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APC anti-mouse NK-1.1 Antibody APC anti-mouse NK-1.1 Antibody

Pricing & Availability
Clone
PK136 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1C, NKR-P1B, Ly-55, CD161, CD161b, CD161c
Isotype
Mouse IgG2a, κ
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Product Citations
publications
PK136_APC_1_110210
C57BL/6 mouse splenocytes were stained with CD49b (DX5) FITC and NK1.1 (clone PK136) APC (top) or mouse IgG2a APC isotype control (bottom).
  • PK136_APC_1_110210
    C57BL/6 mouse splenocytes were stained with CD49b (DX5) FITC and NK1.1 (clone PK136) APC (top) or mouse IgG2a APC isotype control (bottom).
  • PK136_APC_2_110210
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
108710 100 µg SEK2453
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108709 25 µg SEK740
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Description

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The NK-1.1 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3, in vivo depletion4,5,9,10, mediation of in vitro redirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 108712).

Application References
  1. Carlyle JR, et al. 1999. J. Immunol. 162:5917. (IP)
  2. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  3. Koo GC, et al. 1984. Hybridoma 3:301. (Cyt)
  4. Sentman CL, et al. 1989. J. Immunol. 142:1847. (Deplete)
  5. Koo GC, et al. 1986. J. Immunol. 137:3742. (Deplete)
  6. Karlhofer FM, et al. 1991. J. Immunol. 146:3662.
  7. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  8. Reichlin A, et al. 1998. Immunol. Cell Biol. 76:143.
  9. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  10. Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (Deplete)
  11. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  12. Kroemer A, et al. 2008. J. Immunol. 180:7818. PubMed
  13. Kim JY, et al. 2009. Exp Mol Med. 30:288. PubMed
  14. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  15. Lee H, et al. 2014. Invest Ophthalmol Vis Sci. 55:2885. PubMed
  16. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  17. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  2. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  3. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  4. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  5. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  6. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  7. Xin B, et al. 2022. Hepatology. 76:630. PubMed
  8. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  9. Brog RA, et al. 2022. Cancer Immunol Res. 10:962. PubMed
  10. Liu W, et al. 2022. Biomedicines. 10: . PubMed
  11. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  12. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  13. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  14. Zhu X, et al. 2023. Front Immunol. 14:1114802. PubMed
  15. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  16. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  17. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  18. Pi C, et al. 2022. Cancers (Basel). 14:. PubMed
  19. Schroeter CB, et al. 2022. J Neuroinflammation. 19:270. PubMed
  20. Gao L, et al. 2023. J Nanobiotechnology. 21:56. PubMed
  21. Roussel-Queval A, et al. 2023. STAR Protoc. 4:102119. PubMed
  22. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  23. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  24. Yin C, et al. 2023. Sci Rep. 13:3903. PubMed
  25. van Vloten JP, et al. 2022. J Immunother Cancer. 10:. PubMed
  26. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  27. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  28. Liu W, et al. 2020. Mol Ther Oncolytics. 17:350. PubMed
  29. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  30. Wilson RP, et al. 2019. PLoS Pathog. 15:e1007745. PubMed
  31. Farsakoglu Y et al. 2019. Cell reports. 26(9):2307-2315 . PubMed
  32. Shen T, et al. 2019. Cell Death Discov. 5:123. PubMed
  33. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  34. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  35. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  36. Sun SJ, et al. 2022. Commun Biol. 5:867. PubMed
  37. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  38. Liang Y, et al. 2020. J Immunol. 204:2984. PubMed
  39. Chen WS, et al. 2021. Cell Rep. 37:109974. PubMed
  40. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  41. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  42. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  43. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  44. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  45. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  46. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  47. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  48. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  49. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  50. Janakiram N, et al. 2016. Sci Rep. 6:37046. PubMed
  51. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  52. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  53. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  54. Hirata Y, et al. 2015. PLoS One. 10: 0141785. PubMed
  55. Wei SC, et al. 2020. Cancer Discov. . PubMed
  56. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  57. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  58. Guo L, et al. 2021. Front Immunol. 12:785457. PubMed
  59. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  60. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  61. Maluski M, et al. 2019. J Clin Invest. 129:5108. PubMed
  62. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  63. Xu J et al. 2018. Cell. 173(3):762-775 . PubMed
  64. Zenker S, et al. 2014. J Immunol. 192:2830. PubMed
  65. Ray A, et al. 2015. PLoS One. 10: 0137314. PubMed
  66. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  67. Lehmann M, et al. 2016. J Leukoc Biol. 99: 1057 - 1064. PubMed
  68. Hutter K, et al. 2020. FEBS J. . PubMed
  69. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  70. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  71. Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
  72. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  73. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  74. Bourque J, et al. 2021. Heliyon. 7:e08311. PubMed
  75. Kim S, et al. 2021. Elife. 10:. PubMed
  76. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  77. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  78. Lim S, et al. 2016. PLoS One. 11: 0155689. PubMed
  79. Solaymani-Mohammadi S, et al. 2016. J Leukoc Biol. 99: 475 - 482. PubMed
  80. Ballet R, et al. 2014. PLoS Pathog. 10:1004550. PubMed
  81. Stifter SA, et al. 2019. Cell Rep. 29:3539. PubMed
  82. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  83. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  84. Terhorst D, et al. 2015. J Immunol. 195: 4953 - 4961. PubMed
  85. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  86. DiToro D, et al. 2020. Immunity. 650:52. PubMed
  87. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  88. Yu H, et al. 2021. Front Oncol. 11:736882. PubMed
  89. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  90. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  91. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  92. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  93. Tsuzuki S, et al. 2015. Int Immunol. 10.1093/intimm/dxv058. PubMed
  94. Burgener SS, et al. 2019. Cell Rep. 27:3646. PubMed
  95. Schuler F, et al. 2017. Nat Commun. . 10.1038/s41467-017-01850-4. PubMed
  96. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  97. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  98. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  99. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  100. Xu JL, et al. 2022. Front Pharmacol. 13:911663. PubMed
  101. Huang W, et al. 2014. J Leukoc Biol. 96:55. PubMed
  102. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  103. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  104. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  105. Peng V, et al. 2022. Nat Immunol. 23:619. PubMed
  106. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  107. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  108. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  109. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  110. Fleskens V, et al. 2019. Cell Rep. 26:3600. PubMed
  111. Liu CF, et al. 2017. Front Immunol. 1.445833333. PubMed
  112. Zhang S, et al. 2016. PLoS Pathog. 12: 1005617. PubMed
  113. Kujur W, et al. 2020. PLoS Pathog. 16:e1009132. PubMed
  114. Gawish R, et al. 2022. Elife. 11:. PubMed
  115. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  116. Hester AK, et al. 2022. Cell Rep. 38:110363. PubMed
  117. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  118. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  119. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  120. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  121. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  122. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  123. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  124. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  125. Xin B, et al. 2022. Hepatology. 76:630. PubMed
  126. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  127. Brog RA, et al. 2022. Cancer Immunol Res. 10:962. PubMed
  128. Liu W, et al. 2022. Biomedicines. 10: . PubMed
  129. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  130. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  131. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  132. Zhu X, et al. 2023. Front Immunol. 14:1114802. PubMed
  133. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  134. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  135. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  136. Pi C, et al. 2022. Cancers (Basel). 14:. PubMed
  137. Schroeter CB, et al. 2022. J Neuroinflammation. 19:270. PubMed
  138. Gao L, et al. 2023. J Nanobiotechnology. 21:56. PubMed
  139. Roussel-Queval A, et al. 2023. STAR Protoc. 4:102119. PubMed
  140. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  141. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  142. Yin C, et al. 2023. Sci Rep. 13:3903. PubMed
  143. van Vloten JP, et al. 2022. J Immunother Cancer. 10:. PubMed
  144. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  145. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  146. Liu W, et al. 2020. Mol Ther Oncolytics. 17:350. PubMed
  147. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  148. Wilson RP, et al. 2019. PLoS Pathog. 15:e1007745. PubMed
  149. Farsakoglu Y et al. 2019. Cell reports. 26(9):2307-2315 . PubMed
  150. Shen T, et al. 2019. Cell Death Discov. 5:123. PubMed
  151. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  152. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  153. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  154. Sun SJ, et al. 2022. Commun Biol. 5:867. PubMed
  155. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  156. Liang Y, et al. 2020. J Immunol. 204:2984. PubMed
  157. Chen WS, et al. 2021. Cell Rep. 37:109974. PubMed
  158. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  159. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  160. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  161. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  162. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  163. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  164. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  165. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  166. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  167. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  168. Janakiram N, et al. 2016. Sci Rep. 6:37046. PubMed
  169. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  170. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  171. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  172. Hirata Y, et al. 2015. PLoS One. 10: 0141785. PubMed
  173. Wei SC, et al. 2020. Cancer Discov. . PubMed
  174. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  175. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  176. Guo L, et al. 2021. Front Immunol. 12:785457. PubMed
  177. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  178. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  179. Maluski M, et al. 2019. J Clin Invest. 129:5108. PubMed
  180. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  181. Xu J et al. 2018. Cell. 173(3):762-775 . PubMed
  182. Zenker S, et al. 2014. J Immunol. 192:2830. PubMed
  183. Ray A, et al. 2015. PLoS One. 10: 0137314. PubMed
  184. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  185. Lehmann M, et al. 2016. J Leukoc Biol. 99: 1057 - 1064. PubMed
  186. Hutter K, et al. 2020. FEBS J. . PubMed
  187. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  188. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  189. Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
  190. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  191. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  192. Bourque J, et al. 2021. Heliyon. 7:e08311. PubMed
  193. Kim S, et al. 2021. Elife. 10:. PubMed
  194. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  195. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  196. Lim S, et al. 2016. PLoS One. 11: 0155689. PubMed
  197. Solaymani-Mohammadi S, et al. 2016. J Leukoc Biol. 99: 475 - 482. PubMed
  198. Ballet R, et al. 2014. PLoS Pathog. 10:1004550. PubMed
  199. Stifter SA, et al. 2019. Cell Rep. 29:3539. PubMed
  200. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  201. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  202. Terhorst D, et al. 2015. J Immunol. 195: 4953 - 4961. PubMed
  203. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  204. DiToro D, et al. 2020. Immunity. 650:52. PubMed
  205. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  206. Yu H, et al. 2021. Front Oncol. 11:736882. PubMed
  207. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  208. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  209. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  210. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  211. Tsuzuki S, et al. 2015. Int Immunol. 10.1093/intimm/dxv058. PubMed
  212. Burgener SS, et al. 2019. Cell Rep. 27:3646. PubMed
  213. Schuler F, et al. 2017. Nat Commun. . 10.1038/s41467-017-01850-4. PubMed
  214. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  215. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  216. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  217. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  218. Xu JL, et al. 2022. Front Pharmacol. 13:911663. PubMed
  219. Huang W, et al. 2014. J Leukoc Biol. 96:55. PubMed
  220. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  221. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  222. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  223. Peng V, et al. 2022. Nat Immunol. 23:619. PubMed
  224. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  225. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  226. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  227. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  228. Fleskens V, et al. 2019. Cell Rep. 26:3600. PubMed
  229. Liu CF, et al. 2017. Front Immunol. 1.445833333. PubMed
  230. Zhang S, et al. 2016. PLoS Pathog. 12: 1005617. PubMed
  231. Kujur W, et al. 2020. PLoS Pathog. 16:e1009132. PubMed
  232. Gawish R, et al. 2022. Elife. 11:. PubMed
  233. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  234. Hester AK, et al. 2022. Cell Rep. 38:110363. PubMed
  235. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  236. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
RRID
AB_313397 (BioLegend Cat. No. 108710)
AB_313396 (BioLegend Cat. No. 108709)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Lanier LL. 1997. Immunity 6:371.
2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613.
3. Koo GC, et al. 1986. J. Immunol. 137:3742.
4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All NK-1.1 Reagents Request Custom Conjugation
Description Clone Applications
PE/Dazzle™ 594 anti-mouse NK-1.1 PK136 FC
Brilliant Violet 785™ anti-mouse NK-1.1 PK136 FC
APC/Fire™ 750 anti-mouse NK-1.1 PK136 FC
TotalSeq™-A0118 anti-mouse NK-1.1 PK136 PG
Ultra-LEAF™ Purified anti-mouse NK-1.1 PK136 FC,CyTOF®,IP,Depletion,Block,IHC-F
TotalSeq™-B0118 anti-mouse NK-1.1 PK136 PG
TotalSeq™-C0118 anti-mouse NK-1.1 PK136 PG
APC anti-mouse NK-1.1 PK136 FC
Biotin anti-mouse NK-1.1 PK136 FC
FITC anti-mouse NK-1.1 PK136 FC
PE anti-mouse NK-1.1 PK136 FC
Purified anti-mouse NK-1.1 PK136 FC,CyTOF®,IP,Depletion,Block,IHC-F
PE/Cyanine7 anti-mouse NK-1.1 PK136 FC
PE/Cyanine5 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 488 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 647 anti-mouse NK-1.1 PK136 FC
Pacific Blue™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 711™ anti-mouse NK-1.1 PK136 FC
APC/Cyanine7 anti-mouse NK-1.1 PK136 FC
PerCP anti-mouse NK-1.1 PK136 FC
PerCP/Cyanine5.5 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 700 anti-mouse NK-1.1 PK136 FC
Brilliant Violet 421™ anti-mouse NK-1.1 PK136 FC,SB
Brilliant Violet 570™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 650™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 510™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 605™ anti-mouse NK-1.1 PK136 FC
Purified anti-mouse NK-1.1 (Maxpar® Ready) PK136 FC,CyTOF®
PE/Fire™ 810 anti-mouse NK-1.1 PK136 FC
PE/Fire™ 640 anti-mouse NK-1.1 PK136 FC
Spark UV™ 387 anti-mouse NK-1.1 PK136 FC
PE/Fire™ 700 anti-mouse NK-1.1 PK136 FC
Spark YG™ 593 anti-mouse NK-1.1 (Flexi-Fluor™) Antibody PK136 FC
Go To Top Version: 2    Revision Date: 12-08-2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
PK136 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1C, NKR-P1B, Ly-55, CD161, CD161b, CD161c
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
PK136_APC_1_110210
C57BL/6 mouse splenocytes were stained with CD49b (DX5) FITC and NK1.1 (clone PK136) APC (top) or mouse IgG2a APC isotype control (bottom).
  • PK136_APC_1_110210
    C57BL/6 mouse splenocytes were stained with CD49b (DX5) FITC and NK1.1 (clone PK136) APC (top) or mouse IgG2a APC isotype control (bottom).
  • PK136_APC_2_110210
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
108710 100 µg SEK2453
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108709 25 µg SEK740
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Description

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The NK-1.1 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, complement-dependent cytotoxicity3, in vivo depletion4,5,9,10, mediation of in vitro redirected lysis6, blocking of NK cell function7, induction of proliferation8, immunohistochemical staining of frozen sections11, immunofluorescence microscopy11, and spatial biology (IBEX)16,17. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 108712).

Application References
  1. Carlyle JR, et al. 1999. J. Immunol. 162:5917. (IP)
  2. Sentman CL, et al. 1989. Hybridoma 8:605. (IP)
  3. Koo GC, et al. 1984. Hybridoma 3:301. (Cyt)
  4. Sentman CL, et al. 1989. J. Immunol. 142:1847. (Deplete)
  5. Koo GC, et al. 1986. J. Immunol. 137:3742. (Deplete)
  6. Karlhofer FM, et al. 1991. J. Immunol. 146:3662.
  7. Kung SK, et al. 1999. J. Immunol. 162:5876. (Block)
  8. Reichlin A, et al. 1998. Immunol. Cell Biol. 76:143.
  9. Drobyski W, et al. 1996. Blood 87:5355. (Deplete)
  10. Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (Deplete)
  11. Kanwar JR, et al. 2001. J. Natl. Cancer Inst. 93:1541. (IHC, IF)
  12. Kroemer A, et al. 2008. J. Immunol. 180:7818. PubMed
  13. Kim JY, et al. 2009. Exp Mol Med. 30:288. PubMed
  14. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
  15. Lee H, et al. 2014. Invest Ophthalmol Vis Sci. 55:2885. PubMed
  16. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  17. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  2. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  3. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  4. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  5. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  6. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  7. Xin B, et al. 2022. Hepatology. 76:630. PubMed
  8. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  9. Brog RA, et al. 2022. Cancer Immunol Res. 10:962. PubMed
  10. Liu W, et al. 2022. Biomedicines. 10: . PubMed
  11. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  12. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  13. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  14. Zhu X, et al. 2023. Front Immunol. 14:1114802. PubMed
  15. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  16. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  17. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  18. Pi C, et al. 2022. Cancers (Basel). 14:. PubMed
  19. Schroeter CB, et al. 2022. J Neuroinflammation. 19:270. PubMed
  20. Gao L, et al. 2023. J Nanobiotechnology. 21:56. PubMed
  21. Roussel-Queval A, et al. 2023. STAR Protoc. 4:102119. PubMed
  22. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  23. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  24. Yin C, et al. 2023. Sci Rep. 13:3903. PubMed
  25. van Vloten JP, et al. 2022. J Immunother Cancer. 10:. PubMed
  26. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  27. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  28. Liu W, et al. 2020. Mol Ther Oncolytics. 17:350. PubMed
  29. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  30. Wilson RP, et al. 2019. PLoS Pathog. 15:e1007745. PubMed
  31. Farsakoglu Y et al. 2019. Cell reports. 26(9):2307-2315 . PubMed
  32. Shen T, et al. 2019. Cell Death Discov. 5:123. PubMed
  33. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  34. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  35. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  36. Sun SJ, et al. 2022. Commun Biol. 5:867. PubMed
  37. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  38. Liang Y, et al. 2020. J Immunol. 204:2984. PubMed
  39. Chen WS, et al. 2021. Cell Rep. 37:109974. PubMed
  40. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  41. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  42. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  43. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  44. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  45. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  46. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  47. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  48. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  49. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  50. Janakiram N, et al. 2016. Sci Rep. 6:37046. PubMed
  51. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  52. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  53. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  54. Hirata Y, et al. 2015. PLoS One. 10: 0141785. PubMed
  55. Wei SC, et al. 2020. Cancer Discov. . PubMed
  56. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  57. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  58. Guo L, et al. 2021. Front Immunol. 12:785457. PubMed
  59. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  60. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  61. Maluski M, et al. 2019. J Clin Invest. 129:5108. PubMed
  62. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  63. Xu J et al. 2018. Cell. 173(3):762-775 . PubMed
  64. Zenker S, et al. 2014. J Immunol. 192:2830. PubMed
  65. Ray A, et al. 2015. PLoS One. 10: 0137314. PubMed
  66. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  67. Lehmann M, et al. 2016. J Leukoc Biol. 99: 1057 - 1064. PubMed
  68. Hutter K, et al. 2020. FEBS J. . PubMed
  69. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  70. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  71. Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
  72. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  73. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  74. Bourque J, et al. 2021. Heliyon. 7:e08311. PubMed
  75. Kim S, et al. 2021. Elife. 10:. PubMed
  76. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  77. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  78. Lim S, et al. 2016. PLoS One. 11: 0155689. PubMed
  79. Solaymani-Mohammadi S, et al. 2016. J Leukoc Biol. 99: 475 - 482. PubMed
  80. Ballet R, et al. 2014. PLoS Pathog. 10:1004550. PubMed
  81. Stifter SA, et al. 2019. Cell Rep. 29:3539. PubMed
  82. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  83. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  84. Terhorst D, et al. 2015. J Immunol. 195: 4953 - 4961. PubMed
  85. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  86. DiToro D, et al. 2020. Immunity. 650:52. PubMed
  87. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  88. Yu H, et al. 2021. Front Oncol. 11:736882. PubMed
  89. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  90. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  91. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  92. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  93. Tsuzuki S, et al. 2015. Int Immunol. 10.1093/intimm/dxv058. PubMed
  94. Burgener SS, et al. 2019. Cell Rep. 27:3646. PubMed
  95. Schuler F, et al. 2017. Nat Commun. . 10.1038/s41467-017-01850-4. PubMed
  96. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  97. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  98. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  99. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  100. Xu JL, et al. 2022. Front Pharmacol. 13:911663. PubMed
  101. Huang W, et al. 2014. J Leukoc Biol. 96:55. PubMed
  102. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  103. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  104. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  105. Peng V, et al. 2022. Nat Immunol. 23:619. PubMed
  106. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  107. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  108. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  109. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  110. Fleskens V, et al. 2019. Cell Rep. 26:3600. PubMed
  111. Liu CF, et al. 2017. Front Immunol. 1.445833333. PubMed
  112. Zhang S, et al. 2016. PLoS Pathog. 12: 1005617. PubMed
  113. Kujur W, et al. 2020. PLoS Pathog. 16:e1009132. PubMed
  114. Gawish R, et al. 2022. Elife. 11:. PubMed
  115. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  116. Hester AK, et al. 2022. Cell Rep. 38:110363. PubMed
  117. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  118. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  119. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  120. Koyama M, et al. 2015. J Exp Med. 212: 1303 - 1321. PubMed
  121. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  122. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  123. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  124. Zhou Y, et al. 2021. Methods Mol Biol. 2388:35. PubMed
  125. Xin B, et al. 2022. Hepatology. 76:630. PubMed
  126. Zhang H, et al. 2022. Eur J Immunol. 52:978. PubMed
  127. Brog RA, et al. 2022. Cancer Immunol Res. 10:962. PubMed
  128. Liu W, et al. 2022. Biomedicines. 10: . PubMed
  129. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  130. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  131. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  132. Zhu X, et al. 2023. Front Immunol. 14:1114802. PubMed
  133. Kuehm LM, et al. 2021. Cancer Immunol Res. 9:227. PubMed
  134. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  135. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  136. Pi C, et al. 2022. Cancers (Basel). 14:. PubMed
  137. Schroeter CB, et al. 2022. J Neuroinflammation. 19:270. PubMed
  138. Gao L, et al. 2023. J Nanobiotechnology. 21:56. PubMed
  139. Roussel-Queval A, et al. 2023. STAR Protoc. 4:102119. PubMed
  140. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  141. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  142. Yin C, et al. 2023. Sci Rep. 13:3903. PubMed
  143. van Vloten JP, et al. 2022. J Immunother Cancer. 10:. PubMed
  144. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  145. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  146. Liu W, et al. 2020. Mol Ther Oncolytics. 17:350. PubMed
  147. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  148. Wilson RP, et al. 2019. PLoS Pathog. 15:e1007745. PubMed
  149. Farsakoglu Y et al. 2019. Cell reports. 26(9):2307-2315 . PubMed
  150. Shen T, et al. 2019. Cell Death Discov. 5:123. PubMed
  151. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  152. Stegelmeier AA, et al. 2022. Biomedicines. 10:. PubMed
  153. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  154. Sun SJ, et al. 2022. Commun Biol. 5:867. PubMed
  155. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  156. Liang Y, et al. 2020. J Immunol. 204:2984. PubMed
  157. Chen WS, et al. 2021. Cell Rep. 37:109974. PubMed
  158. Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
  159. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  160. Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed
  161. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  162. Starkl P, et al. 2020. Immunity. 53(4):793-804.e9. PubMed
  163. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  164. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  165. Papafragkos I, et al. 2022. Front Immunol. 13:889075. PubMed
  166. Hoffman D, et al. 2021. Immunity. 54:2712. PubMed
  167. Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed
  168. Janakiram N, et al. 2016. Sci Rep. 6:37046. PubMed
  169. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  170. Uchimura T et al. 2018. Immunity. 49(6):1049-1061 . PubMed
  171. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  172. Hirata Y, et al. 2015. PLoS One. 10: 0141785. PubMed
  173. Wei SC, et al. 2020. Cancer Discov. . PubMed
  174. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  175. Haase C, et al. 2022. Nat Methods. 19:1622. PubMed
  176. Guo L, et al. 2021. Front Immunol. 12:785457. PubMed
  177. Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
  178. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  179. Maluski M, et al. 2019. J Clin Invest. 129:5108. PubMed
  180. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  181. Xu J et al. 2018. Cell. 173(3):762-775 . PubMed
  182. Zenker S, et al. 2014. J Immunol. 192:2830. PubMed
  183. Ray A, et al. 2015. PLoS One. 10: 0137314. PubMed
  184. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  185. Lehmann M, et al. 2016. J Leukoc Biol. 99: 1057 - 1064. PubMed
  186. Hutter K, et al. 2020. FEBS J. . PubMed
  187. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  188. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  189. Stotesbury C, et al. 2020. J Immunol. 204:1582. PubMed
  190. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  191. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  192. Bourque J, et al. 2021. Heliyon. 7:e08311. PubMed
  193. Kim S, et al. 2021. Elife. 10:. PubMed
  194. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  195. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  196. Lim S, et al. 2016. PLoS One. 11: 0155689. PubMed
  197. Solaymani-Mohammadi S, et al. 2016. J Leukoc Biol. 99: 475 - 482. PubMed
  198. Ballet R, et al. 2014. PLoS Pathog. 10:1004550. PubMed
  199. Stifter SA, et al. 2019. Cell Rep. 29:3539. PubMed
  200. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  201. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  202. Terhorst D, et al. 2015. J Immunol. 195: 4953 - 4961. PubMed
  203. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  204. DiToro D, et al. 2020. Immunity. 650:52. PubMed
  205. Tuong ZK, et al. 2021. iScience. 24:103326. PubMed
  206. Yu H, et al. 2021. Front Oncol. 11:736882. PubMed
  207. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  208. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  209. Zhang P, et al. 2022. Nat Commun. 13:1588. PubMed
  210. Nahrendorf W, et al. 2021. eLife. 10:00. PubMed
  211. Tsuzuki S, et al. 2015. Int Immunol. 10.1093/intimm/dxv058. PubMed
  212. Burgener SS, et al. 2019. Cell Rep. 27:3646. PubMed
  213. Schuler F, et al. 2017. Nat Commun. . 10.1038/s41467-017-01850-4. PubMed
  214. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  215. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  216. Cartwright ANR, et al. 2021. Cancer Immunol Res. 9:470. PubMed
  217. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  218. Xu JL, et al. 2022. Front Pharmacol. 13:911663. PubMed
  219. Huang W, et al. 2014. J Leukoc Biol. 96:55. PubMed
  220. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  221. Yoshida H, et al. 2019. Cell. 176:897. PubMed
  222. Wagner AK, et al. 2022. iScience. 25:105137. PubMed
  223. Peng V, et al. 2022. Nat Immunol. 23:619. PubMed
  224. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  225. Tomita T, et al. 2021. Nat Commun. 12:3655. PubMed
  226. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  227. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  228. Fleskens V, et al. 2019. Cell Rep. 26:3600. PubMed
  229. Liu CF, et al. 2017. Front Immunol. 1.445833333. PubMed
  230. Zhang S, et al. 2016. PLoS Pathog. 12: 1005617. PubMed
  231. Kujur W, et al. 2020. PLoS Pathog. 16:e1009132. PubMed
  232. Gawish R, et al. 2022. Elife. 11:. PubMed
  233. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  234. Hester AK, et al. 2022. Cell Rep. 38:110363. PubMed
  235. Song X, et al. 2022. Transl Oncol. 15:101306. PubMed
  236. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
RRID
AB_313397 (BioLegend Cat. No. 108710)
AB_313396 (BioLegend Cat. No. 108709)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Lanier LL. 1997. Immunity 6:371.
2. Yokoyama WM, et al. 1993. Ann. Rev. Immunol. 11:613.
3. Koo GC, et al. 1986. J. Immunol. 137:3742.
4. Giorda R, et al. 1991. J. Immunol. 147:1701.

Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

Other Formats

View All NK-1.1 Reagents Request Custom Conjugation
Description Clone Applications
PE/Dazzle™ 594 anti-mouse NK-1.1 PK136 FC
Brilliant Violet 785™ anti-mouse NK-1.1 PK136 FC
APC/Fire™ 750 anti-mouse NK-1.1 PK136 FC
TotalSeq™-A0118 anti-mouse NK-1.1 PK136 PG
Ultra-LEAF™ Purified anti-mouse NK-1.1 PK136 FC,CyTOF®,IP,Depletion,Block,IHC-F
TotalSeq™-B0118 anti-mouse NK-1.1 PK136 PG
TotalSeq™-C0118 anti-mouse NK-1.1 PK136 PG
APC anti-mouse NK-1.1 PK136 FC
Biotin anti-mouse NK-1.1 PK136 FC
FITC anti-mouse NK-1.1 PK136 FC
PE anti-mouse NK-1.1 PK136 FC
Purified anti-mouse NK-1.1 PK136 FC,CyTOF®,IP,Depletion,Block,IHC-F
PE/Cyanine7 anti-mouse NK-1.1 PK136 FC
PE/Cyanine5 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 488 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 647 anti-mouse NK-1.1 PK136 FC
Pacific Blue™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 711™ anti-mouse NK-1.1 PK136 FC
APC/Cyanine7 anti-mouse NK-1.1 PK136 FC
PerCP anti-mouse NK-1.1 PK136 FC
PerCP/Cyanine5.5 anti-mouse NK-1.1 PK136 FC
Alexa Fluor® 700 anti-mouse NK-1.1 PK136 FC
Brilliant Violet 421™ anti-mouse NK-1.1 PK136 FC,SB
Brilliant Violet 570™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 650™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 510™ anti-mouse NK-1.1 PK136 FC
Brilliant Violet 605™ anti-mouse NK-1.1 PK136 FC
Purified anti-mouse NK-1.1 (Maxpar® Ready) PK136 FC,CyTOF®
PE/Fire™ 810 anti-mouse NK-1.1 PK136 FC
PE/Fire™ 640 anti-mouse NK-1.1 PK136 FC
Spark UV™ 387 anti-mouse NK-1.1 PK136 FC
PE/Fire™ 700 anti-mouse NK-1.1 PK136 FC
Spark YG™ 593 anti-mouse NK-1.1 (Flexi-Fluor™) Antibody PK136 FC
Go To Top Version: 2    Revision Date: 12-08-2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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