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Purified anti-mouse CD11c Antibody Purified anti-mouse CD11c Antibody

Pricing & Availability
Clone
N418 (See other available formats)
Regulatory Status
RUO
Other Names
αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype
Armenian Hamster IgG
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Product Citations
publications
N418_A_Purified_Pos_071006.jpg
C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_A_Purified_Pos_071006.jpg
    C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_B_Purified_Neg_071006.jpg
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Cat # Size Price Quantity Check Availability Save
117302 500 µg NOK1164
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117301 50 µg NOK297
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Description

CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IP, IHC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References
  1. Granucci F, et al. 1997. J. Immunol. 159:1794.
  2. Stokes RW, et al. 1998. J. Immunol. 160:5514.
  3. Metlay JP, et al. 1990. J. Exp. Med. 171:1753. (IHC, IP)
  4. Ma XT, et al. 2006. Cancer Research 66:1169.
  5. Chin RK, et al. 2006. J. Immunol. 177:290. (IF)
  6. Cervantes-Barragan L, et al. 2007. Blood 109:1131. (FC) PubMed
  7. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC) PubMed
  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
  11. Wikstrom M, et al.2006. J. Immunol. 177:913. PubMed
  12. Pericolini E, et al. 2008. J. Leukocyte Biol. 83:1286. PubMed
  13. Randall LM, et al. 2008. Infect. Immun.76:3312. PubMed
  14. Fahlen-Yrild L, et al. 2009. J. Immunol. 183:5032. PubMed
  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
  20. Gibbins JD, et al. 2014. Blood. 124:2953. PubMed
  21. White CE, et al. 2015. J Immunol. 194:697. PubMed
  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  24. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Dallari S, et al. 2017. Nat Commun. 8:14830. PubMed
  2. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  3. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  4. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  5. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  6. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  7. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  8. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  9. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  10. Liedmann S, et al. 2022. Mol Cell. 82:2401. PubMed
  11. Campisi L, et al. 2022. Nature. 606:945. PubMed
  12. Chi H, et al. 2022. Cells. 11: . PubMed
  13. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  14. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  15. Hezaveh K, et al. 2022. Immunity. 55:324. PubMed
  16. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  17. Iguchi A, et al. 2023. iScience. 26:106375. PubMed
  18. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  19. Owen KL, et al. 2020. EMBO Rep. 21:e50162. PubMed
  20. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  21. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  22. Bruce DW, et al. 2021. Blood Adv. 5:4578. PubMed
  23. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  24. Martinez LE, et al. 2020. J Virol. 94:00:00. PubMed
  25. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  26. Aguilar EG, et al. 2021. Blood Adv. 5:4219. PubMed
  27. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  28. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  29. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  30. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  31. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  32. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  33. Mendes A, et al. 2021. Life Sci Alliance. 4:00. PubMed
  34. Fahlén-Yrlid L, et al. 2009. J Immunol. 183:5032. PubMed
  35. Osterholzer J, et al. 2009. J Immunol. 183:8044. PubMed
  36. Sun L, et al. 2020. Nat Commun. 2.229166667. PubMed
  37. Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed
  38. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  39. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  40. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  41. Dubrot J, et al. 2018. Life Sci Alliance. 1:e201800164. PubMed
  42. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  43. Field CS, et al. 2018. Oncoimmunology. 7:e1376154. PubMed
  44. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  45. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  46. Bonnefoy F, et al. 2018. Front Immunol. 2.170833333. PubMed
  47. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  48. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  49. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  50. Mayer JU, et al. 2020. Front Immunol. 11:592325. PubMed
  51. Fang C, et al. 2020. Cell Mol Immunol. . PubMed
  52. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  53. Kitai Y, et al. 2017. J Immunol. 198:1649. PubMed
  54. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  55. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  56. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  57. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  58. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  59. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  60. Tal MC, et al. 2020. MBio. 11:00. PubMed
  61. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  62. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  63. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  64. Sun H, et al. 2018. J Cell Biol. 217:1453. PubMed
  65. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  66. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  67. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  68. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  69. Aparicio-Domingo P, et al. 2015. J Exp Med. 101084/jm20150318. PubMed
  70. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  71. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  72. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  73. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  74. Fu H, et al. 2019. Front Immunol. 10:271. PubMed
  75. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  76. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  77. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  78. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  79. Molica F,et al. 2017. Sci Rep.. 10.1038/s41598-017-14130-4. PubMed
  80. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  81. Wang Y, et al. 2021. Sci Transl Med. 13:. PubMed
  82. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  83. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  84. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  85. Mainini F, et al. 2018. Nucleic Acid Ther. 28:225. PubMed
  86. Enders M, et al. 2020. J Immunol. 204:87. PubMed
  87. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  88. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  89. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  90. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  91. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  92. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  93. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  94. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  95. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  96. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  97. Majer O, et al. 2019. Nature. 575:366. PubMed
  98. Pericolini E, et al. 2008. J Leukoc Biol. 83:1286. PubMed
  99. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  100. Oyarce K, et al. 2018. Front Immunol. 9:112. PubMed
  101. Guilliams M, et al. 2022. Cell. 185:379. PubMed
  102. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  103. Blriot C, et al. 2021. Immunity. :. PubMed
  104. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
  105. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  106. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  107. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  108. Zhang Z, et al. 2018. Nat Med. 24:617. PubMed
  109. Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
  110. Rigo MM, et al. 2020. FEBS J. :. PubMed
  111. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  112. Cepeda JR, et al. 2020. MAbs. 12:1836714. PubMed
  113. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  114. Rebouças A, et al. 2021. Microorganisms. 9:. PubMed
  115. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  116. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  117. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  118. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  119. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  120. Wikstrom M, et al. 2006. J Immunol. 177:913. PubMed
  121. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  122. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  123. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  124. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  125. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  126. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  127. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  128. von Roemeling CA, et al. 2020. Nat Commun. 11:1508. PubMed
  129. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  130. Eisenach P, et al. 2010. J Cell Sci. 123:4182. PubMed
  131. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  132. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  133. García G, et al. 2020. Am J Pathol. 844:190. PubMed
  134. Leppin K, et al. 2014. Invest Ophthalmol Vis Sci . 55:3603. PubMed
  135. Benson M, et al. 2007. J Exp Med. 204:1765. PubMed
  136. Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed
  137. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  138. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  139. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
  140. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  141. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  142. Chen B, et al. 2021. Cell. 184:6262. PubMed
  143. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  144. Hung LY, et al. 2019. J Immunol. 203:511. PubMed
  145. Rios–Doria J, et al. 2017. Cancer Res. 77:2686. PubMed
  146. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  147. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  148. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  149. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  150. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  151. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  152. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  153. Dallari S, et al. 2017. Nat Commun. 8:14830. PubMed
  154. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  155. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  156. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  157. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  158. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  159. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  160. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  161. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  162. Liedmann S, et al. 2022. Mol Cell. 82:2401. PubMed
  163. Campisi L, et al. 2022. Nature. 606:945. PubMed
  164. Chi H, et al. 2022. Cells. 11: . PubMed
  165. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  166. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  167. Hezaveh K, et al. 2022. Immunity. 55:324. PubMed
  168. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  169. Iguchi A, et al. 2023. iScience. 26:106375. PubMed
  170. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  171. Owen KL, et al. 2020. EMBO Rep. 21:e50162. PubMed
  172. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  173. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  174. Bruce DW, et al. 2021. Blood Adv. 5:4578. PubMed
  175. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  176. Martinez LE, et al. 2020. J Virol. 94:00:00. PubMed
  177. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  178. Aguilar EG, et al. 2021. Blood Adv. 5:4219. PubMed
  179. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  180. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  181. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  182. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  183. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  184. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  185. Mendes A, et al. 2021. Life Sci Alliance. 4:00. PubMed
  186. Fahlén-Yrlid L, et al. 2009. J Immunol. 183:5032. PubMed
  187. Osterholzer J, et al. 2009. J Immunol. 183:8044. PubMed
  188. Sun L, et al. 2020. Nat Commun. 2.229166667. PubMed
  189. Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed
  190. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  191. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  192. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  193. Dubrot J, et al. 2018. Life Sci Alliance. 1:e201800164. PubMed
  194. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  195. Field CS, et al. 2018. Oncoimmunology. 7:e1376154. PubMed
  196. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  197. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  198. Bonnefoy F, et al. 2018. Front Immunol. 2.170833333. PubMed
  199. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  200. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  201. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  202. Mayer JU, et al. 2020. Front Immunol. 11:592325. PubMed
  203. Fang C, et al. 2020. Cell Mol Immunol. . PubMed
  204. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  205. Kitai Y, et al. 2017. J Immunol. 198:1649. PubMed
  206. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  207. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  208. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  209. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  210. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  211. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  212. Tal MC, et al. 2020. MBio. 11:00. PubMed
  213. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  214. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  215. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  216. Sun H, et al. 2018. J Cell Biol. 217:1453. PubMed
  217. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  218. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  219. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  220. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  221. Aparicio-Domingo P, et al. 2015. J Exp Med. 101084/jm20150318. PubMed
  222. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  223. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  224. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  225. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  226. Fu H, et al. 2019. Front Immunol. 10:271. PubMed
  227. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  228. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  229. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  230. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  231. Molica F,et al. 2017. Sci Rep.. 10.1038/s41598-017-14130-4. PubMed
  232. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  233. Wang Y, et al. 2021. Sci Transl Med. 13:. PubMed
  234. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  235. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  236. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  237. Mainini F, et al. 2018. Nucleic Acid Ther. 28:225. PubMed
  238. Enders M, et al. 2020. J Immunol. 204:87. PubMed
  239. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  240. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  241. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  242. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  243. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  244. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  245. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  246. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  247. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  248. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  249. Majer O, et al. 2019. Nature. 575:366. PubMed
  250. Pericolini E, et al. 2008. J Leukoc Biol. 83:1286. PubMed
  251. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  252. Oyarce K, et al. 2018. Front Immunol. 9:112. PubMed
  253. Guilliams M, et al. 2022. Cell. 185:379. PubMed
  254. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  255. Blriot C, et al. 2021. Immunity. :. PubMed
  256. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
  257. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  258. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  259. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  260. Zhang Z, et al. 2018. Nat Med. 24:617. PubMed
  261. Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
  262. Rigo MM, et al. 2020. FEBS J. :. PubMed
  263. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  264. Cepeda JR, et al. 2020. MAbs. 12:1836714. PubMed
  265. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  266. Rebouças A, et al. 2021. Microorganisms. 9:. PubMed
  267. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  268. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  269. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  270. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  271. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  272. Wikstrom M, et al. 2006. J Immunol. 177:913. PubMed
  273. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  274. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  275. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  276. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  277. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  278. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  279. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  280. von Roemeling CA, et al. 2020. Nat Commun. 11:1508. PubMed
  281. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  282. Eisenach P, et al. 2010. J Cell Sci. 123:4182. PubMed
  283. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  284. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  285. García G, et al. 2020. Am J Pathol. 844:190. PubMed
  286. Leppin K, et al. 2014. Invest Ophthalmol Vis Sci . 55:3603. PubMed
  287. Benson M, et al. 2007. J Exp Med. 204:1765. PubMed
  288. Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed
  289. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  290. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  291. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
  292. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  293. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  294. Chen B, et al. 2021. Cell. 184:6262. PubMed
  295. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  296. Hung LY, et al. 2019. J Immunol. 203:511. PubMed
  297. Rios–Doria J, et al. 2017. Cancer Res. 77:2686. PubMed
  298. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  299. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  300. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  301. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  302. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  303. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  304. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
RRID
AB_313771 (BioLegend Cat. No. 117302)
AB_313770 (BioLegend Cat. No. 117301)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD11c Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse CD11c N418 FC
Biotin anti-mouse CD11c N418 FC,IHC-F
FITC anti-mouse CD11c N418 FC
PE anti-mouse CD11c N418 FC
Purified anti-mouse CD11c N418 FC,CyTOF®,IP,IHC
Brilliant Violet 711™ anti-mouse CD11c N418 FC
APC/Fire™ 750 anti-mouse CD11c N418 FC
TotalSeq™-A0106 anti-mouse CD11c N418 PG
Brilliant Violet 750™ anti-mouse CD11c N418 FC
TotalSeq™-B0106 anti-mouse CD11c N418 PG
TotalSeq™-C0106 anti-mouse CD11c N418 PG
KIRAVIA Blue 520™ anti-mouse CD11c N418 FC
Spark Blue™ 550 anti-mouse CD11c N418 FC
Alexa Fluor® 488 anti-mouse CD11c N418 FC
Alexa Fluor® 647 anti-mouse CD11c N418 FC,IHC,ICC,3D IHC
PE/Cyanine7 anti-mouse CD11c N418 FC
Brilliant Violet 605™ anti-mouse CD11c N418 FC
Alexa Fluor® 700 anti-mouse CD11c N418 FC
PE/Cyanine5 anti-mouse CD11c N418 FC
Pacific Blue™ anti-mouse CD11c N418 FC
APC/Cyanine7 anti-mouse CD11c N418 FC
PerCP/Cyanine5.5 anti-mouse CD11c N418 FC
PerCP anti-mouse CD11c N418 FC
Brilliant Violet 421™ anti-mouse CD11c N418 FC,IHC
Brilliant Violet 570™ anti-mouse CD11c N418 FC
Brilliant Violet 785™ anti-mouse CD11c N418 FC
Brilliant Violet 510™ anti-mouse CD11c N418 FC
Brilliant Violet 650™ anti-mouse CD11c N418 FC
Purified anti-mouse CD11c (Maxpar® Ready) N418 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse CD11c N418 FC
Alexa Fluor® 594 anti-mouse CD11c N418 IHC-F,3D IHC
Spark NIR™ 685 anti-mouse CD11c N418 FC
Spark UV™ 387 anti-mouse CD11c N418 FC
Spark Red™ 718 anti-mouse CD11c N418 FC
Spark Blue™ 515 anti-mouse CD11c N418 FC
PerCP/Fire™ 806 anti-mouse CD11c N418 FC
Spark PLUS UV395™ anti-mouse CD11c N418 FC
Spark Blue™ 574 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark PLUS B550™ anti-mouse CD11c N418 FC
APC/Fire™ 810 anti-mouse CD11c Antibody N418 FC
PE/Fire™ 640 anti-mouse CD11c Antibody N418 FC
Spark YG™ 581 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark YG™ 593 anti-mouse CD11c (Flexi-Fluor™) Antibody N418 FC
Spark PLUS V475™ anti-mouse CD11c Antibody N418 FC
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
N418 (See other available formats)
Regulatory Status
RUO
Other Names
αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype
Armenian Hamster IgG
Ave. Rating
Submit a Review
Product Citations
publications
N418_A_Purified_Pos_071006.jpg
C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_A_Purified_Pos_071006.jpg
    C57BL/6 mouse splenocytes stained with APC anti-mouse I-A/I-E (clone M5/114.15.2) and purified N418 (top) or purified Armenian hamster IgG isotype control (bottom), followed by anti-Armenian hamster IgG FITC
  • N418_B_Purified_Neg_071006.jpg
Compare all formats
Cat # Size Price Quantity Check Availability Save
117302 500 µg NOK1164
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117301 50 µg NOK297
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Description

CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The αXβ2 integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse spleen dendritic cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
IP, IHC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation3, immunohistochemical staining of acetone-fixed frozen sections3, immunofluorescence microscopy5, 9 (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections10), and spatial biology (IBEX)22,23.

Application References
  1. Granucci F, et al. 1997. J. Immunol. 159:1794.
  2. Stokes RW, et al. 1998. J. Immunol. 160:5514.
  3. Metlay JP, et al. 1990. J. Exp. Med. 171:1753. (IHC, IP)
  4. Ma XT, et al. 2006. Cancer Research 66:1169.
  5. Chin RK, et al. 2006. J. Immunol. 177:290. (IF)
  6. Cervantes-Barragan L, et al. 2007. Blood 109:1131. (FC) PubMed
  7. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC) PubMed
  8. Benson MJ, et al. 2007. J. Exp. Med. doi:10.1084/jem.20070719. (FC) PubMed
  9. You Y, et al. 2009. J. Immunol. 182:7343. (IF) PubMed
  10. Roland CL, et al. 2009. Mol. Cancer Res. 8:1761. (IHC, FC) PubMed
  11. Wikstrom M, et al.2006. J. Immunol. 177:913. PubMed
  12. Pericolini E, et al. 2008. J. Leukocyte Biol. 83:1286. PubMed
  13. Randall LM, et al. 2008. Infect. Immun.76:3312. PubMed
  14. Fahlen-Yrild L, et al. 2009. J. Immunol. 183:5032. PubMed
  15. Osterholzer JJ, et al. 2009. J. Immunol. 183:8044. PubMed
  16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  17. Eisenach PA, et al. 2010. J Cell Sci. 123:4182. PubMed
  18. Leppin K, et al. 2014. Invest. Ophthalmol. Vis. Sci. 55:3603. PubMed
  19. Sakai F, et al. 2014. PLoS One. 9:105370. PubMed
  20. Gibbins JD, et al. 2014. Blood. 124:2953. PubMed
  21. White CE, et al. 2015. J Immunol. 194:697. PubMed
  22. Lu X, et al. 2015. J Immunol. 194:2011. PubMed
  23. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  24. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Dallari S, et al. 2017. Nat Commun. 8:14830. PubMed
  2. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  3. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  4. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  5. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  6. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  7. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  8. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  9. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  10. Liedmann S, et al. 2022. Mol Cell. 82:2401. PubMed
  11. Campisi L, et al. 2022. Nature. 606:945. PubMed
  12. Chi H, et al. 2022. Cells. 11: . PubMed
  13. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  14. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  15. Hezaveh K, et al. 2022. Immunity. 55:324. PubMed
  16. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  17. Iguchi A, et al. 2023. iScience. 26:106375. PubMed
  18. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  19. Owen KL, et al. 2020. EMBO Rep. 21:e50162. PubMed
  20. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  21. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  22. Bruce DW, et al. 2021. Blood Adv. 5:4578. PubMed
  23. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  24. Martinez LE, et al. 2020. J Virol. 94:00:00. PubMed
  25. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  26. Aguilar EG, et al. 2021. Blood Adv. 5:4219. PubMed
  27. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  28. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  29. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  30. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  31. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  32. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  33. Mendes A, et al. 2021. Life Sci Alliance. 4:00. PubMed
  34. Fahlén-Yrlid L, et al. 2009. J Immunol. 183:5032. PubMed
  35. Osterholzer J, et al. 2009. J Immunol. 183:8044. PubMed
  36. Sun L, et al. 2020. Nat Commun. 2.229166667. PubMed
  37. Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed
  38. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  39. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  40. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  41. Dubrot J, et al. 2018. Life Sci Alliance. 1:e201800164. PubMed
  42. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  43. Field CS, et al. 2018. Oncoimmunology. 7:e1376154. PubMed
  44. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  45. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  46. Bonnefoy F, et al. 2018. Front Immunol. 2.170833333. PubMed
  47. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  48. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  49. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  50. Mayer JU, et al. 2020. Front Immunol. 11:592325. PubMed
  51. Fang C, et al. 2020. Cell Mol Immunol. . PubMed
  52. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  53. Kitai Y, et al. 2017. J Immunol. 198:1649. PubMed
  54. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  55. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  56. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  57. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  58. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  59. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  60. Tal MC, et al. 2020. MBio. 11:00. PubMed
  61. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  62. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  63. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  64. Sun H, et al. 2018. J Cell Biol. 217:1453. PubMed
  65. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  66. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  67. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  68. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  69. Aparicio-Domingo P, et al. 2015. J Exp Med. 101084/jm20150318. PubMed
  70. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  71. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  72. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  73. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  74. Fu H, et al. 2019. Front Immunol. 10:271. PubMed
  75. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  76. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  77. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  78. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  79. Molica F,et al. 2017. Sci Rep.. 10.1038/s41598-017-14130-4. PubMed
  80. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  81. Wang Y, et al. 2021. Sci Transl Med. 13:. PubMed
  82. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  83. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  84. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  85. Mainini F, et al. 2018. Nucleic Acid Ther. 28:225. PubMed
  86. Enders M, et al. 2020. J Immunol. 204:87. PubMed
  87. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  88. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  89. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  90. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  91. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  92. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  93. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  94. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  95. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  96. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  97. Majer O, et al. 2019. Nature. 575:366. PubMed
  98. Pericolini E, et al. 2008. J Leukoc Biol. 83:1286. PubMed
  99. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  100. Oyarce K, et al. 2018. Front Immunol. 9:112. PubMed
  101. Guilliams M, et al. 2022. Cell. 185:379. PubMed
  102. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  103. Blriot C, et al. 2021. Immunity. :. PubMed
  104. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
  105. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  106. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  107. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  108. Zhang Z, et al. 2018. Nat Med. 24:617. PubMed
  109. Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
  110. Rigo MM, et al. 2020. FEBS J. :. PubMed
  111. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  112. Cepeda JR, et al. 2020. MAbs. 12:1836714. PubMed
  113. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  114. Rebouças A, et al. 2021. Microorganisms. 9:. PubMed
  115. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  116. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  117. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  118. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  119. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  120. Wikstrom M, et al. 2006. J Immunol. 177:913. PubMed
  121. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  122. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  123. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  124. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  125. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  126. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  127. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  128. von Roemeling CA, et al. 2020. Nat Commun. 11:1508. PubMed
  129. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  130. Eisenach P, et al. 2010. J Cell Sci. 123:4182. PubMed
  131. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  132. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  133. García G, et al. 2020. Am J Pathol. 844:190. PubMed
  134. Leppin K, et al. 2014. Invest Ophthalmol Vis Sci . 55:3603. PubMed
  135. Benson M, et al. 2007. J Exp Med. 204:1765. PubMed
  136. Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed
  137. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  138. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  139. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
  140. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  141. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  142. Chen B, et al. 2021. Cell. 184:6262. PubMed
  143. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  144. Hung LY, et al. 2019. J Immunol. 203:511. PubMed
  145. Rios–Doria J, et al. 2017. Cancer Res. 77:2686. PubMed
  146. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  147. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  148. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  149. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  150. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  151. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  152. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  153. Dallari S, et al. 2017. Nat Commun. 8:14830. PubMed
  154. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  155. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  156. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  157. Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed
  158. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  159. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  160. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  161. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  162. Liedmann S, et al. 2022. Mol Cell. 82:2401. PubMed
  163. Campisi L, et al. 2022. Nature. 606:945. PubMed
  164. Chi H, et al. 2022. Cells. 11: . PubMed
  165. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  166. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  167. Hezaveh K, et al. 2022. Immunity. 55:324. PubMed
  168. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  169. Iguchi A, et al. 2023. iScience. 26:106375. PubMed
  170. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  171. Owen KL, et al. 2020. EMBO Rep. 21:e50162. PubMed
  172. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  173. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  174. Bruce DW, et al. 2021. Blood Adv. 5:4578. PubMed
  175. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  176. Martinez LE, et al. 2020. J Virol. 94:00:00. PubMed
  177. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  178. Aguilar EG, et al. 2021. Blood Adv. 5:4219. PubMed
  179. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  180. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  181. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  182. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  183. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  184. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  185. Mendes A, et al. 2021. Life Sci Alliance. 4:00. PubMed
  186. Fahlén-Yrlid L, et al. 2009. J Immunol. 183:5032. PubMed
  187. Osterholzer J, et al. 2009. J Immunol. 183:8044. PubMed
  188. Sun L, et al. 2020. Nat Commun. 2.229166667. PubMed
  189. Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed
  190. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  191. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  192. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  193. Dubrot J, et al. 2018. Life Sci Alliance. 1:e201800164. PubMed
  194. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  195. Field CS, et al. 2018. Oncoimmunology. 7:e1376154. PubMed
  196. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  197. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  198. Bonnefoy F, et al. 2018. Front Immunol. 2.170833333. PubMed
  199. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  200. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  201. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  202. Mayer JU, et al. 2020. Front Immunol. 11:592325. PubMed
  203. Fang C, et al. 2020. Cell Mol Immunol. . PubMed
  204. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  205. Kitai Y, et al. 2017. J Immunol. 198:1649. PubMed
  206. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  207. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  208. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  209. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  210. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  211. Peng V, et al. 2020. J Biol Chem. 295:14866. PubMed
  212. Tal MC, et al. 2020. MBio. 11:00. PubMed
  213. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  214. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  215. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  216. Sun H, et al. 2018. J Cell Biol. 217:1453. PubMed
  217. Hilligan KL, et al. 2020. Nat Commun. 11:5637. PubMed
  218. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  219. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  220. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  221. Aparicio-Domingo P, et al. 2015. J Exp Med. 101084/jm20150318. PubMed
  222. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  223. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  224. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  225. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  226. Fu H, et al. 2019. Front Immunol. 10:271. PubMed
  227. Snell LM, et al. 2018. Immunity. 49:678. PubMed
  228. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  229. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  230. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  231. Molica F,et al. 2017. Sci Rep.. 10.1038/s41598-017-14130-4. PubMed
  232. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  233. Wang Y, et al. 2021. Sci Transl Med. 13:. PubMed
  234. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  235. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  236. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  237. Mainini F, et al. 2018. Nucleic Acid Ther. 28:225. PubMed
  238. Enders M, et al. 2020. J Immunol. 204:87. PubMed
  239. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  240. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  241. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  242. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  243. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  244. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  245. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  246. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  247. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  248. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  249. Majer O, et al. 2019. Nature. 575:366. PubMed
  250. Pericolini E, et al. 2008. J Leukoc Biol. 83:1286. PubMed
  251. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  252. Oyarce K, et al. 2018. Front Immunol. 9:112. PubMed
  253. Guilliams M, et al. 2022. Cell. 185:379. PubMed
  254. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  255. Blriot C, et al. 2021. Immunity. :. PubMed
  256. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
  257. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  258. King IL, et al. 2017. Mucosal Immunol. 10:1160. PubMed
  259. Denny JE, et al. 2019. Sci Rep. 2.786111111. PubMed
  260. Zhang Z, et al. 2018. Nat Med. 24:617. PubMed
  261. Parigi SM, et al. 2018. Sci Rep. 0.440277778. PubMed
  262. Rigo MM, et al. 2020. FEBS J. :. PubMed
  263. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  264. Cepeda JR, et al. 2020. MAbs. 12:1836714. PubMed
  265. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  266. Rebouças A, et al. 2021. Microorganisms. 9:. PubMed
  267. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  268. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  269. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  270. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  271. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  272. Wikstrom M, et al. 2006. J Immunol. 177:913. PubMed
  273. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  274. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  275. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  276. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  277. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  278. Keerthivasan S, et al. 2021. Immunity. 54(7):1511-1526.e8. PubMed
  279. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  280. von Roemeling CA, et al. 2020. Nat Commun. 11:1508. PubMed
  281. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  282. Eisenach P, et al. 2010. J Cell Sci. 123:4182. PubMed
  283. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
  284. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  285. García G, et al. 2020. Am J Pathol. 844:190. PubMed
  286. Leppin K, et al. 2014. Invest Ophthalmol Vis Sci . 55:3603. PubMed
  287. Benson M, et al. 2007. J Exp Med. 204:1765. PubMed
  288. Goltsev Y et al. 2018. Cell. 174(4):968-981 . PubMed
  289. Fitzpatrick Z, et al. 2020. Nature. 587:472. PubMed
  290. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  291. Satoh–Takayama N, et al. 2020. Immunity. 52(4):635-649. PubMed
  292. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  293. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  294. Chen B, et al. 2021. Cell. 184:6262. PubMed
  295. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  296. Hung LY, et al. 2019. J Immunol. 203:511. PubMed
  297. Rios–Doria J, et al. 2017. Cancer Res. 77:2686. PubMed
  298. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  299. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  300. Khameneh HJ, et al. 2017. J Immunol. 198:196. PubMed
  301. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  302. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  303. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  304. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
RRID
AB_313771 (BioLegend Cat. No. 117302)
AB_313770 (BioLegend Cat. No. 117301)

Antigen Details

Structure
Integrin α-chain, associates with integrin β2 (CD18), 150 kD
Distribution

Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells

Function
Cellular adhesion
Ligand/Receptor
iC3b, fibrinogen
Cell Type
Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.

Gene ID
16411 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Other Formats

View All CD11c Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse CD11c N418 FC
Biotin anti-mouse CD11c N418 FC,IHC-F
FITC anti-mouse CD11c N418 FC
PE anti-mouse CD11c N418 FC
Purified anti-mouse CD11c N418 FC,CyTOF®,IP,IHC
Brilliant Violet 711™ anti-mouse CD11c N418 FC
APC/Fire™ 750 anti-mouse CD11c N418 FC
TotalSeq™-A0106 anti-mouse CD11c N418 PG
Brilliant Violet 750™ anti-mouse CD11c N418 FC
TotalSeq™-B0106 anti-mouse CD11c N418 PG
TotalSeq™-C0106 anti-mouse CD11c N418 PG
KIRAVIA Blue 520™ anti-mouse CD11c N418 FC
Spark Blue™ 550 anti-mouse CD11c N418 FC
Alexa Fluor® 488 anti-mouse CD11c N418 FC
Alexa Fluor® 647 anti-mouse CD11c N418 FC,IHC,ICC,3D IHC
PE/Cyanine7 anti-mouse CD11c N418 FC
Brilliant Violet 605™ anti-mouse CD11c N418 FC
Alexa Fluor® 700 anti-mouse CD11c N418 FC
PE/Cyanine5 anti-mouse CD11c N418 FC
Pacific Blue™ anti-mouse CD11c N418 FC
APC/Cyanine7 anti-mouse CD11c N418 FC
PerCP/Cyanine5.5 anti-mouse CD11c N418 FC
PerCP anti-mouse CD11c N418 FC
Brilliant Violet 421™ anti-mouse CD11c N418 FC,IHC
Brilliant Violet 570™ anti-mouse CD11c N418 FC
Brilliant Violet 785™ anti-mouse CD11c N418 FC
Brilliant Violet 510™ anti-mouse CD11c N418 FC
Brilliant Violet 650™ anti-mouse CD11c N418 FC
Purified anti-mouse CD11c (Maxpar® Ready) N418 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse CD11c N418 FC
Alexa Fluor® 594 anti-mouse CD11c N418 IHC-F,3D IHC
Spark NIR™ 685 anti-mouse CD11c N418 FC
Spark UV™ 387 anti-mouse CD11c N418 FC
Spark Red™ 718 anti-mouse CD11c N418 FC
Spark Blue™ 515 anti-mouse CD11c N418 FC
PerCP/Fire™ 806 anti-mouse CD11c N418 FC
Spark PLUS UV395™ anti-mouse CD11c N418 FC
Spark Blue™ 574 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark PLUS B550™ anti-mouse CD11c N418 FC
APC/Fire™ 810 anti-mouse CD11c Antibody N418 FC
PE/Fire™ 640 anti-mouse CD11c Antibody N418 FC
Spark YG™ 581 anti-mouse CD11c (Flexi-Fluor™) N418 FC
Spark YG™ 593 anti-mouse CD11c (Flexi-Fluor™) Antibody N418 FC
Spark PLUS V475™ anti-mouse CD11c Antibody N418 FC
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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