. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  297. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  298. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  299. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  300. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  301. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  302. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  303. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  304. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  305. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  306. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  307. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  308. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  309. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  310. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  311. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  312. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  313. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  314. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  315. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  316. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  317. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  318. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  319. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  320. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  321. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  322. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  323. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  324. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  325. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  326. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  328. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  329. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  330. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  331. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  332. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  333. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  334. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  335. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  336. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  337. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  338. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  339. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  340. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  341. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  342. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  343. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  344. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  345. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  346. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  347. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  348. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  349. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  350. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  351. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  352. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  353. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  354. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  355. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  356. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  357. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  358. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  359. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  360. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  361. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  362. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  363. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  364. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  365. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  366. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  367. Jondle CN, et al. 2021. MBio. 12:. PubMed
  368. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  369. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  370. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  371. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  372. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  373. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  374. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  375. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  376. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  377. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  378. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  379. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  380. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  381. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  382. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  383. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  384. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  385. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  386. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  387. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  388. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  389. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  390. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  391. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  392. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  393. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  394. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  395. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  396. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  397. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  398. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  399. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  400. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  401. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  402. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  403. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  404. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  405. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  406. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  407. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  408. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  409. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  410. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  411. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  412. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  413. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  414. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  415. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  416. Harty N 2011. J Immunol. 186:3836. PubMed
  417. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  418. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  419. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  420. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  421. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  422. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  423. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  424. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  425. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  426. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  427. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  428. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  429. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  430. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  431. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  432. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  433. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  434. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  435. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  436. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  437. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  438. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  439. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  440. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  441. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  442. Ma K, et al. 2022. iScience. 25:104347. PubMed
  443. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  444. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  445. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  446. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  447. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  448. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  449. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  450. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  451. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  452. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  453. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  454. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  455. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  456. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  457. Sekine T, et al. 2020. Cell. 183:158. PubMed
  458. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  459. Guo C, et al. 2018. Immunity. 49:842. PubMed
  460. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  461. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  462. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  463. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  464. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  465. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  466. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  467. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  468. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  469. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  470. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  471. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  472. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  473. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  474. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  475. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  476. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  477. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  478. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  479. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  480. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  481. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  482. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  483. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  484. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  485. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  486. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  487. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  488. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  489. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  490. Markey K, et al. 2009. Blood. 113:5644. PubMed
  491. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  492. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  493. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  494. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  495. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  496. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  497. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  498. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  499. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  500. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  501. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  502. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  503. Rist M, et al. 2015. J Virol. 89:703. PubMed
  504. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  505. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  506. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  507. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  508. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  509. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  510. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  511. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  512. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  513. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  514. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  515. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  516. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  517. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  518. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  519. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  520. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  521. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  522. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  523. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  524. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  525. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  526. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  527. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  528. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  529. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  530. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  531. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  532. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  533. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  534. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Regulatory Status
RUO
Other Names
BFA
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  2. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  3. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  4. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  5. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  6. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  7. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  8. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  9. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  10. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  11. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  12. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  13. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  14. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  15. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  16. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  17. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  18. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  19. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  20. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  21. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  22. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  23. Chan L, et al. 2022. Cells. 12: . PubMed
  24. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  25. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  26. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  27. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  28. Zander R, et al. 2022. Immunity. 55:475. PubMed
  29. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  30. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  31. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  32. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  33. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  34. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  35. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  36. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  37. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  38. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  39. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  40. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  41. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  42. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  43. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  44. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  45. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  46. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  47. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  48. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  49. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  50. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  51. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  52. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  53. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  54. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  55. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  56. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  57. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  58. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  59. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  60. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  61. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  62. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  63. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  64. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  65. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  66. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  67. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  68. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  69. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  70. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  71. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  72. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  73. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  74. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  75. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  76. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  77. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  78. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  79. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  80. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  81. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  82. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  83. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  84. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  85. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  86. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  87. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  88. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  89. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  90. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  91. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  92. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  93. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  94. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  95. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  96. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  97. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  98. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  99. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  100. Jondle CN, et al. 2021. MBio. 12:. PubMed
  101. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  102. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  103. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  104. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  105. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  106. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  107. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  108. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  109. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  110. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  111. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  112. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  113. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  114. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  115. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  116. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  117. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  118. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  119. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  120. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  121. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  122. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  123. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  124. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  125. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  126. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  127. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  128. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  129. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  130. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  131. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  132. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  133. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  134. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  135. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  136. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  137. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  138. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  139. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  140. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  141. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  142. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  143. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  144. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  145. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  146. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  147. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  148. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  149. Harty N 2011. J Immunol. 186:3836. PubMed
  150. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  151. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  152. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  153. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  154. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  155. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  156. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  157. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  158. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  159. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  160. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  161. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  162. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  163. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  164. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  165. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  166. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  167. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  168. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  169. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  170. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  171. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  172. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  173. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  174. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  175. Ma K, et al. 2022. iScience. 25:104347. PubMed
  176. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  177. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  178. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  179. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  180. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  181. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  182. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  183. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  184. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  185. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  186. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  187. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  188. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  189. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  190. Sekine T, et al. 2020. Cell. 183:158. PubMed
  191. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  192. Guo C, et al. 2018. Immunity. 49:842. PubMed
  193. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  194. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  195. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  196. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  197. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  198. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  199. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  200. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  201. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  202. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  203. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  204. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  205. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  206. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  207. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  208. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  209. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  210. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  211. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  212. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  213. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  214. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  215. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  216. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  217. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  218. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  219. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  220. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  221. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  222. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  223. Markey K, et al. 2009. Blood. 113:5644. PubMed
  224. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  225. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  226. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  227. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  228. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  229. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  230. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  231. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  232. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  233. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  234. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  235. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  236. Rist M, et al. 2015. J Virol. 89:703. PubMed
  237. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  238. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  239. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  240. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  241. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  242. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  243. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  244. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  245. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  246. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  247. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  248. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  249. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  250. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  251. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  252. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  253. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  254. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  255. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  256. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  257. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  258. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  259. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  260. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  261. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  262. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  263. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  264. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  265. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  266. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  267. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  268. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  269. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  270. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  271. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  272. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  273. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  274. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  275. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  276. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  277. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  278. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  279. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  280. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  281. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  282. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  283. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  284. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  285. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  286. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  287. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  288. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  289. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  290. Chan L, et al. 2022. Cells. 12: . PubMed
  291. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  292. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  293. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  294. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  295. Zander R, et al. 2022. Immunity. 55:475. PubMed
  296. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  297. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  298. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  299. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  300. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  301. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  302. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  303. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  304. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  305. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  306. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  307. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  308. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  309. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  310. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  311. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  312. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  313. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  314. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  315. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  316. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  317. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  318. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  319. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  320. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  321. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  322. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  323. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  324. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  325. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  326. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  328. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  329. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  330. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  331. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  332. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  333. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  334. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  335. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  336. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  337. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  338. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  339. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  340. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  341. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  342. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  343. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  344. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  345. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  346. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  347. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  348. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  349. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  350. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  351. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  352. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  353. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  354. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  355. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  356. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  357. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  358. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  359. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  360. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  361. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  362. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  363. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  364. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  365. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  366. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  367. Jondle CN, et al. 2021. MBio. 12:. PubMed
  368. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  369. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  370. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  371. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  372. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  373. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  374. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  375. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  376. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  377. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  378. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  379. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  380. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  381. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  382. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  383. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  384. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  385. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  386. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  387. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  388. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  389. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  390. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  391. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  392. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  393. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  394. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  395. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  396. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  397. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  398. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  399. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  400. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  401. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  402. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  403. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  404. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  405. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  406. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  407. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  408. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  409. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  410. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  411. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  412. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  413. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  414. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  415. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  416. Harty N 2011. J Immunol. 186:3836. PubMed
  417. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  418. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  419. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  420. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  421. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  422. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  423. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  424. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  425. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  426. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  427. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  428. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  429. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  430. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  431. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  432. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  433. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  434. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  435. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  436. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  437. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  438. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  439. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  440. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  441. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  442. Ma K, et al. 2022. iScience. 25:104347. PubMed
  443. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  444. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  445. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  446. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  447. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  448. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  449. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  450. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  451. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  452. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  453. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  454. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  455. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  456. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  457. Sekine T, et al. 2020. Cell. 183:158. PubMed
  458. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  459. Guo C, et al. 2018. Immunity. 49:842. PubMed
  460. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  461. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  462. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  463. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  464. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  465. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  466. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  467. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  468. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  469. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  470. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  471. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  472. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  473. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  474. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  475. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  476. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  477. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  478. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  479. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  480. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  481. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  482. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  483. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  484. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  485. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  486. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  487. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  488. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  489. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  490. Markey K, et al. 2009. Blood. 113:5644. PubMed
  491. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  492. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  493. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  494. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  495. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  496. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  497. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  498. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  499. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  500. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  501. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  502. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  503. Rist M, et al. 2015. J Virol. 89:703. PubMed
  504. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  505. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  506. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  507. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  508. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  509. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  510. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  511. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  512. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  513. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  514. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  515. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  516. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  517. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  518. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  519. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  520. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  521. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  522. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  523. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  524. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  525. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  526. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  527. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  528. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  529. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  530. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  531. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  532. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  533. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  534. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

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