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PE anti-mouse CD80 Antibody PE anti-mouse CD80 Antibody

Pricing & Availability
Clone
16-10A1 (See other available formats)
Regulatory Status
RUO
Other Names
B7-1, B7, Ly-53
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
16-10A1_PE_032309.jpg
Thioglycolate-elicited Balb/c mouse peritoneal macrophages stained with 16-10A1 PE
  • 16-10A1_PE_032309.jpg
    Thioglycolate-elicited Balb/c mouse peritoneal macrophages stained with 16-10A1 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
104708 200 µg NOK2418
Check Availability


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104707 50 µg NOK908
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Description

CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Reported Reactivity
Dog
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
CHO cell line transfected with mouse B7 (CD80)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation2, in vitro and in vivo blocking of CTLA-4 Ig to CD80 by blocking costimulation of T cells by activated B cells2-4, and immunohistochemical staining of acetone-fixed frozen sections1,4. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104747-104752).

Application References
  1. Harlan DM, et al. 1994. P. Natl. Acad. Sci. USA 91:3137. (IHC)
  2. Razi-Wolf Z, et al. 1992. P. Natl. Acad. Sci. USA 89:4210. (Block, IP)
  3. Hathcock KS, et al. 1994. J. Exp. Med. 180:631. (Block)
  4. Herold KC, et al. 1997. J. Immunol. 158:984. (Block, IHC)
  5. Ma XT, et al. 2006. Cancer Res. 66:1169.
  6. Andoniou CE, et al. 2005. Nature Immunology 6:1011. (FC)
  7. Lawson BR, et al. 2007. J. Immunol. 178:5366.
  8. Turnquist HR, et al. 2007. J. Immunol. 178:7018.
  9. Misra RS, et al. 2010. J. Exp Med. 207:1775. PubMed
  10. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  11. Philipsen L, et al. 2013. Mol Cell Proteomics. 12:2551. PubMed
Product Citations
  1. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  2. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  3. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  4. Gargaro M, et al. 2022. Immunity. 55:1032. PubMed
  5. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  6. Sun Y, et al. 2023. Bioact Mater. 22:47. PubMed
  7. Liu M, et al. 2022. Cells. 11: . PubMed
  8. Montilla A, et al. 2023. Cell Death Dis. 14:16. PubMed
  9. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  10. Han J, et al. 2023. Front Microbiol. 13:1067725. PubMed
  11. Sohn HS, et al. 2022. Sci Adv. 8:eabo5284. PubMed
  12. Chen H, et al. 2023. Nat Commun. 14:941. PubMed
  13. Cheng K, et al. 2023. Small. 19:e2300125. PubMed
  14. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  15. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  16. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  17. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  18. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  19. Li Y, et al. 2023. Front Cell Infect Microbiol. 13:1117230. PubMed
  20. Wu N, et al. 2023. Front Bioeng Biotechnol. 11:1173381. PubMed
  21. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  22. Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed
  23. Rozanski C, et al. 2011. J Exp Med. 208:1435. PubMed
  24. Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed
  25. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  26. Wilhelm J, et al. 2021. J Control Release. 329:353. PubMed
  27. Kashyap AS, et al. 2019. Cell Rep. 28:3367. PubMed
  28. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  29. Wei H, et al. 2021. Malar J. 20:89. PubMed
  30. Kodumudi KN, et al. 2019. Front Immunol. 10:1939. PubMed
  31. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  32. Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed
  33. Kremenovic M, et al. 2022. J Immunother Cancer. 10:. PubMed
  34. Gruber T, et al. 2020. JCI Insight. 5:00. PubMed
  35. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  36. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  37. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  38. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  39. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  40. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  41. Bhattacharjee P, et al. 2018. Sci Rep. 13:e0199785. PubMed
  42. Wu J, et al. 2021. Mol Med Rep. 23:. PubMed
  43. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  44. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  45. Lin SY, et al. 2017. Autophagy. 14:778. PubMed
  46. Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed
  47. Tsukasaki M, et al. 2020. Cell Reports. 32(10):108124. PubMed
  48. Zhang L, et al. 2021. J Immunother Cancer. 9:. PubMed
  49. Utley A, et al. 2020. Cell Rep. 31:107815. PubMed
  50. Zhang F, et al. 2017. Mol Immunol. 10.1016/j.molimm.2017.06.019. PubMed
  51. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  52. Coe D, et al. 2022. JCI Insight. 7:. PubMed
  53. Glaros V, et al. 2021. Immunity. 54:2005. PubMed
  54. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  55. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  56. Florêncio KGD, et al. 2022. Front Immunol. 13:941757. PubMed
  57. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  58. Guo L, et al. 2021. Vaccines (Basel). 9:. PubMed
  59. Ganesan R, et al. 2020. FASEB J. 34:15888. PubMed
  60. Pilones KA, et al. 2020. Cancer Immunol Res. 8:1054. PubMed
  61. Chen G, et al. 2021. Sci Adv. 7:eabg5686. PubMed
  62. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  63. White C, et al. 2015. J Immunol. 194:697. PubMed
  64. Wong E, et al. 2012. J Immunol. 189:5667. PubMed
  65. Matundan H, et al. 2019. J Virol. 93. PubMed
  66. Wu G, et al. 2022. Wellcome Open Res. 6:134. PubMed
  67. Zheng D, et al. 2022. Acta Pharm Sin B. 12:2740. PubMed
  68. Vogel A, et al. 2022. STAR Protoc. 3:101653. PubMed
  69. Matundan HH, et al. 2021. J Virol. 95:e0103621. PubMed
  70. Sun L, et al. 2015. Sci Rep. 5: 14871. PubMed
  71. Marshall N, et al. 2012. Cancer Res. 72:581. PubMed
  72. Yang C, et al. 2019. Nanomedicine (Lond). 14:2423. PubMed
  73. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  74. Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
  75. Zhang X, et al. 2022. JCI Insight. 7:. PubMed
  76. Fan Q, et al. 2021. Bioact Mater. 6:4014. PubMed
  77. Zhang W, et al. 2020. Nat Commun. 11:1187. PubMed
  78. Ye Y, et al. 2017. Sci Immunol. 2:17. PubMed
  79. Taddio MF, et al. 2021. Mol Imaging Biol. 23:196. PubMed
  80. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  81. Kelly SH, et al. 2021. ACS Biomater Sci Eng. 7:1876. PubMed
  82. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  83. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  84. He J, et al. 2020. Evid Based Complement Alternat Med. 2020:5637507. PubMed
  85. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  86. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  87. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  88. Izumi G, et al. 2021. Nat Commun. 12:5029. PubMed
  89. Qi J, et al. 2021. Nat Commun. 12:4755. PubMed
  90. Li J, et al. 2020. Development. :. PubMed
  91. Wang X, et al. 2021. EMBO J. 40:e105926. PubMed
  92. Simmons D, et al. 2012. J Immunol. 188:3116. PubMed
  93. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  94. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  95. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  96. Feng S, et al. 2021. Exp Ther Med. 21:20. PubMed
  97. Sebina I, et al. 2016. PLoS Pathog. 12:e1005999. PubMed
  98. Tateishi R, et al. 2015. PLoS One. 10: e0141650. PubMed
  99. Kelly SH, et al. 2021. Adv Healthc Mater. 10:e2001614. PubMed
  100. Piñón-Zárate G, et al. 2022. Molecules. 27:. PubMed
  101. Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed
  102. Yang Z, et al. 2021. Nat Commun. 12:4299. PubMed
  103. Miyauchi K, et al. 2021. Nat Commun. 12:3789. PubMed
  104. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  105. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  106. Xiao Z, et al. 2022. Mater Today Bio. 15:100297. PubMed
  107. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  108. Kadir NA, et al. 2020. Pathogens. 9:00. PubMed
  109. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  110. Lightman SM, et al. 2020. Cell Reports. 1.086805556. PubMed
  111. Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
  112. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  113. Wang Y, et al. 2020. Vaccines (Basel). 8:. PubMed
  114. Jeisy-Scott V, et al. 2012. J Virol. 86:10988. PubMed
  115. Liu WL, et al. 2019. Nat Commun. 10:3199. PubMed
  116. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
  117. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  118. Lin YC, et al. 2020. Mol Med Rep. 22:4909. PubMed
  119. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  120. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  121. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  122. Gargaro M, et al. 2022. Immunity. 55:1032. PubMed
  123. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  124. Sun Y, et al. 2023. Bioact Mater. 22:47. PubMed
  125. Liu M, et al. 2022. Cells. 11: . PubMed
  126. Montilla A, et al. 2023. Cell Death Dis. 14:16. PubMed
  127. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  128. Han J, et al. 2023. Front Microbiol. 13:1067725. PubMed
  129. Sohn HS, et al. 2022. Sci Adv. 8:eabo5284. PubMed
  130. Chen H, et al. 2023. Nat Commun. 14:941. PubMed
  131. Cheng K, et al. 2023. Small. 19:e2300125. PubMed
  132. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  133. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  134. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  135. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  136. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  137. Li Y, et al. 2023. Front Cell Infect Microbiol. 13:1117230. PubMed
  138. Wu N, et al. 2023. Front Bioeng Biotechnol. 11:1173381. PubMed
  139. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  140. Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed
  141. Rozanski C, et al. 2011. J Exp Med. 208:1435. PubMed
  142. Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed
  143. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  144. Wilhelm J, et al. 2021. J Control Release. 329:353. PubMed
  145. Kashyap AS, et al. 2019. Cell Rep. 28:3367. PubMed
  146. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  147. Wei H, et al. 2021. Malar J. 20:89. PubMed
  148. Kodumudi KN, et al. 2019. Front Immunol. 10:1939. PubMed
  149. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  150. Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed
  151. Kremenovic M, et al. 2022. J Immunother Cancer. 10:. PubMed
  152. Gruber T, et al. 2020. JCI Insight. 5:00. PubMed
  153. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  154. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  155. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  156. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  157. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  158. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  159. Bhattacharjee P, et al. 2018. Sci Rep. 13:e0199785. PubMed
  160. Wu J, et al. 2021. Mol Med Rep. 23:. PubMed
  161. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  162. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  163. Lin SY, et al. 2017. Autophagy. 14:778. PubMed
  164. Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed
  165. Tsukasaki M, et al. 2020. Cell Reports. 32(10):108124. PubMed
  166. Zhang L, et al. 2021. J Immunother Cancer. 9:. PubMed
  167. Utley A, et al. 2020. Cell Rep. 31:107815. PubMed
  168. Zhang F, et al. 2017. Mol Immunol. 10.1016/j.molimm.2017.06.019. PubMed
  169. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  170. Coe D, et al. 2022. JCI Insight. 7:. PubMed
  171. Glaros V, et al. 2021. Immunity. 54:2005. PubMed
  172. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  173. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  174. Florêncio KGD, et al. 2022. Front Immunol. 13:941757. PubMed
  175. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  176. Guo L, et al. 2021. Vaccines (Basel). 9:. PubMed
  177. Ganesan R, et al. 2020. FASEB J. 34:15888. PubMed
  178. Pilones KA, et al. 2020. Cancer Immunol Res. 8:1054. PubMed
  179. Chen G, et al. 2021. Sci Adv. 7:eabg5686. PubMed
  180. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  181. White C, et al. 2015. J Immunol. 194:697. PubMed
  182. Wong E, et al. 2012. J Immunol. 189:5667. PubMed
  183. Matundan H, et al. 2019. J Virol. 93. PubMed
  184. Wu G, et al. 2022. Wellcome Open Res. 6:134. PubMed
  185. Zheng D, et al. 2022. Acta Pharm Sin B. 12:2740. PubMed
  186. Vogel A, et al. 2022. STAR Protoc. 3:101653. PubMed
  187. Matundan HH, et al. 2021. J Virol. 95:e0103621. PubMed
  188. Sun L, et al. 2015. Sci Rep. 5: 14871. PubMed
  189. Marshall N, et al. 2012. Cancer Res. 72:581. PubMed
  190. Yang C, et al. 2019. Nanomedicine (Lond). 14:2423. PubMed
  191. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  192. Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
  193. Zhang X, et al. 2022. JCI Insight. 7:. PubMed
  194. Fan Q, et al. 2021. Bioact Mater. 6:4014. PubMed
  195. Zhang W, et al. 2020. Nat Commun. 11:1187. PubMed
  196. Ye Y, et al. 2017. Sci Immunol. 2:17. PubMed
  197. Taddio MF, et al. 2021. Mol Imaging Biol. 23:196. PubMed
  198. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  199. Kelly SH, et al. 2021. ACS Biomater Sci Eng. 7:1876. PubMed
  200. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  201. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  202. He J, et al. 2020. Evid Based Complement Alternat Med. 2020:5637507. PubMed
  203. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  204. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  205. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  206. Izumi G, et al. 2021. Nat Commun. 12:5029. PubMed
  207. Qi J, et al. 2021. Nat Commun. 12:4755. PubMed
  208. Li J, et al. 2020. Development. :. PubMed
  209. Wang X, et al. 2021. EMBO J. 40:e105926. PubMed
  210. Simmons D, et al. 2012. J Immunol. 188:3116. PubMed
  211. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  212. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  213. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  214. Feng S, et al. 2021. Exp Ther Med. 21:20. PubMed
  215. Sebina I, et al. 2016. PLoS Pathog. 12:e1005999. PubMed
  216. Tateishi R, et al. 2015. PLoS One. 10: e0141650. PubMed
  217. Kelly SH, et al. 2021. Adv Healthc Mater. 10:e2001614. PubMed
  218. Piñón-Zárate G, et al. 2022. Molecules. 27:. PubMed
  219. Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed
  220. Yang Z, et al. 2021. Nat Commun. 12:4299. PubMed
  221. Miyauchi K, et al. 2021. Nat Commun. 12:3789. PubMed
  222. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  223. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  224. Xiao Z, et al. 2022. Mater Today Bio. 15:100297. PubMed
  225. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  226. Kadir NA, et al. 2020. Pathogens. 9:00. PubMed
  227. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  228. Lightman SM, et al. 2020. Cell Reports. 1.086805556. PubMed
  229. Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
  230. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  231. Wang Y, et al. 2020. Vaccines (Basel). 8:. PubMed
  232. Jeisy-Scott V, et al. 2012. J Virol. 86:10988. PubMed
  233. Liu WL, et al. 2019. Nat Commun. 10:3199. PubMed
  234. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
  235. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  236. Lin YC, et al. 2020. Mol Med Rep. 22:4909. PubMed
RRID
AB_313129 (BioLegend Cat. No. 104708)
AB_313128 (BioLegend Cat. No. 104707)

Antigen Details

Structure
Ig superfamily, 60 kD
Distribution

Macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28 (stimulatory), CD152(CTLA4) (inhibitory)
Cell Type
B cells, Dendritic cells, Macrophages, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Linsley PS, et al. 1991. J. Exp. Med. 174:561.
3. Salomon B, et al. 2001. Annu. Rev. Immunol. 19:225.

Gene ID
12519 View all products for this Gene ID
UniProt
View information about CD80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 02.18.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
16-10A1 (See other available formats)
Regulatory Status
RUO
Other Names
B7-1, B7, Ly-53
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
16-10A1_PE_032309.jpg
Thioglycolate-elicited Balb/c mouse peritoneal macrophages stained with 16-10A1 PE
  • 16-10A1_PE_032309.jpg
    Thioglycolate-elicited Balb/c mouse peritoneal macrophages stained with 16-10A1 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
104708 200 µg NOK2418
Check Availability


Need larger quantities of this item?
Request Bulk Quote
104707 50 µg NOK908
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Reported Reactivity
Dog
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
CHO cell line transfected with mouse B7 (CD80)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation2, in vitro and in vivo blocking of CTLA-4 Ig to CD80 by blocking costimulation of T cells by activated B cells2-4, and immunohistochemical staining of acetone-fixed frozen sections1,4. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 104747-104752).

Application References
  1. Harlan DM, et al. 1994. P. Natl. Acad. Sci. USA 91:3137. (IHC)
  2. Razi-Wolf Z, et al. 1992. P. Natl. Acad. Sci. USA 89:4210. (Block, IP)
  3. Hathcock KS, et al. 1994. J. Exp. Med. 180:631. (Block)
  4. Herold KC, et al. 1997. J. Immunol. 158:984. (Block, IHC)
  5. Ma XT, et al. 2006. Cancer Res. 66:1169.
  6. Andoniou CE, et al. 2005. Nature Immunology 6:1011. (FC)
  7. Lawson BR, et al. 2007. J. Immunol. 178:5366.
  8. Turnquist HR, et al. 2007. J. Immunol. 178:7018.
  9. Misra RS, et al. 2010. J. Exp Med. 207:1775. PubMed
  10. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
  11. Philipsen L, et al. 2013. Mol Cell Proteomics. 12:2551. PubMed
Product Citations
  1. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  2. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  3. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  4. Gargaro M, et al. 2022. Immunity. 55:1032. PubMed
  5. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  6. Sun Y, et al. 2023. Bioact Mater. 22:47. PubMed
  7. Liu M, et al. 2022. Cells. 11: . PubMed
  8. Montilla A, et al. 2023. Cell Death Dis. 14:16. PubMed
  9. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  10. Han J, et al. 2023. Front Microbiol. 13:1067725. PubMed
  11. Sohn HS, et al. 2022. Sci Adv. 8:eabo5284. PubMed
  12. Chen H, et al. 2023. Nat Commun. 14:941. PubMed
  13. Cheng K, et al. 2023. Small. 19:e2300125. PubMed
  14. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  15. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  16. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  17. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  18. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  19. Li Y, et al. 2023. Front Cell Infect Microbiol. 13:1117230. PubMed
  20. Wu N, et al. 2023. Front Bioeng Biotechnol. 11:1173381. PubMed
  21. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  22. Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed
  23. Rozanski C, et al. 2011. J Exp Med. 208:1435. PubMed
  24. Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed
  25. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  26. Wilhelm J, et al. 2021. J Control Release. 329:353. PubMed
  27. Kashyap AS, et al. 2019. Cell Rep. 28:3367. PubMed
  28. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  29. Wei H, et al. 2021. Malar J. 20:89. PubMed
  30. Kodumudi KN, et al. 2019. Front Immunol. 10:1939. PubMed
  31. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  32. Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed
  33. Kremenovic M, et al. 2022. J Immunother Cancer. 10:. PubMed
  34. Gruber T, et al. 2020. JCI Insight. 5:00. PubMed
  35. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  36. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  37. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  38. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  39. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  40. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  41. Bhattacharjee P, et al. 2018. Sci Rep. 13:e0199785. PubMed
  42. Wu J, et al. 2021. Mol Med Rep. 23:. PubMed
  43. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  44. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  45. Lin SY, et al. 2017. Autophagy. 14:778. PubMed
  46. Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed
  47. Tsukasaki M, et al. 2020. Cell Reports. 32(10):108124. PubMed
  48. Zhang L, et al. 2021. J Immunother Cancer. 9:. PubMed
  49. Utley A, et al. 2020. Cell Rep. 31:107815. PubMed
  50. Zhang F, et al. 2017. Mol Immunol. 10.1016/j.molimm.2017.06.019. PubMed
  51. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  52. Coe D, et al. 2022. JCI Insight. 7:. PubMed
  53. Glaros V, et al. 2021. Immunity. 54:2005. PubMed
  54. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  55. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  56. Florêncio KGD, et al. 2022. Front Immunol. 13:941757. PubMed
  57. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  58. Guo L, et al. 2021. Vaccines (Basel). 9:. PubMed
  59. Ganesan R, et al. 2020. FASEB J. 34:15888. PubMed
  60. Pilones KA, et al. 2020. Cancer Immunol Res. 8:1054. PubMed
  61. Chen G, et al. 2021. Sci Adv. 7:eabg5686. PubMed
  62. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  63. White C, et al. 2015. J Immunol. 194:697. PubMed
  64. Wong E, et al. 2012. J Immunol. 189:5667. PubMed
  65. Matundan H, et al. 2019. J Virol. 93. PubMed
  66. Wu G, et al. 2022. Wellcome Open Res. 6:134. PubMed
  67. Zheng D, et al. 2022. Acta Pharm Sin B. 12:2740. PubMed
  68. Vogel A, et al. 2022. STAR Protoc. 3:101653. PubMed
  69. Matundan HH, et al. 2021. J Virol. 95:e0103621. PubMed
  70. Sun L, et al. 2015. Sci Rep. 5: 14871. PubMed
  71. Marshall N, et al. 2012. Cancer Res. 72:581. PubMed
  72. Yang C, et al. 2019. Nanomedicine (Lond). 14:2423. PubMed
  73. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  74. Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
  75. Zhang X, et al. 2022. JCI Insight. 7:. PubMed
  76. Fan Q, et al. 2021. Bioact Mater. 6:4014. PubMed
  77. Zhang W, et al. 2020. Nat Commun. 11:1187. PubMed
  78. Ye Y, et al. 2017. Sci Immunol. 2:17. PubMed
  79. Taddio MF, et al. 2021. Mol Imaging Biol. 23:196. PubMed
  80. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  81. Kelly SH, et al. 2021. ACS Biomater Sci Eng. 7:1876. PubMed
  82. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  83. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  84. He J, et al. 2020. Evid Based Complement Alternat Med. 2020:5637507. PubMed
  85. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  86. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  87. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  88. Izumi G, et al. 2021. Nat Commun. 12:5029. PubMed
  89. Qi J, et al. 2021. Nat Commun. 12:4755. PubMed
  90. Li J, et al. 2020. Development. :. PubMed
  91. Wang X, et al. 2021. EMBO J. 40:e105926. PubMed
  92. Simmons D, et al. 2012. J Immunol. 188:3116. PubMed
  93. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  94. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  95. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  96. Feng S, et al. 2021. Exp Ther Med. 21:20. PubMed
  97. Sebina I, et al. 2016. PLoS Pathog. 12:e1005999. PubMed
  98. Tateishi R, et al. 2015. PLoS One. 10: e0141650. PubMed
  99. Kelly SH, et al. 2021. Adv Healthc Mater. 10:e2001614. PubMed
  100. Piñón-Zárate G, et al. 2022. Molecules. 27:. PubMed
  101. Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed
  102. Yang Z, et al. 2021. Nat Commun. 12:4299. PubMed
  103. Miyauchi K, et al. 2021. Nat Commun. 12:3789. PubMed
  104. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  105. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  106. Xiao Z, et al. 2022. Mater Today Bio. 15:100297. PubMed
  107. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  108. Kadir NA, et al. 2020. Pathogens. 9:00. PubMed
  109. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  110. Lightman SM, et al. 2020. Cell Reports. 1.086805556. PubMed
  111. Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
  112. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  113. Wang Y, et al. 2020. Vaccines (Basel). 8:. PubMed
  114. Jeisy-Scott V, et al. 2012. J Virol. 86:10988. PubMed
  115. Liu WL, et al. 2019. Nat Commun. 10:3199. PubMed
  116. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
  117. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  118. Lin YC, et al. 2020. Mol Med Rep. 22:4909. PubMed
  119. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  120. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  121. Wang S, et al. 2022. Sci Adv. 8:eabn3883. PubMed
  122. Gargaro M, et al. 2022. Immunity. 55:1032. PubMed
  123. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  124. Sun Y, et al. 2023. Bioact Mater. 22:47. PubMed
  125. Liu M, et al. 2022. Cells. 11: . PubMed
  126. Montilla A, et al. 2023. Cell Death Dis. 14:16. PubMed
  127. Lombard-Vadnais F, et al. 2023. iScience. 26:105852. PubMed
  128. Han J, et al. 2023. Front Microbiol. 13:1067725. PubMed
  129. Sohn HS, et al. 2022. Sci Adv. 8:eabo5284. PubMed
  130. Chen H, et al. 2023. Nat Commun. 14:941. PubMed
  131. Cheng K, et al. 2023. Small. 19:e2300125. PubMed
  132. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  133. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  134. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  135. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  136. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  137. Li Y, et al. 2023. Front Cell Infect Microbiol. 13:1117230. PubMed
  138. Wu N, et al. 2023. Front Bioeng Biotechnol. 11:1173381. PubMed
  139. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  140. Wang X, et al. 2023. Stem Cell Rev Rep. . PubMed
  141. Rozanski C, et al. 2011. J Exp Med. 208:1435. PubMed
  142. Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed
  143. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  144. Wilhelm J, et al. 2021. J Control Release. 329:353. PubMed
  145. Kashyap AS, et al. 2019. Cell Rep. 28:3367. PubMed
  146. Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
  147. Wei H, et al. 2021. Malar J. 20:89. PubMed
  148. Kodumudi KN, et al. 2019. Front Immunol. 10:1939. PubMed
  149. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  150. Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed
  151. Kremenovic M, et al. 2022. J Immunother Cancer. 10:. PubMed
  152. Gruber T, et al. 2020. JCI Insight. 5:00. PubMed
  153. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  154. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  155. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  156. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  157. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  158. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  159. Bhattacharjee P, et al. 2018. Sci Rep. 13:e0199785. PubMed
  160. Wu J, et al. 2021. Mol Med Rep. 23:. PubMed
  161. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  162. Uchil PD et al. 2018. Cell host & microbe. 25(1):87-100 . PubMed
  163. Lin SY, et al. 2017. Autophagy. 14:778. PubMed
  164. Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed
  165. Tsukasaki M, et al. 2020. Cell Reports. 32(10):108124. PubMed
  166. Zhang L, et al. 2021. J Immunother Cancer. 9:. PubMed
  167. Utley A, et al. 2020. Cell Rep. 31:107815. PubMed
  168. Zhang F, et al. 2017. Mol Immunol. 10.1016/j.molimm.2017.06.019. PubMed
  169. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  170. Coe D, et al. 2022. JCI Insight. 7:. PubMed
  171. Glaros V, et al. 2021. Immunity. 54:2005. PubMed
  172. Xie Z, et al. 2020. Light Sci Appl. 0.486805556. PubMed
  173. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  174. Florêncio KGD, et al. 2022. Front Immunol. 13:941757. PubMed
  175. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  176. Guo L, et al. 2021. Vaccines (Basel). 9:. PubMed
  177. Ganesan R, et al. 2020. FASEB J. 34:15888. PubMed
  178. Pilones KA, et al. 2020. Cancer Immunol Res. 8:1054. PubMed
  179. Chen G, et al. 2021. Sci Adv. 7:eabg5686. PubMed
  180. Mulas F, et al. 2020. Cell Mol Immunol. . PubMed
  181. White C, et al. 2015. J Immunol. 194:697. PubMed
  182. Wong E, et al. 2012. J Immunol. 189:5667. PubMed
  183. Matundan H, et al. 2019. J Virol. 93. PubMed
  184. Wu G, et al. 2022. Wellcome Open Res. 6:134. PubMed
  185. Zheng D, et al. 2022. Acta Pharm Sin B. 12:2740. PubMed
  186. Vogel A, et al. 2022. STAR Protoc. 3:101653. PubMed
  187. Matundan HH, et al. 2021. J Virol. 95:e0103621. PubMed
  188. Sun L, et al. 2015. Sci Rep. 5: 14871. PubMed
  189. Marshall N, et al. 2012. Cancer Res. 72:581. PubMed
  190. Yang C, et al. 2019. Nanomedicine (Lond). 14:2423. PubMed
  191. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  192. Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
  193. Zhang X, et al. 2022. JCI Insight. 7:. PubMed
  194. Fan Q, et al. 2021. Bioact Mater. 6:4014. PubMed
  195. Zhang W, et al. 2020. Nat Commun. 11:1187. PubMed
  196. Ye Y, et al. 2017. Sci Immunol. 2:17. PubMed
  197. Taddio MF, et al. 2021. Mol Imaging Biol. 23:196. PubMed
  198. Xu Q, et al. 2021. Theranostics. 11:1937. PubMed
  199. Kelly SH, et al. 2021. ACS Biomater Sci Eng. 7:1876. PubMed
  200. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  201. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  202. He J, et al. 2020. Evid Based Complement Alternat Med. 2020:5637507. PubMed
  203. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  204. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  205. Stephens WZ, et al. 2021. Cell Rep. 37:109916. PubMed
  206. Izumi G, et al. 2021. Nat Commun. 12:5029. PubMed
  207. Qi J, et al. 2021. Nat Commun. 12:4755. PubMed
  208. Li J, et al. 2020. Development. :. PubMed
  209. Wang X, et al. 2021. EMBO J. 40:e105926. PubMed
  210. Simmons D, et al. 2012. J Immunol. 188:3116. PubMed
  211. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  212. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  213. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  214. Feng S, et al. 2021. Exp Ther Med. 21:20. PubMed
  215. Sebina I, et al. 2016. PLoS Pathog. 12:e1005999. PubMed
  216. Tateishi R, et al. 2015. PLoS One. 10: e0141650. PubMed
  217. Kelly SH, et al. 2021. Adv Healthc Mater. 10:e2001614. PubMed
  218. Piñón-Zárate G, et al. 2022. Molecules. 27:. PubMed
  219. Vogel A, et al. 2022. Cell Rep. 38:110420. PubMed
  220. Yang Z, et al. 2021. Nat Commun. 12:4299. PubMed
  221. Miyauchi K, et al. 2021. Nat Commun. 12:3789. PubMed
  222. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  223. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  224. Xiao Z, et al. 2022. Mater Today Bio. 15:100297. PubMed
  225. Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
  226. Kadir NA, et al. 2020. Pathogens. 9:00. PubMed
  227. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  228. Lightman SM, et al. 2020. Cell Reports. 1.086805556. PubMed
  229. Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
  230. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  231. Wang Y, et al. 2020. Vaccines (Basel). 8:. PubMed
  232. Jeisy-Scott V, et al. 2012. J Virol. 86:10988. PubMed
  233. Liu WL, et al. 2019. Nat Commun. 10:3199. PubMed
  234. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
  235. Zhang Y, et al. 2022. J Immunother Cancer. 10:. PubMed
  236. Lin YC, et al. 2020. Mol Med Rep. 22:4909. PubMed
RRID
AB_313129 (BioLegend Cat. No. 104708)
AB_313128 (BioLegend Cat. No. 104707)

Antigen Details

Structure
Ig superfamily, 60 kD
Distribution

Macrophages, activated B cells and T cells, dendritic cells

Function
T cell costimulation
Ligand/Receptor
CD28 (stimulatory), CD152(CTLA4) (inhibitory)
Cell Type
B cells, Dendritic cells, Macrophages, T cells, Tregs
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Linsley PS, et al. 1991. J. Exp. Med. 174:561.
3. Salomon B, et al. 2001. Annu. Rev. Immunol. 19:225.

Gene ID
12519 View all products for this Gene ID
UniProt
View information about CD80 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 02.18.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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