Loading...

PE anti-mouse/human CD44 Antibody PE anti-mouse/human CD44 Antibody

Pricing & Availability
Clone
IM7 (See other available formats)
Regulatory Status
RUO
Other Names
Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
IM7_PE_071608.jpg
C57BL/6 mouse splenocytes stained with IM7 PE
  • IM7_PE_071608.jpg
    C57BL/6 mouse splenocytes stained with IM7 PE
  • IM7_PE_human
    Human peripheral blood lymphocytes stained with IM7 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
103008 200 µg SEK1227
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103023 25 tests SEK370
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103007 50 µg SEK471
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103024 100 tests SEK983
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Reported Reactivity
Chimpanzee, Baboon, Cynomolgus, Rhesus, Squirrel Monkey, Horse, Cow, Pig, Dog, Cat
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Dexamethasone-induced myeloid leukemia M1 cells
Formulation
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
µg sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
µg sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. For µg sizes, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone IM7 has been reported to recognize an epitope common to alloantigens and all isoforms of CD4417,18 that is located between amino acids 145 and 18620. This clone has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F). Additional reported applications (for the relevant formats) include: immunohistochemistry of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections6,7, complement-mediated cytotoxicity1, immunoprecipitation1,3, in vivo inhibition of DTH4,5, and spatial biology (IBEX)23,24. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103046, 103065 - 103069).

Cross-reactivity to ferret has been reported by a collaborator, but not verified in house.

Application References
  1. Trowbridge IS, et al. 1982. Immunogenetics 15:299. (ICFC, IP, CMCD)
  2. Katoh S, et al. 1994. J. Immunol. 153:3440. (ELISA)
  3. Budd RC, et al. 1987. J. Immunol. 138:3120. (IP)
  4. Camp RL, et al. 1993. J. Exp. Med. 178:497. (Block)
  5. Weiss JM, et al. 1997. J. Cell Biol. 137:1137. (Block)
  6. Frank NY, et al. 2005. Cancer Res. 65:4320. (IHC) PubMed
  7. Cuff CA, et al. 2001. J. Clin. Invest. 108:1031. (IHC)
  8. Lee JW, et al. 2006. Nature Immunol. 8:181.
  9. Zhang N, et al. 2005. J. Immunol. 174:6967. PubMed
  10. Huabiao C, et al. 2005. J. Immunol. 175:591. PubMed
  11. Gui J, et al. 2007. Int. Immunol. 19:1201. PubMed
  12. Wang XY, et al. 2008. Blood 111:2436. PubMed
  13. Kenna TJ, et al. 2008. Blood 111:2091. PubMed
  14. Yamazaki J, et al. 2009. Blood PubMed
  15. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (FC) PubMed
  16. Chen YW, et al. 2010. Mol. Cancer Ther. 9:2879. PubMed
  17. Zheng Z, et al. 1995. J. Cell. Biol. 130:485.
  18. Wiranowska M, et al. 2010. Int. J. Cancer 127:532.
  19. Hirokawa Y, et al. 2014. Am J Physiol Gastrointerest Liver Physiol. 306:547. PubMed
  20. Sandmaier BM, et al. 1998. Blood 91:3494.
  21. Yang Y, et al. 2015. Hypertension. 65:1047. PubMed
  22. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  23. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  24. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Dong MB, et al. 2020. Cell. 178(5):1189-1204.e23.. PubMed
  2. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  3. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  4. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  5. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  6. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  7. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  8. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  9. Gilazieva Z, et al. 2022. Curr Issues Mol Biol. 44:5363. PubMed
  10. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  11. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  12. Ding D, et al. 2023. J Med Chem. 66:1467. PubMed
  13. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  14. Zhu H, et al. 2022. Cell Transplant. 31:9636897221106996. PubMed
  15. Sugitani N, et al. 2022. Cell Rep. 40:111371. PubMed
  16. Scanlon VM, et al. 2022. Sci Rep. 12:16218. PubMed
  17. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  18. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  19. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  20. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  21. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  22. Tada T, et al. 2023. JCI Insight. 8:. PubMed
  23. Ito M, et al. 2023. Sci Rep. 13:5939. PubMed
  24. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  25. A R, et al. 2023. Front Oncol. 13:1147668. PubMed
  26. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  27. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  28. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  29. Vokshi BH, et al. 2023. Nat Commun. 14:3034. PubMed
  30. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  31. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  32. Chen H, et al. 2005. J Immunol. 175:591. PubMed
  33. Shi Y, et al. 2020. Med Sci Monit. 26:e923328. PubMed
  34. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  35. Hammer A, et al. 2017. J Neuroinflammation. 10.1186/s12974-017-0954-y. PubMed
  36. Wang D, et al. 2018. Immunity. 48:659. PubMed
  37. MacDonald K, et al. 2014. J Immunol. 192:3180. PubMed
  38. Saenz F, et al. 2014. PLoS One. 9:97666. PubMed
  39. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  40. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  41. Yang C, et al. 2022. Cancers (Basel). 14:. PubMed
  42. Volpedo G, et al. 2022. NPJ Vaccines. 7:32. PubMed
  43. Byun JK, et al. 2020. Molecular Cell. 80(4):592-606.e8. PubMed
  44. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
  45. Fan C, et al. 2020. Stem Cell Res Ther. 0.765277778. PubMed
  46. Bhattacharjee S, et al. 2019. Cell Rep. 28:231. PubMed
  47. Trial J, et al. 2017. Basic Research in Cardiology. 10.1007/s00395-017-0623-4. PubMed
  48. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  49. Shao B, et al. 2019. J Immunol. 10.4049/jimmunol.1900680. PubMed
  50. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  51. Davila S, et al. 2014. J Immunol. 192:4284. PubMed
  52. Isakova-Sivak I, et al. 2020. Vaccines (Basel). 8:00. PubMed
  53. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  54. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  55. Zhang Q, et al. 2021. Nat Commun. 12:4592. PubMed
  56. Sung SE, et al. 2021. Vet Sci. 8:. PubMed
  57. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  58. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  59. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  60. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  61. Yu AI, et al. 2020. Cell Rep. 107471:31. PubMed
  62. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  63. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  64. Higashi AY, et al. 2019. J Am Soc Nephrol. 30:80. PubMed
  65. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  66. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  67. Shao W, et al. 2010. Transplant Proc. 42:2777. PubMed
  68. Tyne A, et al. 2013. Vaccine. 31:4322. PubMed
  69. Chulpanova DS, et al. 2020. Bioengineering (Basel). 7:00. PubMed
  70. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  71. Sandborn WJ, et al. 2021. Gastroenterology. 161:1853. PubMed
  72. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  73. Du L et al. 2019. Cell metabolism. 29(6):1363-1375 . PubMed
  74. Miska J et al. 2019. Cell reports. 27(1):226-237 . PubMed
  75. Li P, et al. 2017. Oncogenesis. 10.1038/oncsis.2017.24. PubMed
  76. Zhao J, et al. 2018. Stem Cell Reports. 10:180. PubMed
  77. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  78. Santos CP et al. 2019. Nat Commun. 10(1):4407 . PubMed
  79. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  80. Chen Y, et al. 2010. Mol Cancer Ther. 2.374305556. PubMed
  81. Hrdinka M, et al. 2016. PLoS One. 11: 0162863. PubMed
  82. Hammer A, et al. 2016. Proc Natl Acad Sci U S A. 113(49):14109-14114. PubMed
  83. Kong T, et al. 2020. Cancer Res. 80:444. PubMed
  84. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  85. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  86. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  87. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  88. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  89. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  90. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  91. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  92. Yi X, et al. 2020. Sci Adv. 6:eaba3546. PubMed
  93. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  94. Blacking T, et al. 2011. Vet Immunol Immunopathol. 141:46. PubMed
  95. Sentman A 2011. Blood. 117:6571. PubMed
  96. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  97. Li P, et al. 2018. J Cell Mol Med. 22:3423. PubMed
  98. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  99. Zhang Z, et al. 2019. Cell Death Dis. 10:530. PubMed
  100. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  101. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  102. Tsuchihashi K, et al. 2022. Biochem Biophys Rep. 30:101246. PubMed
  103. Sottnik JL, et al. 2021. Cancer Res. 81:2833. PubMed
  104. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  105. Bian X, et al. 2021. Clin Transl Med. 11:e352. PubMed
  106. Biram A, et al. 2020. Bio Protoc. e3562:10. PubMed
  107. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  108. Kälin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  109. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  110. Yip HYK, et al. 2018. PLoS One. 3. PubMed
  111. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  112. Zhang NN, et al. 2020. Cell. 182(5):1271-1283. PubMed
  113. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  114. Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed
  115. Nair S, et al. 2021. JCI Insight. 6:. PubMed
  116. Ngamsri KC, et al. 2022. Cells. 11:. PubMed
  117. Melhem H, et al. 2022. Mucosal Immunol. 15:443. PubMed
  118. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  119. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  120. Wang S, et al. 2021. Parasite. 28:13. PubMed
  121. Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed
  122. Xu Y, et al. 2020. Stem Cells Int. 8894449:2020. PubMed
  123. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  124. Pardo E, et al. 2017. PLoS One. 12(6):e0177472. PubMed
  125. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  126. Morley S, et al. 2008. J Immunol. 181:4696. PubMed
  127. Fiume G, et al. 2015. Sci Rep. 5: 13864. PubMed
  128. M H, et al. 2016. Open Bio. 6: 150208. PubMed
  129. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  130. Yermanos A, et al. 2020. Front Immunol. 1.143055556. PubMed
  131. Chakraborty M, et al. 2021. Cell Reports. 34(2):108609. PubMed
  132. Yue X, et al. 2021. EMBO Rep. 22:e52716. PubMed
  133. Herbst SA, et al. 2021. iScience. 24:103062. PubMed
  134. Wu J, et al. 2021. STAR Protoc. 2:101022. PubMed
  135. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  136. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  137. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  138. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  139. Girón-Pérez DA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  140. MaruYama T, et al. 2015. J Leukoc Biol. 98: 385-393. PubMed
  141. Lee Y, et al. 2012. Nat Immunol. 13:991. PubMed
  142. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  143. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  144. Lu H, et al. 2019. EBioMedicine. 40:276. PubMed
  145. Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed
  146. Zhu E, et al. 2014. J Immunol. 192:5599. PubMed
  147. Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
  148. Korin B, et al. 2020. Sleep. :43. PubMed
  149. Tsyklauri O, et al. 2021. EMBO Rep. 22:e50785. PubMed
  150. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  151. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  152. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  153. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  154. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  155. Kaji T, et al. 2016. Int Immunol. 28: 267 - 282. PubMed
  156. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  157. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  158. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
  159. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  160. Serr I, et al. 2016. Nat Commun. 7:10991. PubMed
  161. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  162. Seo MS, et al. 2021. Vet Sci. 8:. PubMed
  163. Hung G, et al. 2022. NPJ Aging. 8:10. PubMed
  164. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  165. Pan Y, et al. 2021. NPJ Vaccines. 6:1. PubMed
  166. Velletri T, et al. 2020. Cell Death Differ. . PubMed
  167. Olguín J, et al. 2015. Microbes Infect. 17: 586-595. PubMed
  168. Bonaccorsi-Riani E, et al. 2015. PLoS One. 10: 0136106. PubMed
  169. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
  170. Dong MB, et al. 2020. Cell. 178(5):1189-1204.e23.. PubMed
  171. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  172. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  173. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  174. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  175. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  176. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  177. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  178. Gilazieva Z, et al. 2022. Curr Issues Mol Biol. 44:5363. PubMed
  179. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  180. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  181. Ding D, et al. 2023. J Med Chem. 66:1467. PubMed
  182. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  183. Zhu H, et al. 2022. Cell Transplant. 31:9636897221106996. PubMed
  184. Sugitani N, et al. 2022. Cell Rep. 40:111371. PubMed
  185. Scanlon VM, et al. 2022. Sci Rep. 12:16218. PubMed
  186. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  187. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  188. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  189. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  190. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  191. Tada T, et al. 2023. JCI Insight. 8:. PubMed
  192. Ito M, et al. 2023. Sci Rep. 13:5939. PubMed
  193. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  194. A R, et al. 2023. Front Oncol. 13:1147668. PubMed
  195. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  196. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  197. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  198. Vokshi BH, et al. 2023. Nat Commun. 14:3034. PubMed
  199. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  200. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  201. Chen H, et al. 2005. J Immunol. 175:591. PubMed
  202. Shi Y, et al. 2020. Med Sci Monit. 26:e923328. PubMed
  203. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  204. Hammer A, et al. 2017. J Neuroinflammation. 10.1186/s12974-017-0954-y. PubMed
  205. Wang D, et al. 2018. Immunity. 48:659. PubMed
  206. MacDonald K, et al. 2014. J Immunol. 192:3180. PubMed
  207. Saenz F, et al. 2014. PLoS One. 9:97666. PubMed
  208. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  209. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  210. Yang C, et al. 2022. Cancers (Basel). 14:. PubMed
  211. Volpedo G, et al. 2022. NPJ Vaccines. 7:32. PubMed
  212. Byun JK, et al. 2020. Molecular Cell. 80(4):592-606.e8. PubMed
  213. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
  214. Fan C, et al. 2020. Stem Cell Res Ther. 0.765277778. PubMed
  215. Bhattacharjee S, et al. 2019. Cell Rep. 28:231. PubMed
  216. Trial J, et al. 2017. Basic Research in Cardiology. 10.1007/s00395-017-0623-4. PubMed
  217. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  218. Shao B, et al. 2019. J Immunol. 10.4049/jimmunol.1900680. PubMed
  219. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  220. Davila S, et al. 2014. J Immunol. 192:4284. PubMed
  221. Isakova-Sivak I, et al. 2020. Vaccines (Basel). 8:00. PubMed
  222. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  223. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  224. Zhang Q, et al. 2021. Nat Commun. 12:4592. PubMed
  225. Sung SE, et al. 2021. Vet Sci. 8:. PubMed
  226. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  227. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  228. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  229. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  230. Yu AI, et al. 2020. Cell Rep. 107471:31. PubMed
  231. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  232. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  233. Higashi AY, et al. 2019. J Am Soc Nephrol. 30:80. PubMed
  234. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  235. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  236. Shao W, et al. 2010. Transplant Proc. 42:2777. PubMed
  237. Tyne A, et al. 2013. Vaccine. 31:4322. PubMed
  238. Chulpanova DS, et al. 2020. Bioengineering (Basel). 7:00. PubMed
  239. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  240. Sandborn WJ, et al. 2021. Gastroenterology. 161:1853. PubMed
  241. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  242. Du L et al. 2019. Cell metabolism. 29(6):1363-1375 . PubMed
  243. Miska J et al. 2019. Cell reports. 27(1):226-237 . PubMed
  244. Li P, et al. 2017. Oncogenesis. 10.1038/oncsis.2017.24. PubMed
  245. Zhao J, et al. 2018. Stem Cell Reports. 10:180. PubMed
  246. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  247. Santos CP et al. 2019. Nat Commun. 10(1):4407 . PubMed
  248. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  249. Chen Y, et al. 2010. Mol Cancer Ther. 2.374305556. PubMed
  250. Hrdinka M, et al. 2016. PLoS One. 11: 0162863. PubMed
  251. Hammer A, et al. 2016. Proc Natl Acad Sci U S A. 113(49):14109-14114. PubMed
  252. Kong T, et al. 2020. Cancer Res. 80:444. PubMed
  253. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  254. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  255. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  256. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  257. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  258. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  259. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  260. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  261. Yi X, et al. 2020. Sci Adv. 6:eaba3546. PubMed
  262. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  263. Blacking T, et al. 2011. Vet Immunol Immunopathol. 141:46. PubMed
  264. Sentman A 2011. Blood. 117:6571. PubMed
  265. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  266. Li P, et al. 2018. J Cell Mol Med. 22:3423. PubMed
  267. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  268. Zhang Z, et al. 2019. Cell Death Dis. 10:530. PubMed
  269. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  270. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  271. Tsuchihashi K, et al. 2022. Biochem Biophys Rep. 30:101246. PubMed
  272. Sottnik JL, et al. 2021. Cancer Res. 81:2833. PubMed
  273. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  274. Bian X, et al. 2021. Clin Transl Med. 11:e352. PubMed
  275. Biram A, et al. 2020. Bio Protoc. e3562:10. PubMed
  276. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  277. Kälin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  278. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  279. Yip HYK, et al. 2018. PLoS One. 3. PubMed
  280. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  281. Zhang NN, et al. 2020. Cell. 182(5):1271-1283. PubMed
  282. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  283. Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed
  284. Nair S, et al. 2021. JCI Insight. 6:. PubMed
  285. Ngamsri KC, et al. 2022. Cells. 11:. PubMed
  286. Melhem H, et al. 2022. Mucosal Immunol. 15:443. PubMed
  287. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  288. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  289. Wang S, et al. 2021. Parasite. 28:13. PubMed
  290. Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed
  291. Xu Y, et al. 2020. Stem Cells Int. 8894449:2020. PubMed
  292. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  293. Pardo E, et al. 2017. PLoS One. 12(6):e0177472. PubMed
  294. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  295. Morley S, et al. 2008. J Immunol. 181:4696. PubMed
  296. Fiume G, et al. 2015. Sci Rep. 5: 13864. PubMed
  297. M H, et al. 2016. Open Bio. 6: 150208. PubMed
  298. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  299. Yermanos A, et al. 2020. Front Immunol. 1.143055556. PubMed
  300. Chakraborty M, et al. 2021. Cell Reports. 34(2):108609. PubMed
  301. Yue X, et al. 2021. EMBO Rep. 22:e52716. PubMed
  302. Herbst SA, et al. 2021. iScience. 24:103062. PubMed
  303. Wu J, et al. 2021. STAR Protoc. 2:101022. PubMed
  304. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  305. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  306. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  307. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  308. Girón-Pérez DA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  309. MaruYama T, et al. 2015. J Leukoc Biol. 98: 385-393. PubMed
  310. Lee Y, et al. 2012. Nat Immunol. 13:991. PubMed
  311. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  312. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  313. Lu H, et al. 2019. EBioMedicine. 40:276. PubMed
  314. Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed
  315. Zhu E, et al. 2014. J Immunol. 192:5599. PubMed
  316. Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
  317. Korin B, et al. 2020. Sleep. :43. PubMed
  318. Tsyklauri O, et al. 2021. EMBO Rep. 22:e50785. PubMed
  319. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  320. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  321. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  322. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  323. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  324. Kaji T, et al. 2016. Int Immunol. 28: 267 - 282. PubMed
  325. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  326. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  327. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
  328. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  329. Serr I, et al. 2016. Nat Commun. 7:10991. PubMed
  330. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  331. Seo MS, et al. 2021. Vet Sci. 8:. PubMed
  332. Hung G, et al. 2022. NPJ Aging. 8:10. PubMed
  333. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  334. Pan Y, et al. 2021. NPJ Vaccines. 6:1. PubMed
  335. Velletri T, et al. 2020. Cell Death Differ. . PubMed
  336. Olguín J, et al. 2015. Microbes Infect. 17: 586-595. PubMed
  337. Bonaccorsi-Riani E, et al. 2015. PLoS One. 10: 0136106. PubMed
  338. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
RRID
AB_312959 (BioLegend Cat. No. 103008)
AB_493686 (BioLegend Cat. No. 103023)
AB_312958 (BioLegend Cat. No. 103007)
AB_493687 (BioLegend Cat. No. 103024)

Antigen Details

Structure
Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD
Distribution

All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells

Function
Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM
Ligand/Receptor
Hyaluronan, MIP-1β, fibronectin, collagen
Cell Type
B cells, Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Haynes BF, et al. 1991. Cancer Cells 3:347.
3. Goldstein LA, et al. 1989. Cell 56:1063.
4. Mikecz K, et al. 1995. Nat. Med. 1:558.
5. Hegde V, et al. 2008. J. Leukocyte Biol. 84:134.
6. Liu T, et al. 2009. Biol. Direct 4:40.

Gene ID
12505 View all products for this Gene ID 960 View all products for this Gene ID
UniProt
View information about CD44 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD44 Reagents Request Custom Conjugation
Description Clone Applications
PE/Dazzle™ 594 anti-mouse/human CD44 IM7 FC
Brilliant Violet 711™ anti-mouse/human CD44 IM7 FC
APC/Fire™ 750 anti-mouse/human CD44 IM7 FC
TotalSeq™-A0073 anti-mouse/human CD44 IM7 PG
TotalSeq™-C0073 anti-mouse/human CD44 IM7 PG
TotalSeq™-B0073 anti-mouse/human CD44 IM7 PG
APC anti-mouse/human CD44 IM7 FC
Biotin anti-mouse/human CD44 IM7 FC,ICC,IHC-P
FITC anti-mouse/human CD44 IM7 FC,ICC,IHC-P
PE/Cyanine5 anti-mouse/human CD44 IM7 FC
Purified anti-mouse/human CD44 IM7 FC,IHC-F,CyTOF®,ELISA,ICC,IHC-P,IP,CMCD,Stim
Brilliant Violet 605™ anti-mouse/human CD44 IM7 FC
PE anti-mouse/human CD44 IM7 FC
Alexa Fluor® 488 anti-mouse/human CD44 IM7 FC,ICC,IHC-P,SB
Alexa Fluor® 647 anti-mouse/human CD44 IM7 FC,ICC,SB
Pacific Blue™ anti-mouse/human CD44 IM7 FC
Alexa Fluor® 700 anti-mouse/human CD44 IM7 FC,SB
PE/Cyanine7 anti-mouse/human CD44 IM7 FC
APC/Cyanine7 anti-mouse/human CD44 IM7 FC
PerCP/Cyanine5.5 anti-mouse/human CD44 IM7 FC
PerCP anti-mouse/human CD44 IM7 FC
Brilliant Violet 421™ anti-mouse/human CD44 IM7 FC,ICC,IHC-P
Brilliant Violet 570™ anti-mouse/human CD44 IM7 FC
Brilliant Violet 785™ anti-mouse/human CD44 IM7 FC
Brilliant Violet 510™ anti-mouse/human CD44 IM7 FC
Ultra-LEAF™ Purified anti-mouse/human CD44 IM7 FC,CyTOF®,ELISA,IHC,IP,CMCD,Stim
Brilliant Violet 650™ anti-mouse/human CD44 IM7 FC
Purified anti-mouse/human CD44 (Maxpar® Ready) IM7 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD44 IM7 ICC,FC,IHC-P,SB
Spark YG™ 570 anti-mouse/human CD44 IM7 FC,IHC-P
Spark YG™ 593 anti-mouse/human CD44 IM7 FC
TotalSeq™-D0073 anti-mouse/human CD44 IM7 PG
Brilliant Violet 750™ anti-mouse/human CD44 IM7 FC
PerCP/Fire™ 806 anti-mouse/human CD44 IM7 FC
Spark Red™ 718 anti-mouse/human CD44 IM7 FC
PE/Fire™ 810 anti-mouse/human CD44 IM7 FC
Spark Blue™ 550 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
Spark YG™ 581 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
Spark NIR™ 685 anti-mouse/human CD44 (Flexi-Fluor™) Antibody IM7 FC
Spark UV™ 387 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
StarBright UltraViolet 795 anti-mouse/human CD44 IM7 FC
Go To Top Version: 4    Revision Date: 10-15-2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
IM7 (See other available formats)
Regulatory Status
RUO
Other Names
Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
IM7_PE_071608.jpg
C57BL/6 mouse splenocytes stained with IM7 PE
  • IM7_PE_071608.jpg
    C57BL/6 mouse splenocytes stained with IM7 PE
  • IM7_PE_human
    Human peripheral blood lymphocytes stained with IM7 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
103008 200 µg SEK1227
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103023 25 tests SEK370
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103007 50 µg SEK471
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103024 100 tests SEK983
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human
Reported Reactivity
Chimpanzee, Baboon, Cynomolgus, Rhesus, Squirrel Monkey, Horse, Cow, Pig, Dog, Cat
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Dexamethasone-induced myeloid leukemia M1 cells
Formulation
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
µg sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
µg sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. For µg sizes, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone IM7 has been reported to recognize an epitope common to alloantigens and all isoforms of CD4417,18 that is located between amino acids 145 and 18620. This clone has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F). Additional reported applications (for the relevant formats) include: immunohistochemistry of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections6,7, complement-mediated cytotoxicity1, immunoprecipitation1,3, in vivo inhibition of DTH4,5, and spatial biology (IBEX)23,24. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103046, 103065 - 103069).

Cross-reactivity to ferret has been reported by a collaborator, but not verified in house.

Application References
  1. Trowbridge IS, et al. 1982. Immunogenetics 15:299. (ICFC, IP, CMCD)
  2. Katoh S, et al. 1994. J. Immunol. 153:3440. (ELISA)
  3. Budd RC, et al. 1987. J. Immunol. 138:3120. (IP)
  4. Camp RL, et al. 1993. J. Exp. Med. 178:497. (Block)
  5. Weiss JM, et al. 1997. J. Cell Biol. 137:1137. (Block)
  6. Frank NY, et al. 2005. Cancer Res. 65:4320. (IHC) PubMed
  7. Cuff CA, et al. 2001. J. Clin. Invest. 108:1031. (IHC)
  8. Lee JW, et al. 2006. Nature Immunol. 8:181.
  9. Zhang N, et al. 2005. J. Immunol. 174:6967. PubMed
  10. Huabiao C, et al. 2005. J. Immunol. 175:591. PubMed
  11. Gui J, et al. 2007. Int. Immunol. 19:1201. PubMed
  12. Wang XY, et al. 2008. Blood 111:2436. PubMed
  13. Kenna TJ, et al. 2008. Blood 111:2091. PubMed
  14. Yamazaki J, et al. 2009. Blood PubMed
  15. Kmieciak M, et al. 2009. J. Transl. Med. 7:89. (FC) PubMed
  16. Chen YW, et al. 2010. Mol. Cancer Ther. 9:2879. PubMed
  17. Zheng Z, et al. 1995. J. Cell. Biol. 130:485.
  18. Wiranowska M, et al. 2010. Int. J. Cancer 127:532.
  19. Hirokawa Y, et al. 2014. Am J Physiol Gastrointerest Liver Physiol. 306:547. PubMed
  20. Sandmaier BM, et al. 1998. Blood 91:3494.
  21. Yang Y, et al. 2015. Hypertension. 65:1047. PubMed
  22. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  23. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  24. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Dong MB, et al. 2020. Cell. 178(5):1189-1204.e23.. PubMed
  2. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  3. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  4. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  5. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  6. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  7. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  8. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  9. Gilazieva Z, et al. 2022. Curr Issues Mol Biol. 44:5363. PubMed
  10. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  11. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  12. Ding D, et al. 2023. J Med Chem. 66:1467. PubMed
  13. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  14. Zhu H, et al. 2022. Cell Transplant. 31:9636897221106996. PubMed
  15. Sugitani N, et al. 2022. Cell Rep. 40:111371. PubMed
  16. Scanlon VM, et al. 2022. Sci Rep. 12:16218. PubMed
  17. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  18. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  19. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  20. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  21. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  22. Tada T, et al. 2023. JCI Insight. 8:. PubMed
  23. Ito M, et al. 2023. Sci Rep. 13:5939. PubMed
  24. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  25. A R, et al. 2023. Front Oncol. 13:1147668. PubMed
  26. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  27. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  28. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  29. Vokshi BH, et al. 2023. Nat Commun. 14:3034. PubMed
  30. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  31. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  32. Chen H, et al. 2005. J Immunol. 175:591. PubMed
  33. Shi Y, et al. 2020. Med Sci Monit. 26:e923328. PubMed
  34. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  35. Hammer A, et al. 2017. J Neuroinflammation. 10.1186/s12974-017-0954-y. PubMed
  36. Wang D, et al. 2018. Immunity. 48:659. PubMed
  37. MacDonald K, et al. 2014. J Immunol. 192:3180. PubMed
  38. Saenz F, et al. 2014. PLoS One. 9:97666. PubMed
  39. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  40. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  41. Yang C, et al. 2022. Cancers (Basel). 14:. PubMed
  42. Volpedo G, et al. 2022. NPJ Vaccines. 7:32. PubMed
  43. Byun JK, et al. 2020. Molecular Cell. 80(4):592-606.e8. PubMed
  44. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
  45. Fan C, et al. 2020. Stem Cell Res Ther. 0.765277778. PubMed
  46. Bhattacharjee S, et al. 2019. Cell Rep. 28:231. PubMed
  47. Trial J, et al. 2017. Basic Research in Cardiology. 10.1007/s00395-017-0623-4. PubMed
  48. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  49. Shao B, et al. 2019. J Immunol. 10.4049/jimmunol.1900680. PubMed
  50. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  51. Davila S, et al. 2014. J Immunol. 192:4284. PubMed
  52. Isakova-Sivak I, et al. 2020. Vaccines (Basel). 8:00. PubMed
  53. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  54. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  55. Zhang Q, et al. 2021. Nat Commun. 12:4592. PubMed
  56. Sung SE, et al. 2021. Vet Sci. 8:. PubMed
  57. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  58. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  59. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  60. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  61. Yu AI, et al. 2020. Cell Rep. 107471:31. PubMed
  62. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  63. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  64. Higashi AY, et al. 2019. J Am Soc Nephrol. 30:80. PubMed
  65. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  66. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  67. Shao W, et al. 2010. Transplant Proc. 42:2777. PubMed
  68. Tyne A, et al. 2013. Vaccine. 31:4322. PubMed
  69. Chulpanova DS, et al. 2020. Bioengineering (Basel). 7:00. PubMed
  70. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  71. Sandborn WJ, et al. 2021. Gastroenterology. 161:1853. PubMed
  72. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  73. Du L et al. 2019. Cell metabolism. 29(6):1363-1375 . PubMed
  74. Miska J et al. 2019. Cell reports. 27(1):226-237 . PubMed
  75. Li P, et al. 2017. Oncogenesis. 10.1038/oncsis.2017.24. PubMed
  76. Zhao J, et al. 2018. Stem Cell Reports. 10:180. PubMed
  77. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  78. Santos CP et al. 2019. Nat Commun. 10(1):4407 . PubMed
  79. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  80. Chen Y, et al. 2010. Mol Cancer Ther. 2.374305556. PubMed
  81. Hrdinka M, et al. 2016. PLoS One. 11: 0162863. PubMed
  82. Hammer A, et al. 2016. Proc Natl Acad Sci U S A. 113(49):14109-14114. PubMed
  83. Kong T, et al. 2020. Cancer Res. 80:444. PubMed
  84. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  85. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  86. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  87. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  88. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  89. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  90. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  91. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  92. Yi X, et al. 2020. Sci Adv. 6:eaba3546. PubMed
  93. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  94. Blacking T, et al. 2011. Vet Immunol Immunopathol. 141:46. PubMed
  95. Sentman A 2011. Blood. 117:6571. PubMed
  96. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  97. Li P, et al. 2018. J Cell Mol Med. 22:3423. PubMed
  98. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  99. Zhang Z, et al. 2019. Cell Death Dis. 10:530. PubMed
  100. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  101. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  102. Tsuchihashi K, et al. 2022. Biochem Biophys Rep. 30:101246. PubMed
  103. Sottnik JL, et al. 2021. Cancer Res. 81:2833. PubMed
  104. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  105. Bian X, et al. 2021. Clin Transl Med. 11:e352. PubMed
  106. Biram A, et al. 2020. Bio Protoc. e3562:10. PubMed
  107. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  108. Kälin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  109. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  110. Yip HYK, et al. 2018. PLoS One. 3. PubMed
  111. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  112. Zhang NN, et al. 2020. Cell. 182(5):1271-1283. PubMed
  113. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  114. Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed
  115. Nair S, et al. 2021. JCI Insight. 6:. PubMed
  116. Ngamsri KC, et al. 2022. Cells. 11:. PubMed
  117. Melhem H, et al. 2022. Mucosal Immunol. 15:443. PubMed
  118. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  119. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  120. Wang S, et al. 2021. Parasite. 28:13. PubMed
  121. Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed
  122. Xu Y, et al. 2020. Stem Cells Int. 8894449:2020. PubMed
  123. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  124. Pardo E, et al. 2017. PLoS One. 12(6):e0177472. PubMed
  125. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  126. Morley S, et al. 2008. J Immunol. 181:4696. PubMed
  127. Fiume G, et al. 2015. Sci Rep. 5: 13864. PubMed
  128. M H, et al. 2016. Open Bio. 6: 150208. PubMed
  129. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  130. Yermanos A, et al. 2020. Front Immunol. 1.143055556. PubMed
  131. Chakraborty M, et al. 2021. Cell Reports. 34(2):108609. PubMed
  132. Yue X, et al. 2021. EMBO Rep. 22:e52716. PubMed
  133. Herbst SA, et al. 2021. iScience. 24:103062. PubMed
  134. Wu J, et al. 2021. STAR Protoc. 2:101022. PubMed
  135. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  136. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  137. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  138. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  139. Girón-Pérez DA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  140. MaruYama T, et al. 2015. J Leukoc Biol. 98: 385-393. PubMed
  141. Lee Y, et al. 2012. Nat Immunol. 13:991. PubMed
  142. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  143. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  144. Lu H, et al. 2019. EBioMedicine. 40:276. PubMed
  145. Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed
  146. Zhu E, et al. 2014. J Immunol. 192:5599. PubMed
  147. Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
  148. Korin B, et al. 2020. Sleep. :43. PubMed
  149. Tsyklauri O, et al. 2021. EMBO Rep. 22:e50785. PubMed
  150. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  151. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  152. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  153. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  154. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  155. Kaji T, et al. 2016. Int Immunol. 28: 267 - 282. PubMed
  156. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  157. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  158. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
  159. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  160. Serr I, et al. 2016. Nat Commun. 7:10991. PubMed
  161. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  162. Seo MS, et al. 2021. Vet Sci. 8:. PubMed
  163. Hung G, et al. 2022. NPJ Aging. 8:10. PubMed
  164. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  165. Pan Y, et al. 2021. NPJ Vaccines. 6:1. PubMed
  166. Velletri T, et al. 2020. Cell Death Differ. . PubMed
  167. Olguín J, et al. 2015. Microbes Infect. 17: 586-595. PubMed
  168. Bonaccorsi-Riani E, et al. 2015. PLoS One. 10: 0136106. PubMed
  169. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
  170. Dong MB, et al. 2020. Cell. 178(5):1189-1204.e23.. PubMed
  171. Argüello RJ, et al. 2020. Cell Metab. 32:1063. PubMed
  172. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  173. Xue G, et al. 2021. Cancer Cell. 39:1610. PubMed
  174. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  175. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  176. Grégoire C, et al. 2022. Immunity. 55:1216. PubMed
  177. Hu X, et al. 2022. EBioMedicine. 86:104333. PubMed
  178. Gilazieva Z, et al. 2022. Curr Issues Mol Biol. 44:5363. PubMed
  179. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  180. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  181. Ding D, et al. 2023. J Med Chem. 66:1467. PubMed
  182. Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed
  183. Zhu H, et al. 2022. Cell Transplant. 31:9636897221106996. PubMed
  184. Sugitani N, et al. 2022. Cell Rep. 40:111371. PubMed
  185. Scanlon VM, et al. 2022. Sci Rep. 12:16218. PubMed
  186. Ou W, et al. 2023. Nat Commun. 14:392. PubMed
  187. Lu C, et al. 2023. Antiviral Res. 212:105556. PubMed
  188. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  189. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  190. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  191. Tada T, et al. 2023. JCI Insight. 8:. PubMed
  192. Ito M, et al. 2023. Sci Rep. 13:5939. PubMed
  193. Huang T, et al. 2023. Front Immunol. 14:1124152. PubMed
  194. A R, et al. 2023. Front Oncol. 13:1147668. PubMed
  195. Chen F, et al. 2023. Acta Biomater. 164:387. PubMed
  196. Bhaskar A, et al. 2023. iScience. 26:106644. PubMed
  197. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  198. Vokshi BH, et al. 2023. Nat Commun. 14:3034. PubMed
  199. Gabriely G, et al. 2021. iScience. 24:103347. PubMed
  200. Rezende R, et al. 2015. Nat Commun. 6: 8726. PubMed
  201. Chen H, et al. 2005. J Immunol. 175:591. PubMed
  202. Shi Y, et al. 2020. Med Sci Monit. 26:e923328. PubMed
  203. Lin W, et al. 2020. Theranostics. 10:4871. PubMed
  204. Hammer A, et al. 2017. J Neuroinflammation. 10.1186/s12974-017-0954-y. PubMed
  205. Wang D, et al. 2018. Immunity. 48:659. PubMed
  206. MacDonald K, et al. 2014. J Immunol. 192:3180. PubMed
  207. Saenz F, et al. 2014. PLoS One. 9:97666. PubMed
  208. Shapiro MR, et al. 2020. Front Immunol. 1.972222222. PubMed
  209. Chen L, et al. 2022. Mol Ther Oncolytics. 24:522. PubMed
  210. Yang C, et al. 2022. Cancers (Basel). 14:. PubMed
  211. Volpedo G, et al. 2022. NPJ Vaccines. 7:32. PubMed
  212. Byun JK, et al. 2020. Molecular Cell. 80(4):592-606.e8. PubMed
  213. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
  214. Fan C, et al. 2020. Stem Cell Res Ther. 0.765277778. PubMed
  215. Bhattacharjee S, et al. 2019. Cell Rep. 28:231. PubMed
  216. Trial J, et al. 2017. Basic Research in Cardiology. 10.1007/s00395-017-0623-4. PubMed
  217. Qi X, et al. 2019. Nat Commun. 10:2141. PubMed
  218. Shao B, et al. 2019. J Immunol. 10.4049/jimmunol.1900680. PubMed
  219. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  220. Davila S, et al. 2014. J Immunol. 192:4284. PubMed
  221. Isakova-Sivak I, et al. 2020. Vaccines (Basel). 8:00. PubMed
  222. Bartleson JM, et al. 2020. Nat Immunol. 1384:21. PubMed
  223. Yoon Y, et al. 2021. Cancers (Basel). 13: . PubMed
  224. Zhang Q, et al. 2021. Nat Commun. 12:4592. PubMed
  225. Sung SE, et al. 2021. Vet Sci. 8:. PubMed
  226. Mardomi A, et al. 2021. J Cell Physiol. 236:6328. PubMed
  227. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  228. Xu X, et al. 2021. J Nanobiotechnology. 19:376. PubMed
  229. Li H, et al. 2021. Nat Commun. 12:2773. PubMed
  230. Yu AI, et al. 2020. Cell Rep. 107471:31. PubMed
  231. Lv H, et al. 2020. Cell Metabolism. 33(1):110-127.e5. PubMed
  232. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  233. Higashi AY, et al. 2019. J Am Soc Nephrol. 30:80. PubMed
  234. Sasaki K, et al. 2019. Nat Commun. 10:3878. PubMed
  235. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  236. Shao W, et al. 2010. Transplant Proc. 42:2777. PubMed
  237. Tyne A, et al. 2013. Vaccine. 31:4322. PubMed
  238. Chulpanova DS, et al. 2020. Bioengineering (Basel). 7:00. PubMed
  239. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  240. Sandborn WJ, et al. 2021. Gastroenterology. 161:1853. PubMed
  241. Chen L, et al. 2021. Cell Death Differ. 28:1880. PubMed
  242. Du L et al. 2019. Cell metabolism. 29(6):1363-1375 . PubMed
  243. Miska J et al. 2019. Cell reports. 27(1):226-237 . PubMed
  244. Li P, et al. 2017. Oncogenesis. 10.1038/oncsis.2017.24. PubMed
  245. Zhao J, et al. 2018. Stem Cell Reports. 10:180. PubMed
  246. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  247. Santos CP et al. 2019. Nat Commun. 10(1):4407 . PubMed
  248. Hu Q, et al. 2018. Nat Biomed Eng. 0.660416667. PubMed
  249. Chen Y, et al. 2010. Mol Cancer Ther. 2.374305556. PubMed
  250. Hrdinka M, et al. 2016. PLoS One. 11: 0162863. PubMed
  251. Hammer A, et al. 2016. Proc Natl Acad Sci U S A. 113(49):14109-14114. PubMed
  252. Kong T, et al. 2020. Cancer Res. 80:444. PubMed
  253. Chin AL, et al. 2021. Nat Commun. 12:5138. PubMed
  254. Knizkova D, et al. 2022. Nat Immunol. 23:1644. PubMed
  255. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  256. Yang W, et al. 2020. Methods Mol Biol. 2111:91. PubMed
  257. Luo J, et al. 2022. J Nanobiotechnology. 20:228. PubMed
  258. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
  259. Kulkarni R, et al. 2021. PLoS One. 16:e0257191. PubMed
  260. Ringel AE, et al. 2020. Cell. 183(7):1848-1866.e26. PubMed
  261. Yi X, et al. 2020. Sci Adv. 6:eaba3546. PubMed
  262. Fu X, et al. 2020. Aging (Albany NY). 12:15656. PubMed
  263. Blacking T, et al. 2011. Vet Immunol Immunopathol. 141:46. PubMed
  264. Sentman A 2011. Blood. 117:6571. PubMed
  265. Kumar MP, et al. 2018. Cell Rep. 25:1458. PubMed
  266. Li P, et al. 2018. J Cell Mol Med. 22:3423. PubMed
  267. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  268. Zhang Z, et al. 2019. Cell Death Dis. 10:530. PubMed
  269. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  270. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  271. Tsuchihashi K, et al. 2022. Biochem Biophys Rep. 30:101246. PubMed
  272. Sottnik JL, et al. 2021. Cancer Res. 81:2833. PubMed
  273. De Ponte Conti B, et al. 2021. Elife. 10:. PubMed
  274. Bian X, et al. 2021. Clin Transl Med. 11:e352. PubMed
  275. Biram A, et al. 2020. Bio Protoc. e3562:10. PubMed
  276. Kondo M, et al. 2016. J Immunol. 196: 563 - 572. PubMed
  277. Kälin S et al. 2017. Cell metabolism. 26(3):475-492 . PubMed
  278. Biton M et al. 2018. Cell. 175(5):1307-1320 . PubMed
  279. Yip HYK, et al. 2018. PLoS One. 3. PubMed
  280. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  281. Zhang NN, et al. 2020. Cell. 182(5):1271-1283. PubMed
  282. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  283. Chulpanova DS, et al. 2021. Biology (Basel). 10:. PubMed
  284. Nair S, et al. 2021. JCI Insight. 6:. PubMed
  285. Ngamsri KC, et al. 2022. Cells. 11:. PubMed
  286. Melhem H, et al. 2022. Mucosal Immunol. 15:443. PubMed
  287. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  288. Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
  289. Wang S, et al. 2021. Parasite. 28:13. PubMed
  290. Zhang Q, et al. 2021. Bone Joint Res. 10:226. PubMed
  291. Xu Y, et al. 2020. Stem Cells Int. 8894449:2020. PubMed
  292. Yeung F, et al. 2020. Cell Host & Microbe. 27(5):809-822. PubMed
  293. Pardo E, et al. 2017. PLoS One. 12(6):e0177472. PubMed
  294. Hammer A, et al. 2017. Front Immunol. . 10.3389/fimmu.2017.01922. PubMed
  295. Morley S, et al. 2008. J Immunol. 181:4696. PubMed
  296. Fiume G, et al. 2015. Sci Rep. 5: 13864. PubMed
  297. M H, et al. 2016. Open Bio. 6: 150208. PubMed
  298. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  299. Yermanos A, et al. 2020. Front Immunol. 1.143055556. PubMed
  300. Chakraborty M, et al. 2021. Cell Reports. 34(2):108609. PubMed
  301. Yue X, et al. 2021. EMBO Rep. 22:e52716. PubMed
  302. Herbst SA, et al. 2021. iScience. 24:103062. PubMed
  303. Wu J, et al. 2021. STAR Protoc. 2:101022. PubMed
  304. Zhang J, et al. 2022. Biomater Res. 26:44. PubMed
  305. Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed
  306. Hu J, et al. 2022. J Immunother Cancer. 10:. PubMed
  307. Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed
  308. Girón-Pérez DA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  309. MaruYama T, et al. 2015. J Leukoc Biol. 98: 385-393. PubMed
  310. Lee Y, et al. 2012. Nat Immunol. 13:991. PubMed
  311. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  312. Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed
  313. Lu H, et al. 2019. EBioMedicine. 40:276. PubMed
  314. Velazquez VM, et al. 2017. Mol Ther Methods Clin Dev. 0.277083333. PubMed
  315. Zhu E, et al. 2014. J Immunol. 192:5599. PubMed
  316. Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
  317. Korin B, et al. 2020. Sleep. :43. PubMed
  318. Tsyklauri O, et al. 2021. EMBO Rep. 22:e50785. PubMed
  319. Kim S, et al. 2022. Cancers (Basel). 14:. PubMed
  320. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  321. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  322. Liu X, et al. 2021. Adv Sci (Weinh). 8:e2100233. PubMed
  323. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  324. Kaji T, et al. 2016. Int Immunol. 28: 267 - 282. PubMed
  325. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  326. Timilshina M, et al. 2020. Cell Reports. 27(10):2948-2961.e7.. PubMed
  327. Yang C, et al. 2019. Nat Commun. 10:3931. PubMed
  328. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  329. Serr I, et al. 2016. Nat Commun. 7:10991. PubMed
  330. Angela M, et al. 2016. Nat Commun. 7:13683. PubMed
  331. Seo MS, et al. 2021. Vet Sci. 8:. PubMed
  332. Hung G, et al. 2022. NPJ Aging. 8:10. PubMed
  333. Li CY, et al. 2022. Int J Mol Sci. 23:. PubMed
  334. Pan Y, et al. 2021. NPJ Vaccines. 6:1. PubMed
  335. Velletri T, et al. 2020. Cell Death Differ. . PubMed
  336. Olguín J, et al. 2015. Microbes Infect. 17: 586-595. PubMed
  337. Bonaccorsi-Riani E, et al. 2015. PLoS One. 10: 0136106. PubMed
  338. Upasani V, et al. 2019. Front Immunol. 2.152777778. PubMed
RRID
AB_312959 (BioLegend Cat. No. 103008)
AB_493686 (BioLegend Cat. No. 103023)
AB_312958 (BioLegend Cat. No. 103007)
AB_493687 (BioLegend Cat. No. 103024)

Antigen Details

Structure
Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD
Distribution

All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells

Function
Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM
Ligand/Receptor
Hyaluronan, MIP-1β, fibronectin, collagen
Cell Type
B cells, Endothelial cells, Epithelial cells, Leukocytes, Mesenchymal cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Haynes BF, et al. 1991. Cancer Cells 3:347.
3. Goldstein LA, et al. 1989. Cell 56:1063.
4. Mikecz K, et al. 1995. Nat. Med. 1:558.
5. Hegde V, et al. 2008. J. Leukocyte Biol. 84:134.
6. Liu T, et al. 2009. Biol. Direct 4:40.

Gene ID
12505 View all products for this Gene ID 960 View all products for this Gene ID
UniProt
View information about CD44 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD44 Reagents Request Custom Conjugation
Description Clone Applications
PE/Dazzle™ 594 anti-mouse/human CD44 IM7 FC
Brilliant Violet 711™ anti-mouse/human CD44 IM7 FC
APC/Fire™ 750 anti-mouse/human CD44 IM7 FC
TotalSeq™-A0073 anti-mouse/human CD44 IM7 PG
TotalSeq™-C0073 anti-mouse/human CD44 IM7 PG
TotalSeq™-B0073 anti-mouse/human CD44 IM7 PG
APC anti-mouse/human CD44 IM7 FC
Biotin anti-mouse/human CD44 IM7 FC,ICC,IHC-P
FITC anti-mouse/human CD44 IM7 FC,ICC,IHC-P
PE/Cyanine5 anti-mouse/human CD44 IM7 FC
Purified anti-mouse/human CD44 IM7 FC,IHC-F,CyTOF®,ELISA,ICC,IHC-P,IP,CMCD,Stim
Brilliant Violet 605™ anti-mouse/human CD44 IM7 FC
PE anti-mouse/human CD44 IM7 FC
Alexa Fluor® 488 anti-mouse/human CD44 IM7 FC,ICC,IHC-P,SB
Alexa Fluor® 647 anti-mouse/human CD44 IM7 FC,ICC,SB
Pacific Blue™ anti-mouse/human CD44 IM7 FC
Alexa Fluor® 700 anti-mouse/human CD44 IM7 FC,SB
PE/Cyanine7 anti-mouse/human CD44 IM7 FC
APC/Cyanine7 anti-mouse/human CD44 IM7 FC
PerCP/Cyanine5.5 anti-mouse/human CD44 IM7 FC
PerCP anti-mouse/human CD44 IM7 FC
Brilliant Violet 421™ anti-mouse/human CD44 IM7 FC,ICC,IHC-P
Brilliant Violet 570™ anti-mouse/human CD44 IM7 FC
Brilliant Violet 785™ anti-mouse/human CD44 IM7 FC
Brilliant Violet 510™ anti-mouse/human CD44 IM7 FC
Ultra-LEAF™ Purified anti-mouse/human CD44 IM7 FC,CyTOF®,ELISA,IHC,IP,CMCD,Stim
Brilliant Violet 650™ anti-mouse/human CD44 IM7 FC
Purified anti-mouse/human CD44 (Maxpar® Ready) IM7 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD44 IM7 ICC,FC,IHC-P,SB
Spark YG™ 570 anti-mouse/human CD44 IM7 FC,IHC-P
Spark YG™ 593 anti-mouse/human CD44 IM7 FC
TotalSeq™-D0073 anti-mouse/human CD44 IM7 PG
Brilliant Violet 750™ anti-mouse/human CD44 IM7 FC
PerCP/Fire™ 806 anti-mouse/human CD44 IM7 FC
Spark Red™ 718 anti-mouse/human CD44 IM7 FC
PE/Fire™ 810 anti-mouse/human CD44 IM7 FC
Spark Blue™ 550 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
Spark YG™ 581 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
Spark NIR™ 685 anti-mouse/human CD44 (Flexi-Fluor™) Antibody IM7 FC
Spark UV™ 387 anti-mouse/human CD44 (Flexi-Fluor™) IM7 FC
StarBright UltraViolet 795 anti-mouse/human CD44 IM7 FC
Go To Top Version: 4    Revision Date: 10-15-2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account