Loading...

PE anti-mouse CD206 (MMR) Antibody PE anti-mouse CD206 (MMR) Antibody

Pricing & Availability
Clone
C068C2 (See other available formats)
Regulatory Status
RUO
Other Names
MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
C068C2_PE_1_082911
Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_1_082911
    Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_2_082911
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
141705 25 µg NOK1065
Check Availability


Need larger quantities of this item?
Request Bulk Quote
141706 100 µg NOK2467
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse CD206 (MMR)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
FC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Application References
  1. Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
  2. Ito H, et al. 2012. J Am Soc Nephrol. 23:1797. PubMed
  3. Yang X, et al. 2015. PNAS. 112:2900. PubMed
  4. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  5. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Xiong Y, et al. 2020. J Nanobiotechnology. 18:66. PubMed
  2. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  3. Feng Y, et al. 2018. J Am Soc Nephrol. 29:182. PubMed
  4. Seo JB, et al. 2019. Nat Metab. 1:86. PubMed
  5. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  6. Sun H, et al. 2019. Mol Hum Reprod. 25:05:00. PubMed
  7. Yu L, et al. 2021. Cell Biol Int. 45:2452. PubMed
  8. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  9. Silveira DB, et al. 2022. Cell Biochem Funct. 40:163. PubMed
  10. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  11. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  12. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  13. Li D, et al. 2022. Cell Prolif. 55:e13299. PubMed
  14. Li Y, et al. 2023. Bioact Mater. 20:548. PubMed
  15. Liu Z, et al. 2022. Cancer Commun (Lond). 42:971. PubMed
  16. Meng Z, et al. 2022. Int J Oncol. 61: . PubMed
  17. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  18. Li J, et al. 2023. Front Immunol. 13:945234. PubMed
  19. Choi H, et al. 2023. J Nanobiotechnology. 21:5. PubMed
  20. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  21. Li Y, et al. 2023. Cell Death Dis. 14:28. PubMed
  22. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  23. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  24. Chun J, et al. 2023. Cancers (Basel). 15: . PubMed
  25. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  26. Zhao X, et al. 2022. Cell Mol Immunol. 19:540. PubMed
  27. Lundahl MLE, et al. 2022. Elife. 11:. PubMed
  28. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  29. Bautista CA, et al. 2023. Front Physiol. 14:1122348. PubMed
  30. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  31. Chung JY, et al. 2023. Nat Commun. 14:1794. PubMed
  32. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  33. Pan C, et al. 2023. Front Bioeng Biotechnol. 11:1129187. PubMed
  34. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  35. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  36. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  37. Salemme V, et al. 2023. Nat Commun. 14:2350. PubMed
  38. Zeng S, et al. 2023. Front Oncol. 13:1171926. PubMed
  39. Zhang B, et al. 2022. Front Med (Lausanne). 8:796743. PubMed
  40. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  41. Zhang Z, et al. 2022. Front Pharmacol. 13:906625. PubMed
  42. Cui J, et al. 2021. J Cell Mol Med. 25:5586. PubMed
  43. Hu S, et al. 2018. Front Immunol. 9:01. PubMed
  44. Ying W et al. 2017. Cell. 171(2):372-384 . PubMed
  45. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  46. Nomura M, et al. 2016. Nat Immunol. 17:216-217. PubMed
  47. Hsu SPC, et al. 2020. J Neurooncol. 146:417. PubMed
  48. Clarke F,et al. 2017. PLoS One. 10.1371/journal.pone.0186625. PubMed
  49. Zhang Y, et al. 2018. Sci Rep. 8:5994. PubMed
  50. Li Q, et al. 2021. Front Immunol. 12:707784. PubMed
  51. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  52. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  53. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  54. Dong L, et al. 2021. Cancer Cell. . PubMed
  55. Sadek J, et al. 2021. EMBO Mol Med. 13:e13591. PubMed
  56. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  57. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  58. Krukowski K, et al. 2021. Sci Adv. 7:eabg6702. PubMed
  59. Pajarinen J, et al. 2021. J Biomed Mater Res A. 109:1512. PubMed
  60. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  61. Shao H, et al. 2012. J Biol Chem. 287:35860. PubMed
  62. Mul Fedele ML, et al. 2020. Front Cell Infect Microbiol. 10:100. PubMed
  63. El–Achkar GA, et al. 2019. PLoS One. 14:e0216405. PubMed
  64. Zhang J, et al. 2021. J Leukoc Biol. 110:485. PubMed
  65. Tanner L, et al. 2022. Front Pharmacol. 13:899469. PubMed
  66. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  67. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  68. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  69. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  70. Tang TT, et al. 2020. Sci Adv. 6:eaaz0748. PubMed
  71. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  72. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  73. Kim JS, et al. 2020. Int J Oncol. 56:1405. PubMed
  74. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  75. Zhang Y, et al. 2022. Nat Commun. 13:4553. PubMed
  76. McKee AM, et al. 2021. iScience. 24:103012. PubMed
  77. Farini A, et al. 2020. Front Physiol. 0.738194444. PubMed
  78. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  79. Li J, et al. 2021. Cell Commun Signal. 19:89. PubMed
  80. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  81. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  82. Martins L, et al. 2020. Stem Cell Res Ther. 0.786805556. PubMed
  83. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  84. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  85. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  86. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  87. Lee DH, et al. 2019. PLoS One. 14:e0215727. PubMed
  88. Yu Y, et al. 2018. Mol Med Rep. 17:8212. PubMed
  89. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  90. Wang Y, et al. 2022. Cell Death Dis. 13:748. PubMed
  91. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  92. Cai C, et al. 2021. Sci Rep. 11:13386. PubMed
  93. Toubal A, et al. 2020. Nat Commun. 3755:11. PubMed
  94. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  95. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  96. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  97. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  98. Miura I, et al. 2021. Physiol Rep. 9:e14859. PubMed
  99. Ying W, et al. 2016. Sci Rep. 6:20176. PubMed
  100. Sztwiertnia I, et al. 2020. PLoS One. 15:e0233789. PubMed
  101. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  102. Chu SY, et al. 2019. Nat Commun. 10:1524. PubMed
  103. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  104. Shu Y, et al. 2020. Immunology. 160:345. PubMed
  105. Lu X, et al. 2012. Arterioscler Thromb Vasc Biol. 32:2358. PubMed
  106. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  107. Qiu N, et al. 2021. J Nanobiotechnology. 19:428. PubMed
  108. Yang C, et al. 2022. Nat Commun. 13:4866. PubMed
  109. Zhou K, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16648712. PubMed
  110. Deng W, et al. 2015. Clin Immunol. . PubMed
  111. Lu SW, et al. 2020. Nat Commun. 3.660416667. PubMed
  112. Anderson-Baucum E, et al. 2021. Cell Metab. 33:1883. PubMed
  113. Stevenson ER, et al. 2022. J Pharmacol Exp Ther. 382:356. PubMed
  114. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  115. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  116. Stridh L, et al. 2013. J Neurosci. 33:12401. PubMed
  117. Asterholm I, et al. 2012. J Lipid Res. 53: 1254. PubMed
  118. Long L, et al. 2018. Bio Protoc. 8:e2815. PubMed
  119. Li C, et al. 2019. JCI Insight. 5. PubMed
  120. Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed
  121. Budai Z, et al. 2021. Cells. 10:. PubMed
  122. Krukowski K, et al. 2018. Sci Rep. 8:7857. PubMed
  123. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  124. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  125. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  126. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  127. Suzuki T, et al. 2017. Cell Rep. 18(8):2045-2057. PubMed
  128. Ukah T, et al. 2017. J Immunol. 10.4049/jimmunol.1700410. PubMed
  129. Roediger B et al. 2018. Cell. 175(2):530-543 . PubMed
  130. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  131. Liu C, et al. 2022. Cell Death Discov. 8:269. PubMed
  132. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  133. Browne A, et al. 2015. Cancer Res . 75: 2811 - 2821. PubMed
  134. Moreno M et al. 2014. The Journal of Neuroscience. 34(24):8175-85 . PubMed
  135. Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed
  136. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  137. Liu YS, et al. 2021. Cancers (Basel). 13:. PubMed
  138. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  139. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  140. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  141. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  142. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  143. Li B et al. 2019. Cell reports. 26(10):2720-2737 . PubMed
  144. Morioka S, et al. 2018. Nature. 563:714. PubMed
  145. Mellal K, et al. 2019. Sci Rep. 9:12903. PubMed
  146. Yeini E, et al. 2021. Nat Commun. 12:1912. PubMed
  147. Xu GY, et al. 2022. Small. 18:e2107838. PubMed
  148. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  149. Golabek A, et al. 2021. Exp Ther Med. 21:482. PubMed
  150. Chuan Li et al. 2017. Endocrinology. 158(9):2837-2847 . PubMed
  151. Wen HJ, et al. 2019. Cell Mol Gastroenterol Hepatol. 8:p173. PubMed
  152. Yuan M, et al. 2017. Hum Reprod. 32:94. PubMed
  153. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  154. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  155. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  156. Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
  157. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
  158. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
  159. Xiong Y, et al. 2020. J Nanobiotechnology. 18:66. PubMed
  160. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  161. Feng Y, et al. 2018. J Am Soc Nephrol. 29:182. PubMed
  162. Seo JB, et al. 2019. Nat Metab. 1:86. PubMed
  163. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  164. Sun H, et al. 2019. Mol Hum Reprod. 25:05:00. PubMed
  165. Yu L, et al. 2021. Cell Biol Int. 45:2452. PubMed
  166. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  167. Silveira DB, et al. 2022. Cell Biochem Funct. 40:163. PubMed
  168. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  169. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  170. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  171. Li D, et al. 2022. Cell Prolif. 55:e13299. PubMed
  172. Li Y, et al. 2023. Bioact Mater. 20:548. PubMed
  173. Liu Z, et al. 2022. Cancer Commun (Lond). 42:971. PubMed
  174. Meng Z, et al. 2022. Int J Oncol. 61: . PubMed
  175. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  176. Li J, et al. 2023. Front Immunol. 13:945234. PubMed
  177. Choi H, et al. 2023. J Nanobiotechnology. 21:5. PubMed
  178. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  179. Li Y, et al. 2023. Cell Death Dis. 14:28. PubMed
  180. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  181. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  182. Chun J, et al. 2023. Cancers (Basel). 15: . PubMed
  183. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  184. Zhao X, et al. 2022. Cell Mol Immunol. 19:540. PubMed
  185. Lundahl MLE, et al. 2022. Elife. 11:. PubMed
  186. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  187. Bautista CA, et al. 2023. Front Physiol. 14:1122348. PubMed
  188. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  189. Chung JY, et al. 2023. Nat Commun. 14:1794. PubMed
  190. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  191. Pan C, et al. 2023. Front Bioeng Biotechnol. 11:1129187. PubMed
  192. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  193. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  194. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  195. Salemme V, et al. 2023. Nat Commun. 14:2350. PubMed
  196. Zeng S, et al. 2023. Front Oncol. 13:1171926. PubMed
  197. Zhang B, et al. 2022. Front Med (Lausanne). 8:796743. PubMed
  198. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  199. Zhang Z, et al. 2022. Front Pharmacol. 13:906625. PubMed
  200. Cui J, et al. 2021. J Cell Mol Med. 25:5586. PubMed
  201. Hu S, et al. 2018. Front Immunol. 9:01. PubMed
  202. Ying W et al. 2017. Cell. 171(2):372-384 . PubMed
  203. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  204. Nomura M, et al. 2016. Nat Immunol. 17:216-217. PubMed
  205. Hsu SPC, et al. 2020. J Neurooncol. 146:417. PubMed
  206. Clarke F,et al. 2017. PLoS One. 10.1371/journal.pone.0186625. PubMed
  207. Zhang Y, et al. 2018. Sci Rep. 8:5994. PubMed
  208. Li Q, et al. 2021. Front Immunol. 12:707784. PubMed
  209. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  210. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  211. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  212. Dong L, et al. 2021. Cancer Cell. . PubMed
  213. Sadek J, et al. 2021. EMBO Mol Med. 13:e13591. PubMed
  214. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  215. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  216. Krukowski K, et al. 2021. Sci Adv. 7:eabg6702. PubMed
  217. Pajarinen J, et al. 2021. J Biomed Mater Res A. 109:1512. PubMed
  218. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  219. Shao H, et al. 2012. J Biol Chem. 287:35860. PubMed
  220. Mul Fedele ML, et al. 2020. Front Cell Infect Microbiol. 10:100. PubMed
  221. El–Achkar GA, et al. 2019. PLoS One. 14:e0216405. PubMed
  222. Zhang J, et al. 2021. J Leukoc Biol. 110:485. PubMed
  223. Tanner L, et al. 2022. Front Pharmacol. 13:899469. PubMed
  224. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  225. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  226. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  227. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  228. Tang TT, et al. 2020. Sci Adv. 6:eaaz0748. PubMed
  229. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  230. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  231. Kim JS, et al. 2020. Int J Oncol. 56:1405. PubMed
  232. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  233. Zhang Y, et al. 2022. Nat Commun. 13:4553. PubMed
  234. McKee AM, et al. 2021. iScience. 24:103012. PubMed
  235. Farini A, et al. 2020. Front Physiol. 0.738194444. PubMed
  236. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  237. Li J, et al. 2021. Cell Commun Signal. 19:89. PubMed
  238. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  239. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  240. Martins L, et al. 2020. Stem Cell Res Ther. 0.786805556. PubMed
  241. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  242. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  243. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  244. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  245. Lee DH, et al. 2019. PLoS One. 14:e0215727. PubMed
  246. Yu Y, et al. 2018. Mol Med Rep. 17:8212. PubMed
  247. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  248. Wang Y, et al. 2022. Cell Death Dis. 13:748. PubMed
  249. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  250. Cai C, et al. 2021. Sci Rep. 11:13386. PubMed
  251. Toubal A, et al. 2020. Nat Commun. 3755:11. PubMed
  252. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  253. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  254. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  255. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  256. Miura I, et al. 2021. Physiol Rep. 9:e14859. PubMed
  257. Ying W, et al. 2016. Sci Rep. 6:20176. PubMed
  258. Sztwiertnia I, et al. 2020. PLoS One. 15:e0233789. PubMed
  259. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  260. Chu SY, et al. 2019. Nat Commun. 10:1524. PubMed
  261. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  262. Shu Y, et al. 2020. Immunology. 160:345. PubMed
  263. Lu X, et al. 2012. Arterioscler Thromb Vasc Biol. 32:2358. PubMed
  264. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  265. Qiu N, et al. 2021. J Nanobiotechnology. 19:428. PubMed
  266. Yang C, et al. 2022. Nat Commun. 13:4866. PubMed
  267. Zhou K, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16648712. PubMed
  268. Deng W, et al. 2015. Clin Immunol. . PubMed
  269. Lu SW, et al. 2020. Nat Commun. 3.660416667. PubMed
  270. Anderson-Baucum E, et al. 2021. Cell Metab. 33:1883. PubMed
  271. Stevenson ER, et al. 2022. J Pharmacol Exp Ther. 382:356. PubMed
  272. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  273. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  274. Stridh L, et al. 2013. J Neurosci. 33:12401. PubMed
  275. Asterholm I, et al. 2012. J Lipid Res. 53: 1254. PubMed
  276. Long L, et al. 2018. Bio Protoc. 8:e2815. PubMed
  277. Li C, et al. 2019. JCI Insight. 5. PubMed
  278. Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed
  279. Budai Z, et al. 2021. Cells. 10:. PubMed
  280. Krukowski K, et al. 2018. Sci Rep. 8:7857. PubMed
  281. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  282. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  283. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  284. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  285. Suzuki T, et al. 2017. Cell Rep. 18(8):2045-2057. PubMed
  286. Ukah T, et al. 2017. J Immunol. 10.4049/jimmunol.1700410. PubMed
  287. Roediger B et al. 2018. Cell. 175(2):530-543 . PubMed
  288. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  289. Liu C, et al. 2022. Cell Death Discov. 8:269. PubMed
  290. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  291. Browne A, et al. 2015. Cancer Res . 75: 2811 - 2821. PubMed
  292. Moreno M et al. 2014. The Journal of Neuroscience. 34(24):8175-85 . PubMed
  293. Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed
  294. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  295. Liu YS, et al. 2021. Cancers (Basel). 13:. PubMed
  296. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  297. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  298. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  299. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  300. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  301. Li B et al. 2019. Cell reports. 26(10):2720-2737 . PubMed
  302. Morioka S, et al. 2018. Nature. 563:714. PubMed
  303. Mellal K, et al. 2019. Sci Rep. 9:12903. PubMed
  304. Yeini E, et al. 2021. Nat Commun. 12:1912. PubMed
  305. Xu GY, et al. 2022. Small. 18:e2107838. PubMed
  306. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  307. Golabek A, et al. 2021. Exp Ther Med. 21:482. PubMed
  308. Chuan Li et al. 2017. Endocrinology. 158(9):2837-2847 . PubMed
  309. Wen HJ, et al. 2019. Cell Mol Gastroenterol Hepatol. 8:p173. PubMed
  310. Yuan M, et al. 2017. Hum Reprod. 32:94. PubMed
  311. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  312. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  313. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  314. Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
  315. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
  316. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
RRID
AB_10896421 (BioLegend Cat. No. 141705)
AB_10895754 (BioLegend Cat. No. 141706)

Antigen Details

Structure
Type I transmembrane protein, 175 kD, C-type lectin superfamily
Distribution

Macrophages, dendritic cells, Langerhans cells, liver endothelial cells

Function
Pathogen recognition, endocytosis and phagocytosis, antigen presentation
Ligand/Receptor
Antigen containing mannose, fucose, or an N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Gene ID
17533 View all products for this Gene ID
UniProt
View information about CD206 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Why is mouse CD206 stained intracellularly and not via surface staining?

Typically, mouse CD206 surface level is relatively low under normal conditions and so intracellular staining protocol is required to get better signal.

Other Formats

View All CD206 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 711™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Dazzle™ 594 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Brilliant Violet 785™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 700 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Spark YG™ 570 anti-mouse CD206 (MMR) C068C2 IHC-F
Biotin anti-mouse CD206 (MMR) C068C2 ICFC,FC
APC anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 488 anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F
Alexa Fluor® 647 anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F
Purified anti-mouse CD206 (MMR) C068C2 ICFC,FC
FITC anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE anti-mouse CD206 (MMR) C068C2 ICFC,FC
PerCP/Cyanine5.5 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Brilliant Violet 421™ anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F,SB
Brilliant Violet 650™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Cyanine7 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 594 anti-mouse CD206 (MMR) C068C2 IHC-F
Brilliant Violet 605™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Cyanine5 anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Fire™ 700 anti-mouse CD206 (MMR) C068C2 ICFC,FC
TotalSeq™-B0173 anti-mouse CD206 (MMR) C068C2 ICPG
Spark Red™ 718 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
Spark Blue™ 574 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
TotalSeq™-C0173 anti-mouse CD206 (MMR) Antibody C068C2 ICPG
Spark NIR™ 685 anti-mouse CD206 (MMR) (Flexi-Fluor™) Antibody C068C2 FC
Spark YG™ 593 anti-mouse CD206 (MMR) (Flexi-Fluor™) Antibody C068C2 FC
Spark YG™ 581 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
Go To Top Version: 3    Revision Date: 04.04.2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
C068C2 (See other available formats)
Regulatory Status
RUO
Other Names
MMR (macrophage mannose receptor), MR (mannose receptor), MRC1
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
C068C2_PE_1_082911
Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_1_082911
    Thioglycollate-elicited BALB/c peritoneal macrophages were surface stained with CD107b (Mac-3) APC, and then intracellularly stained with CD206 (clone C068C2) PE (top) or rat IgG2a, κ PE isotype control (bottom).
  • C068C2_PE_2_082911
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
141705 25 µg NOK1065
Check Availability


Need larger quantities of this item?
Request Bulk Quote
141706 100 µg NOK2467
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse CD206 (MMR)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
FC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume.  It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone C068C2 recognizes a region similar to clone MR5D3, based on the ability of the clones to block each other. Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Application References
  1. Keller J, et al. 2012. Biochem Biophys Res Commun. 417:217. PubMed
  2. Ito H, et al. 2012. J Am Soc Nephrol. 23:1797. PubMed
  3. Yang X, et al. 2015. PNAS. 112:2900. PubMed
  4. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  5. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Xiong Y, et al. 2020. J Nanobiotechnology. 18:66. PubMed
  2. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  3. Feng Y, et al. 2018. J Am Soc Nephrol. 29:182. PubMed
  4. Seo JB, et al. 2019. Nat Metab. 1:86. PubMed
  5. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  6. Sun H, et al. 2019. Mol Hum Reprod. 25:05:00. PubMed
  7. Yu L, et al. 2021. Cell Biol Int. 45:2452. PubMed
  8. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  9. Silveira DB, et al. 2022. Cell Biochem Funct. 40:163. PubMed
  10. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  11. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  12. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  13. Li D, et al. 2022. Cell Prolif. 55:e13299. PubMed
  14. Li Y, et al. 2023. Bioact Mater. 20:548. PubMed
  15. Liu Z, et al. 2022. Cancer Commun (Lond). 42:971. PubMed
  16. Meng Z, et al. 2022. Int J Oncol. 61: . PubMed
  17. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  18. Li J, et al. 2023. Front Immunol. 13:945234. PubMed
  19. Choi H, et al. 2023. J Nanobiotechnology. 21:5. PubMed
  20. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  21. Li Y, et al. 2023. Cell Death Dis. 14:28. PubMed
  22. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  23. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  24. Chun J, et al. 2023. Cancers (Basel). 15: . PubMed
  25. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  26. Zhao X, et al. 2022. Cell Mol Immunol. 19:540. PubMed
  27. Lundahl MLE, et al. 2022. Elife. 11:. PubMed
  28. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  29. Bautista CA, et al. 2023. Front Physiol. 14:1122348. PubMed
  30. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  31. Chung JY, et al. 2023. Nat Commun. 14:1794. PubMed
  32. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  33. Pan C, et al. 2023. Front Bioeng Biotechnol. 11:1129187. PubMed
  34. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  35. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  36. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  37. Salemme V, et al. 2023. Nat Commun. 14:2350. PubMed
  38. Zeng S, et al. 2023. Front Oncol. 13:1171926. PubMed
  39. Zhang B, et al. 2022. Front Med (Lausanne). 8:796743. PubMed
  40. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  41. Zhang Z, et al. 2022. Front Pharmacol. 13:906625. PubMed
  42. Cui J, et al. 2021. J Cell Mol Med. 25:5586. PubMed
  43. Hu S, et al. 2018. Front Immunol. 9:01. PubMed
  44. Ying W et al. 2017. Cell. 171(2):372-384 . PubMed
  45. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  46. Nomura M, et al. 2016. Nat Immunol. 17:216-217. PubMed
  47. Hsu SPC, et al. 2020. J Neurooncol. 146:417. PubMed
  48. Clarke F,et al. 2017. PLoS One. 10.1371/journal.pone.0186625. PubMed
  49. Zhang Y, et al. 2018. Sci Rep. 8:5994. PubMed
  50. Li Q, et al. 2021. Front Immunol. 12:707784. PubMed
  51. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  52. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  53. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  54. Dong L, et al. 2021. Cancer Cell. . PubMed
  55. Sadek J, et al. 2021. EMBO Mol Med. 13:e13591. PubMed
  56. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  57. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  58. Krukowski K, et al. 2021. Sci Adv. 7:eabg6702. PubMed
  59. Pajarinen J, et al. 2021. J Biomed Mater Res A. 109:1512. PubMed
  60. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  61. Shao H, et al. 2012. J Biol Chem. 287:35860. PubMed
  62. Mul Fedele ML, et al. 2020. Front Cell Infect Microbiol. 10:100. PubMed
  63. El–Achkar GA, et al. 2019. PLoS One. 14:e0216405. PubMed
  64. Zhang J, et al. 2021. J Leukoc Biol. 110:485. PubMed
  65. Tanner L, et al. 2022. Front Pharmacol. 13:899469. PubMed
  66. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  67. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  68. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  69. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  70. Tang TT, et al. 2020. Sci Adv. 6:eaaz0748. PubMed
  71. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  72. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  73. Kim JS, et al. 2020. Int J Oncol. 56:1405. PubMed
  74. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  75. Zhang Y, et al. 2022. Nat Commun. 13:4553. PubMed
  76. McKee AM, et al. 2021. iScience. 24:103012. PubMed
  77. Farini A, et al. 2020. Front Physiol. 0.738194444. PubMed
  78. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  79. Li J, et al. 2021. Cell Commun Signal. 19:89. PubMed
  80. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  81. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  82. Martins L, et al. 2020. Stem Cell Res Ther. 0.786805556. PubMed
  83. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  84. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  85. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  86. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  87. Lee DH, et al. 2019. PLoS One. 14:e0215727. PubMed
  88. Yu Y, et al. 2018. Mol Med Rep. 17:8212. PubMed
  89. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  90. Wang Y, et al. 2022. Cell Death Dis. 13:748. PubMed
  91. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  92. Cai C, et al. 2021. Sci Rep. 11:13386. PubMed
  93. Toubal A, et al. 2020. Nat Commun. 3755:11. PubMed
  94. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  95. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  96. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  97. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  98. Miura I, et al. 2021. Physiol Rep. 9:e14859. PubMed
  99. Ying W, et al. 2016. Sci Rep. 6:20176. PubMed
  100. Sztwiertnia I, et al. 2020. PLoS One. 15:e0233789. PubMed
  101. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  102. Chu SY, et al. 2019. Nat Commun. 10:1524. PubMed
  103. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  104. Shu Y, et al. 2020. Immunology. 160:345. PubMed
  105. Lu X, et al. 2012. Arterioscler Thromb Vasc Biol. 32:2358. PubMed
  106. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  107. Qiu N, et al. 2021. J Nanobiotechnology. 19:428. PubMed
  108. Yang C, et al. 2022. Nat Commun. 13:4866. PubMed
  109. Zhou K, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16648712. PubMed
  110. Deng W, et al. 2015. Clin Immunol. . PubMed
  111. Lu SW, et al. 2020. Nat Commun. 3.660416667. PubMed
  112. Anderson-Baucum E, et al. 2021. Cell Metab. 33:1883. PubMed
  113. Stevenson ER, et al. 2022. J Pharmacol Exp Ther. 382:356. PubMed
  114. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  115. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  116. Stridh L, et al. 2013. J Neurosci. 33:12401. PubMed
  117. Asterholm I, et al. 2012. J Lipid Res. 53: 1254. PubMed
  118. Long L, et al. 2018. Bio Protoc. 8:e2815. PubMed
  119. Li C, et al. 2019. JCI Insight. 5. PubMed
  120. Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed
  121. Budai Z, et al. 2021. Cells. 10:. PubMed
  122. Krukowski K, et al. 2018. Sci Rep. 8:7857. PubMed
  123. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  124. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  125. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  126. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  127. Suzuki T, et al. 2017. Cell Rep. 18(8):2045-2057. PubMed
  128. Ukah T, et al. 2017. J Immunol. 10.4049/jimmunol.1700410. PubMed
  129. Roediger B et al. 2018. Cell. 175(2):530-543 . PubMed
  130. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  131. Liu C, et al. 2022. Cell Death Discov. 8:269. PubMed
  132. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  133. Browne A, et al. 2015. Cancer Res . 75: 2811 - 2821. PubMed
  134. Moreno M et al. 2014. The Journal of Neuroscience. 34(24):8175-85 . PubMed
  135. Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed
  136. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  137. Liu YS, et al. 2021. Cancers (Basel). 13:. PubMed
  138. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  139. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  140. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  141. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  142. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  143. Li B et al. 2019. Cell reports. 26(10):2720-2737 . PubMed
  144. Morioka S, et al. 2018. Nature. 563:714. PubMed
  145. Mellal K, et al. 2019. Sci Rep. 9:12903. PubMed
  146. Yeini E, et al. 2021. Nat Commun. 12:1912. PubMed
  147. Xu GY, et al. 2022. Small. 18:e2107838. PubMed
  148. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  149. Golabek A, et al. 2021. Exp Ther Med. 21:482. PubMed
  150. Chuan Li et al. 2017. Endocrinology. 158(9):2837-2847 . PubMed
  151. Wen HJ, et al. 2019. Cell Mol Gastroenterol Hepatol. 8:p173. PubMed
  152. Yuan M, et al. 2017. Hum Reprod. 32:94. PubMed
  153. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  154. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  155. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  156. Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
  157. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
  158. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
  159. Xiong Y, et al. 2020. J Nanobiotechnology. 18:66. PubMed
  160. Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed
  161. Feng Y, et al. 2018. J Am Soc Nephrol. 29:182. PubMed
  162. Seo JB, et al. 2019. Nat Metab. 1:86. PubMed
  163. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  164. Sun H, et al. 2019. Mol Hum Reprod. 25:05:00. PubMed
  165. Yu L, et al. 2021. Cell Biol Int. 45:2452. PubMed
  166. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  167. Silveira DB, et al. 2022. Cell Biochem Funct. 40:163. PubMed
  168. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  169. Lee R, et al. 2022. Cancer Discov. 12:1702. PubMed
  170. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  171. Li D, et al. 2022. Cell Prolif. 55:e13299. PubMed
  172. Li Y, et al. 2023. Bioact Mater. 20:548. PubMed
  173. Liu Z, et al. 2022. Cancer Commun (Lond). 42:971. PubMed
  174. Meng Z, et al. 2022. Int J Oncol. 61: . PubMed
  175. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  176. Li J, et al. 2023. Front Immunol. 13:945234. PubMed
  177. Choi H, et al. 2023. J Nanobiotechnology. 21:5. PubMed
  178. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  179. Li Y, et al. 2023. Cell Death Dis. 14:28. PubMed
  180. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  181. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  182. Chun J, et al. 2023. Cancers (Basel). 15: . PubMed
  183. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  184. Zhao X, et al. 2022. Cell Mol Immunol. 19:540. PubMed
  185. Lundahl MLE, et al. 2022. Elife. 11:. PubMed
  186. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  187. Bautista CA, et al. 2023. Front Physiol. 14:1122348. PubMed
  188. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  189. Chung JY, et al. 2023. Nat Commun. 14:1794. PubMed
  190. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  191. Pan C, et al. 2023. Front Bioeng Biotechnol. 11:1129187. PubMed
  192. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  193. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  194. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  195. Salemme V, et al. 2023. Nat Commun. 14:2350. PubMed
  196. Zeng S, et al. 2023. Front Oncol. 13:1171926. PubMed
  197. Zhang B, et al. 2022. Front Med (Lausanne). 8:796743. PubMed
  198. Wang HH, et al. 2022. J Biomed Sci. 29:36. PubMed
  199. Zhang Z, et al. 2022. Front Pharmacol. 13:906625. PubMed
  200. Cui J, et al. 2021. J Cell Mol Med. 25:5586. PubMed
  201. Hu S, et al. 2018. Front Immunol. 9:01. PubMed
  202. Ying W et al. 2017. Cell. 171(2):372-384 . PubMed
  203. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  204. Nomura M, et al. 2016. Nat Immunol. 17:216-217. PubMed
  205. Hsu SPC, et al. 2020. J Neurooncol. 146:417. PubMed
  206. Clarke F,et al. 2017. PLoS One. 10.1371/journal.pone.0186625. PubMed
  207. Zhang Y, et al. 2018. Sci Rep. 8:5994. PubMed
  208. Li Q, et al. 2021. Front Immunol. 12:707784. PubMed
  209. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  210. Zheng W, et al. 2021. Wellcome Open Research. 6:52. PubMed
  211. Uzhachenko RV, et al. 2021. Cell Reports. 35(1):108944. PubMed
  212. Dong L, et al. 2021. Cancer Cell. . PubMed
  213. Sadek J, et al. 2021. EMBO Mol Med. 13:e13591. PubMed
  214. De Vlaeminck Y, et al. 2020. Cancers (Basel). 12:. PubMed
  215. Li J, et al. 2021. Front Immunol. 12:649285. PubMed
  216. Krukowski K, et al. 2021. Sci Adv. 7:eabg6702. PubMed
  217. Pajarinen J, et al. 2021. J Biomed Mater Res A. 109:1512. PubMed
  218. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  219. Shao H, et al. 2012. J Biol Chem. 287:35860. PubMed
  220. Mul Fedele ML, et al. 2020. Front Cell Infect Microbiol. 10:100. PubMed
  221. El–Achkar GA, et al. 2019. PLoS One. 14:e0216405. PubMed
  222. Zhang J, et al. 2021. J Leukoc Biol. 110:485. PubMed
  223. Tanner L, et al. 2022. Front Pharmacol. 13:899469. PubMed
  224. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  225. Johansen AZ, et al. 2022. Pharmaceutics. 14:. PubMed
  226. Jia X, et al. 2021. Front Cell Dev Biol. 9:685522. PubMed
  227. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  228. Tang TT, et al. 2020. Sci Adv. 6:eaaz0748. PubMed
  229. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  230. Dan H, et al. 2020. Mol Oncol. 14:795. PubMed
  231. Kim JS, et al. 2020. Int J Oncol. 56:1405. PubMed
  232. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  233. Zhang Y, et al. 2022. Nat Commun. 13:4553. PubMed
  234. McKee AM, et al. 2021. iScience. 24:103012. PubMed
  235. Farini A, et al. 2020. Front Physiol. 0.738194444. PubMed
  236. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  237. Li J, et al. 2021. Cell Commun Signal. 19:89. PubMed
  238. Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
  239. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  240. Martins L, et al. 2020. Stem Cell Res Ther. 0.786805556. PubMed
  241. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  242. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  243. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  244. Lu X, et al. 2020. Sci Transl Med. 12:. PubMed
  245. Lee DH, et al. 2019. PLoS One. 14:e0215727. PubMed
  246. Yu Y, et al. 2018. Mol Med Rep. 17:8212. PubMed
  247. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  248. Wang Y, et al. 2022. Cell Death Dis. 13:748. PubMed
  249. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  250. Cai C, et al. 2021. Sci Rep. 11:13386. PubMed
  251. Toubal A, et al. 2020. Nat Commun. 3755:11. PubMed
  252. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  253. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  254. Li H, et al. 2021. Nat Commun. 12:7149. PubMed
  255. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  256. Miura I, et al. 2021. Physiol Rep. 9:e14859. PubMed
  257. Ying W, et al. 2016. Sci Rep. 6:20176. PubMed
  258. Sztwiertnia I, et al. 2020. PLoS One. 15:e0233789. PubMed
  259. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  260. Chu SY, et al. 2019. Nat Commun. 10:1524. PubMed
  261. Anderson AE, et al. 2022. NPJ Regen Med. 7:6. PubMed
  262. Shu Y, et al. 2020. Immunology. 160:345. PubMed
  263. Lu X, et al. 2012. Arterioscler Thromb Vasc Biol. 32:2358. PubMed
  264. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  265. Qiu N, et al. 2021. J Nanobiotechnology. 19:428. PubMed
  266. Yang C, et al. 2022. Nat Commun. 13:4866. PubMed
  267. Zhou K, et al. 2016. J Cereb Blood Flow Metab. 10.1177/0271678X16648712. PubMed
  268. Deng W, et al. 2015. Clin Immunol. . PubMed
  269. Lu SW, et al. 2020. Nat Commun. 3.660416667. PubMed
  270. Anderson-Baucum E, et al. 2021. Cell Metab. 33:1883. PubMed
  271. Stevenson ER, et al. 2022. J Pharmacol Exp Ther. 382:356. PubMed
  272. Wang X, et al. 2022. J Biol Chem. 298:101561. PubMed
  273. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  274. Stridh L, et al. 2013. J Neurosci. 33:12401. PubMed
  275. Asterholm I, et al. 2012. J Lipid Res. 53: 1254. PubMed
  276. Long L, et al. 2018. Bio Protoc. 8:e2815. PubMed
  277. Li C, et al. 2019. JCI Insight. 5. PubMed
  278. Zhu Q, et al. 2022. Atherosclerosis. 357:41. PubMed
  279. Budai Z, et al. 2021. Cells. 10:. PubMed
  280. Krukowski K, et al. 2018. Sci Rep. 8:7857. PubMed
  281. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  282. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  283. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  284. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  285. Suzuki T, et al. 2017. Cell Rep. 18(8):2045-2057. PubMed
  286. Ukah T, et al. 2017. J Immunol. 10.4049/jimmunol.1700410. PubMed
  287. Roediger B et al. 2018. Cell. 175(2):530-543 . PubMed
  288. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  289. Liu C, et al. 2022. Cell Death Discov. 8:269. PubMed
  290. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  291. Browne A, et al. 2015. Cancer Res . 75: 2811 - 2821. PubMed
  292. Moreno M et al. 2014. The Journal of Neuroscience. 34(24):8175-85 . PubMed
  293. Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed
  294. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  295. Liu YS, et al. 2021. Cancers (Basel). 13:. PubMed
  296. Budhu S, et al. 2021. Cell Reports. 34(2):108620. PubMed
  297. Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed
  298. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  299. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  300. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  301. Li B et al. 2019. Cell reports. 26(10):2720-2737 . PubMed
  302. Morioka S, et al. 2018. Nature. 563:714. PubMed
  303. Mellal K, et al. 2019. Sci Rep. 9:12903. PubMed
  304. Yeini E, et al. 2021. Nat Commun. 12:1912. PubMed
  305. Xu GY, et al. 2022. Small. 18:e2107838. PubMed
  306. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  307. Golabek A, et al. 2021. Exp Ther Med. 21:482. PubMed
  308. Chuan Li et al. 2017. Endocrinology. 158(9):2837-2847 . PubMed
  309. Wen HJ, et al. 2019. Cell Mol Gastroenterol Hepatol. 8:p173. PubMed
  310. Yuan M, et al. 2017. Hum Reprod. 32:94. PubMed
  311. Riopel M, et al. 2019. Mol Metab. 20:89. PubMed
  312. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  313. Cai T, et al. 2022. Front Immunol. 13:1009932. PubMed
  314. Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
  315. Guo S, et al. 2021. Chronic Dis Transl Med. 7:254. PubMed
  316. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
RRID
AB_10896421 (BioLegend Cat. No. 141705)
AB_10895754 (BioLegend Cat. No. 141706)

Antigen Details

Structure
Type I transmembrane protein, 175 kD, C-type lectin superfamily
Distribution

Macrophages, dendritic cells, Langerhans cells, liver endothelial cells

Function
Pathogen recognition, endocytosis and phagocytosis, antigen presentation
Ligand/Receptor
Antigen containing mannose, fucose, or an N-acetyl glucosamine
Cell Type
Dendritic cells, Endothelial cells, Langerhans cells, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Gene ID
17533 View all products for this Gene ID
UniProt
View information about CD206 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Why is mouse CD206 stained intracellularly and not via surface staining?

Typically, mouse CD206 surface level is relatively low under normal conditions and so intracellular staining protocol is required to get better signal.

Other Formats

View All CD206 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 711™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Dazzle™ 594 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Brilliant Violet 785™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 700 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Spark YG™ 570 anti-mouse CD206 (MMR) C068C2 IHC-F
Biotin anti-mouse CD206 (MMR) C068C2 ICFC,FC
APC anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 488 anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F
Alexa Fluor® 647 anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F
Purified anti-mouse CD206 (MMR) C068C2 ICFC,FC
FITC anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE anti-mouse CD206 (MMR) C068C2 ICFC,FC
PerCP/Cyanine5.5 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Brilliant Violet 421™ anti-mouse CD206 (MMR) C068C2 ICFC,FC,IHC-F,SB
Brilliant Violet 650™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Cyanine7 anti-mouse CD206 (MMR) C068C2 ICFC,FC
Alexa Fluor® 594 anti-mouse CD206 (MMR) C068C2 IHC-F
Brilliant Violet 605™ anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Cyanine5 anti-mouse CD206 (MMR) C068C2 ICFC,FC
PE/Fire™ 700 anti-mouse CD206 (MMR) C068C2 ICFC,FC
TotalSeq™-B0173 anti-mouse CD206 (MMR) C068C2 ICPG
Spark Red™ 718 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
Spark Blue™ 574 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
TotalSeq™-C0173 anti-mouse CD206 (MMR) Antibody C068C2 ICPG
Spark NIR™ 685 anti-mouse CD206 (MMR) (Flexi-Fluor™) Antibody C068C2 FC
Spark YG™ 593 anti-mouse CD206 (MMR) (Flexi-Fluor™) Antibody C068C2 FC
Spark YG™ 581 anti-mouse CD206 (MMR) (Flexi-Fluor™) C068C2 FC
Go To Top Version: 3    Revision Date: 04.04.2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account