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PE anti-mouse IL-17A Antibody PE anti-mouse IL-17A Antibody

Pricing & Availability
Clone
TC11-18H10.1 (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)
Isotype
Rat IgG1, κ
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Product Citations
publications
TC11-18H10.1_PE_041910
PMA/ionomycin-stimulated (5 hours) Th17 polarized C57BL/6 mouse CD4+ T cells surface stained with CD4 (GK1.5) APC, then intracellularly stained with TC11-18H10.1 PE
  • TC11-18H10.1_PE_041910
    PMA/ionomycin-stimulated (5 hours) Th17 polarized C57BL/6 mouse CD4+ T cells surface stained with CD4 (GK1.5) APC, then intracellularly stained with TC11-18H10.1 PE
  • TC11-18H10_PE_060806
    PMA (20 ng/ml) + ionomycin (1 µg/ml) -stimulated (6 hours + monensin, 2 µM) mouse thymoma cell line EL-4 intracellularly stained with TC11-18H10.1 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
506904 100 µg SEK2352
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506903 25 µg SEK924
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Description

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
E. coli expressed, recombinant mouse IL-17A
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The IL-17A antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

ELISA Capture3,4 and ELISPOT Capture5: The purified TC11-18H10.1 antibody is useful as the capture antibody in a sandwich ELISA, when used in conjunction with the biotinylated TC11-8H4 antibody (Cat. No. 507002) as the detecting antibody and recombinant mouse IL-17 (Cat. No. 576009) as the standard.
Flow Cytometry2-4,7,8,11,12: The TC11-18H10.1 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-17-producing cells within mixed cell populations.
Neutralization6,9: The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-17 bioactivity in vivo and in vitro (Cat. No. 506906).

Application References
  1. Kennedy J, et al. 1996. J. Interferon Cytokine Res. 16:611.
  2. Schubert D, et al. 2004. J. Immunol. 172:4503. (ICFC)
  3. Infante-Duarte C, et al. 2000. J. Immunol. 165:6107. (ICFC, ELISA Capture)
  4. Harrington LE, et al. 2005. Nature Immunol. doi:10.1038/ni1254. (ICFC, ELISA Capture)
  5. Nekrasova T, et al. 2005. J. Immunol. 175:2734. (ELISPOT Capture)
  6. Yen D, et al. 2006. J. Clin. Invest. 116:1310. (Neut)
  7. Ehirchiou D, et al. 2007. J. Exp. Med. 204:1519. (ICFC)
  8. Kang SG, et al. 2007. J. Immunol. 179:3724. (ICFC)
  9. Smith E, et al. 2008. J. Immunol. 181:1357. (Neut) PubMed
  10. Neufert C, et al. 2007. Eur. J. Immunol. 37:1809. PubMed
  11. Wang C, et al. 2009. Mucosal Immunol 2:173. (ICFC) PubMed
  12. Cui Y, et al. 2009. Invest. Ophth. Vis. Sci. 50:5811. (ICFC) PubMed
  13. Kivisäkk P, et al. 2009. Ann. Neurol. 65:457. PubMed
  14. Cooney LA, et al. 2011. J. Immunol. 187:4440. PubMed
  15. Ma Y, et al. 2012. PLoS One. 7:e40763. PubMed
  16. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
Product Citations
  1. Kimura S, et al. 2020. Nat Commun. 0.620833333. PubMed
  2. Vono M, et al. 2020. Cell Reports. 28(7):1773-1784.e5.. PubMed
  3. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  4. Laura C Burzynski et al. 2019. Immunity. 50(4):1033-1042 . PubMed
  5. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  6. Yu C, et al. 2022. Invest Ophthalmol Vis Sci. 63:1. PubMed
  7. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  8. Chen C, et al. 2022. Sci Adv. 8:eabo4363. PubMed
  9. Mansouri S, et al. 2022. J Immunol. 209:2114. PubMed
  10. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  11. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  12. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  13. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  14. Weng S, et al. 2022. Front Immunol. 13:1025931. PubMed
  15. Zhao Q, et al. 2023. Nutrients. 15: . PubMed
  16. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  17. Xu R 2023. Cell Reports. 42(2):112054. PubMed
  18. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  19. Zhao L, et al. 2022. Oncogene. 41:4200. PubMed
  20. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  21. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  22. Aso K, et al. 2023. Nat Commun. 14:984. PubMed
  23. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  24. Schwarz A, et al. 2023. Front Immunol. 14:1038689. PubMed
  25. Giampaolo S, et al. 2023. iScience. 26:106234. PubMed
  26. Mabire M, et al. 2023. Nat Commun. 14:1830. PubMed
  27. Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed
  28. Cai X, et al. 2023. Nat Commun. 14:2004. PubMed
  29. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  30. Tian J, et al. 2021. Autophagy. 17:2586. PubMed
  31. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  32. Yamazaki S, et al. 2022. Mucosal Immunol. :. PubMed
  33. Xue F, et al. 2020. Int J Biol Sci. 2.105555556. PubMed
  34. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  35. Du C, et al. 2016. Nat Commun. 7: 11120. PubMed
  36. Kang S, et al. 2007. J Immunol. 179:3724. PubMed
  37. Files M, et al. 2022. NPJ Vaccines. 7:48. PubMed
  38. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  39. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  40. Yang R, et al. 2020. Cell Death Dis. 0.877083333. PubMed
  41. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  42. Angiari S, et al. 2020. Cell Metab. 31:391. PubMed
  43. Yang C, et al. 2018. J Immunol. 200:1316. PubMed
  44. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  45. Kenichi Shimada et al. 2018. Immunity. 49(5):873-885 . PubMed
  46. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  47. Pan Y, et al. 2021. Front Cell Neurosci. 15:664312. PubMed
  48. Zhao Y, et al. 2015. PLoS One. 10: 0134797. PubMed
  49. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  50. Lu Y, et al. 2019. Int J Mol Med. 43:2398. PubMed
  51. Ni J, et al. 2022. Mol Med. 28:65. PubMed
  52. Kuwahara M, et al. 2014. Nat Commun. 5:3555. PubMed
  53. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  54. Yasuoka T, et al. 2016. PLoS One. 11: 0157395. PubMed
  55. Wagner V, et al. 2016. Sci Transl Med. 8: 366ra164. PubMed
  56. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  57. Ogawa C et al. 2018. Cell reports. 25(1):19-28 . PubMed
  58. Han Y et al. 2019. Cell reports. 27(3):835-846 . PubMed
  59. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  60. Sehnert B, et al. 2022. Front Immunol. 13:921488. PubMed
  61. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  62. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  63. Liu YJ, et al. 2020. Theranostics. 10:5225. PubMed
  64. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  65. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  66. He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
  67. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  68. Ni P, et al. 2014. Mol Immunol. 62:199. PubMed
  69. Niwa H, et al. 2009. Clin Immunol. 132:184. PubMed
  70. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  71. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  72. Dar HY, et al. 2018. Sci Rep. 8:2503. PubMed
  73. Pu Y, et al. 2022. Transl Psychiatry. 12:223. PubMed
  74. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  75. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  76. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
  77. Bhattacharya D, et al. 2014. J Biol Chem. 289:16508. PubMed
  78. Dar HY, et al. 2018. Bone Rep. 8:46. PubMed
  79. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  80. Bankoti R, et al. 2017. Sci Rep. 10.1038/s41598-017-12171-3. PubMed
  81. Mara AB, et al. 2022. NPJ Vaccines. 7:86. PubMed
  82. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  83. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  84. Takeshita Y, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  85. Ouyang W, et al. 2021. Invest Ophthalmol Vis Sci. 62:25:00. PubMed
  86. Kawashima H, et al. 2013. J Immunol. 191:3614. PubMed
  87. Luck H, et al. 2015. Cell Metab. 21 527 . PubMed
  88. Castro–Dopico T, et al. 2020. Cell Reports. 32(1):107857. PubMed
  89. Wen M, et al. 2022. JCI Insight. Online ahead of print. PubMed
  90. Tan YY, et al. 2021. Exp Ther Med. 22:1368. PubMed
  91. Deerhake ME, et al. 2021. Immunity. 54(3):484-498.e8. PubMed
  92. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  93. Alhosaini K, et al. 2021. Brain Sci. :11. PubMed
  94. Chou T, et al. 2016. Nat Commun. 7:11904. PubMed
  95. Takeuchi H, et al. 2013. J Immunol. 191:3725. PubMed
  96. Park S, et al. 2011. J Immunol. 187:5813. PubMed
  97. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  98. Lin YW, et al. 2022. Mol Med Rep. 26:. PubMed
  99. Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed
  100. Van Dis E, et al. 2018. Cell Rep. 23:1435. PubMed
  101. Ramakrishnan SK, et al. 2019. Nat Commun. 10:660. PubMed
  102. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  103. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  104. Kang J, Lee J, Chang J 2016. PLoS One. 11: 0157015. PubMed
  105. Gorman JA, et al. 2019. Front Immunol. 10:44. PubMed
  106. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  107. Sanchez M et al. 2017. Cell host & microbe. 22(4):543-551 . PubMed
  108. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  109. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  110. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  111. Derada Troletti C, et al. 2021. Cell Reports. 35(9):109201. PubMed
  112. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  113. Wu B, et al. 2021. Immunity. 54(2):308-323.e6. PubMed
  114. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  115. Li X, et al. 2016. MBio. 7: 02232-15. PubMed
  116. Ehirchiou D, et al. 2007. J Exp Med . 204:1519. PubMed
  117. Kang YH, et al. 2019. Nat Commun. 10:912. PubMed
  118. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  119. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  120. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  121. Mizutani N, et al. 2012. J Immunol. 188:5694. PubMed
  122. Suhail A, et al. 2019. Cell Rep. 29:3522. PubMed
  123. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  124. Zhang Y, et al. 2021. Commun Biol. 344:4. PubMed
  125. Jeon Y, et al. 2015. PLoS One. 10: e0139845. PubMed
  126. Castro‐Dopico T et al. 2019. Immunity. 50(4):1099-1114 . PubMed
  127. Zegarra‐Ruiz DF et al. 2018. Cell host & microbe. 25(1):113-127 . PubMed
  128. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  129. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  130. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  131. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  132. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  133. Huang LJ, et al. 2021. Immunity. 54(8):1728-1744.e7. PubMed
  134. Li J, et al. 2012. Arthritis Rheum. 64:1098. PubMed
  135. Li C, et al. 2014. J Immunol. 192:1425. PubMed
  136. Lai NY, et al. 2020. Cell. 180:33:00. PubMed
  137. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  138. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  139. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  140. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  141. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  142. Toriyama K, et al. 2020. Commun Biol. 0.398611111. PubMed
  143. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  144. Ge Y, et al. 2020. Mucosal Immunol. 13:34. PubMed
  145. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  146. Aggarwal N, et al. 2021. Cell Rep. 37:110170. PubMed
  147. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  148. Pahari S, et al. 2020. Autophagy. 1.375694444. PubMed
  149. Kimura S, et al. 2020. Nat Commun. 0.620833333. PubMed
  150. Vono M, et al. 2020. Cell Reports. 28(7):1773-1784.e5.. PubMed
  151. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  152. Laura C Burzynski et al. 2019. Immunity. 50(4):1033-1042 . PubMed
  153. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  154. Yu C, et al. 2022. Invest Ophthalmol Vis Sci. 63:1. PubMed
  155. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  156. Chen C, et al. 2022. Sci Adv. 8:eabo4363. PubMed
  157. Mansouri S, et al. 2022. J Immunol. 209:2114. PubMed
  158. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  159. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  160. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  161. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  162. Weng S, et al. 2022. Front Immunol. 13:1025931. PubMed
  163. Zhao Q, et al. 2023. Nutrients. 15: . PubMed
  164. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  165. Xu R 2023. Cell Reports. 42(2):112054. PubMed
  166. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  167. Zhao L, et al. 2022. Oncogene. 41:4200. PubMed
  168. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  169. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  170. Aso K, et al. 2023. Nat Commun. 14:984. PubMed
  171. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  172. Schwarz A, et al. 2023. Front Immunol. 14:1038689. PubMed
  173. Giampaolo S, et al. 2023. iScience. 26:106234. PubMed
  174. Mabire M, et al. 2023. Nat Commun. 14:1830. PubMed
  175. Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed
  176. Cai X, et al. 2023. Nat Commun. 14:2004. PubMed
  177. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  178. Tian J, et al. 2021. Autophagy. 17:2586. PubMed
  179. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  180. Yamazaki S, et al. 2022. Mucosal Immunol. :. PubMed
  181. Xue F, et al. 2020. Int J Biol Sci. 2.105555556. PubMed
  182. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  183. Du C, et al. 2016. Nat Commun. 7: 11120. PubMed
  184. Kang S, et al. 2007. J Immunol. 179:3724. PubMed
  185. Files M, et al. 2022. NPJ Vaccines. 7:48. PubMed
  186. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  187. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  188. Yang R, et al. 2020. Cell Death Dis. 0.877083333. PubMed
  189. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  190. Angiari S, et al. 2020. Cell Metab. 31:391. PubMed
  191. Yang C, et al. 2018. J Immunol. 200:1316. PubMed
  192. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  193. Kenichi Shimada et al. 2018. Immunity. 49(5):873-885 . PubMed
  194. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  195. Pan Y, et al. 2021. Front Cell Neurosci. 15:664312. PubMed
  196. Zhao Y, et al. 2015. PLoS One. 10: 0134797. PubMed
  197. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  198. Lu Y, et al. 2019. Int J Mol Med. 43:2398. PubMed
  199. Ni J, et al. 2022. Mol Med. 28:65. PubMed
  200. Kuwahara M, et al. 2014. Nat Commun. 5:3555. PubMed
  201. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  202. Yasuoka T, et al. 2016. PLoS One. 11: 0157395. PubMed
  203. Wagner V, et al. 2016. Sci Transl Med. 8: 366ra164. PubMed
  204. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  205. Ogawa C et al. 2018. Cell reports. 25(1):19-28 . PubMed
  206. Han Y et al. 2019. Cell reports. 27(3):835-846 . PubMed
  207. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  208. Sehnert B, et al. 2022. Front Immunol. 13:921488. PubMed
  209. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  210. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  211. Liu YJ, et al. 2020. Theranostics. 10:5225. PubMed
  212. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  213. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  214. He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
  215. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  216. Ni P, et al. 2014. Mol Immunol. 62:199. PubMed
  217. Niwa H, et al. 2009. Clin Immunol. 132:184. PubMed
  218. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  219. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  220. Dar HY, et al. 2018. Sci Rep. 8:2503. PubMed
  221. Pu Y, et al. 2022. Transl Psychiatry. 12:223. PubMed
  222. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  223. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  224. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
  225. Bhattacharya D, et al. 2014. J Biol Chem. 289:16508. PubMed
  226. Dar HY, et al. 2018. Bone Rep. 8:46. PubMed
  227. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  228. Bankoti R, et al. 2017. Sci Rep. 10.1038/s41598-017-12171-3. PubMed
  229. Mara AB, et al. 2022. NPJ Vaccines. 7:86. PubMed
  230. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  231. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  232. Takeshita Y, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  233. Ouyang W, et al. 2021. Invest Ophthalmol Vis Sci. 62:25:00. PubMed
  234. Kawashima H, et al. 2013. J Immunol. 191:3614. PubMed
  235. Luck H, et al. 2015. Cell Metab. 21 527 . PubMed
  236. Castro–Dopico T, et al. 2020. Cell Reports. 32(1):107857. PubMed
  237. Wen M, et al. 2022. JCI Insight. Online ahead of print. PubMed
  238. Tan YY, et al. 2021. Exp Ther Med. 22:1368. PubMed
  239. Deerhake ME, et al. 2021. Immunity. 54(3):484-498.e8. PubMed
  240. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  241. Alhosaini K, et al. 2021. Brain Sci. :11. PubMed
  242. Chou T, et al. 2016. Nat Commun. 7:11904. PubMed
  243. Takeuchi H, et al. 2013. J Immunol. 191:3725. PubMed
  244. Park S, et al. 2011. J Immunol. 187:5813. PubMed
  245. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  246. Lin YW, et al. 2022. Mol Med Rep. 26:. PubMed
  247. Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed
  248. Van Dis E, et al. 2018. Cell Rep. 23:1435. PubMed
  249. Ramakrishnan SK, et al. 2019. Nat Commun. 10:660. PubMed
  250. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  251. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  252. Kang J, Lee J, Chang J 2016. PLoS One. 11: 0157015. PubMed
  253. Gorman JA, et al. 2019. Front Immunol. 10:44. PubMed
  254. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  255. Sanchez M et al. 2017. Cell host & microbe. 22(4):543-551 . PubMed
  256. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  257. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  258. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  259. Derada Troletti C, et al. 2021. Cell Reports. 35(9):109201. PubMed
  260. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  261. Wu B, et al. 2021. Immunity. 54(2):308-323.e6. PubMed
  262. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  263. Li X, et al. 2016. MBio. 7: 02232-15. PubMed
  264. Ehirchiou D, et al. 2007. J Exp Med . 204:1519. PubMed
  265. Kang YH, et al. 2019. Nat Commun. 10:912. PubMed
  266. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  267. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  268. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  269. Mizutani N, et al. 2012. J Immunol. 188:5694. PubMed
  270. Suhail A, et al. 2019. Cell Rep. 29:3522. PubMed
  271. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  272. Zhang Y, et al. 2021. Commun Biol. 344:4. PubMed
  273. Jeon Y, et al. 2015. PLoS One. 10: e0139845. PubMed
  274. Castro‐Dopico T et al. 2019. Immunity. 50(4):1099-1114 . PubMed
  275. Zegarra‐Ruiz DF et al. 2018. Cell host & microbe. 25(1):113-127 . PubMed
  276. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  277. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  278. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  279. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  280. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  281. Huang LJ, et al. 2021. Immunity. 54(8):1728-1744.e7. PubMed
  282. Li J, et al. 2012. Arthritis Rheum. 64:1098. PubMed
  283. Li C, et al. 2014. J Immunol. 192:1425. PubMed
  284. Lai NY, et al. 2020. Cell. 180:33:00. PubMed
  285. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  286. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  287. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  288. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  289. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  290. Toriyama K, et al. 2020. Commun Biol. 0.398611111. PubMed
  291. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  292. Ge Y, et al. 2020. Mucosal Immunol. 13:34. PubMed
  293. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  294. Aggarwal N, et al. 2021. Cell Rep. 37:110170. PubMed
  295. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  296. Pahari S, et al. 2020. Autophagy. 1.375694444. PubMed
RRID
AB_315464 (BioLegend Cat. No. 506904)
AB_315463 (BioLegend Cat. No. 506903)

Antigen Details

Structure
Cytokine; dimer; 15 kD (Mammalian).
Bioactivity
Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells
Cell Sources
CD4+ memory T cells
Cell Targets
Fibroblasts, epithelial and endothelial cells, stromal cells
Receptors
IL-17R (CD217)
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Numasaki M, et al. 2002. Blood 101:2620.
3. Fossiez F, et al. 1996. J. Exp. Med. 183:2593.
4. Yao Z, et al. 1997. Cytokine 9:794.
5. Dong C. 2006. Nat. Rev. Immunol. 6:329.
6. Hofstetter HH, et al. 2005 Cell. Immunol. 237:123.

Gene ID
16171 View all products for this Gene ID
UniProt
View information about IL-17A on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Does the anti-mouse IL-17 antibody (clone TC11-18H10.1) recognize the A or F isoform?
Clone TC11-18H10.1 recognizes IL-17A isoform, but it also recognizes the IL-17A/F heterodimer via IL-17A binding.
Go To Top Version: 2    Revision Date: 10-16-2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
TC11-18H10.1 (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
TC11-18H10.1_PE_041910
PMA/ionomycin-stimulated (5 hours) Th17 polarized C57BL/6 mouse CD4+ T cells surface stained with CD4 (GK1.5) APC, then intracellularly stained with TC11-18H10.1 PE
  • TC11-18H10.1_PE_041910
    PMA/ionomycin-stimulated (5 hours) Th17 polarized C57BL/6 mouse CD4+ T cells surface stained with CD4 (GK1.5) APC, then intracellularly stained with TC11-18H10.1 PE
  • TC11-18H10_PE_060806
    PMA (20 ng/ml) + ionomycin (1 µg/ml) -stimulated (6 hours + monensin, 2 µM) mouse thymoma cell line EL-4 intracellularly stained with TC11-18H10.1 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
506904 100 µg SEK2352
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506903 25 µg SEK924
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Description

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
E. coli expressed, recombinant mouse IL-17A
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The IL-17A antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

ELISA Capture3,4 and ELISPOT Capture5: The purified TC11-18H10.1 antibody is useful as the capture antibody in a sandwich ELISA, when used in conjunction with the biotinylated TC11-8H4 antibody (Cat. No. 507002) as the detecting antibody and recombinant mouse IL-17 (Cat. No. 576009) as the standard.
Flow Cytometry2-4,7,8,11,12: The TC11-18H10.1 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-17-producing cells within mixed cell populations.
Neutralization6,9: The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-17 bioactivity in vivo and in vitro (Cat. No. 506906).

Application References
  1. Kennedy J, et al. 1996. J. Interferon Cytokine Res. 16:611.
  2. Schubert D, et al. 2004. J. Immunol. 172:4503. (ICFC)
  3. Infante-Duarte C, et al. 2000. J. Immunol. 165:6107. (ICFC, ELISA Capture)
  4. Harrington LE, et al. 2005. Nature Immunol. doi:10.1038/ni1254. (ICFC, ELISA Capture)
  5. Nekrasova T, et al. 2005. J. Immunol. 175:2734. (ELISPOT Capture)
  6. Yen D, et al. 2006. J. Clin. Invest. 116:1310. (Neut)
  7. Ehirchiou D, et al. 2007. J. Exp. Med. 204:1519. (ICFC)
  8. Kang SG, et al. 2007. J. Immunol. 179:3724. (ICFC)
  9. Smith E, et al. 2008. J. Immunol. 181:1357. (Neut) PubMed
  10. Neufert C, et al. 2007. Eur. J. Immunol. 37:1809. PubMed
  11. Wang C, et al. 2009. Mucosal Immunol 2:173. (ICFC) PubMed
  12. Cui Y, et al. 2009. Invest. Ophth. Vis. Sci. 50:5811. (ICFC) PubMed
  13. Kivisäkk P, et al. 2009. Ann. Neurol. 65:457. PubMed
  14. Cooney LA, et al. 2011. J. Immunol. 187:4440. PubMed
  15. Ma Y, et al. 2012. PLoS One. 7:e40763. PubMed
  16. Murakami R, et al. 2013. PLoS One. 8:73270. PubMed
Product Citations
  1. Kimura S, et al. 2020. Nat Commun. 0.620833333. PubMed
  2. Vono M, et al. 2020. Cell Reports. 28(7):1773-1784.e5.. PubMed
  3. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  4. Laura C Burzynski et al. 2019. Immunity. 50(4):1033-1042 . PubMed
  5. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  6. Yu C, et al. 2022. Invest Ophthalmol Vis Sci. 63:1. PubMed
  7. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  8. Chen C, et al. 2022. Sci Adv. 8:eabo4363. PubMed
  9. Mansouri S, et al. 2022. J Immunol. 209:2114. PubMed
  10. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  11. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  12. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  13. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  14. Weng S, et al. 2022. Front Immunol. 13:1025931. PubMed
  15. Zhao Q, et al. 2023. Nutrients. 15: . PubMed
  16. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  17. Xu R 2023. Cell Reports. 42(2):112054. PubMed
  18. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  19. Zhao L, et al. 2022. Oncogene. 41:4200. PubMed
  20. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  21. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  22. Aso K, et al. 2023. Nat Commun. 14:984. PubMed
  23. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  24. Schwarz A, et al. 2023. Front Immunol. 14:1038689. PubMed
  25. Giampaolo S, et al. 2023. iScience. 26:106234. PubMed
  26. Mabire M, et al. 2023. Nat Commun. 14:1830. PubMed
  27. Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed
  28. Cai X, et al. 2023. Nat Commun. 14:2004. PubMed
  29. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  30. Tian J, et al. 2021. Autophagy. 17:2586. PubMed
  31. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  32. Yamazaki S, et al. 2022. Mucosal Immunol. :. PubMed
  33. Xue F, et al. 2020. Int J Biol Sci. 2.105555556. PubMed
  34. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  35. Du C, et al. 2016. Nat Commun. 7: 11120. PubMed
  36. Kang S, et al. 2007. J Immunol. 179:3724. PubMed
  37. Files M, et al. 2022. NPJ Vaccines. 7:48. PubMed
  38. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  39. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  40. Yang R, et al. 2020. Cell Death Dis. 0.877083333. PubMed
  41. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  42. Angiari S, et al. 2020. Cell Metab. 31:391. PubMed
  43. Yang C, et al. 2018. J Immunol. 200:1316. PubMed
  44. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  45. Kenichi Shimada et al. 2018. Immunity. 49(5):873-885 . PubMed
  46. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  47. Pan Y, et al. 2021. Front Cell Neurosci. 15:664312. PubMed
  48. Zhao Y, et al. 2015. PLoS One. 10: 0134797. PubMed
  49. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  50. Lu Y, et al. 2019. Int J Mol Med. 43:2398. PubMed
  51. Ni J, et al. 2022. Mol Med. 28:65. PubMed
  52. Kuwahara M, et al. 2014. Nat Commun. 5:3555. PubMed
  53. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  54. Yasuoka T, et al. 2016. PLoS One. 11: 0157395. PubMed
  55. Wagner V, et al. 2016. Sci Transl Med. 8: 366ra164. PubMed
  56. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  57. Ogawa C et al. 2018. Cell reports. 25(1):19-28 . PubMed
  58. Han Y et al. 2019. Cell reports. 27(3):835-846 . PubMed
  59. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  60. Sehnert B, et al. 2022. Front Immunol. 13:921488. PubMed
  61. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  62. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  63. Liu YJ, et al. 2020. Theranostics. 10:5225. PubMed
  64. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  65. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  66. He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
  67. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  68. Ni P, et al. 2014. Mol Immunol. 62:199. PubMed
  69. Niwa H, et al. 2009. Clin Immunol. 132:184. PubMed
  70. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  71. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  72. Dar HY, et al. 2018. Sci Rep. 8:2503. PubMed
  73. Pu Y, et al. 2022. Transl Psychiatry. 12:223. PubMed
  74. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  75. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  76. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
  77. Bhattacharya D, et al. 2014. J Biol Chem. 289:16508. PubMed
  78. Dar HY, et al. 2018. Bone Rep. 8:46. PubMed
  79. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  80. Bankoti R, et al. 2017. Sci Rep. 10.1038/s41598-017-12171-3. PubMed
  81. Mara AB, et al. 2022. NPJ Vaccines. 7:86. PubMed
  82. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  83. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  84. Takeshita Y, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  85. Ouyang W, et al. 2021. Invest Ophthalmol Vis Sci. 62:25:00. PubMed
  86. Kawashima H, et al. 2013. J Immunol. 191:3614. PubMed
  87. Luck H, et al. 2015. Cell Metab. 21 527 . PubMed
  88. Castro–Dopico T, et al. 2020. Cell Reports. 32(1):107857. PubMed
  89. Wen M, et al. 2022. JCI Insight. Online ahead of print. PubMed
  90. Tan YY, et al. 2021. Exp Ther Med. 22:1368. PubMed
  91. Deerhake ME, et al. 2021. Immunity. 54(3):484-498.e8. PubMed
  92. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  93. Alhosaini K, et al. 2021. Brain Sci. :11. PubMed
  94. Chou T, et al. 2016. Nat Commun. 7:11904. PubMed
  95. Takeuchi H, et al. 2013. J Immunol. 191:3725. PubMed
  96. Park S, et al. 2011. J Immunol. 187:5813. PubMed
  97. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  98. Lin YW, et al. 2022. Mol Med Rep. 26:. PubMed
  99. Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed
  100. Van Dis E, et al. 2018. Cell Rep. 23:1435. PubMed
  101. Ramakrishnan SK, et al. 2019. Nat Commun. 10:660. PubMed
  102. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  103. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  104. Kang J, Lee J, Chang J 2016. PLoS One. 11: 0157015. PubMed
  105. Gorman JA, et al. 2019. Front Immunol. 10:44. PubMed
  106. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  107. Sanchez M et al. 2017. Cell host & microbe. 22(4):543-551 . PubMed
  108. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  109. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  110. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  111. Derada Troletti C, et al. 2021. Cell Reports. 35(9):109201. PubMed
  112. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  113. Wu B, et al. 2021. Immunity. 54(2):308-323.e6. PubMed
  114. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  115. Li X, et al. 2016. MBio. 7: 02232-15. PubMed
  116. Ehirchiou D, et al. 2007. J Exp Med . 204:1519. PubMed
  117. Kang YH, et al. 2019. Nat Commun. 10:912. PubMed
  118. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  119. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  120. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  121. Mizutani N, et al. 2012. J Immunol. 188:5694. PubMed
  122. Suhail A, et al. 2019. Cell Rep. 29:3522. PubMed
  123. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  124. Zhang Y, et al. 2021. Commun Biol. 344:4. PubMed
  125. Jeon Y, et al. 2015. PLoS One. 10: e0139845. PubMed
  126. Castro‐Dopico T et al. 2019. Immunity. 50(4):1099-1114 . PubMed
  127. Zegarra‐Ruiz DF et al. 2018. Cell host & microbe. 25(1):113-127 . PubMed
  128. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  129. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  130. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  131. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  132. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  133. Huang LJ, et al. 2021. Immunity. 54(8):1728-1744.e7. PubMed
  134. Li J, et al. 2012. Arthritis Rheum. 64:1098. PubMed
  135. Li C, et al. 2014. J Immunol. 192:1425. PubMed
  136. Lai NY, et al. 2020. Cell. 180:33:00. PubMed
  137. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  138. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  139. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  140. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  141. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  142. Toriyama K, et al. 2020. Commun Biol. 0.398611111. PubMed
  143. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  144. Ge Y, et al. 2020. Mucosal Immunol. 13:34. PubMed
  145. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  146. Aggarwal N, et al. 2021. Cell Rep. 37:110170. PubMed
  147. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  148. Pahari S, et al. 2020. Autophagy. 1.375694444. PubMed
  149. Kimura S, et al. 2020. Nat Commun. 0.620833333. PubMed
  150. Vono M, et al. 2020. Cell Reports. 28(7):1773-1784.e5.. PubMed
  151. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
  152. Laura C Burzynski et al. 2019. Immunity. 50(4):1033-1042 . PubMed
  153. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  154. Yu C, et al. 2022. Invest Ophthalmol Vis Sci. 63:1. PubMed
  155. Hong Y, et al. 2022. J Leukoc Biol. 112:425. PubMed
  156. Chen C, et al. 2022. Sci Adv. 8:eabo4363. PubMed
  157. Mansouri S, et al. 2022. J Immunol. 209:2114. PubMed
  158. Ge Y, et al. 2022. iScience. 25:105437. PubMed
  159. Dölz M, et al. 2022. iScience. 25:105372. PubMed
  160. Zhu M, et al. 2022. Front Immunol. 13:1019248. PubMed
  161. Xu H, et al. 2022. Aging Dis. 13:1875. PubMed
  162. Weng S, et al. 2022. Front Immunol. 13:1025931. PubMed
  163. Zhao Q, et al. 2023. Nutrients. 15: . PubMed
  164. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  165. Xu R 2023. Cell Reports. 42(2):112054. PubMed
  166. Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed
  167. Zhao L, et al. 2022. Oncogene. 41:4200. PubMed
  168. Deák P, et al. 2022. Cell Rep. 41:111563. PubMed
  169. Wilson NG, et al. 2023. iScience. 26:105991. PubMed
  170. Aso K, et al. 2023. Nat Commun. 14:984. PubMed
  171. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  172. Schwarz A, et al. 2023. Front Immunol. 14:1038689. PubMed
  173. Giampaolo S, et al. 2023. iScience. 26:106234. PubMed
  174. Mabire M, et al. 2023. Nat Commun. 14:1830. PubMed
  175. Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed
  176. Cai X, et al. 2023. Nat Commun. 14:2004. PubMed
  177. Levra Levron C, et al. 2023. Nat Cell Biol. 25:740. PubMed
  178. Tian J, et al. 2021. Autophagy. 17:2586. PubMed
  179. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  180. Yamazaki S, et al. 2022. Mucosal Immunol. :. PubMed
  181. Xue F, et al. 2020. Int J Biol Sci. 2.105555556. PubMed
  182. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  183. Du C, et al. 2016. Nat Commun. 7: 11120. PubMed
  184. Kang S, et al. 2007. J Immunol. 179:3724. PubMed
  185. Files M, et al. 2022. NPJ Vaccines. 7:48. PubMed
  186. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  187. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  188. Yang R, et al. 2020. Cell Death Dis. 0.877083333. PubMed
  189. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  190. Angiari S, et al. 2020. Cell Metab. 31:391. PubMed
  191. Yang C, et al. 2018. J Immunol. 200:1316. PubMed
  192. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  193. Kenichi Shimada et al. 2018. Immunity. 49(5):873-885 . PubMed
  194. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
  195. Pan Y, et al. 2021. Front Cell Neurosci. 15:664312. PubMed
  196. Zhao Y, et al. 2015. PLoS One. 10: 0134797. PubMed
  197. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  198. Lu Y, et al. 2019. Int J Mol Med. 43:2398. PubMed
  199. Ni J, et al. 2022. Mol Med. 28:65. PubMed
  200. Kuwahara M, et al. 2014. Nat Commun. 5:3555. PubMed
  201. Nagaoka M, et al. 2014. J Immunol. 193:2812. PubMed
  202. Yasuoka T, et al. 2016. PLoS One. 11: 0157395. PubMed
  203. Wagner V, et al. 2016. Sci Transl Med. 8: 366ra164. PubMed
  204. D Kim, S Lee, H Jun 2016. Immunol Cell Biol. 10.1038/icb.2016.98. PubMed
  205. Ogawa C et al. 2018. Cell reports. 25(1):19-28 . PubMed
  206. Han Y et al. 2019. Cell reports. 27(3):835-846 . PubMed
  207. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  208. Sehnert B, et al. 2022. Front Immunol. 13:921488. PubMed
  209. Okuniewska M, et al. 2021. Cell Reports. 36(2):109368. PubMed
  210. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
  211. Liu YJ, et al. 2020. Theranostics. 10:5225. PubMed
  212. Britton GJ et al. 2019. Immunity. 50(1):212-224 . PubMed
  213. Alissafi T, et al. 2020. Cell Metabolism. 32(4):591-604.e7. PubMed
  214. He J, et al. 2020. Cell Reports. 29(9):2718-2730.e6.. PubMed
  215. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  216. Ni P, et al. 2014. Mol Immunol. 62:199. PubMed
  217. Niwa H, et al. 2009. Clin Immunol. 132:184. PubMed
  218. Luo Y et al. 2019. Cell reports. 26(7):1869-1879 . PubMed
  219. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  220. Dar HY, et al. 2018. Sci Rep. 8:2503. PubMed
  221. Pu Y, et al. 2022. Transl Psychiatry. 12:223. PubMed
  222. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  223. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  224. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
  225. Bhattacharya D, et al. 2014. J Biol Chem. 289:16508. PubMed
  226. Dar HY, et al. 2018. Bone Rep. 8:46. PubMed
  227. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  228. Bankoti R, et al. 2017. Sci Rep. 10.1038/s41598-017-12171-3. PubMed
  229. Mara AB, et al. 2022. NPJ Vaccines. 7:86. PubMed
  230. Yong L, et al. 2022. Nat Commun. 13:4255. PubMed
  231. Zeng Q, et al. 2022. Front Immunol. 13:740805. PubMed
  232. Takeshita Y, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  233. Ouyang W, et al. 2021. Invest Ophthalmol Vis Sci. 62:25:00. PubMed
  234. Kawashima H, et al. 2013. J Immunol. 191:3614. PubMed
  235. Luck H, et al. 2015. Cell Metab. 21 527 . PubMed
  236. Castro–Dopico T, et al. 2020. Cell Reports. 32(1):107857. PubMed
  237. Wen M, et al. 2022. JCI Insight. Online ahead of print. PubMed
  238. Tan YY, et al. 2021. Exp Ther Med. 22:1368. PubMed
  239. Deerhake ME, et al. 2021. Immunity. 54(3):484-498.e8. PubMed
  240. Vaena S, et al. 2021. Cell Reports. 35(5):109076. PubMed
  241. Alhosaini K, et al. 2021. Brain Sci. :11. PubMed
  242. Chou T, et al. 2016. Nat Commun. 7:11904. PubMed
  243. Takeuchi H, et al. 2013. J Immunol. 191:3725. PubMed
  244. Park S, et al. 2011. J Immunol. 187:5813. PubMed
  245. Chatterjee S et al. 2017. Cell metabolism. 27(1):85-100 . PubMed
  246. Lin YW, et al. 2022. Mol Med Rep. 26:. PubMed
  247. Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed
  248. Van Dis E, et al. 2018. Cell Rep. 23:1435. PubMed
  249. Ramakrishnan SK, et al. 2019. Nat Commun. 10:660. PubMed
  250. Katagiri T, et al. 2019. Mucosal Immunol. 12:p1104. PubMed
  251. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  252. Kang J, Lee J, Chang J 2016. PLoS One. 11: 0157015. PubMed
  253. Gorman JA, et al. 2019. Front Immunol. 10:44. PubMed
  254. Ouyang S, et al. 2019. J Immunol. 202:1441. PubMed
  255. Sanchez M et al. 2017. Cell host & microbe. 22(4):543-551 . PubMed
  256. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  257. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  258. Ghorbani S, et al. 2022. Nat Commun. 13:2445. PubMed
  259. Derada Troletti C, et al. 2021. Cell Reports. 35(9):109201. PubMed
  260. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  261. Wu B, et al. 2021. Immunity. 54(2):308-323.e6. PubMed
  262. Mansouri S, et al. 2020. Mucosal Immunol. 0.954861111. PubMed
  263. Li X, et al. 2016. MBio. 7: 02232-15. PubMed
  264. Ehirchiou D, et al. 2007. J Exp Med . 204:1519. PubMed
  265. Kang YH, et al. 2019. Nat Commun. 10:912. PubMed
  266. Karanika S, et al. 2022. Front Immunol. 13:972266. PubMed
  267. Lai Y, et al. 2022. Clin Transl Med. 12:e999. PubMed
  268. Miura N, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.020. PubMed
  269. Mizutani N, et al. 2012. J Immunol. 188:5694. PubMed
  270. Suhail A, et al. 2019. Cell Rep. 29:3522. PubMed
  271. Tian D, et al. 2019. Nat Commun. 10:4246. PubMed
  272. Zhang Y, et al. 2021. Commun Biol. 344:4. PubMed
  273. Jeon Y, et al. 2015. PLoS One. 10: e0139845. PubMed
  274. Castro‐Dopico T et al. 2019. Immunity. 50(4):1099-1114 . PubMed
  275. Zegarra‐Ruiz DF et al. 2018. Cell host & microbe. 25(1):113-127 . PubMed
  276. Yu H, et al. 2015. PLoS One. 10: 0143001. PubMed
  277. Charlton J, et al. 2015. PLoS One. 10:119200. PubMed
  278. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  279. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  280. Yue T, et al. 2022. Cell Death Differ. 29:218. PubMed
  281. Huang LJ, et al. 2021. Immunity. 54(8):1728-1744.e7. PubMed
  282. Li J, et al. 2012. Arthritis Rheum. 64:1098. PubMed
  283. Li C, et al. 2014. J Immunol. 192:1425. PubMed
  284. Lai NY, et al. 2020. Cell. 180:33:00. PubMed
  285. Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed
  286. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  287. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  288. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  289. Jaeger N, et al. 2020. Cell Rep. 33:108331. PubMed
  290. Toriyama K, et al. 2020. Commun Biol. 0.398611111. PubMed
  291. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  292. Ge Y, et al. 2020. Mucosal Immunol. 13:34. PubMed
  293. Bing Wu et al. 2018. Immunity. 49(5):886-898 . PubMed
  294. Aggarwal N, et al. 2021. Cell Rep. 37:110170. PubMed
  295. Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
  296. Pahari S, et al. 2020. Autophagy. 1.375694444. PubMed
RRID
AB_315464 (BioLegend Cat. No. 506904)
AB_315463 (BioLegend Cat. No. 506903)

Antigen Details

Structure
Cytokine; dimer; 15 kD (Mammalian).
Bioactivity
Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells
Cell Sources
CD4+ memory T cells
Cell Targets
Fibroblasts, epithelial and endothelial cells, stromal cells
Receptors
IL-17R (CD217)
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Numasaki M, et al. 2002. Blood 101:2620.
3. Fossiez F, et al. 1996. J. Exp. Med. 183:2593.
4. Yao Z, et al. 1997. Cytokine 9:794.
5. Dong C. 2006. Nat. Rev. Immunol. 6:329.
6. Hofstetter HH, et al. 2005 Cell. Immunol. 237:123.

Gene ID
16171 View all products for this Gene ID
UniProt
View information about IL-17A on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Does the anti-mouse IL-17 antibody (clone TC11-18H10.1) recognize the A or F isoform?
Clone TC11-18H10.1 recognizes IL-17A isoform, but it also recognizes the IL-17A/F heterodimer via IL-17A binding.
Go To Top Version: 2    Revision Date: 10-16-2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

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