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Propidium Iodide Solution Propidium Iodide Solution

Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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Product Citations
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421301 2 mL DKK321
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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  4. Sakimoto I, et al. 2006. Cancer Research 66:2287.PubMed
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  9. Beggs KM, et al. 2014. Toxicol Sci. 137:91. PubMed
  10. Ewald SE, et al. 2014. Infect Immun. 82:460. PubMed
  11. Tsou WI, et al. 2014. J Biol Chem. 289:25750. PubMed
  12. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
Product Citations
  1. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  2. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  3. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  4. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  5. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  6. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  7. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  8. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  9. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  10. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  11. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  12. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  13. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  14. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  15. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  16. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  17. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  18. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  19. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  20. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  21. Quintela M, et al. 2023. Br J Cancer. . PubMed
  22. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  23. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
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  25. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  26. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  27. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  28. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  29. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  30. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  31. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  32. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  33. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  34. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  35. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  36. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  37. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  38. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  39. McNeal AS, et al. 2021. Elife. 10:. PubMed
  40. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  41. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  42. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  43. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  44. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  45. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  46. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  47. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  48. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  49. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  50. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  51. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  52. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  53. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  54. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  56. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  57. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  58. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  59. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  60. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  61. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  62. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  63. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  64. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  65. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  66. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  67. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  68. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  70. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  71. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  72. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  73. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  74. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  75. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  76. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  77. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  78. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  82. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  83. Wang J, et al. 2022. J Clin Invest. :. PubMed
  84. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  85. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  86. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  87. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  88. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  89. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  90. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  91. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  92. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  93. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  94. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  95. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  96. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  97. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  100. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  101. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  102. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  103. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  104. Harro CM, et al. 2020. J Clin Invest. . PubMed
  105. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  106. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  107. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  108. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  109. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  110. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  111. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  112. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  113. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  114. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  115. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  116. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  117. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  121. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  122. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  123. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  130. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  131. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  132. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  133. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  134. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  135. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  137. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  138. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  140. Vulin M, et al. 2022. Oncogene. :. PubMed
  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  144. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  145. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  146. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  147. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  148. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  149. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  150. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  151. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  152. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  153. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  154. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  155. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  156. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  157. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  158. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  159. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  160. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  161. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  162. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  163. Quintela M, et al. 2023. Br J Cancer. . PubMed
  164. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  165. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  166. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  167. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  168. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  169. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  170. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  171. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  172. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  183. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  184. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  185. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  186. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  187. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  190. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  191. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  192. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  193. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  194. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  200. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  201. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  202. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  203. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  214. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  215. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  216. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  217. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  218. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  219. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  220. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  224. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  225. Wang J, et al. 2022. J Clin Invest. :. PubMed
  226. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  227. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  228. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  229. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  230. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  231. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  232. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  233. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  234. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  244. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  245. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  251. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  252. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  253. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  256. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  257. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  263. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  264. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  265. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  272. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  273. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  274. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  275. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  276. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  277. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  279. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  280. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  281. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  282. Vulin M, et al. 2022. Oncogene. :. PubMed
  283. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  284. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed

Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10/08/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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Product Citations
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421301 2 mL DKK321
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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Product Citations
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  2. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
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  53. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
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  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
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  57. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
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  59. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
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  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
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  71. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  72. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  73. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  74. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  75. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  76. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  77. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  78. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  82. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  83. Wang J, et al. 2022. J Clin Invest. :. PubMed
  84. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
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  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
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  101. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  102. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  103. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
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  105. Imura Y, et al. 2020. JCI Insight. :5. PubMed
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  107. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  108. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
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  110. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
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  112. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  113. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  114. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  115. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  116. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  117. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  121. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  122. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  123. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  130. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  131. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  132. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  133. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  134. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  135. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  137. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  138. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  140. Vulin M, et al. 2022. Oncogene. :. PubMed
  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  144. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  145. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  146. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  147. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  148. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  149. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  150. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  151. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  152. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  153. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  154. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  155. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  156. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  157. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  158. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  159. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  160. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  161. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  162. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  163. Quintela M, et al. 2023. Br J Cancer. . PubMed
  164. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  165. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  166. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  167. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  168. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  169. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  170. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  171. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  172. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  183. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  184. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  185. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  186. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  187. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  190. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  191. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  192. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  193. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  194. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  200. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  201. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  202. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  203. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  214. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  215. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  216. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  217. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  218. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  219. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  220. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  224. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  225. Wang J, et al. 2022. J Clin Invest. :. PubMed
  226. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  227. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  228. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  229. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  230. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  231. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  232. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  233. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  234. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  244. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  245. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  251. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  252. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  253. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  256. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  257. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  263. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  264. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  265. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  272. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  273. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  274. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  275. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  276. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  277. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  279. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
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Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10/08/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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