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Purified anti-mouse CD68 Antibody Purified anti-mouse CD68 Antibody

Pricing & Availability
Clone
FA-11 (See other available formats)
Regulatory Status
RUO
Other Names
Macrosialin
Isotype
Rat IgG2a
Ave. Rating
Submit a Review
Product Citations
publications
FA-11_A647_021810
Thioglycolate-elicited Balb/c peritoneal macrophages intracellularly stained with FA-11 Alexa Fluor® 647
  • FA-11_A647_021810
    Thioglycolate-elicited Balb/c peritoneal macrophages intracellularly stained with FA-11 Alexa Fluor® 647
Compare all formats
Cat # Size Price Quantity Check Availability Save
137002 500 µg NOK3540
Check Availability


Need larger quantities of this item?
Request Bulk Quote
137001 50 µg NOK834
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Description

Mouse CD68, also known as macrosialin, is an 85-115 kD member of the lysosomal-associated membrane protein (LAMP) family. It is a heavily glycosylated and predominantly intracellular protein, mainly in late endosomes. Macrosialin is the murine homolog to the human macrophage glycoprotein CD68. It is expressed on tissue macrophages, Langerhans cells and at low levels on dendritic cells. Lamp proteins may have functions relating to cell-cell interaction or cell-ligand interaction. The biological function of CD68 is not completely understood.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Purified Con A receptor glycoproteins from the P815 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
FC - Verified
IP, WB, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported (for relevant formats) applications include: immunoprecipitation1, 2, Western Blot1, 2, immunohistochemical staining of frozen sections2 and paraformaldehyde-fixed paraffin-embedded sections3, and spatial biology (IBEX)9,10.

Application References
  1. Silva RP, et al. 1999. Biochem. J. 338:687. (IP, WB)
  2. Rabinowitz SS, et al. 1991. J. Exp. Med. 174:827. (IP, WB, IHC)
  3. Wu J, et al. 2008. P. Natl. Acad. Sci. USA 105:16934. (IHC)
  4. Kayama H, et al. 2012. PNAS. 109:5010. PubMed
  5. Park S, et al. 2013. Biomaterials. 34:598. PubMed
  6. Guiducci C, et al. 2013. J Exp Med. 210:2903. PubMed
  7. McKinstry SU, et al. 2014. J Neurosci. 34:9455. PubMed
  8. Li X, et al. 2015. J Am Heart Assoc. 6:4. PubMed
  9. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  10. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Milasan A, et al. 2017. J Am Heart Assoc. 10.1161/JAHA.117.006892. PubMed
  2. Filipello F et al. 2018. Immunity. 48(5):979-991 . PubMed
  3. Miho Sato‐Hashimoto et al. 2019. eLife. 8 pii: e42025. PubMed
  4. Ruan S, et al. 2023. Front Pharmacol. 14:1088957. PubMed
  5. Michurina S, et al. 2023. Int J Mol Sci. 24:. PubMed
  6. Ritzel RM, et al. 2023. Sci Adv. 9:eadd1101. PubMed
  7. Yin XY, et al. 2023. J Neuroinflammation. 20:69. PubMed
  8. Rodriguez Y, et al. 2022. Liver Res. 6:227. PubMed
  9. Zhang R, et al. 2023. Stroke Vasc Neurol. . PubMed
  10. Dietsch B, et al. 2023. BMC Cancer. 23:436. PubMed
  11. Schake MA, et al. 2023. iScience. 26:106760. PubMed
  12. Taniguchi M, et al. 2023. Mol Pharmacol. . PubMed
  13. Preda MB, et al. 2021. Cell Death Dis. 12:566. PubMed
  14. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  15. Mathew DJ, et al. 2021. Sci Rep. 11:22880. PubMed
  16. Da Mesquita S, et al. 2021. Nature. 593:255. PubMed
  17. Meng J, et al. 2022. J Neurosci. 42:4958. PubMed
  18. Mugarza E, et al. 2022. Sci Adv. 8:eabm8780. PubMed
  19. Block CL, et al. 2022. Cell Rep. 40:111161. PubMed
  20. Saraswathula A, et al. 2023. Int Forum Allergy Rhinol. 13:230. PubMed
  21. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  22. Ohkubo R, et al. 2022. Cell Rep. 41:111803. PubMed
  23. Wu J, et al. 2023. Cell Mol Biol Lett. 28:11. PubMed
  24. , et al. 2022. JACC Basic Transl Sci. 7:I. PubMed
  25. Guiducci C, et al. 2013. J Exp Med. 210:2903. PubMed
  26. Zaman R, et al. 2021. Immunity. :. PubMed
  27. Fang W, et al. 2020. Transl Res. 222:28. PubMed
  28. Spencer WJ, et al. 2019. Proc Natl Acad Sci U S A. 116:13087. PubMed
  29. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  30. Guimbal S, et al. 2021. Arterioscler Thromb Vasc Biol. 41:e193. PubMed
  31. McKinstry S, et al. 2014. J Neurosci. 34:9455. PubMed
  32. Henjum K, et al. 2020. Sci Rep. 10:10590. PubMed
  33. Sherafat A, et al. 2021. Nat Commun. 12:2265. PubMed
  34. Park S, et al. 2013. Biomaterials. 34:598. PubMed
  35. Trus I, et al. 2020. Front Immunol. 2.553472222. PubMed
  36. Shen L et al. 2019. Br J Pharmacol. 176(14):2559-2572 . PubMed
  37. Tian K, et al. 2021. J Immunol Res. 2021:6297332. PubMed
  38. Gomez-Pastor R, et al. 2017. Nat Commun. 8:14405. PubMed
  39. Brocker CN, et al. 2017. Am J Physiol Gastrointest Liver Physiol. 312:G283. PubMed
  40. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  41. Burrus CJ, et al. 2020. Cell Rep. 30:642. PubMed
  42. Lyras EM, et al. 2022. Elife. 11: . PubMed
  43. Li X, et al. 2015. J Am Heart Assoc. 6:4. PubMed
  44. Mariot V, et al. 2021. J Cachexia Sarcopenia Muscle. Online ahead of print. PubMed
  45. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  46. Batool M, et al. 2020. Basic Res Cardiol. 115:68. PubMed
  47. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  48. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  49. Silburt J, et al. 2022. J Neuroinflammation. 19:24. PubMed
  50. Kim H, et al. 2020. ACS Nano. 14:6519. PubMed
  51. Mori H, et al. 2015. Toxicol Pathol. 43: 883-889. PubMed
  52. Goldblatt DL, et al. 2020. British Journal of Pharmacology. 177(10):2256-2273.. PubMed
  53. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  54. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  55. Carvalho K, et al. 2022. J Neuroinflammation. 19:178. PubMed
  56. Stafeev I, et al. 2022. Front Nutr. 8:809732. PubMed
  57. Shi W, et al. 2021. Biosci Rep. 41:. PubMed
  58. Godoy-Calderón MJ, et al. 2018. Oncotarget. 8:11370. PubMed
  59. Wu Y, et al. 2019. Nat Commun. 10:58. PubMed
  60. Cornelison RC, et al. 2022. NPJ Precis Oncol. 6:54. PubMed
  61. Collier AF, et al. 2018. J Pharmacol Exp Ther. 364:409. PubMed
  62. Choi SH, et al. 2020. Arterioscler Thromb Vasc Biol. :ATVBAHA120315485. PubMed
  63. Wang L, et al. 2020. Sci Rep. 10:16326. PubMed
  64. Cushing EM, et al. 2018. J Lipid Res. 59:1230. PubMed
  65. Ikezoe T, et al. 2021. Biomolecules. 11:. PubMed
  66. Koch PS, et al. 2021. Front Physiol. 12:722394. PubMed
  67. Milasan A, et al. 2019. Atherosclerosis. 283:106. PubMed
  68. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  69. Tsai MS, et al. 2021. Int J Mol Sci. 22:. PubMed
  70. Phua T, et al. 2017. Sci Rep. 10.1038/srep44351. PubMed
  71. Cheng X, et al. 2021. Redox Biol. 40:101863. PubMed
  72. Ni K, et al. 2018. Respir Res. 0.865972222. PubMed
  73. Dong Y, et al. 2021. STAR Protoc. 2:100853. PubMed
  74. Yue F, et al. 2021. Mol Ther. 29:132. PubMed
  75. Kayama H, et al. 2012. Proc Natl Acad Sci U S A. 109:5010. PubMed
  76. Han X, et al. 2020. Mol Carcinog. 59:1088. PubMed
  77. Healy A, et al. 2020. Arterioscler Thromb Vasc Biol. 40:714. PubMed
  78. Milasan A, et al. 2017. J Am Heart Assoc. 10.1161/JAHA.117.006892. PubMed
  79. Filipello F et al. 2018. Immunity. 48(5):979-991 . PubMed
  80. Miho Sato‐Hashimoto et al. 2019. eLife. 8 pii: e42025. PubMed
  81. Ruan S, et al. 2023. Front Pharmacol. 14:1088957. PubMed
  82. Michurina S, et al. 2023. Int J Mol Sci. 24:. PubMed
  83. Ritzel RM, et al. 2023. Sci Adv. 9:eadd1101. PubMed
  84. Yin XY, et al. 2023. J Neuroinflammation. 20:69. PubMed
  85. Rodriguez Y, et al. 2022. Liver Res. 6:227. PubMed
  86. Zhang R, et al. 2023. Stroke Vasc Neurol. . PubMed
  87. Dietsch B, et al. 2023. BMC Cancer. 23:436. PubMed
  88. Schake MA, et al. 2023. iScience. 26:106760. PubMed
  89. Taniguchi M, et al. 2023. Mol Pharmacol. . PubMed
  90. Preda MB, et al. 2021. Cell Death Dis. 12:566. PubMed
  91. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  92. Mathew DJ, et al. 2021. Sci Rep. 11:22880. PubMed
  93. Da Mesquita S, et al. 2021. Nature. 593:255. PubMed
  94. Meng J, et al. 2022. J Neurosci. 42:4958. PubMed
  95. Mugarza E, et al. 2022. Sci Adv. 8:eabm8780. PubMed
  96. Block CL, et al. 2022. Cell Rep. 40:111161. PubMed
  97. Saraswathula A, et al. 2023. Int Forum Allergy Rhinol. 13:230. PubMed
  98. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  99. Ohkubo R, et al. 2022. Cell Rep. 41:111803. PubMed
  100. Wu J, et al. 2023. Cell Mol Biol Lett. 28:11. PubMed
  101. , et al. 2022. JACC Basic Transl Sci. 7:I. PubMed
  102. Guiducci C, et al. 2013. J Exp Med. 210:2903. PubMed
  103. Zaman R, et al. 2021. Immunity. :. PubMed
  104. Fang W, et al. 2020. Transl Res. 222:28. PubMed
  105. Spencer WJ, et al. 2019. Proc Natl Acad Sci U S A. 116:13087. PubMed
  106. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  107. Guimbal S, et al. 2021. Arterioscler Thromb Vasc Biol. 41:e193. PubMed
  108. McKinstry S, et al. 2014. J Neurosci. 34:9455. PubMed
  109. Henjum K, et al. 2020. Sci Rep. 10:10590. PubMed
  110. Sherafat A, et al. 2021. Nat Commun. 12:2265. PubMed
  111. Park S, et al. 2013. Biomaterials. 34:598. PubMed
  112. Trus I, et al. 2020. Front Immunol. 2.553472222. PubMed
  113. Shen L et al. 2019. Br J Pharmacol. 176(14):2559-2572 . PubMed
  114. Tian K, et al. 2021. J Immunol Res. 2021:6297332. PubMed
  115. Gomez-Pastor R, et al. 2017. Nat Commun. 8:14405. PubMed
  116. Brocker CN, et al. 2017. Am J Physiol Gastrointest Liver Physiol. 312:G283. PubMed
  117. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  118. Burrus CJ, et al. 2020. Cell Rep. 30:642. PubMed
  119. Lyras EM, et al. 2022. Elife. 11: . PubMed
  120. Li X, et al. 2015. J Am Heart Assoc. 6:4. PubMed
  121. Mariot V, et al. 2021. J Cachexia Sarcopenia Muscle. Online ahead of print. PubMed
  122. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  123. Batool M, et al. 2020. Basic Res Cardiol. 115:68. PubMed
  124. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  125. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  126. Silburt J, et al. 2022. J Neuroinflammation. 19:24. PubMed
  127. Kim H, et al. 2020. ACS Nano. 14:6519. PubMed
  128. Mori H, et al. 2015. Toxicol Pathol. 43: 883-889. PubMed
  129. Goldblatt DL, et al. 2020. British Journal of Pharmacology. 177(10):2256-2273.. PubMed
  130. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  131. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  132. Carvalho K, et al. 2022. J Neuroinflammation. 19:178. PubMed
  133. Stafeev I, et al. 2022. Front Nutr. 8:809732. PubMed
  134. Shi W, et al. 2021. Biosci Rep. 41:. PubMed
  135. Godoy-Calderón MJ, et al. 2018. Oncotarget. 8:11370. PubMed
  136. Wu Y, et al. 2019. Nat Commun. 10:58. PubMed
  137. Cornelison RC, et al. 2022. NPJ Precis Oncol. 6:54. PubMed
  138. Collier AF, et al. 2018. J Pharmacol Exp Ther. 364:409. PubMed
  139. Choi SH, et al. 2020. Arterioscler Thromb Vasc Biol. :ATVBAHA120315485. PubMed
  140. Wang L, et al. 2020. Sci Rep. 10:16326. PubMed
  141. Cushing EM, et al. 2018. J Lipid Res. 59:1230. PubMed
  142. Ikezoe T, et al. 2021. Biomolecules. 11:. PubMed
  143. Koch PS, et al. 2021. Front Physiol. 12:722394. PubMed
  144. Milasan A, et al. 2019. Atherosclerosis. 283:106. PubMed
  145. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  146. Tsai MS, et al. 2021. Int J Mol Sci. 22:. PubMed
  147. Phua T, et al. 2017. Sci Rep. 10.1038/srep44351. PubMed
  148. Cheng X, et al. 2021. Redox Biol. 40:101863. PubMed
  149. Ni K, et al. 2018. Respir Res. 0.865972222. PubMed
  150. Dong Y, et al. 2021. STAR Protoc. 2:100853. PubMed
  151. Yue F, et al. 2021. Mol Ther. 29:132. PubMed
  152. Kayama H, et al. 2012. Proc Natl Acad Sci U S A. 109:5010. PubMed
  153. Han X, et al. 2020. Mol Carcinog. 59:1088. PubMed
  154. Healy A, et al. 2020. Arterioscler Thromb Vasc Biol. 40:714. PubMed
RRID
AB_2044004 (BioLegend Cat. No. 137002)
AB_2044003 (BioLegend Cat. No. 137001)

Antigen Details

Structure
A member of the lysosomal-associated membrane protein (lamp) family.
Distribution

Expressed on tissue macrophages, Langerhans cells, and at low levels on dendritic cells.

Function
Involved in cell-cell interaction or cell-ligand interaction, still not completely understood.
Cell Type
Antigen-presenting cells, Dendritic cells, Langerhans cells, Leukocytes, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules, Innate Immune Signaling
Antigen References

1. Ramprasad MP, et al. 1996. Proc. Natl. Acad. Sci. USA 93:14833.
2. Smith MJ, et al. 1987. J. Cell. Sci. 87:113.

Gene ID
12514 View all products for this Gene ID
UniProt
View information about CD68 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 04.26.2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
FA-11 (See other available formats)
Regulatory Status
RUO
Other Names
Macrosialin
Isotype
Rat IgG2a
Ave. Rating
Submit a Review
Product Citations
publications
FA-11_A647_021810
Thioglycolate-elicited Balb/c peritoneal macrophages intracellularly stained with FA-11 Alexa Fluor® 647
  • FA-11_A647_021810
    Thioglycolate-elicited Balb/c peritoneal macrophages intracellularly stained with FA-11 Alexa Fluor® 647
Compare all formats
Cat # Size Price Quantity Check Availability Save
137002 500 µg NOK3540
Check Availability


Need larger quantities of this item?
Request Bulk Quote
137001 50 µg NOK834
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Mouse CD68, also known as macrosialin, is an 85-115 kD member of the lysosomal-associated membrane protein (LAMP) family. It is a heavily glycosylated and predominantly intracellular protein, mainly in late endosomes. Macrosialin is the murine homolog to the human macrophage glycoprotein CD68. It is expressed on tissue macrophages, Langerhans cells and at low levels on dendritic cells. Lamp proteins may have functions relating to cell-cell interaction or cell-ligand interaction. The biological function of CD68 is not completely understood.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Purified Con A receptor glycoproteins from the P815 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
FC - Verified
IP, WB, IHC-F - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported (for relevant formats) applications include: immunoprecipitation1, 2, Western Blot1, 2, immunohistochemical staining of frozen sections2 and paraformaldehyde-fixed paraffin-embedded sections3, and spatial biology (IBEX)9,10.

Application References
  1. Silva RP, et al. 1999. Biochem. J. 338:687. (IP, WB)
  2. Rabinowitz SS, et al. 1991. J. Exp. Med. 174:827. (IP, WB, IHC)
  3. Wu J, et al. 2008. P. Natl. Acad. Sci. USA 105:16934. (IHC)
  4. Kayama H, et al. 2012. PNAS. 109:5010. PubMed
  5. Park S, et al. 2013. Biomaterials. 34:598. PubMed
  6. Guiducci C, et al. 2013. J Exp Med. 210:2903. PubMed
  7. McKinstry SU, et al. 2014. J Neurosci. 34:9455. PubMed
  8. Li X, et al. 2015. J Am Heart Assoc. 6:4. PubMed
  9. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  10. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Milasan A, et al. 2017. J Am Heart Assoc. 10.1161/JAHA.117.006892. PubMed
  2. Filipello F et al. 2018. Immunity. 48(5):979-991 . PubMed
  3. Miho Sato‐Hashimoto et al. 2019. eLife. 8 pii: e42025. PubMed
  4. Ruan S, et al. 2023. Front Pharmacol. 14:1088957. PubMed
  5. Michurina S, et al. 2023. Int J Mol Sci. 24:. PubMed
  6. Ritzel RM, et al. 2023. Sci Adv. 9:eadd1101. PubMed
  7. Yin XY, et al. 2023. J Neuroinflammation. 20:69. PubMed
  8. Rodriguez Y, et al. 2022. Liver Res. 6:227. PubMed
  9. Zhang R, et al. 2023. Stroke Vasc Neurol. . PubMed
  10. Dietsch B, et al. 2023. BMC Cancer. 23:436. PubMed
  11. Schake MA, et al. 2023. iScience. 26:106760. PubMed
  12. Taniguchi M, et al. 2023. Mol Pharmacol. . PubMed
  13. Preda MB, et al. 2021. Cell Death Dis. 12:566. PubMed
  14. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  15. Mathew DJ, et al. 2021. Sci Rep. 11:22880. PubMed
  16. Da Mesquita S, et al. 2021. Nature. 593:255. PubMed
  17. Meng J, et al. 2022. J Neurosci. 42:4958. PubMed
  18. Mugarza E, et al. 2022. Sci Adv. 8:eabm8780. PubMed
  19. Block CL, et al. 2022. Cell Rep. 40:111161. PubMed
  20. Saraswathula A, et al. 2023. Int Forum Allergy Rhinol. 13:230. PubMed
  21. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  22. Ohkubo R, et al. 2022. Cell Rep. 41:111803. PubMed
  23. Wu J, et al. 2023. Cell Mol Biol Lett. 28:11. PubMed
  24. , et al. 2022. JACC Basic Transl Sci. 7:I. PubMed
  25. Guiducci C, et al. 2013. J Exp Med. 210:2903. PubMed
  26. Zaman R, et al. 2021. Immunity. :. PubMed
  27. Fang W, et al. 2020. Transl Res. 222:28. PubMed
  28. Spencer WJ, et al. 2019. Proc Natl Acad Sci U S A. 116:13087. PubMed
  29. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  30. Guimbal S, et al. 2021. Arterioscler Thromb Vasc Biol. 41:e193. PubMed
  31. McKinstry S, et al. 2014. J Neurosci. 34:9455. PubMed
  32. Henjum K, et al. 2020. Sci Rep. 10:10590. PubMed
  33. Sherafat A, et al. 2021. Nat Commun. 12:2265. PubMed
  34. Park S, et al. 2013. Biomaterials. 34:598. PubMed
  35. Trus I, et al. 2020. Front Immunol. 2.553472222. PubMed
  36. Shen L et al. 2019. Br J Pharmacol. 176(14):2559-2572 . PubMed
  37. Tian K, et al. 2021. J Immunol Res. 2021:6297332. PubMed
  38. Gomez-Pastor R, et al. 2017. Nat Commun. 8:14405. PubMed
  39. Brocker CN, et al. 2017. Am J Physiol Gastrointest Liver Physiol. 312:G283. PubMed
  40. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  41. Burrus CJ, et al. 2020. Cell Rep. 30:642. PubMed
  42. Lyras EM, et al. 2022. Elife. 11: . PubMed
  43. Li X, et al. 2015. J Am Heart Assoc. 6:4. PubMed
  44. Mariot V, et al. 2021. J Cachexia Sarcopenia Muscle. Online ahead of print. PubMed
  45. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  46. Batool M, et al. 2020. Basic Res Cardiol. 115:68. PubMed
  47. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  48. Hulsmans M et al. 2017. Cell. 169(3):510-522 . PubMed
  49. Silburt J, et al. 2022. J Neuroinflammation. 19:24. PubMed
  50. Kim H, et al. 2020. ACS Nano. 14:6519. PubMed
  51. Mori H, et al. 2015. Toxicol Pathol. 43: 883-889. PubMed
  52. Goldblatt DL, et al. 2020. British Journal of Pharmacology. 177(10):2256-2273.. PubMed
  53. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  54. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  55. Carvalho K, et al. 2022. J Neuroinflammation. 19:178. PubMed
  56. Stafeev I, et al. 2022. Front Nutr. 8:809732. PubMed
  57. Shi W, et al. 2021. Biosci Rep. 41:. PubMed
  58. Godoy-Calderón MJ, et al. 2018. Oncotarget. 8:11370. PubMed
  59. Wu Y, et al. 2019. Nat Commun. 10:58. PubMed
  60. Cornelison RC, et al. 2022. NPJ Precis Oncol. 6:54. PubMed
  61. Collier AF, et al. 2018. J Pharmacol Exp Ther. 364:409. PubMed
  62. Choi SH, et al. 2020. Arterioscler Thromb Vasc Biol. :ATVBAHA120315485. PubMed
  63. Wang L, et al. 2020. Sci Rep. 10:16326. PubMed
  64. Cushing EM, et al. 2018. J Lipid Res. 59:1230. PubMed
  65. Ikezoe T, et al. 2021. Biomolecules. 11:. PubMed
  66. Koch PS, et al. 2021. Front Physiol. 12:722394. PubMed
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RRID
AB_2044004 (BioLegend Cat. No. 137002)
AB_2044003 (BioLegend Cat. No. 137001)

Antigen Details

Structure
A member of the lysosomal-associated membrane protein (lamp) family.
Distribution

Expressed on tissue macrophages, Langerhans cells, and at low levels on dendritic cells.

Function
Involved in cell-cell interaction or cell-ligand interaction, still not completely understood.
Cell Type
Antigen-presenting cells, Dendritic cells, Langerhans cells, Leukocytes, Macrophages
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules, Innate Immune Signaling
Antigen References

1. Ramprasad MP, et al. 1996. Proc. Natl. Acad. Sci. USA 93:14833.
2. Smith MJ, et al. 1987. J. Cell. Sci. 87:113.

Gene ID
12514 View all products for this Gene ID
UniProt
View information about CD68 on UniProt.org
Go To Top Version: 2    Revision Date: 04.26.2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

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