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Brefeldin A Solution (1,000X) Brefeldin A Solution (1,000X)

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Regulatory Status
RUO
Other Names
BFA
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420601 1 mL SEK546
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  2. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  3. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  4. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  5. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  6. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  7. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  8. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  9. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  10. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  11. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  12. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  13. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  14. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  15. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  16. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  17. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  18. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  19. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  20. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  21. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  22. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  23. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  24. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  25. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  26. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  27. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  28. Chan L, et al. 2022. Cells. 12: . PubMed
  29. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  30. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  31. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  32. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  33. Zander R, et al. 2022. Immunity. 55:475. PubMed
  34. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  35. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  36. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  37. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  38. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  39. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  40. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  41. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  42. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  43. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  44. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  45. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  46. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  47. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  48. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  49. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  50. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  51. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  52. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  53. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  54. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  55. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  56. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  57. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  58. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  59. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  60. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  61. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  62. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  63. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  64. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  65. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  66. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  67. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  68. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  69. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  70. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  71. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  72. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  73. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  74. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  75. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  76. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  77. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  78. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  79. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  80. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  81. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  84. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  85. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  86. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  87. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  88. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  89. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  90. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  91. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  92. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  93. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  94. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  95. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  96. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  97. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  98. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  99. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  100. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  101. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  102. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  103. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  104. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  105. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  106. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  107. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  108. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  109. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  110. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  111. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  112. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  113. Jondle CN, et al. 2021. MBio. 12:. PubMed
  114. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  115. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  116. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  117. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  118. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  119. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  120. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  121. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  122. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  123. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  124. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  125. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  126. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  127. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  128. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  129. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  130. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  131. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  132. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  133. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  134. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  135. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  136. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  137. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  138. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  139. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  140. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  141. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  142. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  143. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  144. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  145. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  146. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  147. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  148. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  149. Harty N 2011. J Immunol. 186:3836. PubMed
  150. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  151. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  152. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  153. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  154. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  155. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  156. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  157. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  158. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  159. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  160. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  161. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  162. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  163. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  164. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  165. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  166. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  167. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  168. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  169. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  170. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  171. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  172. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  173. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  174. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  175. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  176. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  177. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  178. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  179. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  180. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  181. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  182. Ma K, et al. 2022. iScience. 25:104347. PubMed
  183. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  184. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  185. Sekine T, et al. 2020. Cell. 183:158. PubMed
  186. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  187. Guo C, et al. 2018. Immunity. 49:842. PubMed
  188. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  189. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  190. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  191. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  192. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  193. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  194. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  195. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  196. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  197. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  198. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  199. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  200. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  201. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  202. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  203. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  204. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  205. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  206. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  207. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  208. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  209. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  210. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  211. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  212. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  213. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  214. Markey K, et al. 2009. Blood. 113:5644. PubMed
  215. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  216. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  217. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  218. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  219. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  220. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  221. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  222. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  223. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  224. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  225. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  226. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  227. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  228. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  229. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  230. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  231. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  232. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  233. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  234. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  235. Rist M, et al. 2015. J Virol. 89:703. PubMed
  236. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  237. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  238. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  239. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  240. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  241. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  242. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  243. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  244. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  245. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  246. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  247. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  249. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  250. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  251. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  252. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  253. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  254. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  255. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  256. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  257. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  258. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  259. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  260. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  261. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  262. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  263. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  264. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  265. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  266. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  267. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  268. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  269. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  270. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  271. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  272. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  273. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  274. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  275. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  276. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  277. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  278. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  279. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  280. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  281. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  282. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  283. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  284. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  285. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  286. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  287. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  288. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  289. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  290. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  291. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  292. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  293. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  294. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  295. Chan L, et al. 2022. Cells. 12: . PubMed
  296. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  297. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  298. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  299. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  300. Zander R, et al. 2022. Immunity. 55:475. PubMed
  301. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  302. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  303. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  304. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  305. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  306. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  307. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  308. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  309. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  310. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  311. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  312. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  313. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  314. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  315. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  316. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  317. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  318. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  319. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  320. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  321. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  322. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  323. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  324. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  325. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  326. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  328. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  329. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  330. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  331. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  332. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  333. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  334. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  335. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  336. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  337. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  338. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  339. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  340. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  341. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  342. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  343. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  344. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  345. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  346. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  347. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  348. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  349. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  350. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  351. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  352. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  353. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  354. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  355. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  356. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  357. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  358. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  359. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  360. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  361. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  362. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  363. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  364. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  365. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  366. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  367. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  368. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  369. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  370. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  371. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  372. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  373. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  374. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  375. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  376. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  377. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  378. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  379. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  380. Jondle CN, et al. 2021. MBio. 12:. PubMed
  381. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  382. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  383. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  384. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  385. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  386. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  387. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  388. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  389. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  390. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  391. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  392. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  393. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  394. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  395. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  396. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  397. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  398. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  399. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  400. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  401. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  402. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  403. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  404. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  405. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  406. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  407. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  408. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  409. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  410. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  411. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  412. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  413. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  414. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  415. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  416. Harty N 2011. J Immunol. 186:3836. PubMed
  417. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  418. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  419. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  420. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  421. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  422. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  423. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  424. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  425. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  426. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  427. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  428. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  429. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  430. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  431. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  432. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  433. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  434. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  435. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  436. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  437. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  438. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  439. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  440. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  441. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  442. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  443. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  444. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  445. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  446. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  447. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  448. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  449. Ma K, et al. 2022. iScience. 25:104347. PubMed
  450. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  451. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  452. Sekine T, et al. 2020. Cell. 183:158. PubMed
  453. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  454. Guo C, et al. 2018. Immunity. 49:842. PubMed
  455. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  456. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  457. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  458. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  459. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  460. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  461. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  462. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  463. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  464. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  465. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  466. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  467. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  468. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  469. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  470. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  471. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  472. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  473. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  474. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  475. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  476. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  477. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  478. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  479. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  480. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  481. Markey K, et al. 2009. Blood. 113:5644. PubMed
  482. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  483. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  484. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  485. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  486. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  487. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  488. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  489. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  490. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  491. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  492. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  493. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  494. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  495. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  496. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  497. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  498. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  499. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  500. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  501. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  502. Rist M, et al. 2015. J Virol. 89:703. PubMed
  503. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  504. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  505. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  506. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  507. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  508. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  509. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  510. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  511. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  512. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  513. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  514. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  515. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  516. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  517. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  518. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  519. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  520. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  521. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  522. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  523. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  524. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  525. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  526. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  527. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  528. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  529. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  530. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  531. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  532. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  533. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  534. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

Go To Top Version: 1    Revision Date: 11-30-2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Regulatory Status
RUO
Other Names
BFA
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  2. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  3. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  4. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  5. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  6. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  7. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  8. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  9. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  10. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  11. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  12. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  13. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  14. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  15. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  16. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  17. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  18. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  19. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  20. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  21. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  22. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  23. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  24. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  25. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  26. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  27. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  28. Chan L, et al. 2022. Cells. 12: . PubMed
  29. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  30. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  31. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  32. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  33. Zander R, et al. 2022. Immunity. 55:475. PubMed
  34. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  35. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  36. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  37. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  38. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  39. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  40. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  41. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  42. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  43. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  44. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  45. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  46. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  47. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  48. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  49. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  50. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  51. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  52. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  53. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  54. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  55. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  56. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  57. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  58. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  59. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  60. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  61. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  62. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  63. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  64. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  65. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  66. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  67. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  68. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  69. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  70. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  71. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  72. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  73. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  74. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  75. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  76. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  77. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  78. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  79. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  80. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  81. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  84. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  85. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  86. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  87. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  88. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  89. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  90. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  91. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  92. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  93. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  94. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  95. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  96. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  97. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  98. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  99. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  100. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  101. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  102. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  103. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  104. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  105. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  106. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  107. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  108. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  109. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  110. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  111. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  112. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  113. Jondle CN, et al. 2021. MBio. 12:. PubMed
  114. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  115. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  116. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  117. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  118. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  119. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  120. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  121. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  122. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  123. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  124. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  125. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  126. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  127. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  128. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  129. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  130. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  131. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  132. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  133. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  134. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  135. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  136. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  137. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  138. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  139. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  140. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  141. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  142. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  143. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  144. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  145. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  146. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  147. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  148. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  149. Harty N 2011. J Immunol. 186:3836. PubMed
  150. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  151. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  152. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  153. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  154. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  155. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  156. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  157. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  158. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  159. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  160. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  161. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  162. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  163. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  164. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  165. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  166. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  167. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  168. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  169. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  170. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  171. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  172. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  173. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  174. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  175. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  176. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  177. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  178. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  179. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  180. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  181. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  182. Ma K, et al. 2022. iScience. 25:104347. PubMed
  183. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  184. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  185. Sekine T, et al. 2020. Cell. 183:158. PubMed
  186. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  187. Guo C, et al. 2018. Immunity. 49:842. PubMed
  188. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  189. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  190. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  191. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  192. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  193. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  194. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  195. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  196. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  197. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  198. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  199. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  200. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  201. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  202. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  203. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  204. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  205. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  206. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  207. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  208. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  209. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  210. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  211. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  212. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  213. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  214. Markey K, et al. 2009. Blood. 113:5644. PubMed
  215. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  216. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  217. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  218. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  219. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  220. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  221. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  222. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  223. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  224. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  225. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  226. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  227. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  228. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  229. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  230. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  231. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  232. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  233. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  234. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  235. Rist M, et al. 2015. J Virol. 89:703. PubMed
  236. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  237. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  238. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  239. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  240. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  241. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  242. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  243. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  244. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  245. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  246. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  247. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  249. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  250. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  251. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  252. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  253. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  254. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  255. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  256. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  257. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  258. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  259. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  260. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  261. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  262. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  263. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  264. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  265. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  266. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  267. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  268. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  269. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  270. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  271. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  272. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  273. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  274. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  275. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  276. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  277. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  278. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  279. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  280. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  281. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  282. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  283. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  284. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  285. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  286. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  287. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  288. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  289. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  290. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  291. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  292. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  293. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  294. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  295. Chan L, et al. 2022. Cells. 12: . PubMed
  296. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  297. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  298. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  299. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  300. Zander R, et al. 2022. Immunity. 55:475. PubMed
  301. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  302. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  303. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  304. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  305. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  306. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  307. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  308. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  309. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  310. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  311. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  312. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  313. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  314. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  315. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  316. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  317. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  318. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  319. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  320. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  321. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  322. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  323. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  324. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  325. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  326. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  328. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  329. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  330. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  331. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  332. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  333. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  334. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  335. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  336. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  337. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  338. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  339. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  340. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  341. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  342. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  343. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  344. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  345. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  346. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  347. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  348. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  349. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  350. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  351. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  352. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  353. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  354. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  355. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  356. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  357. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  358. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  359. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  360. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  361. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  362. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  363. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  364. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  365. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  366. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  367. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  368. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  369. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  370. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  371. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  372. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  373. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  374. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  375. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  376. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  377. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  378. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  379. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  380. Jondle CN, et al. 2021. MBio. 12:. PubMed
  381. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  382. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  383. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  384. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  385. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  386. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  387. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  388. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  389. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  390. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  391. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  392. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  393. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  394. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  395. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  396. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  397. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  398. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  399. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  400. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  401. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  402. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  403. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  404. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  405. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  406. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  407. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  408. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  409. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  410. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  411. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  412. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  413. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  414. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  415. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  416. Harty N 2011. J Immunol. 186:3836. PubMed
  417. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  418. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  419. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  420. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  421. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  422. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  423. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  424. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  425. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  426. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  427. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  428. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  429. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  430. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  431. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  432. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  433. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  434. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  435. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  436. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  437. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  438. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  439. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  440. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  441. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  442. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  443. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  444. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  445. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  446. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  447. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  448. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  449. Ma K, et al. 2022. iScience. 25:104347. PubMed
  450. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  451. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  452. Sekine T, et al. 2020. Cell. 183:158. PubMed
  453. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  454. Guo C, et al. 2018. Immunity. 49:842. PubMed
  455. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  456. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  457. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  458. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  459. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  460. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  461. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  462. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  463. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  464. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  465. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  466. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  467. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  468. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  469. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  470. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  471. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  472. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  473. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  474. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  475. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  476. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  477. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  478. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  479. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  480. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  481. Markey K, et al. 2009. Blood. 113:5644. PubMed
  482. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  483. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  484. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  485. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  486. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  487. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  488. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  489. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  490. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  491. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  492. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  493. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  494. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  495. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  496. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  497. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  498. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  499. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  500. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  501. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  502. Rist M, et al. 2015. J Virol. 89:703. PubMed
  503. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  504. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  505. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  506. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  507. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  508. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  509. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  510. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  511. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  512. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  513. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  514. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  515. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  516. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  517. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  518. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  519. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  520. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  521. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  522. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  523. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  524. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  525. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  526. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  527. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  528. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  529. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  530. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  531. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  532. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  533. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  534. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

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