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FITC anti-mouse CD4 Antibody FITC anti-mouse CD4 Antibody

Pricing & Availability
Clone
GK1.5 (See other available formats)
Regulatory Status
RUO
Other Names
L3T4, T4
Isotype
Rat IgG2b, κ
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Product Citations
publications
GK1.5_FITC_102110
C57BL/6 mouse splenocytes were stained with CD4 (clone GK1.5) FITC (filled histogram) or rat IgG2b, κ FITC isotype control (open histogram).
  • GK1.5_FITC_102110
    C57BL/6 mouse splenocytes were stained with CD4 (clone GK1.5) FITC (filled histogram) or rat IgG2b, κ FITC isotype control (open histogram).
Compare all formats See FITC spectral data
Cat # Size Price Quantity Check Availability Save
100405 50 µg SEK252
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100406 500 µg SEK832
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Description

CD4 is a 55 kD protein also known as L3T4 or T4. It is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosin kinase, lck.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CTL clone V4
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The CD4 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: blocking of CD4+ T cell activation1,4,11, thymocyte costimulation3, in vitro and in vivo depletion2,5-8, blocking of egg-sperm cell adhesion1,4, immunohistochemical staining of acetone-fixed frozen sections9,10, immunoprecipitation1,2, and spatial biology (IBEX)12,13. The GK1.5 antibody is able to block CD4 mediated cell adhesion and T cell activation. Binding of GK1.5 antibody to CD4 T cells can be blocked by RM4-5 antibody, but not RM4-4 antibody. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 100442) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin < 0.01 EU/µg).

Application References
  1. Dialynas DP, et al. 1983. J. Immunol. 131:2445. (Block, IP)
  2. Dialynas DP, et al. 1983. Immunol. Rev. 74:29. (IP, Deplete)
  3. Wu L, et al. 1991. J. Exp. Med. 174:1617. (Costim)
  4. Godfrey DI, et al. 1994. J. Immunol. 152:4783. (Block)
  5. Gavett SH, et al. 1994. Am. J. Respir. Cell. Mol. Biol. 10:587. (Deplete)
  6. Schuyler M, et al. 1994. Am. J. Respir. Crit. Care Med. 149:1286. (Deplete)
  7. Ghobrial RR, et al. 1989. Clin. Immunol. Immunopathol. 52:486. (Deplete)
  8. Israelski DM, et al. 1989. J. Immunol. 142:954. (Deplete)
  9. Zheng B, et al. 1996. J. Exp. Med. 184:1083. (IHC)
  10. Frei K, et al. 1997. J. Exp. Med. 185:2177. (IHC)
  11. Felix NJ, et al. 2007. Nat. Immunol. 8:388. (Block)
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  2. Katsumura KR, et al. 2018. Proc Natl Acad Sci U S A. 115:E10109. PubMed
  3. Valanparambil RM, et al. 2017. PLoS Pathog. 13:e1006647. PubMed
  4. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  5. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  6. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  7. Zhao J, et al. 2021. Emerg Microbes Infect. 10:913. PubMed
  8. Liu J, et al. 2021. Front Immunol. 12:747730. PubMed
  9. Su Y, et al. 2022. J Hematol Oncol. 15:99. PubMed
  10. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  11. Mills EL, et al. 2022. Cell Metab. 34:140. PubMed
  12. Li X, et al. 2022. J Clin Invest. 132: . PubMed
  13. Wu R, et al. 2022. J Dermatol. 49:432. PubMed
  14. Mi Z, et al. 2021. Vaccines (Basel). 10: . PubMed
  15. Corral D, et al. 2022. Cell Rep. 39:110715. PubMed
  16. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  17. Shen Z, et al. 2022. EBioMedicine. 85:104285. PubMed
  18. Balood M, et al. 2022. Nature. 611:405. PubMed
  19. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  20. Zhang Z, et al. 2022. Integr Cancer Ther. 21:15347354221138534. PubMed
  21. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  22. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  23. Chen C, et al. 2022. J Neuroinflammation. 19:315. PubMed
  24. Qin S, et al. 2023. Acta Pharm Sin B. :. PubMed
  25. Merk VM, et al. 2023. Genes Immun. 24:52. PubMed
  26. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  27. Sun Y, et al. 2023. Cell Mol Life Sci. 80:63. PubMed
  28. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  29. Sylvester MA, et al. 2022. Am J Physiol Renal Physiol. 322:F245. PubMed
  30. Zander R, et al. 2022. Immunity. 55:475. PubMed
  31. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  32. Zelenka T, et al. 2022. Nat Commun. 13:6954. PubMed
  33. Qiu Z, et al. 2022. J Exp Med. 219:. PubMed
  34. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  35. Hamdi L, et al. 2022. Ann Clin Transl Neurol. 9:1792. PubMed
  36. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  37. Zhu C, et al. 2022. Chemotherapy. 67:211. PubMed
  38. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  39. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  40. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  41. Mackin S, et al. 2023. Nat Microbiol. 8:569. PubMed
  42. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  43. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  44. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  45. Fiedler T, et al. 2023. J Neuroinflammation. 20:100. PubMed
  46. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  47. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  48. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  49. Peymanfar Y, et al. 2023. Int J Mol Sci. 24:. PubMed
  50. Wang X, et al. 2023. Nat Commun. 14:3440. PubMed
  51. Yao RQ, et al. 2023. Mil Med Res. 10:27. PubMed
  52. Iwanami N, et al. 2023. Nat Commun. 14:3645. PubMed
  53. Solvay M, et al. 2023. J Immunother Cancer. 11:. PubMed
  54. Wang Z, et al. 2023. Sci Adv. 9:eabo4100. PubMed
  55. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  56. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  57. Rosenkranz SC, et al. 2021. eLife. 10:00. PubMed
  58. Furuta Y, et al. 2017. PLoS One. 12(2):e0172509. PubMed
  59. Yang Z, et al. 2022. J Immunother Cancer. 10:. PubMed
  60. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  61. Schönberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  62. He R, et al. 2021. J Immunol. 206:2353. PubMed
  63. Ma J, et al. 2020. Adv Sci (Weinh). 7:2000609. PubMed
  64. Fan L, et al. 2021. Cancers (Basel). 13:. PubMed
  65. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  66. Sega E, et al. 2008. Int J Radiat Oncol Biol Phys. 71:559. PubMed
  67. Lua Y, et al. 2012. Mol Immunol. 52:229. PubMed
  68. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  69. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  70. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  71. Luo R, et al. 2021. Theranostics. 11:117. PubMed
  72. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  73. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  74. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  75. Toomer G, et al. 2022. Viruses. 14:. PubMed
  76. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  77. Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed
  78. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  79. Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
  80. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  81. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  84. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  85. Jazowiecka-Rakus J, et al. 2021. Cancers (Basel). 13:. PubMed
  86. Chen J, et al. 2022. J Nanobiotechnology. 20:283. PubMed
  87. Wu M, et al. 2021. Nat Commun. 12:3500. PubMed
  88. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  89. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  90. Guan H, et al. 2012. PLoS One. 7:e35650. PubMed
  91. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  92. He C, et al. 2020. Clin Transl Med. 10:e39. PubMed
  93. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  94. Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed
  95. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  96. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
  97. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  98. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  99. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  100. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  101. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  102. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  103. Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed
  104. Thomas S, et al. 2019. J Immunother Cancer. 7:214. PubMed
  105. Tritama E, et al. 2018. Hum Vaccin Immunother. 14:1524. PubMed
  106. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  107. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  108. White C, et al. 2014. J Immunol. 193:5933. PubMed
  109. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  110. Liu Y, et al. 2022. Nat Commun. 13:2665. PubMed
  111. Anastasiou M, et al. 2021. JCI Insight. 6:. PubMed
  112. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  113. Zongyi Y, et al. 2017. PLoS One. 10.1371/journal.pone.0189617. PubMed
  114. Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed
  115. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  116. Edwards CJ, et al. 2021. Br J Cancer. . PubMed
  117. Jing L, et al. 2022. Front Immunol. 13:864995. PubMed
  118. Feng H, et al. 2020. J Dermatol. 47:147. PubMed
  119. Ren HZ, et al. 2022. J Clin Transl Hepatol. 10:1138. PubMed
  120. Pedraza–Zamora CP, et al. 2017. Parasite Immunol. 39:4. PubMed
  121. Wang Z, et al. 2020. J Clin Invest. 130:3717. PubMed
  122. Raineri D, et al. 2021. Biomedicines. 10:. PubMed
  123. He X, et al. 2021. Small. 17:e2007165. PubMed
  124. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  125. He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
  126. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  127. Zhang W, et al. 2019. Oncol Lett. 17:815. PubMed
  128. Cervera–Carrascon V, et al. 2020. Oncoimmunology. 9:1761229. PubMed
  129. Paul S, et al. 2018. Appl Microbiol Biotechnol. 102:8895. PubMed
  130. Vigeland C, et al. 2016. PLoS One. 11: 0163288. PubMed
  131. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  132. Deng Z, et al. 2020. World J Gastrointest Oncol. 1091:12. PubMed
  133. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  134. Wang Z, et al. 2022. Nat Biomed Eng. 6:791. PubMed
  135. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  136. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  137. Kim JH, et al. 2019. Mol Med. 25:33. PubMed
  138. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  139. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  140. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  141. Knocke S, et al. 2016. Cell Rep. 17:2234-2246. PubMed
  142. Ahmari N, et al. 2016. Physiol Genomics. 48: 526 - 536. PubMed
  143. Ito C, et al. 2015. PLoS One. 10: e0140808. PubMed
  144. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  145. Zhou H, et al. 2022. Oncoimmunology. 11:2057892. PubMed
  146. He X, et al. 2022. Cancer Immunol Res. 10:314. PubMed
  147. Hum NR, et al. 2022. Front Oncol. 12:928474. PubMed
  148. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  149. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  150. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  151. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  152. Uddback I, et al. 2016. Sci Rep. 6:20137. PubMed
  153. Toomer K, et al. 2016. J Immunol. 196: 3665 - 3676. PubMed
  154. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  155. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  156. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  157. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  158. Wang Y, et al. 2021. Front Microbiol. 12:701566. PubMed
  159. Gebre MS, et al. 2022. NPJ Vaccines. 7:88. PubMed
  160. Yang B, et al. 2022. Bioengineered. 13:2685. PubMed
  161. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  162. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  163. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  164. Mencl S, et al. 2014. J Neuroimmunol. 274:125. PubMed
  165. Sun H, et al. 2022. Front Immunol. 13:818017. PubMed
  166. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  167. Ding P, et al. 2022. Bone Res. 10:42. PubMed
  168. Lang V, et al. 2021. Elife. 10:. PubMed
  169. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  170. Huang L, et al. 2021. Breast Cancer Res Treat. Online ahead of print. PubMed
  171. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  172. Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed
  173. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  174. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  175. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  176. Kmieciak M, et al. 2011. J Vis Exp. 47: 2381. PubMed
  177. Li Y, Kaneda T 2016. Sci Rep. 6: 25077. PubMed
  178. Timilshina M, et al. 2017. PLoS One. 10.1371/journal.pone.0168942. PubMed
  179. Wang X, et al. 2020. Nat Commun. 4.505555556. PubMed
  180. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  181. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  182. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  183. Ma K, et al. 2022. iScience. 25:104347. PubMed
  184. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  185. Gao X, et al. 2022. Front Immunol. 13:799331. PubMed
  186. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  187. Kamata T, et al. 2020. Cell Reports. 31(12):107802. PubMed
  188. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  189. Reynolds CJ, et al. 2018. Sci Rep. 8:672. PubMed
  190. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  191. Liu Y, et al. 2020. Oncol Lett. 2369:20. PubMed
  192. Martomo SA, et al. 2021. Mol Cancer Ther. 1.074305556. PubMed
  193. Zan H, et al. 2017. Nat Commun. 8:14244. PubMed
  194. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  195. He C, et al. 2022. Nat Commun. 13:5459. PubMed
  196. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  197. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  198. Yuan M, et al. 2022. Oxid Med Cell Longev. 2022:5479491. PubMed
  199. Li J, et al. 2020. Development. :. PubMed
  200. Shibuya M, et al. 2021. iScience. 24:103131. PubMed
  201. Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed
  202. Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
  203. Xia Y, et al. 2018. Cell. 175:1059. PubMed
  204. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  205. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  206. Ligon MM, et al. 2020. Mucosal Immunol. 1.172222222. PubMed
  207. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  208. Wedekind MF, et al. 2021. iScience. 24(7):102759. PubMed
  209. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  210. Jazowiecka-Rakus J, et al. 2020. Mol Ther Oncolytics. 18:335. PubMed
  211. Soria-Castro R, et al. 2020. Sci Rep. 10:17802. PubMed
  212. Chen H, et al. 2022. Front Pharmacol. 13:827520. PubMed
  213. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  214. Khosravi N, et al. 2018. Cancer Immunol Res. 0.797222222. PubMed
  215. Kos S, et al. 2019. PLoS One. 14:e0217762. PubMed
  216. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  217. Habtetsion T et al. 2018. Cell metabolism. 28(2):228-242 . PubMed
  218. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  219. Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed
  220. Pan L, et al. 2022. Front Immunol. 13:837497. PubMed
  221. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  222. He X, et al. 2021. J Immunother Cancer. 9:. PubMed
  223. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  224. Liu Y, et al. 2020. Cell Death Dis. 11:1062. PubMed
  225. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  226. Sivapatham S, et al. 2019. Front Immunol. 1.865277778. PubMed
  227. Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed
  228. Bryan Hart, Sunhee Lee 2016. PLoS Negl Trop Dis. 10:e0005229. PubMed
  229. Blaszczak AM, et al. 2020. Immunometabolism. 2:00. PubMed
  230. Yang C, et al. 2020. Cell Host Microbe. 467:27. PubMed
  231. Sun F, et al. 2022. Cell Death Dis. 13:181. PubMed
  232. Zhong C, et al. 2021. J Virol. 95:e0092521. PubMed
  233. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  234. Xu Y, et al. 2021. iScience. 24:103445. PubMed
  235. Zhou S, et al. 2021. Adv Funct Mater. 31:. PubMed
  236. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  237. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  238. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  239. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  240. Blaszczak AM, et al. 2019. J Immunol. 202:2451. PubMed
  241. Liang Z, et al. 2017. Autophagy. 14:505. PubMed
  242. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  243. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  244. Hart B, et al. 2015. PLoS Negl Trop Dis. 9: 0004046. PubMed
  245. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  246. Wang Y, et al. 2022. Nat Commun. 13:1454. PubMed
  247. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  249. Li Z, et al. 2022. Evid Based Complement Alternat Med. 2022:7421265. PubMed
  250. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  251. Bartley A, et al. 2018. Front Physiol. 9:1593. PubMed
  252. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  253. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  254. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  255. Gardenier J, et al. 2017. Nat Commun. 8:14345. PubMed
  256. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  257. Zeng A, et al. 2020. Oncol Rep. . PubMed
  258. Hsu HP, et al. 2021. J Biol Chem. 296:100419. PubMed
  259. Zhang M, et al. 2022. iScience. 25:104490. PubMed
  260. Chen Y, et al. 2021. Braz J Med Biol Res. 54:e9570. PubMed
  261. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  262. Kathania M, et al. 2022. Cell Rep. 40:111345. PubMed
  263. Gawish R, et al. 2022. Elife. 11:. PubMed
  264. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  265. Zhou T, et al. 2018. Mol Med Rep. 17:4883. PubMed
  266. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  267. Cortez MA, et al. 2020. Nat Commun. 3.819444444. PubMed
  268. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  269. Liang Z, et al. 2022. iScience. 25:105233. PubMed
  270. Lestari SR, et al. 2020. J Ayurveda Integr Med. 11:414. PubMed
  271. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  272. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  273. Ding X, et al. 2021. Front Immunol. 12:667136. PubMed
  274. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  275. Katsumura KR, et al. 2018. Proc Natl Acad Sci U S A. 115:E10109. PubMed
  276. Valanparambil RM, et al. 2017. PLoS Pathog. 13:e1006647. PubMed
  277. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  278. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  279. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  280. Zhao J, et al. 2021. Emerg Microbes Infect. 10:913. PubMed
  281. Liu J, et al. 2021. Front Immunol. 12:747730. PubMed
  282. Su Y, et al. 2022. J Hematol Oncol. 15:99. PubMed
  283. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  284. Mills EL, et al. 2022. Cell Metab. 34:140. PubMed
  285. Li X, et al. 2022. J Clin Invest. 132: . PubMed
  286. Wu R, et al. 2022. J Dermatol. 49:432. PubMed
  287. Mi Z, et al. 2021. Vaccines (Basel). 10: . PubMed
  288. Corral D, et al. 2022. Cell Rep. 39:110715. PubMed
  289. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  290. Shen Z, et al. 2022. EBioMedicine. 85:104285. PubMed
  291. Balood M, et al. 2022. Nature. 611:405. PubMed
  292. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  293. Zhang Z, et al. 2022. Integr Cancer Ther. 21:15347354221138534. PubMed
  294. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  295. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  296. Chen C, et al. 2022. J Neuroinflammation. 19:315. PubMed
  297. Qin S, et al. 2023. Acta Pharm Sin B. :. PubMed
  298. Merk VM, et al. 2023. Genes Immun. 24:52. PubMed
  299. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  300. Sun Y, et al. 2023. Cell Mol Life Sci. 80:63. PubMed
  301. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  302. Sylvester MA, et al. 2022. Am J Physiol Renal Physiol. 322:F245. PubMed
  303. Zander R, et al. 2022. Immunity. 55:475. PubMed
  304. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  305. Zelenka T, et al. 2022. Nat Commun. 13:6954. PubMed
  306. Qiu Z, et al. 2022. J Exp Med. 219:. PubMed
  307. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  308. Hamdi L, et al. 2022. Ann Clin Transl Neurol. 9:1792. PubMed
  309. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  310. Zhu C, et al. 2022. Chemotherapy. 67:211. PubMed
  311. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  312. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  313. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  314. Mackin S, et al. 2023. Nat Microbiol. 8:569. PubMed
  315. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  316. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  317. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  318. Fiedler T, et al. 2023. J Neuroinflammation. 20:100. PubMed
  319. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  320. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  321. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  322. Peymanfar Y, et al. 2023. Int J Mol Sci. 24:. PubMed
  323. Wang X, et al. 2023. Nat Commun. 14:3440. PubMed
  324. Yao RQ, et al. 2023. Mil Med Res. 10:27. PubMed
  325. Iwanami N, et al. 2023. Nat Commun. 14:3645. PubMed
  326. Solvay M, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Wang Z, et al. 2023. Sci Adv. 9:eabo4100. PubMed
  328. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  329. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  330. Rosenkranz SC, et al. 2021. eLife. 10:00. PubMed
  331. Furuta Y, et al. 2017. PLoS One. 12(2):e0172509. PubMed
  332. Yang Z, et al. 2022. J Immunother Cancer. 10:. PubMed
  333. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  334. Schönberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  335. He R, et al. 2021. J Immunol. 206:2353. PubMed
  336. Ma J, et al. 2020. Adv Sci (Weinh). 7:2000609. PubMed
  337. Fan L, et al. 2021. Cancers (Basel). 13:. PubMed
  338. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  339. Sega E, et al. 2008. Int J Radiat Oncol Biol Phys. 71:559. PubMed
  340. Lua Y, et al. 2012. Mol Immunol. 52:229. PubMed
  341. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  342. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  343. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  344. Luo R, et al. 2021. Theranostics. 11:117. PubMed
  345. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  346. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  347. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  348. Toomer G, et al. 2022. Viruses. 14:. PubMed
  349. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  350. Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed
  351. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  352. Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
  353. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  354. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  355. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  356. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  357. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  358. Jazowiecka-Rakus J, et al. 2021. Cancers (Basel). 13:. PubMed
  359. Chen J, et al. 2022. J Nanobiotechnology. 20:283. PubMed
  360. Wu M, et al. 2021. Nat Commun. 12:3500. PubMed
  361. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  362. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  363. Guan H, et al. 2012. PLoS One. 7:e35650. PubMed
  364. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  365. He C, et al. 2020. Clin Transl Med. 10:e39. PubMed
  366. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  367. Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed
  368. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  369. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
  370. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  371. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  372. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  373. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  374. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  375. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  376. Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed
  377. Thomas S, et al. 2019. J Immunother Cancer. 7:214. PubMed
  378. Tritama E, et al. 2018. Hum Vaccin Immunother. 14:1524. PubMed
  379. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  380. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  381. White C, et al. 2014. J Immunol. 193:5933. PubMed
  382. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  383. Liu Y, et al. 2022. Nat Commun. 13:2665. PubMed
  384. Anastasiou M, et al. 2021. JCI Insight. 6:. PubMed
  385. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  386. Zongyi Y, et al. 2017. PLoS One. 10.1371/journal.pone.0189617. PubMed
  387. Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed
  388. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  389. Edwards CJ, et al. 2021. Br J Cancer. . PubMed
  390. Jing L, et al. 2022. Front Immunol. 13:864995. PubMed
  391. Feng H, et al. 2020. J Dermatol. 47:147. PubMed
  392. Ren HZ, et al. 2022. J Clin Transl Hepatol. 10:1138. PubMed
  393. Pedraza–Zamora CP, et al. 2017. Parasite Immunol. 39:4. PubMed
  394. Wang Z, et al. 2020. J Clin Invest. 130:3717. PubMed
  395. Raineri D, et al. 2021. Biomedicines. 10:. PubMed
  396. He X, et al. 2021. Small. 17:e2007165. PubMed
  397. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  398. He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
  399. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  400. Zhang W, et al. 2019. Oncol Lett. 17:815. PubMed
  401. Cervera–Carrascon V, et al. 2020. Oncoimmunology. 9:1761229. PubMed
  402. Paul S, et al. 2018. Appl Microbiol Biotechnol. 102:8895. PubMed
  403. Vigeland C, et al. 2016. PLoS One. 11: 0163288. PubMed
  404. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  405. Deng Z, et al. 2020. World J Gastrointest Oncol. 1091:12. PubMed
  406. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  407. Wang Z, et al. 2022. Nat Biomed Eng. 6:791. PubMed
  408. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  409. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  410. Kim JH, et al. 2019. Mol Med. 25:33. PubMed
  411. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  412. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  413. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  414. Knocke S, et al. 2016. Cell Rep. 17:2234-2246. PubMed
  415. Ahmari N, et al. 2016. Physiol Genomics. 48: 526 - 536. PubMed
  416. Ito C, et al. 2015. PLoS One. 10: e0140808. PubMed
  417. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  418. Zhou H, et al. 2022. Oncoimmunology. 11:2057892. PubMed
  419. He X, et al. 2022. Cancer Immunol Res. 10:314. PubMed
  420. Hum NR, et al. 2022. Front Oncol. 12:928474. PubMed
  421. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  422. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  423. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  424. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  425. Uddback I, et al. 2016. Sci Rep. 6:20137. PubMed
  426. Toomer K, et al. 2016. J Immunol. 196: 3665 - 3676. PubMed
  427. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  428. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  429. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  430. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  431. Wang Y, et al. 2021. Front Microbiol. 12:701566. PubMed
  432. Gebre MS, et al. 2022. NPJ Vaccines. 7:88. PubMed
  433. Yang B, et al. 2022. Bioengineered. 13:2685. PubMed
  434. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  435. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  436. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  437. Mencl S, et al. 2014. J Neuroimmunol. 274:125. PubMed
  438. Sun H, et al. 2022. Front Immunol. 13:818017. PubMed
  439. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  440. Ding P, et al. 2022. Bone Res. 10:42. PubMed
  441. Lang V, et al. 2021. Elife. 10:. PubMed
  442. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  443. Huang L, et al. 2021. Breast Cancer Res Treat. Online ahead of print. PubMed
  444. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  445. Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed
  446. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  447. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  448. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  449. Kmieciak M, et al. 2011. J Vis Exp. 47: 2381. PubMed
  450. Li Y, Kaneda T 2016. Sci Rep. 6: 25077. PubMed
  451. Timilshina M, et al. 2017. PLoS One. 10.1371/journal.pone.0168942. PubMed
  452. Wang X, et al. 2020. Nat Commun. 4.505555556. PubMed
  453. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  454. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  455. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  456. Ma K, et al. 2022. iScience. 25:104347. PubMed
  457. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  458. Gao X, et al. 2022. Front Immunol. 13:799331. PubMed
  459. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  460. Kamata T, et al. 2020. Cell Reports. 31(12):107802. PubMed
  461. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  462. Reynolds CJ, et al. 2018. Sci Rep. 8:672. PubMed
  463. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  464. Liu Y, et al. 2020. Oncol Lett. 2369:20. PubMed
  465. Martomo SA, et al. 2021. Mol Cancer Ther. 1.074305556. PubMed
  466. Zan H, et al. 2017. Nat Commun. 8:14244. PubMed
  467. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  468. He C, et al. 2022. Nat Commun. 13:5459. PubMed
  469. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  470. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  471. Yuan M, et al. 2022. Oxid Med Cell Longev. 2022:5479491. PubMed
  472. Li J, et al. 2020. Development. :. PubMed
  473. Shibuya M, et al. 2021. iScience. 24:103131. PubMed
  474. Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed
  475. Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
  476. Xia Y, et al. 2018. Cell. 175:1059. PubMed
  477. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  478. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  479. Ligon MM, et al. 2020. Mucosal Immunol. 1.172222222. PubMed
  480. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  481. Wedekind MF, et al. 2021. iScience. 24(7):102759. PubMed
  482. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  483. Jazowiecka-Rakus J, et al. 2020. Mol Ther Oncolytics. 18:335. PubMed
  484. Soria-Castro R, et al. 2020. Sci Rep. 10:17802. PubMed
  485. Chen H, et al. 2022. Front Pharmacol. 13:827520. PubMed
  486. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  487. Khosravi N, et al. 2018. Cancer Immunol Res. 0.797222222. PubMed
  488. Kos S, et al. 2019. PLoS One. 14:e0217762. PubMed
  489. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  490. Habtetsion T et al. 2018. Cell metabolism. 28(2):228-242 . PubMed
  491. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  492. Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed
  493. Pan L, et al. 2022. Front Immunol. 13:837497. PubMed
  494. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  495. He X, et al. 2021. J Immunother Cancer. 9:. PubMed
  496. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  497. Liu Y, et al. 2020. Cell Death Dis. 11:1062. PubMed
  498. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  499. Sivapatham S, et al. 2019. Front Immunol. 1.865277778. PubMed
  500. Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed
  501. Bryan Hart, Sunhee Lee 2016. PLoS Negl Trop Dis. 10:e0005229. PubMed
  502. Blaszczak AM, et al. 2020. Immunometabolism. 2:00. PubMed
  503. Yang C, et al. 2020. Cell Host Microbe. 467:27. PubMed
  504. Sun F, et al. 2022. Cell Death Dis. 13:181. PubMed
  505. Zhong C, et al. 2021. J Virol. 95:e0092521. PubMed
  506. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  507. Xu Y, et al. 2021. iScience. 24:103445. PubMed
  508. Zhou S, et al. 2021. Adv Funct Mater. 31:. PubMed
  509. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  510. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  511. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  512. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  513. Blaszczak AM, et al. 2019. J Immunol. 202:2451. PubMed
  514. Liang Z, et al. 2017. Autophagy. 14:505. PubMed
  515. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  516. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  517. Hart B, et al. 2015. PLoS Negl Trop Dis. 9: 0004046. PubMed
  518. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  519. Wang Y, et al. 2022. Nat Commun. 13:1454. PubMed
  520. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  521. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  522. Li Z, et al. 2022. Evid Based Complement Alternat Med. 2022:7421265. PubMed
  523. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  524. Bartley A, et al. 2018. Front Physiol. 9:1593. PubMed
  525. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  526. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  527. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  528. Gardenier J, et al. 2017. Nat Commun. 8:14345. PubMed
  529. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  530. Zeng A, et al. 2020. Oncol Rep. . PubMed
  531. Hsu HP, et al. 2021. J Biol Chem. 296:100419. PubMed
  532. Zhang M, et al. 2022. iScience. 25:104490. PubMed
  533. Chen Y, et al. 2021. Braz J Med Biol Res. 54:e9570. PubMed
  534. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  535. Kathania M, et al. 2022. Cell Rep. 40:111345. PubMed
  536. Gawish R, et al. 2022. Elife. 11:. PubMed
  537. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  538. Zhou T, et al. 2018. Mol Med Rep. 17:4883. PubMed
  539. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  540. Cortez MA, et al. 2020. Nat Commun. 3.819444444. PubMed
  541. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  542. Liang Z, et al. 2022. iScience. 25:105233. PubMed
  543. Lestari SR, et al. 2020. J Ayurveda Integr Med. 11:414. PubMed
  544. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  545. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  546. Ding X, et al. 2021. Front Immunol. 12:667136. PubMed
RRID
AB_312690 (BioLegend Cat. No. 100405)
AB_312691 (BioLegend Cat. No. 100406)

Antigen Details

Structure
Ig superfamily, 55 kD
Distribution

Majority of thymocytes, T cell subset

Function
TCR co-receptor, T cell activation
Ligand/Receptor
MHC class II molecule
Cell Type
Dendritic cells, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Bierer BE, et al. 1989. Annu. Rev. Immunol. 7:579.
3. Janeway CA. 1992. Annu. Rev. Immunol. 10:645.

Gene ID
12504 View all products for this Gene ID
UniProt
View information about CD4 on UniProt.org

Related FAQs

I am unable to see expression of T cell markers such as CD3 and CD4 post activation.
TCR-CD3 complexes on the T-lymphocyte surface are rapidly downregulated upon activation with peptide-MHC complex, superantigen or cross-linking with anti-TCR or anti-CD3 antibodies. PMA/Ionomycin treatment has been shown to downregulate surface CD4 expression. Receptor downregulation is a common biological phenomenon and so make sure that your stimulation treatment is not causing it in your sample type.

Other Formats

View All CD4 Reagents Request Custom Conjugation
Description Clone Applications
APC/Cyanine7 anti-mouse CD4 GK1.5 FC
Brilliant Violet 711™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 510™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 605™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 785™ anti-mouse CD4 GK1.5 FC
PE/Dazzle™ 594 anti-mouse CD4 GK1.5 FC
APC/Fire™ 750 anti-mouse CD4 GK1.5 FC
GoInVivo™ Purified anti-mouse CD4 GK1.5 FC
Brilliant Violet 750™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 650™ anti-mouse CD4 GK1.5 FC
Spark Blue™ 550 anti-mouse CD4 GK1.5 FC
Spark NIR™ 685 anti-mouse CD4 GK1.5 FC
APC/Fire™ 810 anti-mouse CD4 GK1.5 FC
KIRAVIA Blue 520™ anti-mouse CD4 GK1.5 FC
PE/Fire™ 640 anti-mouse CD4 GK1.5 FC
PE/Fire™ 700 anti-mouse CD4 GK1.5 FC
PE anti-mouse CD4 GK1.5 FC
PE/Cyanine5 anti-mouse CD4 GK1.5 FC
Purified anti-mouse CD4 GK1.5 FC,IHC-F,ICC,IP,Costim,Block,Depletion
APC anti-mouse CD4 GK1.5 FC
Biotin anti-mouse CD4 GK1.5 FC,IHC-F,ICC
FITC anti-mouse CD4 GK1.5 FC
Alexa Fluor® 647 anti-mouse CD4 GK1.5 FC,IHC-F
Alexa Fluor® 488 anti-mouse CD4 GK1.5 FC,IHC-F
Alexa Fluor® 700 anti-mouse CD4 GK1.5 FC
Pacific Blue™ anti-mouse CD4 GK1.5 FC
PerCP/Cyanine5.5 anti-mouse CD4 GK1.5 FC
PerCP anti-mouse CD4 GK1.5 FC
Brilliant Violet 421™ anti-mouse CD4 GK1.5 FC,ICC,IHC-F
Ultra-LEAF™ Purified anti-mouse CD4 GK1.5 FC,Block,Costim,Depletion,IHC,IP
Alexa Fluor® 594 anti-mouse CD4 GK1.5 IHC-F,FC,SB
Spark Violet™ 538 anti-mouse CD4 GK1.5 FC
Spark YG™ 593 anti-mouse CD4 GK1.5 FC
Spark Blue™ 574 anti-mouse CD4 Antibody GK1.5 FC
Spark UV™ 387 anti-mouse CD4 GK1.5 FC
Spark Blue™ 515 anti-mouse CD4 GK1.5 FC
Spark PLUS UV395™ anti-mouse CD4 GK1.5 FC
Spark Red™ 718 anti-mouse CD4 (Flexi-Fluor™) GK1.5 FC
PerCP/Fire™ 806 anti-mouse CD4 Antibody GK1.5 FC
PerCP/Fire™ 780 anti-mouse CD4 Antibody GK1.5 FC
Spark YG™ 581 anti-mouse CD4 (Flexi-Fluor™) GK1.5 FC
StarBright UltraViolet 795 anti-mouse CD4 GK1.5 FC
Spark PLUS V475™ anti-mouse CD4 GK1.5 FC
Spark PLUS B488™ anti-mouse CD4 GK1.5 FC
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For Research Use Only. Not for diagnostic or therapeutic use.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Pricing & Availability
Clone
GK1.5 (See other available formats)
Regulatory Status
RUO
Other Names
L3T4, T4
Isotype
Rat IgG2b, κ
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Product Citations
publications
GK1.5_FITC_102110
C57BL/6 mouse splenocytes were stained with CD4 (clone GK1.5) FITC (filled histogram) or rat IgG2b, κ FITC isotype control (open histogram).
  • GK1.5_FITC_102110
    C57BL/6 mouse splenocytes were stained with CD4 (clone GK1.5) FITC (filled histogram) or rat IgG2b, κ FITC isotype control (open histogram).
Compare all formats See FITC spectral data
Cat # Size Price Quantity Check Availability Save
100405 50 µg SEK252
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100406 500 µg SEK832
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Description

CD4 is a 55 kD protein also known as L3T4 or T4. It is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosin kinase, lck.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CTL clone V4
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The CD4 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Additional reported applications (for the relevant formats) include: blocking of CD4+ T cell activation1,4,11, thymocyte costimulation3, in vitro and in vivo depletion2,5-8, blocking of egg-sperm cell adhesion1,4, immunohistochemical staining of acetone-fixed frozen sections9,10, immunoprecipitation1,2, and spatial biology (IBEX)12,13. The GK1.5 antibody is able to block CD4 mediated cell adhesion and T cell activation. Binding of GK1.5 antibody to CD4 T cells can be blocked by RM4-5 antibody, but not RM4-4 antibody. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 100442) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin < 0.01 EU/µg).

Application References
  1. Dialynas DP, et al. 1983. J. Immunol. 131:2445. (Block, IP)
  2. Dialynas DP, et al. 1983. Immunol. Rev. 74:29. (IP, Deplete)
  3. Wu L, et al. 1991. J. Exp. Med. 174:1617. (Costim)
  4. Godfrey DI, et al. 1994. J. Immunol. 152:4783. (Block)
  5. Gavett SH, et al. 1994. Am. J. Respir. Cell. Mol. Biol. 10:587. (Deplete)
  6. Schuyler M, et al. 1994. Am. J. Respir. Crit. Care Med. 149:1286. (Deplete)
  7. Ghobrial RR, et al. 1989. Clin. Immunol. Immunopathol. 52:486. (Deplete)
  8. Israelski DM, et al. 1989. J. Immunol. 142:954. (Deplete)
  9. Zheng B, et al. 1996. J. Exp. Med. 184:1083. (IHC)
  10. Frei K, et al. 1997. J. Exp. Med. 185:2177. (IHC)
  11. Felix NJ, et al. 2007. Nat. Immunol. 8:388. (Block)
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  2. Katsumura KR, et al. 2018. Proc Natl Acad Sci U S A. 115:E10109. PubMed
  3. Valanparambil RM, et al. 2017. PLoS Pathog. 13:e1006647. PubMed
  4. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  5. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  6. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  7. Zhao J, et al. 2021. Emerg Microbes Infect. 10:913. PubMed
  8. Liu J, et al. 2021. Front Immunol. 12:747730. PubMed
  9. Su Y, et al. 2022. J Hematol Oncol. 15:99. PubMed
  10. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  11. Mills EL, et al. 2022. Cell Metab. 34:140. PubMed
  12. Li X, et al. 2022. J Clin Invest. 132: . PubMed
  13. Wu R, et al. 2022. J Dermatol. 49:432. PubMed
  14. Mi Z, et al. 2021. Vaccines (Basel). 10: . PubMed
  15. Corral D, et al. 2022. Cell Rep. 39:110715. PubMed
  16. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  17. Shen Z, et al. 2022. EBioMedicine. 85:104285. PubMed
  18. Balood M, et al. 2022. Nature. 611:405. PubMed
  19. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  20. Zhang Z, et al. 2022. Integr Cancer Ther. 21:15347354221138534. PubMed
  21. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  22. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  23. Chen C, et al. 2022. J Neuroinflammation. 19:315. PubMed
  24. Qin S, et al. 2023. Acta Pharm Sin B. :. PubMed
  25. Merk VM, et al. 2023. Genes Immun. 24:52. PubMed
  26. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  27. Sun Y, et al. 2023. Cell Mol Life Sci. 80:63. PubMed
  28. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  29. Sylvester MA, et al. 2022. Am J Physiol Renal Physiol. 322:F245. PubMed
  30. Zander R, et al. 2022. Immunity. 55:475. PubMed
  31. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  32. Zelenka T, et al. 2022. Nat Commun. 13:6954. PubMed
  33. Qiu Z, et al. 2022. J Exp Med. 219:. PubMed
  34. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  35. Hamdi L, et al. 2022. Ann Clin Transl Neurol. 9:1792. PubMed
  36. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  37. Zhu C, et al. 2022. Chemotherapy. 67:211. PubMed
  38. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  39. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  40. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  41. Mackin S, et al. 2023. Nat Microbiol. 8:569. PubMed
  42. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  43. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  44. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  45. Fiedler T, et al. 2023. J Neuroinflammation. 20:100. PubMed
  46. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  47. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  48. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  49. Peymanfar Y, et al. 2023. Int J Mol Sci. 24:. PubMed
  50. Wang X, et al. 2023. Nat Commun. 14:3440. PubMed
  51. Yao RQ, et al. 2023. Mil Med Res. 10:27. PubMed
  52. Iwanami N, et al. 2023. Nat Commun. 14:3645. PubMed
  53. Solvay M, et al. 2023. J Immunother Cancer. 11:. PubMed
  54. Wang Z, et al. 2023. Sci Adv. 9:eabo4100. PubMed
  55. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  56. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  57. Rosenkranz SC, et al. 2021. eLife. 10:00. PubMed
  58. Furuta Y, et al. 2017. PLoS One. 12(2):e0172509. PubMed
  59. Yang Z, et al. 2022. J Immunother Cancer. 10:. PubMed
  60. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  61. Schönberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  62. He R, et al. 2021. J Immunol. 206:2353. PubMed
  63. Ma J, et al. 2020. Adv Sci (Weinh). 7:2000609. PubMed
  64. Fan L, et al. 2021. Cancers (Basel). 13:. PubMed
  65. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  66. Sega E, et al. 2008. Int J Radiat Oncol Biol Phys. 71:559. PubMed
  67. Lua Y, et al. 2012. Mol Immunol. 52:229. PubMed
  68. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  69. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  70. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  71. Luo R, et al. 2021. Theranostics. 11:117. PubMed
  72. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  73. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  74. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  75. Toomer G, et al. 2022. Viruses. 14:. PubMed
  76. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  77. Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed
  78. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  79. Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
  80. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  81. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  84. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  85. Jazowiecka-Rakus J, et al. 2021. Cancers (Basel). 13:. PubMed
  86. Chen J, et al. 2022. J Nanobiotechnology. 20:283. PubMed
  87. Wu M, et al. 2021. Nat Commun. 12:3500. PubMed
  88. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  89. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  90. Guan H, et al. 2012. PLoS One. 7:e35650. PubMed
  91. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  92. He C, et al. 2020. Clin Transl Med. 10:e39. PubMed
  93. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  94. Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed
  95. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  96. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
  97. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  98. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  99. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  100. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  101. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  102. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  103. Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed
  104. Thomas S, et al. 2019. J Immunother Cancer. 7:214. PubMed
  105. Tritama E, et al. 2018. Hum Vaccin Immunother. 14:1524. PubMed
  106. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  107. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  108. White C, et al. 2014. J Immunol. 193:5933. PubMed
  109. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  110. Liu Y, et al. 2022. Nat Commun. 13:2665. PubMed
  111. Anastasiou M, et al. 2021. JCI Insight. 6:. PubMed
  112. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  113. Zongyi Y, et al. 2017. PLoS One. 10.1371/journal.pone.0189617. PubMed
  114. Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed
  115. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  116. Edwards CJ, et al. 2021. Br J Cancer. . PubMed
  117. Jing L, et al. 2022. Front Immunol. 13:864995. PubMed
  118. Feng H, et al. 2020. J Dermatol. 47:147. PubMed
  119. Ren HZ, et al. 2022. J Clin Transl Hepatol. 10:1138. PubMed
  120. Pedraza–Zamora CP, et al. 2017. Parasite Immunol. 39:4. PubMed
  121. Wang Z, et al. 2020. J Clin Invest. 130:3717. PubMed
  122. Raineri D, et al. 2021. Biomedicines. 10:. PubMed
  123. He X, et al. 2021. Small. 17:e2007165. PubMed
  124. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  125. He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
  126. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  127. Zhang W, et al. 2019. Oncol Lett. 17:815. PubMed
  128. Cervera–Carrascon V, et al. 2020. Oncoimmunology. 9:1761229. PubMed
  129. Paul S, et al. 2018. Appl Microbiol Biotechnol. 102:8895. PubMed
  130. Vigeland C, et al. 2016. PLoS One. 11: 0163288. PubMed
  131. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  132. Deng Z, et al. 2020. World J Gastrointest Oncol. 1091:12. PubMed
  133. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  134. Wang Z, et al. 2022. Nat Biomed Eng. 6:791. PubMed
  135. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  136. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  137. Kim JH, et al. 2019. Mol Med. 25:33. PubMed
  138. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  139. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  140. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  141. Knocke S, et al. 2016. Cell Rep. 17:2234-2246. PubMed
  142. Ahmari N, et al. 2016. Physiol Genomics. 48: 526 - 536. PubMed
  143. Ito C, et al. 2015. PLoS One. 10: e0140808. PubMed
  144. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  145. Zhou H, et al. 2022. Oncoimmunology. 11:2057892. PubMed
  146. He X, et al. 2022. Cancer Immunol Res. 10:314. PubMed
  147. Hum NR, et al. 2022. Front Oncol. 12:928474. PubMed
  148. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  149. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  150. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  151. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  152. Uddback I, et al. 2016. Sci Rep. 6:20137. PubMed
  153. Toomer K, et al. 2016. J Immunol. 196: 3665 - 3676. PubMed
  154. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  155. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  156. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  157. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  158. Wang Y, et al. 2021. Front Microbiol. 12:701566. PubMed
  159. Gebre MS, et al. 2022. NPJ Vaccines. 7:88. PubMed
  160. Yang B, et al. 2022. Bioengineered. 13:2685. PubMed
  161. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  162. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  163. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  164. Mencl S, et al. 2014. J Neuroimmunol. 274:125. PubMed
  165. Sun H, et al. 2022. Front Immunol. 13:818017. PubMed
  166. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  167. Ding P, et al. 2022. Bone Res. 10:42. PubMed
  168. Lang V, et al. 2021. Elife. 10:. PubMed
  169. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  170. Huang L, et al. 2021. Breast Cancer Res Treat. Online ahead of print. PubMed
  171. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  172. Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed
  173. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  174. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  175. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  176. Kmieciak M, et al. 2011. J Vis Exp. 47: 2381. PubMed
  177. Li Y, Kaneda T 2016. Sci Rep. 6: 25077. PubMed
  178. Timilshina M, et al. 2017. PLoS One. 10.1371/journal.pone.0168942. PubMed
  179. Wang X, et al. 2020. Nat Commun. 4.505555556. PubMed
  180. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  181. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  182. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  183. Ma K, et al. 2022. iScience. 25:104347. PubMed
  184. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  185. Gao X, et al. 2022. Front Immunol. 13:799331. PubMed
  186. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  187. Kamata T, et al. 2020. Cell Reports. 31(12):107802. PubMed
  188. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  189. Reynolds CJ, et al. 2018. Sci Rep. 8:672. PubMed
  190. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  191. Liu Y, et al. 2020. Oncol Lett. 2369:20. PubMed
  192. Martomo SA, et al. 2021. Mol Cancer Ther. 1.074305556. PubMed
  193. Zan H, et al. 2017. Nat Commun. 8:14244. PubMed
  194. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  195. He C, et al. 2022. Nat Commun. 13:5459. PubMed
  196. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  197. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  198. Yuan M, et al. 2022. Oxid Med Cell Longev. 2022:5479491. PubMed
  199. Li J, et al. 2020. Development. :. PubMed
  200. Shibuya M, et al. 2021. iScience. 24:103131. PubMed
  201. Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed
  202. Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
  203. Xia Y, et al. 2018. Cell. 175:1059. PubMed
  204. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  205. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  206. Ligon MM, et al. 2020. Mucosal Immunol. 1.172222222. PubMed
  207. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  208. Wedekind MF, et al. 2021. iScience. 24(7):102759. PubMed
  209. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  210. Jazowiecka-Rakus J, et al. 2020. Mol Ther Oncolytics. 18:335. PubMed
  211. Soria-Castro R, et al. 2020. Sci Rep. 10:17802. PubMed
  212. Chen H, et al. 2022. Front Pharmacol. 13:827520. PubMed
  213. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  214. Khosravi N, et al. 2018. Cancer Immunol Res. 0.797222222. PubMed
  215. Kos S, et al. 2019. PLoS One. 14:e0217762. PubMed
  216. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  217. Habtetsion T et al. 2018. Cell metabolism. 28(2):228-242 . PubMed
  218. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  219. Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed
  220. Pan L, et al. 2022. Front Immunol. 13:837497. PubMed
  221. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  222. He X, et al. 2021. J Immunother Cancer. 9:. PubMed
  223. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  224. Liu Y, et al. 2020. Cell Death Dis. 11:1062. PubMed
  225. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  226. Sivapatham S, et al. 2019. Front Immunol. 1.865277778. PubMed
  227. Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed
  228. Bryan Hart, Sunhee Lee 2016. PLoS Negl Trop Dis. 10:e0005229. PubMed
  229. Blaszczak AM, et al. 2020. Immunometabolism. 2:00. PubMed
  230. Yang C, et al. 2020. Cell Host Microbe. 467:27. PubMed
  231. Sun F, et al. 2022. Cell Death Dis. 13:181. PubMed
  232. Zhong C, et al. 2021. J Virol. 95:e0092521. PubMed
  233. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  234. Xu Y, et al. 2021. iScience. 24:103445. PubMed
  235. Zhou S, et al. 2021. Adv Funct Mater. 31:. PubMed
  236. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  237. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  238. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  239. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  240. Blaszczak AM, et al. 2019. J Immunol. 202:2451. PubMed
  241. Liang Z, et al. 2017. Autophagy. 14:505. PubMed
  242. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  243. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  244. Hart B, et al. 2015. PLoS Negl Trop Dis. 9: 0004046. PubMed
  245. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  246. Wang Y, et al. 2022. Nat Commun. 13:1454. PubMed
  247. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  249. Li Z, et al. 2022. Evid Based Complement Alternat Med. 2022:7421265. PubMed
  250. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  251. Bartley A, et al. 2018. Front Physiol. 9:1593. PubMed
  252. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  253. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  254. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  255. Gardenier J, et al. 2017. Nat Commun. 8:14345. PubMed
  256. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  257. Zeng A, et al. 2020. Oncol Rep. . PubMed
  258. Hsu HP, et al. 2021. J Biol Chem. 296:100419. PubMed
  259. Zhang M, et al. 2022. iScience. 25:104490. PubMed
  260. Chen Y, et al. 2021. Braz J Med Biol Res. 54:e9570. PubMed
  261. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  262. Kathania M, et al. 2022. Cell Rep. 40:111345. PubMed
  263. Gawish R, et al. 2022. Elife. 11:. PubMed
  264. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  265. Zhou T, et al. 2018. Mol Med Rep. 17:4883. PubMed
  266. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  267. Cortez MA, et al. 2020. Nat Commun. 3.819444444. PubMed
  268. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  269. Liang Z, et al. 2022. iScience. 25:105233. PubMed
  270. Lestari SR, et al. 2020. J Ayurveda Integr Med. 11:414. PubMed
  271. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  272. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  273. Ding X, et al. 2021. Front Immunol. 12:667136. PubMed
  274. Djokić V, et al. 2019. Front Immunol. 9:2891. PubMed
  275. Katsumura KR, et al. 2018. Proc Natl Acad Sci U S A. 115:E10109. PubMed
  276. Valanparambil RM, et al. 2017. PLoS Pathog. 13:e1006647. PubMed
  277. Wang X, et al. 2019. Cell Res. 29:787. PubMed
  278. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  279. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  280. Zhao J, et al. 2021. Emerg Microbes Infect. 10:913. PubMed
  281. Liu J, et al. 2021. Front Immunol. 12:747730. PubMed
  282. Su Y, et al. 2022. J Hematol Oncol. 15:99. PubMed
  283. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  284. Mills EL, et al. 2022. Cell Metab. 34:140. PubMed
  285. Li X, et al. 2022. J Clin Invest. 132: . PubMed
  286. Wu R, et al. 2022. J Dermatol. 49:432. PubMed
  287. Mi Z, et al. 2021. Vaccines (Basel). 10: . PubMed
  288. Corral D, et al. 2022. Cell Rep. 39:110715. PubMed
  289. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  290. Shen Z, et al. 2022. EBioMedicine. 85:104285. PubMed
  291. Balood M, et al. 2022. Nature. 611:405. PubMed
  292. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  293. Zhang Z, et al. 2022. Integr Cancer Ther. 21:15347354221138534. PubMed
  294. Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed
  295. Wang H, et al. 2022. J Nanobiotechnology. 20:513. PubMed
  296. Chen C, et al. 2022. J Neuroinflammation. 19:315. PubMed
  297. Qin S, et al. 2023. Acta Pharm Sin B. :. PubMed
  298. Merk VM, et al. 2023. Genes Immun. 24:52. PubMed
  299. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  300. Sun Y, et al. 2023. Cell Mol Life Sci. 80:63. PubMed
  301. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  302. Sylvester MA, et al. 2022. Am J Physiol Renal Physiol. 322:F245. PubMed
  303. Zander R, et al. 2022. Immunity. 55:475. PubMed
  304. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  305. Zelenka T, et al. 2022. Nat Commun. 13:6954. PubMed
  306. Qiu Z, et al. 2022. J Exp Med. 219:. PubMed
  307. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  308. Hamdi L, et al. 2022. Ann Clin Transl Neurol. 9:1792. PubMed
  309. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  310. Zhu C, et al. 2022. Chemotherapy. 67:211. PubMed
  311. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  312. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  313. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  314. Mackin S, et al. 2023. Nat Microbiol. 8:569. PubMed
  315. Shi Y, et al. 2023. Nat Commun. 14:1884. PubMed
  316. Liu H, et al. 2023. Breast Cancer Res. 25:43. PubMed
  317. Fu S, et al. 2023. Nat Commun. 14:2248. PubMed
  318. Fiedler T, et al. 2023. J Neuroinflammation. 20:100. PubMed
  319. Yu L, et al. 2023. Front Oncol. 13:1174713. PubMed
  320. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  321. Vereertbrugghen A, et al. 2023. J Neuroinflammation. 20:120. PubMed
  322. Peymanfar Y, et al. 2023. Int J Mol Sci. 24:. PubMed
  323. Wang X, et al. 2023. Nat Commun. 14:3440. PubMed
  324. Yao RQ, et al. 2023. Mil Med Res. 10:27. PubMed
  325. Iwanami N, et al. 2023. Nat Commun. 14:3645. PubMed
  326. Solvay M, et al. 2023. J Immunother Cancer. 11:. PubMed
  327. Wang Z, et al. 2023. Sci Adv. 9:eabo4100. PubMed
  328. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  329. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  330. Rosenkranz SC, et al. 2021. eLife. 10:00. PubMed
  331. Furuta Y, et al. 2017. PLoS One. 12(2):e0172509. PubMed
  332. Yang Z, et al. 2022. J Immunother Cancer. 10:. PubMed
  333. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
  334. Schönberger K, et al. 2022. Cell Stem Cell. 29:131. PubMed
  335. He R, et al. 2021. J Immunol. 206:2353. PubMed
  336. Ma J, et al. 2020. Adv Sci (Weinh). 7:2000609. PubMed
  337. Fan L, et al. 2021. Cancers (Basel). 13:. PubMed
  338. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  339. Sega E, et al. 2008. Int J Radiat Oncol Biol Phys. 71:559. PubMed
  340. Lua Y, et al. 2012. Mol Immunol. 52:229. PubMed
  341. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  342. Aguilera T, et al. 2016. Nat Commun. 7:13898. PubMed
  343. Yang F, et al. 2021. Front Microbiol. 11:512581. PubMed
  344. Luo R, et al. 2021. Theranostics. 11:117. PubMed
  345. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  346. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  347. Jiang W, et al. 2022. Front Immunol. 13:878832. PubMed
  348. Toomer G, et al. 2022. Viruses. 14:. PubMed
  349. Periasamy S, et al. 2017. Nat Commun. 8:15564. PubMed
  350. Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed
  351. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  352. Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
  353. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  354. Tang Y, et al. 2020. Front Immunol. 11:585918. PubMed
  355. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  356. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  357. Bangs DJ, et al. 2022. Cell Rep. 38:110266. PubMed
  358. Jazowiecka-Rakus J, et al. 2021. Cancers (Basel). 13:. PubMed
  359. Chen J, et al. 2022. J Nanobiotechnology. 20:283. PubMed
  360. Wu M, et al. 2021. Nat Commun. 12:3500. PubMed
  361. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  362. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  363. Guan H, et al. 2012. PLoS One. 7:e35650. PubMed
  364. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  365. He C, et al. 2020. Clin Transl Med. 10:e39. PubMed
  366. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  367. Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed
  368. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  369. Hu D, et al. 2021. J Cell Mol Med. 25:2900. PubMed
  370. Shi S, et al. 2020. Clin Cancer Res. 26:5990. PubMed
  371. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  372. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  373. Liang Z, et al. 2021. J Cell Physiol. 236:4725. PubMed
  374. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  375. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  376. Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed
  377. Thomas S, et al. 2019. J Immunother Cancer. 7:214. PubMed
  378. Tritama E, et al. 2018. Hum Vaccin Immunother. 14:1524. PubMed
  379. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  380. Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed
  381. White C, et al. 2014. J Immunol. 193:5933. PubMed
  382. Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed
  383. Liu Y, et al. 2022. Nat Commun. 13:2665. PubMed
  384. Anastasiou M, et al. 2021. JCI Insight. 6:. PubMed
  385. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  386. Zongyi Y, et al. 2017. PLoS One. 10.1371/journal.pone.0189617. PubMed
  387. Ma X, et al. 2021. Cell Metabolism. 33(5):1001-1012.e5. PubMed
  388. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  389. Edwards CJ, et al. 2021. Br J Cancer. . PubMed
  390. Jing L, et al. 2022. Front Immunol. 13:864995. PubMed
  391. Feng H, et al. 2020. J Dermatol. 47:147. PubMed
  392. Ren HZ, et al. 2022. J Clin Transl Hepatol. 10:1138. PubMed
  393. Pedraza–Zamora CP, et al. 2017. Parasite Immunol. 39:4. PubMed
  394. Wang Z, et al. 2020. J Clin Invest. 130:3717. PubMed
  395. Raineri D, et al. 2021. Biomedicines. 10:. PubMed
  396. He X, et al. 2021. Small. 17:e2007165. PubMed
  397. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  398. He X, et al. 2021. Adv Sci (Weinh). 8:e2103023. PubMed
  399. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  400. Zhang W, et al. 2019. Oncol Lett. 17:815. PubMed
  401. Cervera–Carrascon V, et al. 2020. Oncoimmunology. 9:1761229. PubMed
  402. Paul S, et al. 2018. Appl Microbiol Biotechnol. 102:8895. PubMed
  403. Vigeland C, et al. 2016. PLoS One. 11: 0163288. PubMed
  404. Lu X, et al. 2016. Nat Commun. 7: 12719. PubMed
  405. Deng Z, et al. 2020. World J Gastrointest Oncol. 1091:12. PubMed
  406. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  407. Wang Z, et al. 2022. Nat Biomed Eng. 6:791. PubMed
  408. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  409. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  410. Kim JH, et al. 2019. Mol Med. 25:33. PubMed
  411. Niknam S, et al. 2018. Clin Cancer Res. 24:5735. PubMed
  412. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  413. Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed
  414. Knocke S, et al. 2016. Cell Rep. 17:2234-2246. PubMed
  415. Ahmari N, et al. 2016. Physiol Genomics. 48: 526 - 536. PubMed
  416. Ito C, et al. 2015. PLoS One. 10: e0140808. PubMed
  417. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  418. Zhou H, et al. 2022. Oncoimmunology. 11:2057892. PubMed
  419. He X, et al. 2022. Cancer Immunol Res. 10:314. PubMed
  420. Hum NR, et al. 2022. Front Oncol. 12:928474. PubMed
  421. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  422. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  423. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  424. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  425. Uddback I, et al. 2016. Sci Rep. 6:20137. PubMed
  426. Toomer K, et al. 2016. J Immunol. 196: 3665 - 3676. PubMed
  427. Faust HJ, et al. 2020. J Clin Invest. 130:5493. PubMed
  428. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  429. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  430. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  431. Wang Y, et al. 2021. Front Microbiol. 12:701566. PubMed
  432. Gebre MS, et al. 2022. NPJ Vaccines. 7:88. PubMed
  433. Yang B, et al. 2022. Bioengineered. 13:2685. PubMed
  434. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  435. Yan J, et al. 2020. Cell Rep. 107820:31. PubMed
  436. Shannon JP, et al. 2021. Immunity. 54(2):276-290.e5. PubMed
  437. Mencl S, et al. 2014. J Neuroimmunol. 274:125. PubMed
  438. Sun H, et al. 2022. Front Immunol. 13:818017. PubMed
  439. Frost JN, et al. 2021. Med (N Y). 2:164. PubMed
  440. Ding P, et al. 2022. Bone Res. 10:42. PubMed
  441. Lang V, et al. 2021. Elife. 10:. PubMed
  442. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  443. Huang L, et al. 2021. Breast Cancer Res Treat. Online ahead of print. PubMed
  444. Lu J, et al. 2021. Cell Death Discov. 7:165. PubMed
  445. Han F, et al. 2020. Invest Ophthalmol Vis Sci. 61:24. PubMed
  446. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  447. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  448. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  449. Kmieciak M, et al. 2011. J Vis Exp. 47: 2381. PubMed
  450. Li Y, Kaneda T 2016. Sci Rep. 6: 25077. PubMed
  451. Timilshina M, et al. 2017. PLoS One. 10.1371/journal.pone.0168942. PubMed
  452. Wang X, et al. 2020. Nat Commun. 4.505555556. PubMed
  453. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  454. Zhang Q, et al. 2021. Front Cell Dev Biol. 9:655552. PubMed
  455. Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
  456. Ma K, et al. 2022. iScience. 25:104347. PubMed
  457. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  458. Gao X, et al. 2022. Front Immunol. 13:799331. PubMed
  459. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  460. Kamata T, et al. 2020. Cell Reports. 31(12):107802. PubMed
  461. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  462. Reynolds CJ, et al. 2018. Sci Rep. 8:672. PubMed
  463. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  464. Liu Y, et al. 2020. Oncol Lett. 2369:20. PubMed
  465. Martomo SA, et al. 2021. Mol Cancer Ther. 1.074305556. PubMed
  466. Zan H, et al. 2017. Nat Commun. 8:14244. PubMed
  467. Li Z, et al. 2022. Nat Commun. 13:6321. PubMed
  468. He C, et al. 2022. Nat Commun. 13:5459. PubMed
  469. Takaku S, et al. 2022. Evid Based Complement Alternat Med. 2022:6122955. PubMed
  470. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  471. Yuan M, et al. 2022. Oxid Med Cell Longev. 2022:5479491. PubMed
  472. Li J, et al. 2020. Development. :. PubMed
  473. Shibuya M, et al. 2021. iScience. 24:103131. PubMed
  474. Nasarre P, et al. 2021. Cancers (Basel). 13: . PubMed
  475. Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
  476. Xia Y, et al. 2018. Cell. 175:1059. PubMed
  477. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  478. Yao C, et al. 2018. Autophagy. 1.854861111. PubMed
  479. Ligon MM, et al. 2020. Mucosal Immunol. 1.172222222. PubMed
  480. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  481. Wedekind MF, et al. 2021. iScience. 24(7):102759. PubMed
  482. Zhang Q, et al. 2022. Commun Biol. 5:544. PubMed
  483. Jazowiecka-Rakus J, et al. 2020. Mol Ther Oncolytics. 18:335. PubMed
  484. Soria-Castro R, et al. 2020. Sci Rep. 10:17802. PubMed
  485. Chen H, et al. 2022. Front Pharmacol. 13:827520. PubMed
  486. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  487. Khosravi N, et al. 2018. Cancer Immunol Res. 0.797222222. PubMed
  488. Kos S, et al. 2019. PLoS One. 14:e0217762. PubMed
  489. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  490. Habtetsion T et al. 2018. Cell metabolism. 28(2):228-242 . PubMed
  491. Coley WD et al. 2018. F1000Research. 2018 Mar 14 [revised 2018 Jan 1] 0.5125. PubMed
  492. Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed
  493. Pan L, et al. 2022. Front Immunol. 13:837497. PubMed
  494. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  495. He X, et al. 2021. J Immunother Cancer. 9:. PubMed
  496. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  497. Liu Y, et al. 2020. Cell Death Dis. 11:1062. PubMed
  498. Golan K et al. 2018. Cell stem cell. 23(4):572-585 . PubMed
  499. Sivapatham S, et al. 2019. Front Immunol. 1.865277778. PubMed
  500. Zhao Y, et al. 2020. Front Immunol. 2.572222222. PubMed
  501. Bryan Hart, Sunhee Lee 2016. PLoS Negl Trop Dis. 10:e0005229. PubMed
  502. Blaszczak AM, et al. 2020. Immunometabolism. 2:00. PubMed
  503. Yang C, et al. 2020. Cell Host Microbe. 467:27. PubMed
  504. Sun F, et al. 2022. Cell Death Dis. 13:181. PubMed
  505. Zhong C, et al. 2021. J Virol. 95:e0092521. PubMed
  506. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  507. Xu Y, et al. 2021. iScience. 24:103445. PubMed
  508. Zhou S, et al. 2021. Adv Funct Mater. 31:. PubMed
  509. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  510. Sears SM, et al. 2022. Kidney360. 3:818. PubMed
  511. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  512. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  513. Blaszczak AM, et al. 2019. J Immunol. 202:2451. PubMed
  514. Liang Z, et al. 2017. Autophagy. 14:505. PubMed
  515. Aguilera TA, et al. 2020. Clin Cancer Res. 26:2972. PubMed
  516. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  517. Hart B, et al. 2015. PLoS Negl Trop Dis. 9: 0004046. PubMed
  518. Nakao R, et al. 2022. NPJ Vaccines. 7:153. PubMed
  519. Wang Y, et al. 2022. Nat Commun. 13:1454. PubMed
  520. Barsoumian HB, et al. 2022. Cancers (Basel). 14:. PubMed
  521. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  522. Li Z, et al. 2022. Evid Based Complement Alternat Med. 2022:7421265. PubMed
  523. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  524. Bartley A, et al. 2018. Front Physiol. 9:1593. PubMed
  525. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  526. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  527. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  528. Gardenier J, et al. 2017. Nat Commun. 8:14345. PubMed
  529. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  530. Zeng A, et al. 2020. Oncol Rep. . PubMed
  531. Hsu HP, et al. 2021. J Biol Chem. 296:100419. PubMed
  532. Zhang M, et al. 2022. iScience. 25:104490. PubMed
  533. Chen Y, et al. 2021. Braz J Med Biol Res. 54:e9570. PubMed
  534. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  535. Kathania M, et al. 2022. Cell Rep. 40:111345. PubMed
  536. Gawish R, et al. 2022. Elife. 11:. PubMed
  537. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  538. Zhou T, et al. 2018. Mol Med Rep. 17:4883. PubMed
  539. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  540. Cortez MA, et al. 2020. Nat Commun. 3.819444444. PubMed
  541. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  542. Liang Z, et al. 2022. iScience. 25:105233. PubMed
  543. Lestari SR, et al. 2020. J Ayurveda Integr Med. 11:414. PubMed
  544. Jiang W, et al. 2021. Cell Rep. 37:110112. PubMed
  545. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  546. Ding X, et al. 2021. Front Immunol. 12:667136. PubMed
RRID
AB_312690 (BioLegend Cat. No. 100405)
AB_312691 (BioLegend Cat. No. 100406)

Antigen Details

Structure
Ig superfamily, 55 kD
Distribution

Majority of thymocytes, T cell subset

Function
TCR co-receptor, T cell activation
Ligand/Receptor
MHC class II molecule
Cell Type
Dendritic cells, T cells, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Bierer BE, et al. 1989. Annu. Rev. Immunol. 7:579.
3. Janeway CA. 1992. Annu. Rev. Immunol. 10:645.

Gene ID
12504 View all products for this Gene ID
UniProt
View information about CD4 on UniProt.org

Related FAQs

I am unable to see expression of T cell markers such as CD3 and CD4 post activation.
TCR-CD3 complexes on the T-lymphocyte surface are rapidly downregulated upon activation with peptide-MHC complex, superantigen or cross-linking with anti-TCR or anti-CD3 antibodies. PMA/Ionomycin treatment has been shown to downregulate surface CD4 expression. Receptor downregulation is a common biological phenomenon and so make sure that your stimulation treatment is not causing it in your sample type.

Other Formats

View All CD4 Reagents Request Custom Conjugation
Description Clone Applications
APC/Cyanine7 anti-mouse CD4 GK1.5 FC
Brilliant Violet 711™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 510™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 605™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 785™ anti-mouse CD4 GK1.5 FC
PE/Dazzle™ 594 anti-mouse CD4 GK1.5 FC
APC/Fire™ 750 anti-mouse CD4 GK1.5 FC
GoInVivo™ Purified anti-mouse CD4 GK1.5 FC
Brilliant Violet 750™ anti-mouse CD4 GK1.5 FC
Brilliant Violet 650™ anti-mouse CD4 GK1.5 FC
Spark Blue™ 550 anti-mouse CD4 GK1.5 FC
Spark NIR™ 685 anti-mouse CD4 GK1.5 FC
APC/Fire™ 810 anti-mouse CD4 GK1.5 FC
KIRAVIA Blue 520™ anti-mouse CD4 GK1.5 FC
PE/Fire™ 640 anti-mouse CD4 GK1.5 FC
PE/Fire™ 700 anti-mouse CD4 GK1.5 FC
PE anti-mouse CD4 GK1.5 FC
PE/Cyanine5 anti-mouse CD4 GK1.5 FC
Purified anti-mouse CD4 GK1.5 FC,IHC-F,ICC,IP,Costim,Block,Depletion
APC anti-mouse CD4 GK1.5 FC
Biotin anti-mouse CD4 GK1.5 FC,IHC-F,ICC
FITC anti-mouse CD4 GK1.5 FC
Alexa Fluor® 647 anti-mouse CD4 GK1.5 FC,IHC-F
Alexa Fluor® 488 anti-mouse CD4 GK1.5 FC,IHC-F
Alexa Fluor® 700 anti-mouse CD4 GK1.5 FC
Pacific Blue™ anti-mouse CD4 GK1.5 FC
PerCP/Cyanine5.5 anti-mouse CD4 GK1.5 FC
PerCP anti-mouse CD4 GK1.5 FC
Brilliant Violet 421™ anti-mouse CD4 GK1.5 FC,ICC,IHC-F
Ultra-LEAF™ Purified anti-mouse CD4 GK1.5 FC,Block,Costim,Depletion,IHC,IP
Alexa Fluor® 594 anti-mouse CD4 GK1.5 IHC-F,FC,SB
Spark Violet™ 538 anti-mouse CD4 GK1.5 FC
Spark YG™ 593 anti-mouse CD4 GK1.5 FC
Spark Blue™ 574 anti-mouse CD4 Antibody GK1.5 FC
Spark UV™ 387 anti-mouse CD4 GK1.5 FC
Spark Blue™ 515 anti-mouse CD4 GK1.5 FC
Spark PLUS UV395™ anti-mouse CD4 GK1.5 FC
Spark Red™ 718 anti-mouse CD4 (Flexi-Fluor™) GK1.5 FC
PerCP/Fire™ 806 anti-mouse CD4 Antibody GK1.5 FC
PerCP/Fire™ 780 anti-mouse CD4 Antibody GK1.5 FC
Spark YG™ 581 anti-mouse CD4 (Flexi-Fluor™) GK1.5 FC
StarBright UltraViolet 795 anti-mouse CD4 GK1.5 FC
Spark PLUS V475™ anti-mouse CD4 GK1.5 FC
Spark PLUS B488™ anti-mouse CD4 GK1.5 FC
Go To Top Version: 1    Revision Date: 11-30-2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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