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Propidium Iodide Solution Propidium Iodide Solution

Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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  4. Sakimoto I, et al. 2006. Cancer Research 66:2287.PubMed
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  9. Beggs KM, et al. 2014. Toxicol Sci. 137:91. PubMed
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  11. Tsou WI, et al. 2014. J Biol Chem. 289:25750. PubMed
  12. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
Product Citations
  1. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  2. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  3. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  4. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  5. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  6. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  7. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  8. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  9. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  10. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  11. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  12. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  13. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  14. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  15. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  16. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  17. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  18. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  19. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  20. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
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  22. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  23. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
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  25. Quintela M, et al. 2023. Br J Cancer. . PubMed
  26. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  27. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  28. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  29. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  30. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  31. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  32. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  33. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  34. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  35. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  36. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  37. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  38. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  39. McNeal AS, et al. 2021. Elife. 10:. PubMed
  40. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  41. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  42. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  43. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  44. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  45. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  46. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  47. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  48. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  49. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  50. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  51. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  52. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  53. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  54. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  55. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  56. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  57. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  58. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  59. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  60. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  61. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  62. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  63. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  64. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  65. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  66. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  67. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  68. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  70. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  71. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  72. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  73. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  74. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  75. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  76. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  77. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  78. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  79. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  80. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  81. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  82. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  83. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  84. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  85. Wang J, et al. 2022. J Clin Invest. :. PubMed
  86. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  87. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  88. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  89. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  90. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  91. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  92. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  93. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  94. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  95. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  96. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  97. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  100. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  101. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  102. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  103. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  104. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  105. Harro CM, et al. 2020. J Clin Invest. . PubMed
  106. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  107. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  108. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  109. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  110. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  111. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  112. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  113. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  114. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  115. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  116. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  117. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  118. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  119. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  120. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  121. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  122. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  123. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  124. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  125. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  126. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  130. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  131. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  132. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  133. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  134. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  135. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  136. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  137. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  138. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  139. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  140. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  141. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  142. Vulin M, et al. 2022. Oncogene. :. PubMed
  143. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  144. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  145. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  146. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  147. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  148. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  149. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  150. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  151. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  152. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  153. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  154. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  155. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  156. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  157. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  158. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  159. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  160. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  161. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  162. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  163. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  164. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  165. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  166. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  167. Quintela M, et al. 2023. Br J Cancer. . PubMed
  168. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  169. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  170. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  171. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  172. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  173. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  174. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  175. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  183. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  184. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  185. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  186. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  187. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  188. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  189. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  190. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  191. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  192. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  193. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  194. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  195. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  196. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  197. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  198. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  199. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  200. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  201. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  202. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  203. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  204. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  205. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  206. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  207. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  208. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  209. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  214. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  215. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  216. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  217. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  218. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  219. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  220. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  221. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  222. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  223. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  224. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  225. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  226. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  227. Wang J, et al. 2022. J Clin Invest. :. PubMed
  228. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  229. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  230. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  231. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  232. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  233. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  234. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  235. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  236. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  237. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  242. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  243. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  244. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  245. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  246. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  247. Harro CM, et al. 2020. J Clin Invest. . PubMed
  248. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  249. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  250. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  251. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  252. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  253. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  254. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  255. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  256. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  257. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  260. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  261. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  262. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  263. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  264. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  265. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  266. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  267. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  268. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  272. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  273. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  274. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  275. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  276. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  277. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  278. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  279. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  280. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  281. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  282. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  283. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  284. Vulin M, et al. 2022. Oncogene. :. PubMed

Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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See Propidium Iodide spectral data
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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Product Citations
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  75. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
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  77. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  78. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  79. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  80. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  81. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  82. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  83. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
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  122. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  123. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  124. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  125. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  126. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  130. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  131. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  132. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  133. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
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  135. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  136. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  137. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  138. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
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  142. Vulin M, et al. 2022. Oncogene. :. PubMed
  143. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  144. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  145. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  146. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  147. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  148. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  149. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  150. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  151. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  152. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  153. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  154. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  155. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  156. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  157. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  158. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  159. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  160. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  161. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  162. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  163. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  164. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  165. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  166. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  167. Quintela M, et al. 2023. Br J Cancer. . PubMed
  168. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  169. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  170. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  171. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  172. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  173. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  174. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  175. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  183. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  184. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  185. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  186. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  187. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  188. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  189. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  190. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  191. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  192. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  193. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  194. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  195. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  196. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  197. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  198. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  199. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  200. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  201. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  202. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  203. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  204. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  205. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  206. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  207. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  208. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  209. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  214. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  215. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  216. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  217. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  218. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  219. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  220. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  221. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  222. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  223. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  224. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  225. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  226. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  227. Wang J, et al. 2022. J Clin Invest. :. PubMed
  228. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  229. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  230. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  231. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  232. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  233. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  234. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  235. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  236. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  237. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  242. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  243. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  244. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  245. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  246. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  247. Harro CM, et al. 2020. J Clin Invest. . PubMed
  248. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  249. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  250. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  251. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  252. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  253. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  254. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  255. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  256. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  257. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  260. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  261. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  262. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  263. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  264. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  265. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  266. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  267. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  268. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  272. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  273. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  274. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  275. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  276. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  277. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  278. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
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Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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