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Propidium Iodide Solution Propidium Iodide Solution

Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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  4. Sakimoto I, et al. 2006. Cancer Research 66:2287.PubMed
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  7. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  8. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  9. Beggs KM, et al. 2014. Toxicol Sci. 137:91. PubMed
  10. Ewald SE, et al. 2014. Infect Immun. 82:460. PubMed
  11. Tsou WI, et al. 2014. J Biol Chem. 289:25750. PubMed
  12. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
Product Citations
  1. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  2. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  3. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  4. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  5. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  6. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  7. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  8. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  9. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  10. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  11. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  12. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  13. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  14. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  15. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  16. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  17. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  18. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  19. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  20. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  21. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  22. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  23. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  24. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  25. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  26. Quintela M, et al. 2023. Br J Cancer. . PubMed
  27. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  28. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  29. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  30. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  31. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  32. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  33. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  34. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  35. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  36. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  37. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  38. McNeal AS, et al. 2021. Elife. 10:. PubMed
  39. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  40. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  41. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  42. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  43. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  44. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  45. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  46. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  47. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  48. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  49. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  50. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  51. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  52. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  53. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  54. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  56. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  57. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  58. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  59. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  60. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  61. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  62. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  63. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  64. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  65. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  66. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  67. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  68. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  70. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  71. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  72. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  73. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  74. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  75. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  76. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  77. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  78. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  79. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  80. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  81. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  82. Wang J, et al. 2022. J Clin Invest. :. PubMed
  83. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  84. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  85. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  86. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  87. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  88. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  89. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  90. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  91. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  92. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  93. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  94. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  95. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  96. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  97. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  100. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  101. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  102. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  103. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  104. Harro CM, et al. 2020. J Clin Invest. . PubMed
  105. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  106. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  107. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  108. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  109. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  110. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  111. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  112. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  113. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  114. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  115. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  116. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  117. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  121. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  122. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  123. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  126. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  127. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  128. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  129. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  130. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  131. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  132. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  133. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  134. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  135. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  137. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  138. Vulin M, et al. 2022. Oncogene. :. PubMed
  139. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  140. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  144. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  145. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  146. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  147. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  148. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  149. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  150. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  151. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  152. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  153. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  154. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  155. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  156. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  157. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  158. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  159. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  160. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  161. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  162. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  163. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  164. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  165. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  166. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  167. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  168. Quintela M, et al. 2023. Br J Cancer. . PubMed
  169. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  170. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  171. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  172. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  173. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  176. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  177. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  178. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  179. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  180. McNeal AS, et al. 2021. Elife. 10:. PubMed
  181. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  182. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  183. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  184. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  185. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  186. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  187. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  188. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  189. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  190. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  191. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  192. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  193. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  194. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  200. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  201. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  202. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  203. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  214. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  215. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  216. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  217. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  218. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  219. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  220. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  221. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  222. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  223. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  224. Wang J, et al. 2022. J Clin Invest. :. PubMed
  225. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  226. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  227. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  228. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  229. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  230. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  231. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  232. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  233. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  234. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  235. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  236. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  244. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  245. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  251. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  252. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  253. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  256. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  257. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  258. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  259. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  263. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  264. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  265. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  268. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  269. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  270. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  271. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  272. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  273. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  274. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  275. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  276. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  277. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  279. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  280. Vulin M, et al. 2022. Oncogene. :. PubMed
  281. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  282. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  283. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  284. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed

Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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Product Citations
  1. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
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  52. Wang Y, et al. 2019. Cell. 179:1144. PubMed
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  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
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  57. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
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  59. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
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  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
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  71. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  72. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  73. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  74. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  75. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  76. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  77. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  78. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  79. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  80. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  81. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  82. Wang J, et al. 2022. J Clin Invest. :. PubMed
  83. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
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  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  100. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  101. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  102. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
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  108. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  109. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
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  112. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
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  114. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  115. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  116. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  117. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  121. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  122. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  123. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  126. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  127. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  128. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  129. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  130. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  131. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  132. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  133. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  134. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  135. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  137. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  138. Vulin M, et al. 2022. Oncogene. :. PubMed
  139. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  140. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  144. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  145. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  146. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  147. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  148. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  149. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  150. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  151. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  152. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  153. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  154. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  155. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  156. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  157. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  158. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  159. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  160. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  161. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  162. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  163. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  164. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  165. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  166. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  167. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  168. Quintela M, et al. 2023. Br J Cancer. . PubMed
  169. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  170. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  171. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  172. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  173. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  176. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  177. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  178. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  179. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  180. McNeal AS, et al. 2021. Elife. 10:. PubMed
  181. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  182. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  183. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  184. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  185. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  186. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  187. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  188. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  189. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  190. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  191. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  192. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  193. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  194. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  200. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  201. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  202. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  203. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  214. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  215. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  216. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  217. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  218. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  219. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  220. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  221. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  222. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  223. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  224. Wang J, et al. 2022. J Clin Invest. :. PubMed
  225. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  226. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  227. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  228. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  229. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  230. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  231. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  232. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  233. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  234. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  235. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  236. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  244. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  245. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  251. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  252. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  253. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  256. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  257. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  258. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  259. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  263. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  264. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  265. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  268. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  269. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  270. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  271. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  272. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  273. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  274. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  275. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  276. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  277. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  279. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
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Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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