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APC anti-mouse Ly-6C Antibody APC anti-mouse Ly-6C Antibody

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
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Product Citations
publications
HK1dot4_APC_082509
C57BL/6 bone marrow cells stained with HK1.4 APC
  • HK1dot4_APC_082509
    C57BL/6 bone marrow cells stained with HK1.4 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
128016 100 µg NOK2360
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128015 25 µg NOK957
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Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Guo H, et al. 2020. Curr Protoc Immunol. 131:e107. PubMed
  2. Pierson M, et al. 2021. Curr Protoc. 1:e53. PubMed
  3. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  4. Bettke JA, et al. 2022. Infect Immun. 90:e0007022. PubMed
  5. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  6. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  7. Poh AR, et al. 2022. Cell Rep. 41:111479. PubMed
  8. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  9. Papaxenopoulou LA, et al. 2022. iScience. 25:105522. PubMed
  10. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  11. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  12. Drummer C, et al. 2023. Front Immunol. 14:1113883. PubMed
  13. Hamdan F, et al. 2023. Mol Ther Oncolytics. 28:264. PubMed
  14. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  15. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  16. Cozzolino M, et al. 2023. Int J Mol Sci. 24:. PubMed
  17. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  18. MohanKumar K, et al. 2019. Nat Commun. 10:3494. PubMed
  19. Tebartz C, et al. 2015. J Immunol. 194:1100. PubMed
  20. D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed
  21. Tan L, et al. 2022. Biochem Biophys Rep. 32:101351. PubMed
  22. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  23. Borggrewe M, et al. 2018. Glia. 66:2645. PubMed
  24. Iwamoto H et al. 2018. Cell metabolism. 28(1):104-117 . PubMed
  25. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  26. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  27. Nocera D, et al. 2016. J Immunol. 196: 2860 - 2869. PubMed
  28. Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed
  29. Jahan S, et al. 2022. J Biol Chem. :102386. PubMed
  30. Kurelac I, et al. 2019. Nat Commun. 10:903. PubMed
  31. Price P, et al. 2014. J Virol. 88:10840. PubMed
  32. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  33. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  34. Shu T, et al. 2022. Eur Respir J. Online ahead of print. PubMed
  35. Biffi G, et al. 2018. Cancer Discov. 2:282. PubMed
  36. Cheng G, et al. 2021. iScience. 24:102673. PubMed
  37. Pingili AK, et al. 2021. Cell Reports. 35(12):109285. PubMed
  38. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  39. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  40. Zhang X, et al. 2022. J Neuroinflammation. 19:111. PubMed
  41. Ye M, et al. 2022. Nat Nanotechnol. 17:880. PubMed
  42. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  43. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  44. Murphy M, et al. 2017. Eur J Immunol. 47:880. PubMed
  45. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  46. Martin R, et al. 2014. J Leukoc Biol. 96:151. PubMed
  47. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  48. Godbersen-Palmer C, et al. 2020. J Immunol. 204:2973. PubMed
  49. Mastandrea I, et al. 2022. STAR Protoc. 3:101106. PubMed
  50. Kienzl M, et al. 2020. Oncoimmunology. 9:1776059. PubMed
  51. Werneburg S, et al. 2020. Immunity. 52(1):167-182.e7.. PubMed
  52. Anderson MC, et al. 2018. Cell Chem Biol. 25:483. PubMed
  53. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  54. Magod P, et al. 2021. Cell Reports. 36(5):109480. PubMed
  55. Ray A, et al. 2014. J Immunol. 192:5109. PubMed
  56. Zhang J, et al. 2022. iScience. 25:104963. PubMed
  57. Parlet CP, et al. 2019. Cell Rep. 27:187. PubMed
  58. Green DP, et al. 2019. Neuron. 101:412. PubMed
  59. Zhang S, et al. 2019. Cell Metab. 29:443. PubMed
  60. Chakraborty S, et al. 2022. Sci Transl Med. . PubMed
  61. Li Y, et al. 2021. Brain Behav Immun. 91:267. PubMed
  62. McLaughlin PA et al. 2019. PLoS Pathog. 15(7):e1007847 . PubMed
  63. Ye Z, et al. 2019. Mediators Inflamm. 2019:8709583. PubMed
  64. Korangath P, et al. 2020. Bio Protoc. 10:e3822. PubMed
  65. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  66. Ohgomori T, et al. 2020. Neuropharmacology. 176:108227. PubMed
  67. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  68. Morales-Mantilla DE, et al. 2022. Elife. 11:. PubMed
  69. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  70. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  71. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  72. Christ A, et al. 2018. Cell. 172:162. PubMed
  73. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  74. Heng Y, et al. 2021. J Neuroinflammation. 18:57. PubMed
  75. Radjabova V, et al. 2015. J Immunol. 195: 3149 - 3159. PubMed
  76. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  77. Liu H, et al. 2022. Front Pharmacol. 13:949316. PubMed
  78. Deczkowska A, et al. 2017. Nat Commun. 8:717. PubMed
  79. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  80. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  81. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  82. Shao M, et al. 2021. Cell Stem Cell. 28(4):685-701.e7. PubMed
  83. Liu X, et al. 2021. Int J Nanomedicine. 16:5675. PubMed
  84. Kolodziejczyk AA, et al. 2020. Nat Med. 26:1899. PubMed
  85. Daneshmandi S, et al. 2021. Elife. 10:. PubMed
  86. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  87. Joffin N, et al. 2021. Cell Stem Cell. 28(4):702-717.e8. PubMed
  88. Ritzel RM, et al. 2021. Glia. 69:746. PubMed
  89. Sauter K, et al. 2014. J Leukoc Biol. 96:265. PubMed
  90. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  91. Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
  92. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  93. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  94. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  95. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  96. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  97. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  98. Clemente C, et al. 2018. Nat Commun. 9:910. PubMed
  99. Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
  100. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  101. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  102. Bordas M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  103. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  104. Karki R, et al. 2020. bioRxiv. . PubMed
  105. Li N, et al. 2022. Nat Commun. 13:7281. PubMed
  106. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  107. Steele NG, et al. 2021. Clin Cancer Res. 27:2023. PubMed
  108. Karki R, et al. 2021. Cell. 184:149. PubMed
  109. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  110. Mukovozov I, et al. 2015. J Immunol. 195: 3334 - 3344. PubMed
  111. Li Y, et al. 2022. Theranostics. 12:5364. PubMed
  112. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  113. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  114. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  115. Molgora M, et al. 2020. Cell. 182:886. PubMed
  116. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  117. Li Y, et al. 2020. Theranostics. 10:11376. PubMed
  118. Hsia HC, et al. 2017. J Leukoc Biol. 101:1053. PubMed
  119. Kitamoto S, et al. 2020. Cell. 182(2):447-462.e14. PubMed
  120. Kratochvill F, et al. 2015. Cancer Res. 75: 3054-3064. PubMed
  121. Pisano F, et al. 2014. PLoS One. 9:103541. PubMed
  122. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  123. Rivera CA, et al. 2022. Immunity. 55:129. PubMed
  124. Ghosh S, et al. 2019. Commun Biol. 0.325. PubMed
  125. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  126. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  127. Hamdan F, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(8):. PubMed
  128. Tian T, et al. 2020. Cancer Immunol Res. 660:8. PubMed
  129. Kim I et al. 2015. Brain and behavior. 5(12):e00403 . PubMed
  130. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  131. Zhang X, et al. 2020. Glia. . PubMed
  132. Guo H, et al. 2020. Curr Protoc Immunol. 131:e107. PubMed
  133. Pierson M, et al. 2021. Curr Protoc. 1:e53. PubMed
  134. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  135. Bettke JA, et al. 2022. Infect Immun. 90:e0007022. PubMed
  136. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  137. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  138. Poh AR, et al. 2022. Cell Rep. 41:111479. PubMed
  139. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  140. Papaxenopoulou LA, et al. 2022. iScience. 25:105522. PubMed
  141. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  142. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  143. Drummer C, et al. 2023. Front Immunol. 14:1113883. PubMed
  144. Hamdan F, et al. 2023. Mol Ther Oncolytics. 28:264. PubMed
  145. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  146. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  147. Cozzolino M, et al. 2023. Int J Mol Sci. 24:. PubMed
  148. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  149. MohanKumar K, et al. 2019. Nat Commun. 10:3494. PubMed
  150. Tebartz C, et al. 2015. J Immunol. 194:1100. PubMed
  151. D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed
  152. Tan L, et al. 2022. Biochem Biophys Rep. 32:101351. PubMed
  153. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  154. Borggrewe M, et al. 2018. Glia. 66:2645. PubMed
  155. Iwamoto H et al. 2018. Cell metabolism. 28(1):104-117 . PubMed
  156. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  157. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  158. Nocera D, et al. 2016. J Immunol. 196: 2860 - 2869. PubMed
  159. Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed
  160. Jahan S, et al. 2022. J Biol Chem. :102386. PubMed
  161. Kurelac I, et al. 2019. Nat Commun. 10:903. PubMed
  162. Price P, et al. 2014. J Virol. 88:10840. PubMed
  163. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  164. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  165. Shu T, et al. 2022. Eur Respir J. Online ahead of print. PubMed
  166. Biffi G, et al. 2018. Cancer Discov. 2:282. PubMed
  167. Cheng G, et al. 2021. iScience. 24:102673. PubMed
  168. Pingili AK, et al. 2021. Cell Reports. 35(12):109285. PubMed
  169. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  170. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  171. Zhang X, et al. 2022. J Neuroinflammation. 19:111. PubMed
  172. Ye M, et al. 2022. Nat Nanotechnol. 17:880. PubMed
  173. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  174. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  175. Murphy M, et al. 2017. Eur J Immunol. 47:880. PubMed
  176. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  177. Martin R, et al. 2014. J Leukoc Biol. 96:151. PubMed
  178. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  179. Godbersen-Palmer C, et al. 2020. J Immunol. 204:2973. PubMed
  180. Mastandrea I, et al. 2022. STAR Protoc. 3:101106. PubMed
  181. Kienzl M, et al. 2020. Oncoimmunology. 9:1776059. PubMed
  182. Werneburg S, et al. 2020. Immunity. 52(1):167-182.e7.. PubMed
  183. Anderson MC, et al. 2018. Cell Chem Biol. 25:483. PubMed
  184. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  185. Magod P, et al. 2021. Cell Reports. 36(5):109480. PubMed
  186. Ray A, et al. 2014. J Immunol. 192:5109. PubMed
  187. Zhang J, et al. 2022. iScience. 25:104963. PubMed
  188. Parlet CP, et al. 2019. Cell Rep. 27:187. PubMed
  189. Green DP, et al. 2019. Neuron. 101:412. PubMed
  190. Zhang S, et al. 2019. Cell Metab. 29:443. PubMed
  191. Chakraborty S, et al. 2022. Sci Transl Med. . PubMed
  192. Li Y, et al. 2021. Brain Behav Immun. 91:267. PubMed
  193. McLaughlin PA et al. 2019. PLoS Pathog. 15(7):e1007847 . PubMed
  194. Ye Z, et al. 2019. Mediators Inflamm. 2019:8709583. PubMed
  195. Korangath P, et al. 2020. Bio Protoc. 10:e3822. PubMed
  196. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  197. Ohgomori T, et al. 2020. Neuropharmacology. 176:108227. PubMed
  198. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  199. Morales-Mantilla DE, et al. 2022. Elife. 11:. PubMed
  200. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  201. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  202. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  203. Christ A, et al. 2018. Cell. 172:162. PubMed
  204. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  205. Heng Y, et al. 2021. J Neuroinflammation. 18:57. PubMed
  206. Radjabova V, et al. 2015. J Immunol. 195: 3149 - 3159. PubMed
  207. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  208. Liu H, et al. 2022. Front Pharmacol. 13:949316. PubMed
  209. Deczkowska A, et al. 2017. Nat Commun. 8:717. PubMed
  210. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  211. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  212. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  213. Shao M, et al. 2021. Cell Stem Cell. 28(4):685-701.e7. PubMed
  214. Liu X, et al. 2021. Int J Nanomedicine. 16:5675. PubMed
  215. Kolodziejczyk AA, et al. 2020. Nat Med. 26:1899. PubMed
  216. Daneshmandi S, et al. 2021. Elife. 10:. PubMed
  217. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  218. Joffin N, et al. 2021. Cell Stem Cell. 28(4):702-717.e8. PubMed
  219. Ritzel RM, et al. 2021. Glia. 69:746. PubMed
  220. Sauter K, et al. 2014. J Leukoc Biol. 96:265. PubMed
  221. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  222. Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
  223. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  224. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  225. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  226. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  227. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  228. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  229. Clemente C, et al. 2018. Nat Commun. 9:910. PubMed
  230. Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
  231. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  232. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  233. Bordas M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  234. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  235. Karki R, et al. 2020. bioRxiv. . PubMed
  236. Li N, et al. 2022. Nat Commun. 13:7281. PubMed
  237. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  238. Steele NG, et al. 2021. Clin Cancer Res. 27:2023. PubMed
  239. Karki R, et al. 2021. Cell. 184:149. PubMed
  240. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  241. Mukovozov I, et al. 2015. J Immunol. 195: 3334 - 3344. PubMed
  242. Li Y, et al. 2022. Theranostics. 12:5364. PubMed
  243. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  244. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  245. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  246. Molgora M, et al. 2020. Cell. 182:886. PubMed
  247. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  248. Li Y, et al. 2020. Theranostics. 10:11376. PubMed
  249. Hsia HC, et al. 2017. J Leukoc Biol. 101:1053. PubMed
  250. Kitamoto S, et al. 2020. Cell. 182(2):447-462.e14. PubMed
  251. Kratochvill F, et al. 2015. Cancer Res. 75: 3054-3064. PubMed
  252. Pisano F, et al. 2014. PLoS One. 9:103541. PubMed
  253. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  254. Rivera CA, et al. 2022. Immunity. 55:129. PubMed
  255. Ghosh S, et al. 2019. Commun Biol. 0.325. PubMed
  256. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  257. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  258. Hamdan F, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(8):. PubMed
  259. Tian T, et al. 2020. Cancer Immunol Res. 660:8. PubMed
  260. Kim I et al. 2015. Brain and behavior. 5(12):e00403 . PubMed
  261. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  262. Zhang X, et al. 2020. Glia. . PubMed
RRID
AB_1732076 (BioLegend Cat. No. 128016)
AB_1732087 (BioLegend Cat. No. 128015)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
StarBright UltraViolet 740 anti-mouse Ly-6C HK1.4 FC
StarBright UltraViolet 795 anti-mouse Ly-6C HK1.4 FC
Spark PLUS UV395™ anti-mouse Ly-6C HK1.4 FC
Go To Top Version: 2    Revision Date: 12.09.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
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Product Citations
publications
HK1dot4_APC_082509
C57BL/6 bone marrow cells stained with HK1.4 APC
  • HK1dot4_APC_082509
    C57BL/6 bone marrow cells stained with HK1.4 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
128016 100 µg NOK2360
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128015 25 µg NOK957
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Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
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  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
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  2. Pierson M, et al. 2021. Curr Protoc. 1:e53. PubMed
  3. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  4. Bettke JA, et al. 2022. Infect Immun. 90:e0007022. PubMed
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  6. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  7. Poh AR, et al. 2022. Cell Rep. 41:111479. PubMed
  8. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  9. Papaxenopoulou LA, et al. 2022. iScience. 25:105522. PubMed
  10. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  11. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  12. Drummer C, et al. 2023. Front Immunol. 14:1113883. PubMed
  13. Hamdan F, et al. 2023. Mol Ther Oncolytics. 28:264. PubMed
  14. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  15. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  16. Cozzolino M, et al. 2023. Int J Mol Sci. 24:. PubMed
  17. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  18. MohanKumar K, et al. 2019. Nat Commun. 10:3494. PubMed
  19. Tebartz C, et al. 2015. J Immunol. 194:1100. PubMed
  20. D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed
  21. Tan L, et al. 2022. Biochem Biophys Rep. 32:101351. PubMed
  22. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  23. Borggrewe M, et al. 2018. Glia. 66:2645. PubMed
  24. Iwamoto H et al. 2018. Cell metabolism. 28(1):104-117 . PubMed
  25. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  26. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  27. Nocera D, et al. 2016. J Immunol. 196: 2860 - 2869. PubMed
  28. Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed
  29. Jahan S, et al. 2022. J Biol Chem. :102386. PubMed
  30. Kurelac I, et al. 2019. Nat Commun. 10:903. PubMed
  31. Price P, et al. 2014. J Virol. 88:10840. PubMed
  32. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  33. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  34. Shu T, et al. 2022. Eur Respir J. Online ahead of print. PubMed
  35. Biffi G, et al. 2018. Cancer Discov. 2:282. PubMed
  36. Cheng G, et al. 2021. iScience. 24:102673. PubMed
  37. Pingili AK, et al. 2021. Cell Reports. 35(12):109285. PubMed
  38. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  39. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  40. Zhang X, et al. 2022. J Neuroinflammation. 19:111. PubMed
  41. Ye M, et al. 2022. Nat Nanotechnol. 17:880. PubMed
  42. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  43. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  44. Murphy M, et al. 2017. Eur J Immunol. 47:880. PubMed
  45. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  46. Martin R, et al. 2014. J Leukoc Biol. 96:151. PubMed
  47. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  48. Godbersen-Palmer C, et al. 2020. J Immunol. 204:2973. PubMed
  49. Mastandrea I, et al. 2022. STAR Protoc. 3:101106. PubMed
  50. Kienzl M, et al. 2020. Oncoimmunology. 9:1776059. PubMed
  51. Werneburg S, et al. 2020. Immunity. 52(1):167-182.e7.. PubMed
  52. Anderson MC, et al. 2018. Cell Chem Biol. 25:483. PubMed
  53. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  54. Magod P, et al. 2021. Cell Reports. 36(5):109480. PubMed
  55. Ray A, et al. 2014. J Immunol. 192:5109. PubMed
  56. Zhang J, et al. 2022. iScience. 25:104963. PubMed
  57. Parlet CP, et al. 2019. Cell Rep. 27:187. PubMed
  58. Green DP, et al. 2019. Neuron. 101:412. PubMed
  59. Zhang S, et al. 2019. Cell Metab. 29:443. PubMed
  60. Chakraborty S, et al. 2022. Sci Transl Med. . PubMed
  61. Li Y, et al. 2021. Brain Behav Immun. 91:267. PubMed
  62. McLaughlin PA et al. 2019. PLoS Pathog. 15(7):e1007847 . PubMed
  63. Ye Z, et al. 2019. Mediators Inflamm. 2019:8709583. PubMed
  64. Korangath P, et al. 2020. Bio Protoc. 10:e3822. PubMed
  65. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  66. Ohgomori T, et al. 2020. Neuropharmacology. 176:108227. PubMed
  67. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  68. Morales-Mantilla DE, et al. 2022. Elife. 11:. PubMed
  69. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  70. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  71. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  72. Christ A, et al. 2018. Cell. 172:162. PubMed
  73. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  74. Heng Y, et al. 2021. J Neuroinflammation. 18:57. PubMed
  75. Radjabova V, et al. 2015. J Immunol. 195: 3149 - 3159. PubMed
  76. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  77. Liu H, et al. 2022. Front Pharmacol. 13:949316. PubMed
  78. Deczkowska A, et al. 2017. Nat Commun. 8:717. PubMed
  79. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  80. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  81. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  82. Shao M, et al. 2021. Cell Stem Cell. 28(4):685-701.e7. PubMed
  83. Liu X, et al. 2021. Int J Nanomedicine. 16:5675. PubMed
  84. Kolodziejczyk AA, et al. 2020. Nat Med. 26:1899. PubMed
  85. Daneshmandi S, et al. 2021. Elife. 10:. PubMed
  86. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  87. Joffin N, et al. 2021. Cell Stem Cell. 28(4):702-717.e8. PubMed
  88. Ritzel RM, et al. 2021. Glia. 69:746. PubMed
  89. Sauter K, et al. 2014. J Leukoc Biol. 96:265. PubMed
  90. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  91. Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
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  93. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  94. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  95. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  96. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  97. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  98. Clemente C, et al. 2018. Nat Commun. 9:910. PubMed
  99. Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
  100. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  101. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  102. Bordas M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  103. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  104. Karki R, et al. 2020. bioRxiv. . PubMed
  105. Li N, et al. 2022. Nat Commun. 13:7281. PubMed
  106. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  107. Steele NG, et al. 2021. Clin Cancer Res. 27:2023. PubMed
  108. Karki R, et al. 2021. Cell. 184:149. PubMed
  109. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  110. Mukovozov I, et al. 2015. J Immunol. 195: 3334 - 3344. PubMed
  111. Li Y, et al. 2022. Theranostics. 12:5364. PubMed
  112. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  113. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  114. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  115. Molgora M, et al. 2020. Cell. 182:886. PubMed
  116. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  117. Li Y, et al. 2020. Theranostics. 10:11376. PubMed
  118. Hsia HC, et al. 2017. J Leukoc Biol. 101:1053. PubMed
  119. Kitamoto S, et al. 2020. Cell. 182(2):447-462.e14. PubMed
  120. Kratochvill F, et al. 2015. Cancer Res. 75: 3054-3064. PubMed
  121. Pisano F, et al. 2014. PLoS One. 9:103541. PubMed
  122. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  123. Rivera CA, et al. 2022. Immunity. 55:129. PubMed
  124. Ghosh S, et al. 2019. Commun Biol. 0.325. PubMed
  125. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  126. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  127. Hamdan F, et al. 2021. Journal for ImmunoTherapy of Cancer. 9(8):. PubMed
  128. Tian T, et al. 2020. Cancer Immunol Res. 660:8. PubMed
  129. Kim I et al. 2015. Brain and behavior. 5(12):e00403 . PubMed
  130. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  131. Zhang X, et al. 2020. Glia. . PubMed
  132. Guo H, et al. 2020. Curr Protoc Immunol. 131:e107. PubMed
  133. Pierson M, et al. 2021. Curr Protoc. 1:e53. PubMed
  134. Alam A, et al. 2022. Cancer Cell. 40:153. PubMed
  135. Bettke JA, et al. 2022. Infect Immun. 90:e0007022. PubMed
  136. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  137. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  138. Poh AR, et al. 2022. Cell Rep. 41:111479. PubMed
  139. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  140. Papaxenopoulou LA, et al. 2022. iScience. 25:105522. PubMed
  141. Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed
  142. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  143. Drummer C, et al. 2023. Front Immunol. 14:1113883. PubMed
  144. Hamdan F, et al. 2023. Mol Ther Oncolytics. 28:264. PubMed
  145. Saha S, et al. 2023. Sci Rep. 13:4609. PubMed
  146. Fukuzaki Y, et al. 2023. iScience. 26:106340. PubMed
  147. Cozzolino M, et al. 2023. Int J Mol Sci. 24:. PubMed
  148. Yang QC, et al. 2023. iScience. 26:106916. PubMed
  149. MohanKumar K, et al. 2019. Nat Commun. 10:3494. PubMed
  150. Tebartz C, et al. 2015. J Immunol. 194:1100. PubMed
  151. D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed
  152. Tan L, et al. 2022. Biochem Biophys Rep. 32:101351. PubMed
  153. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  154. Borggrewe M, et al. 2018. Glia. 66:2645. PubMed
  155. Iwamoto H et al. 2018. Cell metabolism. 28(1):104-117 . PubMed
  156. Aggen DH, et al. 2020. Clin Cancer Res. . PubMed
  157. Kim JS, et al. 2020. Immunity. 54(1):176-190.e7. PubMed
  158. Nocera D, et al. 2016. J Immunol. 196: 2860 - 2869. PubMed
  159. Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed
  160. Jahan S, et al. 2022. J Biol Chem. :102386. PubMed
  161. Kurelac I, et al. 2019. Nat Commun. 10:903. PubMed
  162. Price P, et al. 2014. J Virol. 88:10840. PubMed
  163. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  164. Su N, Xiong Y 2016. Sci Rep. 6:22658. PubMed
  165. Shu T, et al. 2022. Eur Respir J. Online ahead of print. PubMed
  166. Biffi G, et al. 2018. Cancer Discov. 2:282. PubMed
  167. Cheng G, et al. 2021. iScience. 24:102673. PubMed
  168. Pingili AK, et al. 2021. Cell Reports. 35(12):109285. PubMed
  169. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  170. Liang W, et al. 2020. Nat Commun. 4.563888889. PubMed
  171. Zhang X, et al. 2022. J Neuroinflammation. 19:111. PubMed
  172. Ye M, et al. 2022. Nat Nanotechnol. 17:880. PubMed
  173. Lubkin A et al. 2019. Cell host & microbe. 25(3):463-470 . PubMed
  174. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  175. Murphy M, et al. 2017. Eur J Immunol. 47:880. PubMed
  176. Getts D, et al. 2014. Sci Transl Med. 15:219. PubMed
  177. Martin R, et al. 2014. J Leukoc Biol. 96:151. PubMed
  178. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  179. Godbersen-Palmer C, et al. 2020. J Immunol. 204:2973. PubMed
  180. Mastandrea I, et al. 2022. STAR Protoc. 3:101106. PubMed
  181. Kienzl M, et al. 2020. Oncoimmunology. 9:1776059. PubMed
  182. Werneburg S, et al. 2020. Immunity. 52(1):167-182.e7.. PubMed
  183. Anderson MC, et al. 2018. Cell Chem Biol. 25:483. PubMed
  184. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  185. Magod P, et al. 2021. Cell Reports. 36(5):109480. PubMed
  186. Ray A, et al. 2014. J Immunol. 192:5109. PubMed
  187. Zhang J, et al. 2022. iScience. 25:104963. PubMed
  188. Parlet CP, et al. 2019. Cell Rep. 27:187. PubMed
  189. Green DP, et al. 2019. Neuron. 101:412. PubMed
  190. Zhang S, et al. 2019. Cell Metab. 29:443. PubMed
  191. Chakraborty S, et al. 2022. Sci Transl Med. . PubMed
  192. Li Y, et al. 2021. Brain Behav Immun. 91:267. PubMed
  193. McLaughlin PA et al. 2019. PLoS Pathog. 15(7):e1007847 . PubMed
  194. Ye Z, et al. 2019. Mediators Inflamm. 2019:8709583. PubMed
  195. Korangath P, et al. 2020. Bio Protoc. 10:e3822. PubMed
  196. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  197. Ohgomori T, et al. 2020. Neuropharmacology. 176:108227. PubMed
  198. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  199. Morales-Mantilla DE, et al. 2022. Elife. 11:. PubMed
  200. Codina A, et al. 2019. Cell Syst. 8:136. PubMed
  201. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  202. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  203. Christ A, et al. 2018. Cell. 172:162. PubMed
  204. Hepler C et al. 2018. eLife. 7 pii: e39636. PubMed
  205. Heng Y, et al. 2021. J Neuroinflammation. 18:57. PubMed
  206. Radjabova V, et al. 2015. J Immunol. 195: 3149 - 3159. PubMed
  207. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  208. Liu H, et al. 2022. Front Pharmacol. 13:949316. PubMed
  209. Deczkowska A, et al. 2017. Nat Commun. 8:717. PubMed
  210. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  211. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  212. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  213. Shao M, et al. 2021. Cell Stem Cell. 28(4):685-701.e7. PubMed
  214. Liu X, et al. 2021. Int J Nanomedicine. 16:5675. PubMed
  215. Kolodziejczyk AA, et al. 2020. Nat Med. 26:1899. PubMed
  216. Daneshmandi S, et al. 2021. Elife. 10:. PubMed
  217. Pundir P, et al. 2020. Cell Host & Microbe. 26(1):114-122. PubMed
  218. Joffin N, et al. 2021. Cell Stem Cell. 28(4):702-717.e8. PubMed
  219. Ritzel RM, et al. 2021. Glia. 69:746. PubMed
  220. Sauter K, et al. 2014. J Leukoc Biol. 96:265. PubMed
  221. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  222. Ryan NM, et al. 2022. Front Immunol. 13:932742. PubMed
  223. Lingegowda H, et al. 2022. Front Reprod Health. 3:726936. PubMed
  224. Melo-Silva CR, et al. 2021. PLOS Pathogens. 17(5):e1009593. PubMed
  225. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  226. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  227. Shan B, et al. 2020. Nat Metab. 1332:2. PubMed
  228. Wong NR, et al. 2021. Immunity. 54:2072. PubMed
  229. Clemente C, et al. 2018. Nat Commun. 9:910. PubMed
  230. Wang T et al. 2018. Immunity. 49(3):504-514 . PubMed
  231. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  232. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  233. Bordas M, et al. 2020. Int J Mol Sci. 21:00. PubMed
  234. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  235. Karki R, et al. 2020. bioRxiv. . PubMed
  236. Li N, et al. 2022. Nat Commun. 13:7281. PubMed
  237. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  238. Steele NG, et al. 2021. Clin Cancer Res. 27:2023. PubMed
  239. Karki R, et al. 2021. Cell. 184:149. PubMed
  240. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  241. Mukovozov I, et al. 2015. J Immunol. 195: 3334 - 3344. PubMed
  242. Li Y, et al. 2022. Theranostics. 12:5364. PubMed
  243. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  244. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  245. Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed
  246. Molgora M, et al. 2020. Cell. 182:886. PubMed
  247. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  248. Li Y, et al. 2020. Theranostics. 10:11376. PubMed
  249. Hsia HC, et al. 2017. J Leukoc Biol. 101:1053. PubMed
  250. Kitamoto S, et al. 2020. Cell. 182(2):447-462.e14. PubMed
  251. Kratochvill F, et al. 2015. Cancer Res. 75: 3054-3064. PubMed
  252. Pisano F, et al. 2014. PLoS One. 9:103541. PubMed
  253. Shin SH, et al. 2022. Clin Exp Otorhinolaryngol. . PubMed
  254. Rivera CA, et al. 2022. Immunity. 55:129. PubMed
  255. Ghosh S, et al. 2019. Commun Biol. 0.325. PubMed
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RRID
AB_1732076 (BioLegend Cat. No. 128016)
AB_1732087 (BioLegend Cat. No. 128015)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
StarBright UltraViolet 740 anti-mouse Ly-6C HK1.4 FC
StarBright UltraViolet 795 anti-mouse Ly-6C HK1.4 FC
Spark PLUS UV395™ anti-mouse Ly-6C HK1.4 FC
Go To Top Version: 2    Revision Date: 12.09.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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