Loading...

Purified anti-mouse CD45 Antibody Purified anti-mouse CD45 Antibody

Pricing & Availability
Clone
30-F11 (See other available formats)
Regulatory Status
RUO
Other Names
T200, Ly-5, LCA
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
30-F11_Pure_071608.jpg
BALB/c splenocytes stained with 30-F11 purified, followed by anti-rat IgG FITC
  • 30-F11_Pure_071608.jpg
    BALB/c splenocytes stained with 30-F11 purified, followed by anti-rat IgG FITC
  • 30-F11_Pure_CD45_Antibody_2_102518
    Fresh, frozen mouse spleen was stained with purified CD45 clone 30-F11 conjugated and detected with a FITC CODEX™ oligonucleotide duplex (red). Samples were counterstained with CollagenIV Cy5 (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
Compare all formats
Cat # Size Price Quantity Check Availability Save
103101 50 µg SEK303
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103102 500 µg SEK958
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from variable splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, CyTOF® - Verified
IP, CMCD, IHC, WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone 30-F11 reacts with all isoforms and both CD45.1 and CD45.2 alloantigens of CD45.

Additional reported applications (for relevant formats) include: immunoprecipitation3, complement-dependent cytotoxicity1,5, immunohistochemistry (acetone-fixed frozen sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections)4,6, Western blotting7, and spatial biology (IBEX)10,11. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103163 and 103164).

Application References
  1. Podd BS, et al. 2006. J. Immunol. 176:6532. (FC, CMCD) PubMed
  2. Haynes NM, et al. 2007. J. Immunol. 179:5099. (FC)
  3. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IP)
  4. Simon DI, et al. 2000. J. Clin. Invest. 105:293. (IHC)
  5. Seaman WE. 1983. J. Immunol. 130:1713. (CMCD)
  6. Cornet A, et al. 2001. P. Natl. Acad. Sci. USA 98:13306. (IHC)
  7. Tsuboi S and Fukuda M. 1998. J. Biol. Chem. 273:30680. (WB) PubMed
  8. Liu F, et al. 2012. Blood. 119:3295. PubMed
  9. Pelletier AN, et al. 2012. J. Immunol. 188:5561. PubMed
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Davies M, et al. 2017. PLoS Pathogens. 13(6):e1006435. PubMed
  2. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  3. Schneider H, et al. 2017. J Neurochem. 140:170. PubMed
  4. Shafer MER, et al. 2017. Stem Cell Reports. 1.040277778. PubMed
  5. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  6. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  7. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  8. Claveria-Cabello A, et al. 2020. Cancers (Basel). 12:00. PubMed
  9. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  10. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  11. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  12. Tremblay M, et al. 2020. Elife. 9: . PubMed
  13. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  14. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  15. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  16. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  17. Park JY, et al. 2022. Cell Rep. 38:110219. PubMed
  18. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  19. Lee NK, et al. 2022. Biomedicines. 10: . PubMed
  20. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  21. Li S, et al. 2022. Nat Commun. 13:7371. PubMed
  22. Abby E, et al. 2023. Nat Genet. 55:232. PubMed
  23. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  24. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  25. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  26. Wang Y, et al. 2023. J Neuroinflammation. 20:41. PubMed
  27. García Fallit M, et al. 2023. Viruses. 15:. PubMed
  28. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  29. Rafaiee R, et al. 2023. Bioimpacts. 13:97. PubMed
  30. Blomberg E, et al. 2022. Neurooncol Adv. 4:vdac148. PubMed
  31. Murai K, et al. 2022. Nat Commun. 13:6206. PubMed
  32. Kondo H, et al. 2020. J Biol Chem. 295:1658. PubMed
  33. Fernandes V, et al. 2020. PLoS Pathog. 16:e1008464. PubMed
  34. Nguyen R, et al. 2021. Cancer Immunol Immunother. 70:721. PubMed
  35. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  36. Maestro S, et al. 2021. Viruses. 13: . PubMed
  37. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  38. Chamberlin T, et al. 2020. Cancer Research. 80(20):4465-4475. PubMed
  39. Li X, et al. 2020. Cell Rep. 31:107765. PubMed
  40. Vitiello GA, et al. 2018. Clin Cancer Res. 24:972. PubMed
  41. Rothchild AC, et al. 2019. Sci Immunol. 4:eaaw6693. PubMed
  42. Widjaja AA, et al. 2019. Gastroenterology. 157:777. PubMed
  43. Moon H et al. 2017. Cell stem cell. 21(5):665-678 . PubMed
  44. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  45. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  46. Goel S, et al. 2017. Nature. 548:471. PubMed
  47. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  48. Paulo E, et al. 2018. Sci Rep. 8:11001. PubMed
  49. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  50. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  51. Cooper STE, et al. 2022. Int J Mol Sci. 23:. PubMed
  52. Deppermann C, et al. 2020. J Exp Med. 217:. PubMed
  53. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  54. Gao H, et al. 2021. J Virol. :. PubMed
  55. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  56. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  57. Liu X, et al. 2020. Nature. . PubMed
  58. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  59. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  60. Lee S, et al. 2020. Cell Host & Microbe. 27(6):937-949. PubMed
  61. Thulasingam S, et al. 2019. Int J Mol Sci. 20. PubMed
  62. Gao J, et al. 2017. Oncol Lett. 14:2954. PubMed
  63. Starossom SC, et al. 2019. Nat Commun. 10:217. PubMed
  64. Zabaleta N, et al. 2018. Nat Commun. 9:5454. PubMed
  65. Zhu F, et al. 2019. J Immunol. 203:2644. PubMed
  66. Li Y et al. 2019. Endocrinology. 160(4):938-946 . PubMed
  67. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
  68. Schafflick D, et al. 2020. Nat Commun. 247:11. PubMed
  69. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  70. Wang G, et al. 2021. Nat Commun. 12:5733. PubMed
  71. Quintana E, et al. 2020. Cancer Res. 80:2889. PubMed
  72. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  73. Paprckova D, et al. 2022. Front Immunol. 13:1009198. PubMed
  74. Janghorban M, et al. 2022. Cancer Res. 82:885. PubMed
  75. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  76. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  77. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  78. Baraibar-Churio A, et al. 2021. Life (Basel). 11:. PubMed
  79. Nam J, et al. 2021. Front Cell Neurosci. 15:640084. PubMed
  80. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  81. Podd B, et al. 2006. J Immunol. 176:6532. PubMed
  82. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  83. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  84. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  85. Rhee S, et al. 2018. Nat Commun. 9:368. PubMed
  86. Finn J et al. 2019. Cell reports. 26(11):2942-2954 . PubMed
  87. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  88. Fiege JK, et al. 2019. PLoS Pathog. 15:e1008077. PubMed
  89. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  90. Melchor SJ, et al. 2020. Sci Rep. 10:15724. PubMed
  91. Hagan AS, et al. 2020. Development. 147:00:00. PubMed
  92. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  93. Baluk P, et al. 2020. Am J Pathol. 190:2355. PubMed
  94. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  95. Gil-Melgosa L, et al. 2021. Biomedicines. 10:. PubMed
  96. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  97. Yim AKY, et al. 2022. Nat Neurosci. 25:238. PubMed
  98. Singh PP, et al. 2021. Ocul Surf. 21:271. PubMed
  99. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  100. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  101. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  102. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  103. Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed
  104. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  105. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  106. Ito S, et al. 2020. PLoS One. 15:e0229888. PubMed
  107. Latasa M, et al. 2010. PLoS One. 5:e15690. PubMed
  108. Fu H, et al. 2020. Front Immunol. 11:595813. PubMed
  109. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  110. Bruno KA, et al. 2021. Int J Mol Sci. 22:. PubMed
  111. Crawford LB, et al. 2020. Microorganisms. 8:. PubMed
  112. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  113. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  114. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  115. Zhong L, et al. 2022. JCI Insight. 7:. PubMed
  116. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  117. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  118. Qiu X, et al. 2018. Lab Chip. 18:2776. PubMed
  119. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  120. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  121. Vu LT, et al. 2019. J Extracell Vesicles. 8:1599680. PubMed
  122. Jones KB et al. 2018. Cell stem cell. 24(1):183-192 . PubMed
  123. Murai K et al. 2018. Cell stem cell. 23(5):687-699 . PubMed
  124. Morita S et al. 2017. Cell metabolism. 25(4):883-897 . PubMed
  125. Sheppard S, et al. 2018. Front Immunol. 1.630555556. PubMed
  126. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  127. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  128. Nikolaou K, et al. 2014. EMBO J. 34:430. PubMed
  129. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  130. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  131. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  132. Hashimoto M, et al. 2021. J Neurochem. 156:834. PubMed
  133. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  134. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  135. Lopes N, et al. 2021. Nat Immunol. 22:179. PubMed
  136. Perdigoto AL, et al. 2022. JCI Insight. 7:. PubMed
  137. Ejima R, et al. 2021. Nutrients. 13:. PubMed
  138. Hu CF, et al. 2021. Front Immunol. 12:638381. PubMed
  139. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  140. Chen Q, et al. 2021. STAR Protocols. 2(1):100241. PubMed
  141. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  142. Bar O, et al. 2020. Fluids Barriers CNS. 17:27. PubMed
  143. Langer V, et al. 2019. J Clin Invest. 129:4691. PubMed
  144. Poulos MG, et al. 2017. J Clin Invest. 127:4163. PubMed
  145. Janela B, et al. 2019. Immunity. 50:1069. PubMed
  146. Baluk P, et al. 2018. Methods Mol Biol. 1846:161. PubMed
  147. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  148. Mensurado S, et al. 2018. PLoS Biol. 16:e2004990. PubMed
  149. Prizant H, et al. 2021. Cell Reports. 36:109523. PubMed
  150. Yu W, et al. 2020. J Clin Invest. . PubMed
  151. Geng T, et al. 2021. J Infect Dis. 223:2186. PubMed
  152. Ishigaki K, et al. 2021. Sci Rep. 11:13958. PubMed
  153. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  154. Somasundaram R, et al. 2021. Blood. 137:3037. PubMed
  155. Wang Z, et al. 2021. Drug Discov Ther. 14:304. PubMed
  156. Levy BD, et al. 2020. J Allergy Clin Immunol. 145:335. PubMed
  157. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  158. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  159. Chen X, et al. 2019. Methods Mol Biol. 2048:131. PubMed
  160. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  161. Moon H, et al. 2019. Nat Commun. 10:2225. PubMed
  162. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  163. Tamburini BAJ, et al. 2019. Front Immunol. 10:1036. PubMed
  164. Cha J, et al. 2015. J Biol Chem. 290:15337. PubMed
  165. Mori Y, et al. 2021. Diabetes and Vascular Disease Research. 18(3):14791641211027324. PubMed
  166. Dora D, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:1617. PubMed
  167. Fahy N, et al. 2021. Front Immunol. 12:715267. PubMed
  168. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  169. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  170. Penny HL, et al. 2021. Int J Mol Sci. 22:. PubMed
  171. Rincón E, et al. 2017. Oncotarget. 8:45415. PubMed
  172. Deng W et al. 2019. Cell reports. 27(6):1755-1768 . PubMed
  173. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  174. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  175. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  176. DeFalco T, et al. 2014. Proc Natl Acad Sci U S A. 111:2384. PubMed
  177. Li Y, et al. 2020. Elife. 9:00. PubMed
  178. Parodi B, et al. 2021. Front Immunol. 12:655212. PubMed
  179. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  180. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  181. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  182. Van Winkle JA, et al. 2020. J Virol. 94:. PubMed
  183. Maier B, et al. 2020. Nature. 580:257. PubMed
  184. Wang J, et al. 2021. Am J Cancer Res. 11:2005. PubMed
  185. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  186. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  187. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  188. Burton OT, et al. 2018. Clin Exp Allergy. 48:288. PubMed
  189. Stokes KL, et al. 2019. Oncogenesis. 8:24. PubMed
  190. Krenzlin H, et al. 2019. J Clin Invest. 130:1671. PubMed
  191. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  192. Huppé CA, et al. 2018. Mucosal Immunol. 0.536111111. PubMed
  193. Bernard S, et al. 2018. J Mammary Gland Biol Neoplasia. 23:249. PubMed
  194. Leist SR, et al. 2019. PLoS One. 14:e0220126. PubMed
  195. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  196. Kästle M, et al. 2020. Cell Commun Signal. 183:18. PubMed
  197. Hassel C, et al. 2021. Front Immunol. 12:754661. PubMed
  198. Obst J, et al. 2020. Front Immunol. 11:579000. PubMed
  199. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  200. Wilke JBH, et al. 2021. Mol Psychiatry. 26:7746. PubMed
  201. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  202. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  203. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  204. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  205. Haber AL, et al. 2017. Nature. 551:333. PubMed
  206. Emrick JJ, et al. 2018. Proc Natl Acad Sci U S A. 115:E12091. PubMed
  207. Seehus CR, et al. 2017. Nat Commun. 8:1900. PubMed
  208. Cédile O, Wlodarczyk A, and Owens T 2017. APMIS.. 10.1111/apm.12740. PubMed
  209. Davies M, et al. 2017. PLoS Pathogens. 13(6):e1006435. PubMed
  210. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  211. Schneider H, et al. 2017. J Neurochem. 140:170. PubMed
  212. Shafer MER, et al. 2017. Stem Cell Reports. 1.040277778. PubMed
  213. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  214. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  215. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  216. Claveria-Cabello A, et al. 2020. Cancers (Basel). 12:00. PubMed
  217. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  218. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  219. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  220. Tremblay M, et al. 2020. Elife. 9: . PubMed
  221. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  222. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  223. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  224. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  225. Park JY, et al. 2022. Cell Rep. 38:110219. PubMed
  226. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  227. Lee NK, et al. 2022. Biomedicines. 10: . PubMed
  228. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  229. Li S, et al. 2022. Nat Commun. 13:7371. PubMed
  230. Abby E, et al. 2023. Nat Genet. 55:232. PubMed
  231. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  232. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  233. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  234. Wang Y, et al. 2023. J Neuroinflammation. 20:41. PubMed
  235. García Fallit M, et al. 2023. Viruses. 15:. PubMed
  236. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  237. Rafaiee R, et al. 2023. Bioimpacts. 13:97. PubMed
  238. Blomberg E, et al. 2022. Neurooncol Adv. 4:vdac148. PubMed
  239. Murai K, et al. 2022. Nat Commun. 13:6206. PubMed
  240. Kondo H, et al. 2020. J Biol Chem. 295:1658. PubMed
  241. Fernandes V, et al. 2020. PLoS Pathog. 16:e1008464. PubMed
  242. Nguyen R, et al. 2021. Cancer Immunol Immunother. 70:721. PubMed
  243. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  244. Maestro S, et al. 2021. Viruses. 13: . PubMed
  245. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  246. Chamberlin T, et al. 2020. Cancer Research. 80(20):4465-4475. PubMed
  247. Li X, et al. 2020. Cell Rep. 31:107765. PubMed
  248. Vitiello GA, et al. 2018. Clin Cancer Res. 24:972. PubMed
  249. Rothchild AC, et al. 2019. Sci Immunol. 4:eaaw6693. PubMed
  250. Widjaja AA, et al. 2019. Gastroenterology. 157:777. PubMed
  251. Moon H et al. 2017. Cell stem cell. 21(5):665-678 . PubMed
  252. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  253. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  254. Goel S, et al. 2017. Nature. 548:471. PubMed
  255. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  256. Paulo E, et al. 2018. Sci Rep. 8:11001. PubMed
  257. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  258. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  259. Cooper STE, et al. 2022. Int J Mol Sci. 23:. PubMed
  260. Deppermann C, et al. 2020. J Exp Med. 217:. PubMed
  261. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  262. Gao H, et al. 2021. J Virol. :. PubMed
  263. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  264. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  265. Liu X, et al. 2020. Nature. . PubMed
  266. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  267. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  268. Lee S, et al. 2020. Cell Host & Microbe. 27(6):937-949. PubMed
  269. Thulasingam S, et al. 2019. Int J Mol Sci. 20. PubMed
  270. Gao J, et al. 2017. Oncol Lett. 14:2954. PubMed
  271. Starossom SC, et al. 2019. Nat Commun. 10:217. PubMed
  272. Zabaleta N, et al. 2018. Nat Commun. 9:5454. PubMed
  273. Zhu F, et al. 2019. J Immunol. 203:2644. PubMed
  274. Li Y et al. 2019. Endocrinology. 160(4):938-946 . PubMed
  275. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
  276. Schafflick D, et al. 2020. Nat Commun. 247:11. PubMed
  277. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  278. Wang G, et al. 2021. Nat Commun. 12:5733. PubMed
  279. Quintana E, et al. 2020. Cancer Res. 80:2889. PubMed
  280. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  281. Paprckova D, et al. 2022. Front Immunol. 13:1009198. PubMed
  282. Janghorban M, et al. 2022. Cancer Res. 82:885. PubMed
  283. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  284. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  285. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  286. Baraibar-Churio A, et al. 2021. Life (Basel). 11:. PubMed
  287. Nam J, et al. 2021. Front Cell Neurosci. 15:640084. PubMed
  288. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  289. Podd B, et al. 2006. J Immunol. 176:6532. PubMed
  290. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  291. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  292. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  293. Rhee S, et al. 2018. Nat Commun. 9:368. PubMed
  294. Finn J et al. 2019. Cell reports. 26(11):2942-2954 . PubMed
  295. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  296. Fiege JK, et al. 2019. PLoS Pathog. 15:e1008077. PubMed
  297. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  298. Melchor SJ, et al. 2020. Sci Rep. 10:15724. PubMed
  299. Hagan AS, et al. 2020. Development. 147:00:00. PubMed
  300. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  301. Baluk P, et al. 2020. Am J Pathol. 190:2355. PubMed
  302. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  303. Gil-Melgosa L, et al. 2021. Biomedicines. 10:. PubMed
  304. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  305. Yim AKY, et al. 2022. Nat Neurosci. 25:238. PubMed
  306. Singh PP, et al. 2021. Ocul Surf. 21:271. PubMed
  307. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  308. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  309. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  310. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  311. Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed
  312. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  313. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  314. Ito S, et al. 2020. PLoS One. 15:e0229888. PubMed
  315. Latasa M, et al. 2010. PLoS One. 5:e15690. PubMed
  316. Fu H, et al. 2020. Front Immunol. 11:595813. PubMed
  317. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  318. Bruno KA, et al. 2021. Int J Mol Sci. 22:. PubMed
  319. Crawford LB, et al. 2020. Microorganisms. 8:. PubMed
  320. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  321. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  322. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  323. Zhong L, et al. 2022. JCI Insight. 7:. PubMed
  324. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  325. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  326. Qiu X, et al. 2018. Lab Chip. 18:2776. PubMed
  327. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  328. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  329. Vu LT, et al. 2019. J Extracell Vesicles. 8:1599680. PubMed
  330. Jones KB et al. 2018. Cell stem cell. 24(1):183-192 . PubMed
  331. Murai K et al. 2018. Cell stem cell. 23(5):687-699 . PubMed
  332. Morita S et al. 2017. Cell metabolism. 25(4):883-897 . PubMed
  333. Sheppard S, et al. 2018. Front Immunol. 1.630555556. PubMed
  334. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  335. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  336. Nikolaou K, et al. 2014. EMBO J. 34:430. PubMed
  337. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  338. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  339. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  340. Hashimoto M, et al. 2021. J Neurochem. 156:834. PubMed
  341. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  342. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  343. Lopes N, et al. 2021. Nat Immunol. 22:179. PubMed
  344. Perdigoto AL, et al. 2022. JCI Insight. 7:. PubMed
  345. Ejima R, et al. 2021. Nutrients. 13:. PubMed
  346. Hu CF, et al. 2021. Front Immunol. 12:638381. PubMed
  347. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  348. Chen Q, et al. 2021. STAR Protocols. 2(1):100241. PubMed
  349. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  350. Bar O, et al. 2020. Fluids Barriers CNS. 17:27. PubMed
  351. Langer V, et al. 2019. J Clin Invest. 129:4691. PubMed
  352. Poulos MG, et al. 2017. J Clin Invest. 127:4163. PubMed
  353. Janela B, et al. 2019. Immunity. 50:1069. PubMed
  354. Baluk P, et al. 2018. Methods Mol Biol. 1846:161. PubMed
  355. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  356. Mensurado S, et al. 2018. PLoS Biol. 16:e2004990. PubMed
  357. Prizant H, et al. 2021. Cell Reports. 36:109523. PubMed
  358. Yu W, et al. 2020. J Clin Invest. . PubMed
  359. Geng T, et al. 2021. J Infect Dis. 223:2186. PubMed
  360. Ishigaki K, et al. 2021. Sci Rep. 11:13958. PubMed
  361. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  362. Somasundaram R, et al. 2021. Blood. 137:3037. PubMed
  363. Wang Z, et al. 2021. Drug Discov Ther. 14:304. PubMed
  364. Levy BD, et al. 2020. J Allergy Clin Immunol. 145:335. PubMed
  365. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  366. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  367. Chen X, et al. 2019. Methods Mol Biol. 2048:131. PubMed
  368. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  369. Moon H, et al. 2019. Nat Commun. 10:2225. PubMed
  370. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  371. Tamburini BAJ, et al. 2019. Front Immunol. 10:1036. PubMed
  372. Cha J, et al. 2015. J Biol Chem. 290:15337. PubMed
  373. Mori Y, et al. 2021. Diabetes and Vascular Disease Research. 18(3):14791641211027324. PubMed
  374. Dora D, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:1617. PubMed
  375. Fahy N, et al. 2021. Front Immunol. 12:715267. PubMed
  376. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  377. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  378. Penny HL, et al. 2021. Int J Mol Sci. 22:. PubMed
  379. Rincón E, et al. 2017. Oncotarget. 8:45415. PubMed
  380. Deng W et al. 2019. Cell reports. 27(6):1755-1768 . PubMed
  381. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  382. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  383. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  384. DeFalco T, et al. 2014. Proc Natl Acad Sci U S A. 111:2384. PubMed
  385. Li Y, et al. 2020. Elife. 9:00. PubMed
  386. Parodi B, et al. 2021. Front Immunol. 12:655212. PubMed
  387. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  388. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  389. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  390. Van Winkle JA, et al. 2020. J Virol. 94:. PubMed
  391. Maier B, et al. 2020. Nature. 580:257. PubMed
  392. Wang J, et al. 2021. Am J Cancer Res. 11:2005. PubMed
  393. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  394. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  395. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  396. Burton OT, et al. 2018. Clin Exp Allergy. 48:288. PubMed
  397. Stokes KL, et al. 2019. Oncogenesis. 8:24. PubMed
  398. Krenzlin H, et al. 2019. J Clin Invest. 130:1671. PubMed
  399. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  400. Huppé CA, et al. 2018. Mucosal Immunol. 0.536111111. PubMed
  401. Bernard S, et al. 2018. J Mammary Gland Biol Neoplasia. 23:249. PubMed
  402. Leist SR, et al. 2019. PLoS One. 14:e0220126. PubMed
  403. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  404. Kästle M, et al. 2020. Cell Commun Signal. 183:18. PubMed
  405. Hassel C, et al. 2021. Front Immunol. 12:754661. PubMed
  406. Obst J, et al. 2020. Front Immunol. 11:579000. PubMed
  407. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  408. Wilke JBH, et al. 2021. Mol Psychiatry. 26:7746. PubMed
  409. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  410. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  411. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  412. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  413. Haber AL, et al. 2017. Nature. 551:333. PubMed
  414. Emrick JJ, et al. 2018. Proc Natl Acad Sci U S A. 115:E12091. PubMed
  415. Seehus CR, et al. 2017. Nat Commun. 8:1900. PubMed
  416. Cédile O, Wlodarczyk A, and Owens T 2017. APMIS.. 10.1111/apm.12740. PubMed
RRID
AB_312966 (BioLegend Cat. No. 103101)
AB_312967 (BioLegend Cat. No. 103102)

Antigen Details

Structure
Protein tyrosine phosphatase (PTP) family, 180-240 kD
Distribution

All hematopoietic cells except mature erythrocytes and platelets

Function
Phosphatase, T and B cell activation
Ligand/Receptor
Galectin-1, CD2, CD3, CD4, TCR, CD22, Thy-1
Cell Type
B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Trowbridge IS, et al. 1993. Annu. Rev. Immunol. 12:85.
3. Kishihara K, et al. 1993. Cell 74:143.
4. Pulido R, et al. 1988. J. Immunol. 140:3851.

Gene ID
19264 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD45 Reagents Request Custom Conjugation
Description Clone Applications
PE anti-mouse CD45 30-F11 FC
PE/Cyanine5 anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 30-F11 FC,IHC-F,CyTOF®,IP,CMCD,IHC,WB
PE/Cyanine7 anti-mouse CD45 30-F11 FC
PE/Dazzle™ 594 anti-mouse CD45 30-F11 FC
Brilliant Violet 711™ anti-mouse CD45 30-F11 FC
Brilliant Violet 785™ anti-mouse CD45 30-F11 FC
Brilliant Violet 650™ anti-mouse CD45 30-F11 FC
APC/Fire™ 750 anti-mouse CD45 30-F11 FC
Brilliant Violet 750™ anti-mouse CD45 30-F11 FC
TotalSeq™-A0096 anti-mouse CD45 30-F11 PG
TotalSeq™-B0096 anti-mouse CD45 30-F11 PG
Ultra-LEAF™ Purified anti-mouse CD45 30-F11 FC,CyTOF®,IP,CMCD,IHC,WB
Spark Blue™ 550 anti-mouse CD45 30-F11 FC
Spark NIR™ 685 anti-mouse CD45 30-F11 FC
TotalSeq™-C0096 anti-mouse CD45 30-F11 PG
Spark YG™ 570 anti-mouse CD45 30-F11 IHC-F
PE/Fire™ 640 anti-mouse CD45 30-F11 FC
APC/Fire™ 810 anti-mouse CD45 30-F11 FC
PE/Fire™ 700 anti-mouse CD45 30-F11 FC
APC anti-mouse CD45 30-F11 FC
Biotin anti-mouse CD45 30-F11 FC
FITC anti-mouse CD45 30-F11 FC
APC/Cyanine7 anti-mouse CD45 30-F11 FC
Alexa Fluor® 488 anti-mouse CD45 30-F11 FC,SB
Alexa Fluor® 647 anti-mouse CD45 30-F11 FC,ICC,IHC,3D IHC,SB
Pacific Blue™ anti-mouse CD45 30-F11 FC
Alexa Fluor® 700 anti-mouse CD45 30-F11 FC,SB
PerCP/Cyanine5.5 anti-mouse CD45 30-F11 FC
PerCP anti-mouse CD45 30-F11 FC
Alexa Fluor® 594 anti-mouse CD45 30-F11 IHC-F,FC,3D IHC
Brilliant Violet 421™ anti-mouse CD45 30-F11 FC,SB
Brilliant Violet 570™ anti-mouse CD45 30-F11 FC
Brilliant Violet 510™ anti-mouse CD45 30-F11 FC
Brilliant Violet 605™ anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 (Maxpar® Ready) 30-F11 FC,CyTOF®
Spark Violet™ 538 anti-mouse CD45 30-F11 FC
Spark YG™ 593 anti-mouse CD45 30-F11 FC
Spark Blue™ 574 anti-mouse CD45 Antibody 30-F11 FC
Spark Blue™ 515 anti-mouse CD45 30-F11 FC
Spark UV™ 387 anti-mouse CD45 30-F11 FC
PE/Fire™ 810 anti-mouse CD45 30-F11 FC
Spark PLUS UV395™ anti-mouse CD45 30-F11 FC
Spark Red™ 718 anti-mouse CD45 30-F11 FC
Spark YG™ 581 anti-mouse CD45 (Flexi-Fluor™) 30-F11 FC
Spark PLUS V475™ anti-mouse CD45 Antibody 30-F11 FC
StarBright UltraViolet 740 anti-mouse CD45 30-F11 FC
Go To Top Version: 3    Revision Date: 10-25-2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
30-F11 (See other available formats)
Regulatory Status
RUO
Other Names
T200, Ly-5, LCA
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
30-F11_Pure_071608.jpg
BALB/c splenocytes stained with 30-F11 purified, followed by anti-rat IgG FITC
  • 30-F11_Pure_071608.jpg
    BALB/c splenocytes stained with 30-F11 purified, followed by anti-rat IgG FITC
  • 30-F11_Pure_CD45_Antibody_2_102518
    Fresh, frozen mouse spleen was stained with purified CD45 clone 30-F11 conjugated and detected with a FITC CODEX™ oligonucleotide duplex (red). Samples were counterstained with CollagenIV Cy5 (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
Compare all formats
Cat # Size Price Quantity Check Availability Save
103101 50 µg SEK303
Check Availability


Need larger quantities of this item?
Request Bulk Quote
103102 500 µg SEK958
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from variable splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse thymus or spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, CyTOF® - Verified
IP, CMCD, IHC, WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone 30-F11 reacts with all isoforms and both CD45.1 and CD45.2 alloantigens of CD45.

Additional reported applications (for relevant formats) include: immunoprecipitation3, complement-dependent cytotoxicity1,5, immunohistochemistry (acetone-fixed frozen sections, zinc-fixed paraffin-embedded sections and formalin-fixed paraffin-embedded sections)4,6, Western blotting7, and spatial biology (IBEX)10,11. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 103163 and 103164).

Application References
  1. Podd BS, et al. 2006. J. Immunol. 176:6532. (FC, CMCD) PubMed
  2. Haynes NM, et al. 2007. J. Immunol. 179:5099. (FC)
  3. Ledbetter JA, et al. 1979. Immunol. Rev. 47:63. (IP)
  4. Simon DI, et al. 2000. J. Clin. Invest. 105:293. (IHC)
  5. Seaman WE. 1983. J. Immunol. 130:1713. (CMCD)
  6. Cornet A, et al. 2001. P. Natl. Acad. Sci. USA 98:13306. (IHC)
  7. Tsuboi S and Fukuda M. 1998. J. Biol. Chem. 273:30680. (WB) PubMed
  8. Liu F, et al. 2012. Blood. 119:3295. PubMed
  9. Pelletier AN, et al. 2012. J. Immunol. 188:5561. PubMed
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Davies M, et al. 2017. PLoS Pathogens. 13(6):e1006435. PubMed
  2. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  3. Schneider H, et al. 2017. J Neurochem. 140:170. PubMed
  4. Shafer MER, et al. 2017. Stem Cell Reports. 1.040277778. PubMed
  5. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  6. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  7. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  8. Claveria-Cabello A, et al. 2020. Cancers (Basel). 12:00. PubMed
  9. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  10. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  11. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  12. Tremblay M, et al. 2020. Elife. 9: . PubMed
  13. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  14. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  15. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  16. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  17. Park JY, et al. 2022. Cell Rep. 38:110219. PubMed
  18. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  19. Lee NK, et al. 2022. Biomedicines. 10: . PubMed
  20. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  21. Li S, et al. 2022. Nat Commun. 13:7371. PubMed
  22. Abby E, et al. 2023. Nat Genet. 55:232. PubMed
  23. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  24. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  25. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  26. Wang Y, et al. 2023. J Neuroinflammation. 20:41. PubMed
  27. García Fallit M, et al. 2023. Viruses. 15:. PubMed
  28. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  29. Rafaiee R, et al. 2023. Bioimpacts. 13:97. PubMed
  30. Blomberg E, et al. 2022. Neurooncol Adv. 4:vdac148. PubMed
  31. Murai K, et al. 2022. Nat Commun. 13:6206. PubMed
  32. Kondo H, et al. 2020. J Biol Chem. 295:1658. PubMed
  33. Fernandes V, et al. 2020. PLoS Pathog. 16:e1008464. PubMed
  34. Nguyen R, et al. 2021. Cancer Immunol Immunother. 70:721. PubMed
  35. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  36. Maestro S, et al. 2021. Viruses. 13: . PubMed
  37. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  38. Chamberlin T, et al. 2020. Cancer Research. 80(20):4465-4475. PubMed
  39. Li X, et al. 2020. Cell Rep. 31:107765. PubMed
  40. Vitiello GA, et al. 2018. Clin Cancer Res. 24:972. PubMed
  41. Rothchild AC, et al. 2019. Sci Immunol. 4:eaaw6693. PubMed
  42. Widjaja AA, et al. 2019. Gastroenterology. 157:777. PubMed
  43. Moon H et al. 2017. Cell stem cell. 21(5):665-678 . PubMed
  44. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  45. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  46. Goel S, et al. 2017. Nature. 548:471. PubMed
  47. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  48. Paulo E, et al. 2018. Sci Rep. 8:11001. PubMed
  49. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  50. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  51. Cooper STE, et al. 2022. Int J Mol Sci. 23:. PubMed
  52. Deppermann C, et al. 2020. J Exp Med. 217:. PubMed
  53. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  54. Gao H, et al. 2021. J Virol. :. PubMed
  55. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  56. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  57. Liu X, et al. 2020. Nature. . PubMed
  58. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  59. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  60. Lee S, et al. 2020. Cell Host & Microbe. 27(6):937-949. PubMed
  61. Thulasingam S, et al. 2019. Int J Mol Sci. 20. PubMed
  62. Gao J, et al. 2017. Oncol Lett. 14:2954. PubMed
  63. Starossom SC, et al. 2019. Nat Commun. 10:217. PubMed
  64. Zabaleta N, et al. 2018. Nat Commun. 9:5454. PubMed
  65. Zhu F, et al. 2019. J Immunol. 203:2644. PubMed
  66. Li Y et al. 2019. Endocrinology. 160(4):938-946 . PubMed
  67. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
  68. Schafflick D, et al. 2020. Nat Commun. 247:11. PubMed
  69. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  70. Wang G, et al. 2021. Nat Commun. 12:5733. PubMed
  71. Quintana E, et al. 2020. Cancer Res. 80:2889. PubMed
  72. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  73. Paprckova D, et al. 2022. Front Immunol. 13:1009198. PubMed
  74. Janghorban M, et al. 2022. Cancer Res. 82:885. PubMed
  75. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  76. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  77. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  78. Baraibar-Churio A, et al. 2021. Life (Basel). 11:. PubMed
  79. Nam J, et al. 2021. Front Cell Neurosci. 15:640084. PubMed
  80. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  81. Podd B, et al. 2006. J Immunol. 176:6532. PubMed
  82. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  83. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  84. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  85. Rhee S, et al. 2018. Nat Commun. 9:368. PubMed
  86. Finn J et al. 2019. Cell reports. 26(11):2942-2954 . PubMed
  87. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  88. Fiege JK, et al. 2019. PLoS Pathog. 15:e1008077. PubMed
  89. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  90. Melchor SJ, et al. 2020. Sci Rep. 10:15724. PubMed
  91. Hagan AS, et al. 2020. Development. 147:00:00. PubMed
  92. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  93. Baluk P, et al. 2020. Am J Pathol. 190:2355. PubMed
  94. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  95. Gil-Melgosa L, et al. 2021. Biomedicines. 10:. PubMed
  96. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  97. Yim AKY, et al. 2022. Nat Neurosci. 25:238. PubMed
  98. Singh PP, et al. 2021. Ocul Surf. 21:271. PubMed
  99. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  100. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  101. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  102. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  103. Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed
  104. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  105. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  106. Ito S, et al. 2020. PLoS One. 15:e0229888. PubMed
  107. Latasa M, et al. 2010. PLoS One. 5:e15690. PubMed
  108. Fu H, et al. 2020. Front Immunol. 11:595813. PubMed
  109. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  110. Bruno KA, et al. 2021. Int J Mol Sci. 22:. PubMed
  111. Crawford LB, et al. 2020. Microorganisms. 8:. PubMed
  112. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  113. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  114. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  115. Zhong L, et al. 2022. JCI Insight. 7:. PubMed
  116. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  117. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  118. Qiu X, et al. 2018. Lab Chip. 18:2776. PubMed
  119. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  120. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  121. Vu LT, et al. 2019. J Extracell Vesicles. 8:1599680. PubMed
  122. Jones KB et al. 2018. Cell stem cell. 24(1):183-192 . PubMed
  123. Murai K et al. 2018. Cell stem cell. 23(5):687-699 . PubMed
  124. Morita S et al. 2017. Cell metabolism. 25(4):883-897 . PubMed
  125. Sheppard S, et al. 2018. Front Immunol. 1.630555556. PubMed
  126. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  127. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  128. Nikolaou K, et al. 2014. EMBO J. 34:430. PubMed
  129. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  130. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  131. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  132. Hashimoto M, et al. 2021. J Neurochem. 156:834. PubMed
  133. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  134. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  135. Lopes N, et al. 2021. Nat Immunol. 22:179. PubMed
  136. Perdigoto AL, et al. 2022. JCI Insight. 7:. PubMed
  137. Ejima R, et al. 2021. Nutrients. 13:. PubMed
  138. Hu CF, et al. 2021. Front Immunol. 12:638381. PubMed
  139. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  140. Chen Q, et al. 2021. STAR Protocols. 2(1):100241. PubMed
  141. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  142. Bar O, et al. 2020. Fluids Barriers CNS. 17:27. PubMed
  143. Langer V, et al. 2019. J Clin Invest. 129:4691. PubMed
  144. Poulos MG, et al. 2017. J Clin Invest. 127:4163. PubMed
  145. Janela B, et al. 2019. Immunity. 50:1069. PubMed
  146. Baluk P, et al. 2018. Methods Mol Biol. 1846:161. PubMed
  147. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  148. Mensurado S, et al. 2018. PLoS Biol. 16:e2004990. PubMed
  149. Prizant H, et al. 2021. Cell Reports. 36:109523. PubMed
  150. Yu W, et al. 2020. J Clin Invest. . PubMed
  151. Geng T, et al. 2021. J Infect Dis. 223:2186. PubMed
  152. Ishigaki K, et al. 2021. Sci Rep. 11:13958. PubMed
  153. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  154. Somasundaram R, et al. 2021. Blood. 137:3037. PubMed
  155. Wang Z, et al. 2021. Drug Discov Ther. 14:304. PubMed
  156. Levy BD, et al. 2020. J Allergy Clin Immunol. 145:335. PubMed
  157. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  158. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  159. Chen X, et al. 2019. Methods Mol Biol. 2048:131. PubMed
  160. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  161. Moon H, et al. 2019. Nat Commun. 10:2225. PubMed
  162. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  163. Tamburini BAJ, et al. 2019. Front Immunol. 10:1036. PubMed
  164. Cha J, et al. 2015. J Biol Chem. 290:15337. PubMed
  165. Mori Y, et al. 2021. Diabetes and Vascular Disease Research. 18(3):14791641211027324. PubMed
  166. Dora D, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:1617. PubMed
  167. Fahy N, et al. 2021. Front Immunol. 12:715267. PubMed
  168. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  169. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  170. Penny HL, et al. 2021. Int J Mol Sci. 22:. PubMed
  171. Rincón E, et al. 2017. Oncotarget. 8:45415. PubMed
  172. Deng W et al. 2019. Cell reports. 27(6):1755-1768 . PubMed
  173. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  174. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  175. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  176. DeFalco T, et al. 2014. Proc Natl Acad Sci U S A. 111:2384. PubMed
  177. Li Y, et al. 2020. Elife. 9:00. PubMed
  178. Parodi B, et al. 2021. Front Immunol. 12:655212. PubMed
  179. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  180. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  181. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  182. Van Winkle JA, et al. 2020. J Virol. 94:. PubMed
  183. Maier B, et al. 2020. Nature. 580:257. PubMed
  184. Wang J, et al. 2021. Am J Cancer Res. 11:2005. PubMed
  185. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  186. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  187. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  188. Burton OT, et al. 2018. Clin Exp Allergy. 48:288. PubMed
  189. Stokes KL, et al. 2019. Oncogenesis. 8:24. PubMed
  190. Krenzlin H, et al. 2019. J Clin Invest. 130:1671. PubMed
  191. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  192. Huppé CA, et al. 2018. Mucosal Immunol. 0.536111111. PubMed
  193. Bernard S, et al. 2018. J Mammary Gland Biol Neoplasia. 23:249. PubMed
  194. Leist SR, et al. 2019. PLoS One. 14:e0220126. PubMed
  195. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  196. Kästle M, et al. 2020. Cell Commun Signal. 183:18. PubMed
  197. Hassel C, et al. 2021. Front Immunol. 12:754661. PubMed
  198. Obst J, et al. 2020. Front Immunol. 11:579000. PubMed
  199. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  200. Wilke JBH, et al. 2021. Mol Psychiatry. 26:7746. PubMed
  201. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  202. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  203. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  204. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  205. Haber AL, et al. 2017. Nature. 551:333. PubMed
  206. Emrick JJ, et al. 2018. Proc Natl Acad Sci U S A. 115:E12091. PubMed
  207. Seehus CR, et al. 2017. Nat Commun. 8:1900. PubMed
  208. Cédile O, Wlodarczyk A, and Owens T 2017. APMIS.. 10.1111/apm.12740. PubMed
  209. Davies M, et al. 2017. PLoS Pathogens. 13(6):e1006435. PubMed
  210. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  211. Schneider H, et al. 2017. J Neurochem. 140:170. PubMed
  212. Shafer MER, et al. 2017. Stem Cell Reports. 1.040277778. PubMed
  213. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  214. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  215. Hernández-Santana YE, et al. 2020. Life Sci Alliance. 3:00. PubMed
  216. Claveria-Cabello A, et al. 2020. Cancers (Basel). 12:00. PubMed
  217. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  218. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  219. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  220. Tremblay M, et al. 2020. Elife. 9: . PubMed
  221. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  222. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  223. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  224. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  225. Park JY, et al. 2022. Cell Rep. 38:110219. PubMed
  226. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  227. Lee NK, et al. 2022. Biomedicines. 10: . PubMed
  228. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  229. Li S, et al. 2022. Nat Commun. 13:7371. PubMed
  230. Abby E, et al. 2023. Nat Genet. 55:232. PubMed
  231. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  232. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  233. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  234. Wang Y, et al. 2023. J Neuroinflammation. 20:41. PubMed
  235. García Fallit M, et al. 2023. Viruses. 15:. PubMed
  236. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  237. Rafaiee R, et al. 2023. Bioimpacts. 13:97. PubMed
  238. Blomberg E, et al. 2022. Neurooncol Adv. 4:vdac148. PubMed
  239. Murai K, et al. 2022. Nat Commun. 13:6206. PubMed
  240. Kondo H, et al. 2020. J Biol Chem. 295:1658. PubMed
  241. Fernandes V, et al. 2020. PLoS Pathog. 16:e1008464. PubMed
  242. Nguyen R, et al. 2021. Cancer Immunol Immunother. 70:721. PubMed
  243. Wan Mohd Zawawi WFA, et al. 2021. Sci Rep. 11:10278. PubMed
  244. Maestro S, et al. 2021. Viruses. 13: . PubMed
  245. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  246. Chamberlin T, et al. 2020. Cancer Research. 80(20):4465-4475. PubMed
  247. Li X, et al. 2020. Cell Rep. 31:107765. PubMed
  248. Vitiello GA, et al. 2018. Clin Cancer Res. 24:972. PubMed
  249. Rothchild AC, et al. 2019. Sci Immunol. 4:eaaw6693. PubMed
  250. Widjaja AA, et al. 2019. Gastroenterology. 157:777. PubMed
  251. Moon H et al. 2017. Cell stem cell. 21(5):665-678 . PubMed
  252. Rieck M, et al. 2017. Eur J Immunol. 47:677. PubMed
  253. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  254. Goel S, et al. 2017. Nature. 548:471. PubMed
  255. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  256. Paulo E, et al. 2018. Sci Rep. 8:11001. PubMed
  257. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  258. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  259. Cooper STE, et al. 2022. Int J Mol Sci. 23:. PubMed
  260. Deppermann C, et al. 2020. J Exp Med. 217:. PubMed
  261. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  262. Gao H, et al. 2021. J Virol. :. PubMed
  263. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  264. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  265. Liu X, et al. 2020. Nature. . PubMed
  266. Altshuler A, et al. 2021. Cell Stem Cell. 28(7):1248-1261.e8. PubMed
  267. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  268. Lee S, et al. 2020. Cell Host & Microbe. 27(6):937-949. PubMed
  269. Thulasingam S, et al. 2019. Int J Mol Sci. 20. PubMed
  270. Gao J, et al. 2017. Oncol Lett. 14:2954. PubMed
  271. Starossom SC, et al. 2019. Nat Commun. 10:217. PubMed
  272. Zabaleta N, et al. 2018. Nat Commun. 9:5454. PubMed
  273. Zhu F, et al. 2019. J Immunol. 203:2644. PubMed
  274. Li Y et al. 2019. Endocrinology. 160(4):938-946 . PubMed
  275. Murad JP, et al. 2018. Front Immunol. 1.95. PubMed
  276. Schafflick D, et al. 2020. Nat Commun. 247:11. PubMed
  277. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  278. Wang G, et al. 2021. Nat Commun. 12:5733. PubMed
  279. Quintana E, et al. 2020. Cancer Res. 80:2889. PubMed
  280. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  281. Paprckova D, et al. 2022. Front Immunol. 13:1009198. PubMed
  282. Janghorban M, et al. 2022. Cancer Res. 82:885. PubMed
  283. Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed
  284. Mayer KA, et al. 2021. FASEB J. 35:e21217. PubMed
  285. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  286. Baraibar-Churio A, et al. 2021. Life (Basel). 11:. PubMed
  287. Nam J, et al. 2021. Front Cell Neurosci. 15:640084. PubMed
  288. Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed
  289. Podd B, et al. 2006. J Immunol. 176:6532. PubMed
  290. Hitchcock JR, et al. 2020. FEBS J. 287:250. PubMed
  291. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  292. Sutton C, et al. 2017. Nat Commun.. 10.1038/s41467-017-02111-0. PubMed
  293. Rhee S, et al. 2018. Nat Commun. 9:368. PubMed
  294. Finn J et al. 2019. Cell reports. 26(11):2942-2954 . PubMed
  295. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  296. Fiege JK, et al. 2019. PLoS Pathog. 15:e1008077. PubMed
  297. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  298. Melchor SJ, et al. 2020. Sci Rep. 10:15724. PubMed
  299. Hagan AS, et al. 2020. Development. 147:00:00. PubMed
  300. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  301. Baluk P, et al. 2020. Am J Pathol. 190:2355. PubMed
  302. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  303. Gil-Melgosa L, et al. 2021. Biomedicines. 10:. PubMed
  304. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  305. Yim AKY, et al. 2022. Nat Neurosci. 25:238. PubMed
  306. Singh PP, et al. 2021. Ocul Surf. 21:271. PubMed
  307. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  308. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  309. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  310. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  311. Yoshihara S, et al. 2019. Front Immunol. 0.545833333. PubMed
  312. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  313. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  314. Ito S, et al. 2020. PLoS One. 15:e0229888. PubMed
  315. Latasa M, et al. 2010. PLoS One. 5:e15690. PubMed
  316. Fu H, et al. 2020. Front Immunol. 11:595813. PubMed
  317. Progatzky F, et al. 2021. Nature. 599:125. PubMed
  318. Bruno KA, et al. 2021. Int J Mol Sci. 22:. PubMed
  319. Crawford LB, et al. 2020. Microorganisms. 8:. PubMed
  320. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  321. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  322. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  323. Zhong L, et al. 2022. JCI Insight. 7:. PubMed
  324. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  325. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  326. Qiu X, et al. 2018. Lab Chip. 18:2776. PubMed
  327. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  328. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  329. Vu LT, et al. 2019. J Extracell Vesicles. 8:1599680. PubMed
  330. Jones KB et al. 2018. Cell stem cell. 24(1):183-192 . PubMed
  331. Murai K et al. 2018. Cell stem cell. 23(5):687-699 . PubMed
  332. Morita S et al. 2017. Cell metabolism. 25(4):883-897 . PubMed
  333. Sheppard S, et al. 2018. Front Immunol. 1.630555556. PubMed
  334. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  335. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  336. Nikolaou K, et al. 2014. EMBO J. 34:430. PubMed
  337. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  338. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  339. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  340. Hashimoto M, et al. 2021. J Neurochem. 156:834. PubMed
  341. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  342. Scur M, et al. 2022. Nat Commun. 13:7272. PubMed
  343. Lopes N, et al. 2021. Nat Immunol. 22:179. PubMed
  344. Perdigoto AL, et al. 2022. JCI Insight. 7:. PubMed
  345. Ejima R, et al. 2021. Nutrients. 13:. PubMed
  346. Hu CF, et al. 2021. Front Immunol. 12:638381. PubMed
  347. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  348. Chen Q, et al. 2021. STAR Protocols. 2(1):100241. PubMed
  349. Matsuo K, et al. 2018. J Invest Dermatol. 138:1764. PubMed
  350. Bar O, et al. 2020. Fluids Barriers CNS. 17:27. PubMed
  351. Langer V, et al. 2019. J Clin Invest. 129:4691. PubMed
  352. Poulos MG, et al. 2017. J Clin Invest. 127:4163. PubMed
  353. Janela B, et al. 2019. Immunity. 50:1069. PubMed
  354. Baluk P, et al. 2018. Methods Mol Biol. 1846:161. PubMed
  355. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  356. Mensurado S, et al. 2018. PLoS Biol. 16:e2004990. PubMed
  357. Prizant H, et al. 2021. Cell Reports. 36:109523. PubMed
  358. Yu W, et al. 2020. J Clin Invest. . PubMed
  359. Geng T, et al. 2021. J Infect Dis. 223:2186. PubMed
  360. Ishigaki K, et al. 2021. Sci Rep. 11:13958. PubMed
  361. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  362. Somasundaram R, et al. 2021. Blood. 137:3037. PubMed
  363. Wang Z, et al. 2021. Drug Discov Ther. 14:304. PubMed
  364. Levy BD, et al. 2020. J Allergy Clin Immunol. 145:335. PubMed
  365. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  366. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  367. Chen X, et al. 2019. Methods Mol Biol. 2048:131. PubMed
  368. Nagatake T, et al. 2018. J Allergy Clin Immunol. 142:470. PubMed
  369. Moon H, et al. 2019. Nat Commun. 10:2225. PubMed
  370. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  371. Tamburini BAJ, et al. 2019. Front Immunol. 10:1036. PubMed
  372. Cha J, et al. 2015. J Biol Chem. 290:15337. PubMed
  373. Mori Y, et al. 2021. Diabetes and Vascular Disease Research. 18(3):14791641211027324. PubMed
  374. Dora D, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:1617. PubMed
  375. Fahy N, et al. 2021. Front Immunol. 12:715267. PubMed
  376. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  377. Van Der Zande HJP, et al. 2021. FASEB J. 35:e21331. PubMed
  378. Penny HL, et al. 2021. Int J Mol Sci. 22:. PubMed
  379. Rincón E, et al. 2017. Oncotarget. 8:45415. PubMed
  380. Deng W et al. 2019. Cell reports. 27(6):1755-1768 . PubMed
  381. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  382. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  383. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  384. DeFalco T, et al. 2014. Proc Natl Acad Sci U S A. 111:2384. PubMed
  385. Li Y, et al. 2020. Elife. 9:00. PubMed
  386. Parodi B, et al. 2021. Front Immunol. 12:655212. PubMed
  387. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  388. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  389. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  390. Van Winkle JA, et al. 2020. J Virol. 94:. PubMed
  391. Maier B, et al. 2020. Nature. 580:257. PubMed
  392. Wang J, et al. 2021. Am J Cancer Res. 11:2005. PubMed
  393. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  394. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  395. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  396. Burton OT, et al. 2018. Clin Exp Allergy. 48:288. PubMed
  397. Stokes KL, et al. 2019. Oncogenesis. 8:24. PubMed
  398. Krenzlin H, et al. 2019. J Clin Invest. 130:1671. PubMed
  399. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  400. Huppé CA, et al. 2018. Mucosal Immunol. 0.536111111. PubMed
  401. Bernard S, et al. 2018. J Mammary Gland Biol Neoplasia. 23:249. PubMed
  402. Leist SR, et al. 2019. PLoS One. 14:e0220126. PubMed
  403. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  404. Kästle M, et al. 2020. Cell Commun Signal. 183:18. PubMed
  405. Hassel C, et al. 2021. Front Immunol. 12:754661. PubMed
  406. Obst J, et al. 2020. Front Immunol. 11:579000. PubMed
  407. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  408. Wilke JBH, et al. 2021. Mol Psychiatry. 26:7746. PubMed
  409. Umeda M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  410. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  411. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  412. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  413. Haber AL, et al. 2017. Nature. 551:333. PubMed
  414. Emrick JJ, et al. 2018. Proc Natl Acad Sci U S A. 115:E12091. PubMed
  415. Seehus CR, et al. 2017. Nat Commun. 8:1900. PubMed
  416. Cédile O, Wlodarczyk A, and Owens T 2017. APMIS.. 10.1111/apm.12740. PubMed
RRID
AB_312966 (BioLegend Cat. No. 103101)
AB_312967 (BioLegend Cat. No. 103102)

Antigen Details

Structure
Protein tyrosine phosphatase (PTP) family, 180-240 kD
Distribution

All hematopoietic cells except mature erythrocytes and platelets

Function
Phosphatase, T and B cell activation
Ligand/Receptor
Galectin-1, CD2, CD3, CD4, TCR, CD22, Thy-1
Cell Type
B cells, Dendritic cells, Mesenchymal Stem Cells, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Innate Immunity, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Trowbridge IS, et al. 1993. Annu. Rev. Immunol. 12:85.
3. Kishihara K, et al. 1993. Cell 74:143.
4. Pulido R, et al. 1988. J. Immunol. 140:3851.

Gene ID
19264 View all products for this Gene ID
UniProt
View information about CD45 on UniProt.org

Other Formats

View All CD45 Reagents Request Custom Conjugation
Description Clone Applications
PE anti-mouse CD45 30-F11 FC
PE/Cyanine5 anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 30-F11 FC,IHC-F,CyTOF®,IP,CMCD,IHC,WB
PE/Cyanine7 anti-mouse CD45 30-F11 FC
PE/Dazzle™ 594 anti-mouse CD45 30-F11 FC
Brilliant Violet 711™ anti-mouse CD45 30-F11 FC
Brilliant Violet 785™ anti-mouse CD45 30-F11 FC
Brilliant Violet 650™ anti-mouse CD45 30-F11 FC
APC/Fire™ 750 anti-mouse CD45 30-F11 FC
Brilliant Violet 750™ anti-mouse CD45 30-F11 FC
TotalSeq™-A0096 anti-mouse CD45 30-F11 PG
TotalSeq™-B0096 anti-mouse CD45 30-F11 PG
Ultra-LEAF™ Purified anti-mouse CD45 30-F11 FC,CyTOF®,IP,CMCD,IHC,WB
Spark Blue™ 550 anti-mouse CD45 30-F11 FC
Spark NIR™ 685 anti-mouse CD45 30-F11 FC
TotalSeq™-C0096 anti-mouse CD45 30-F11 PG
Spark YG™ 570 anti-mouse CD45 30-F11 IHC-F
PE/Fire™ 640 anti-mouse CD45 30-F11 FC
APC/Fire™ 810 anti-mouse CD45 30-F11 FC
PE/Fire™ 700 anti-mouse CD45 30-F11 FC
APC anti-mouse CD45 30-F11 FC
Biotin anti-mouse CD45 30-F11 FC
FITC anti-mouse CD45 30-F11 FC
APC/Cyanine7 anti-mouse CD45 30-F11 FC
Alexa Fluor® 488 anti-mouse CD45 30-F11 FC,SB
Alexa Fluor® 647 anti-mouse CD45 30-F11 FC,ICC,IHC,3D IHC,SB
Pacific Blue™ anti-mouse CD45 30-F11 FC
Alexa Fluor® 700 anti-mouse CD45 30-F11 FC,SB
PerCP/Cyanine5.5 anti-mouse CD45 30-F11 FC
PerCP anti-mouse CD45 30-F11 FC
Alexa Fluor® 594 anti-mouse CD45 30-F11 IHC-F,FC,3D IHC
Brilliant Violet 421™ anti-mouse CD45 30-F11 FC,SB
Brilliant Violet 570™ anti-mouse CD45 30-F11 FC
Brilliant Violet 510™ anti-mouse CD45 30-F11 FC
Brilliant Violet 605™ anti-mouse CD45 30-F11 FC
Purified anti-mouse CD45 (Maxpar® Ready) 30-F11 FC,CyTOF®
Spark Violet™ 538 anti-mouse CD45 30-F11 FC
Spark YG™ 593 anti-mouse CD45 30-F11 FC
Spark Blue™ 574 anti-mouse CD45 Antibody 30-F11 FC
Spark Blue™ 515 anti-mouse CD45 30-F11 FC
Spark UV™ 387 anti-mouse CD45 30-F11 FC
PE/Fire™ 810 anti-mouse CD45 30-F11 FC
Spark PLUS UV395™ anti-mouse CD45 30-F11 FC
Spark Red™ 718 anti-mouse CD45 30-F11 FC
Spark YG™ 581 anti-mouse CD45 (Flexi-Fluor™) 30-F11 FC
Spark PLUS V475™ anti-mouse CD45 Antibody 30-F11 FC
StarBright UltraViolet 740 anti-mouse CD45 30-F11 FC
Go To Top Version: 3    Revision Date: 10-25-2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account