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PE anti-mouse CD127 (IL-7Rα) Antibody PE anti-mouse CD127 (IL-7Rα) Antibody

Pricing & Availability
Clone
A7R34 (See other available formats)
Regulatory Status
RUO
Other Names
IL-7 receptor α chain, IL-7Rα
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
A_A7R34_PE_100809
C57BL/6 mouse splenocytes stained with rat IgG2a (RTK2758) PE isotype control and CD3 (145-2C11) APC
  • A_A7R34_PE_100809
    C57BL/6 mouse splenocytes stained with rat IgG2a (RTK2758) PE isotype control and CD3 (145-2C11) APC
  • B_A7R34_PE_100809
    C57BL/6 mouse splenocytes stained with A7R34 PE and CD3 (145-2C11) APC
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
135009 50 µg SEK924
Check Availability


Need larger quantities of this item?
Request Bulk Quote
135010 200 µg SEK3066
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
IL-7Ra-IgG1 fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone A7R34 is able to completely block the binding of clone S18006K to IL-7Rα. It does not block SB/199.

Application References
  1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
  2. Hashi H, et al. 2001. J. Immunol. 166:3702.
  3. Taylor R, et al. 2007. J. Immunol. 178:5659.
  4. Mazzon C, et al. 2011. Blood. 118:2733. PubMed
  5. Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
Product Citations
  1. Fan NW, et al. 2023. FASEB J. 37:e22855. PubMed
  2. Petrova T, et al. 2020. Sci Rep. 10:3479. PubMed
  3. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  4. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  5. Kuczynski EA, et al. 2022. EMBO Mol Med. 14:e15816. PubMed
  6. Campisi L, et al. 2022. Nature. 606:945. PubMed
  7. Lin YH 2023. Immunity. 56(1):207-223.e8. PubMed
  8. Kasuya T, et al. 2023. Sci Rep. 13:1653. PubMed
  9. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  10. Wei H, et al. 2021. Malar J. 20:89. PubMed
  11. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  12. Wang D, et al. 2018. Immunity. 48:659. PubMed
  13. Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
  14. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  15. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  16. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  17. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  18. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  19. Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
  20. Emgård J, et al. 2018. Immunity. 143:419. PubMed
  21. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  22. Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed
  23. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  24. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  25. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  26. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  27. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  28. de Lucía Finkel P, et al. 2021. Sci Rep. 11:12233. PubMed
  29. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  30. Belyaev N, et al. 2010. Nat Immunol. 11:477. PubMed
  31. White C, et al. 2015. J Immunol. 194:697. PubMed
  32. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  33. Chen H, et al. 2021. iScience. 24:103387. PubMed
  34. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  35. Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
  36. Chang P, et al. 2012. J Immunol. 189: 701. PubMed
  37. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  38. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  39. Bajaña S, et al. 2022. iScience. 25:103732. PubMed
  40. Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
  41. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  42. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  43. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  44. Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed
  45. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  46. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  47. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  48. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  49. Fan NW, et al. 2023. FASEB J. 37:e22855. PubMed
  50. Petrova T, et al. 2020. Sci Rep. 10:3479. PubMed
  51. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  52. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  53. Kuczynski EA, et al. 2022. EMBO Mol Med. 14:e15816. PubMed
  54. Campisi L, et al. 2022. Nature. 606:945. PubMed
  55. Lin YH 2023. Immunity. 56(1):207-223.e8. PubMed
  56. Kasuya T, et al. 2023. Sci Rep. 13:1653. PubMed
  57. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  58. Wei H, et al. 2021. Malar J. 20:89. PubMed
  59. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  60. Wang D, et al. 2018. Immunity. 48:659. PubMed
  61. Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
  62. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  63. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  64. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  65. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  66. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  67. Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
  68. Emgård J, et al. 2018. Immunity. 143:419. PubMed
  69. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  70. Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed
  71. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  72. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  73. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  74. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  75. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  76. de Lucía Finkel P, et al. 2021. Sci Rep. 11:12233. PubMed
  77. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  78. Belyaev N, et al. 2010. Nat Immunol. 11:477. PubMed
  79. White C, et al. 2015. J Immunol. 194:697. PubMed
  80. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  81. Chen H, et al. 2021. iScience. 24:103387. PubMed
  82. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  83. Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
  84. Chang P, et al. 2012. J Immunol. 189: 701. PubMed
  85. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  86. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  87. Bajaña S, et al. 2022. iScience. 25:103732. PubMed
  88. Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
  89. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  90. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  91. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  92. Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed
  93. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  94. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  95. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  96. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
RRID
AB_1937252 (BioLegend Cat. No. 135009)
AB_1937251 (BioLegend Cat. No. 135010)

Antigen Details

Structure
Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution

Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells

Function
T cell and immature B cell proliferation and development
Ligand/Receptor
IL-7
Cell Type
B cells, T cells, Thymocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.

Gene ID
16197 View all products for this Gene ID
UniProt
View information about CD127 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD127 Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-mouse CD127 (IL-7Rα) (Maxpar® Ready) A7R34 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 510™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 711™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 785™ anti-mouse CD127 (IL-7Rα) A7R34 FC
APC/Cyanine7 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 650™ anti-mouse CD127 (IL-7Rα) A7R34 FC
TotalSeq™-A0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
TotalSeq™-C0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
Ultra-LEAF™ Purified anti-mouse CD127 (IL-7Rα) A7R34 FC,IP,WB,Block,IHC,ICC
TotalSeq™-B0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
Purified anti-mouse CD127 (IL-7Rα) A7R34 FC,IP,WB,IHC,ICC
FITC anti-mouse CD127 (IL-7Rα) A7R34 FC
PE anti-mouse CD127 (IL-7Rα) A7R34 FC
APC anti-mouse CD127 (IL-7Rα) A7R34 FC
PE/Cyanine7 anti-mouse CD127 (IL-7Rα) A7R34 FC
PE/Cyanine5 anti-mouse CD127 (IL-7Rα) A7R34 FC
Alexa Fluor® 488 anti-mouse CD127 (IL-7Rα) A7R34 FC
Alexa Fluor® 647 anti-mouse CD127 (IL-7Rα) A7R34 FC
PerCP/Cyanine5.5 anti-mouse CD127 (IL-7Rα) A7R34 FC
Biotin anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 421™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 605™ anti-mouse CD127 (IL-7Rα) A7R34 FC
PerCP/Fire™ 780 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 750™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Spark PLUS B488™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Spark UV™ 387 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark YG™ 581 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark YG™ 593 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark NIR™ 685 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Go To Top Version: 1    Revision Date: 11-30-2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
A7R34 (See other available formats)
Regulatory Status
RUO
Other Names
IL-7 receptor α chain, IL-7Rα
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
A_A7R34_PE_100809
C57BL/6 mouse splenocytes stained with rat IgG2a (RTK2758) PE isotype control and CD3 (145-2C11) APC
  • A_A7R34_PE_100809
    C57BL/6 mouse splenocytes stained with rat IgG2a (RTK2758) PE isotype control and CD3 (145-2C11) APC
  • B_A7R34_PE_100809
    C57BL/6 mouse splenocytes stained with A7R34 PE and CD3 (145-2C11) APC
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
135009 50 µg SEK924
Check Availability


Need larger quantities of this item?
Request Bulk Quote
135010 200 µg SEK3066
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
IL-7Ra-IgG1 fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone A7R34 is able to completely block the binding of clone S18006K to IL-7Rα. It does not block SB/199.

Application References
  1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
  2. Hashi H, et al. 2001. J. Immunol. 166:3702.
  3. Taylor R, et al. 2007. J. Immunol. 178:5659.
  4. Mazzon C, et al. 2011. Blood. 118:2733. PubMed
  5. Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed
Product Citations
  1. Fan NW, et al. 2023. FASEB J. 37:e22855. PubMed
  2. Petrova T, et al. 2020. Sci Rep. 10:3479. PubMed
  3. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  4. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  5. Kuczynski EA, et al. 2022. EMBO Mol Med. 14:e15816. PubMed
  6. Campisi L, et al. 2022. Nature. 606:945. PubMed
  7. Lin YH 2023. Immunity. 56(1):207-223.e8. PubMed
  8. Kasuya T, et al. 2023. Sci Rep. 13:1653. PubMed
  9. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  10. Wei H, et al. 2021. Malar J. 20:89. PubMed
  11. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  12. Wang D, et al. 2018. Immunity. 48:659. PubMed
  13. Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
  14. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  15. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  16. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  17. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  18. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  19. Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
  20. Emgård J, et al. 2018. Immunity. 143:419. PubMed
  21. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  22. Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed
  23. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  24. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  25. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  26. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  27. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  28. de Lucía Finkel P, et al. 2021. Sci Rep. 11:12233. PubMed
  29. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  30. Belyaev N, et al. 2010. Nat Immunol. 11:477. PubMed
  31. White C, et al. 2015. J Immunol. 194:697. PubMed
  32. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  33. Chen H, et al. 2021. iScience. 24:103387. PubMed
  34. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  35. Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
  36. Chang P, et al. 2012. J Immunol. 189: 701. PubMed
  37. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  38. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  39. Bajaña S, et al. 2022. iScience. 25:103732. PubMed
  40. Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
  41. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  42. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  43. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  44. Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed
  45. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  46. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  47. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  48. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  49. Fan NW, et al. 2023. FASEB J. 37:e22855. PubMed
  50. Petrova T, et al. 2020. Sci Rep. 10:3479. PubMed
  51. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  52. Kfoury YS, et al. 2021. Cell Stem Cell. 28:2090. PubMed
  53. Kuczynski EA, et al. 2022. EMBO Mol Med. 14:e15816. PubMed
  54. Campisi L, et al. 2022. Nature. 606:945. PubMed
  55. Lin YH 2023. Immunity. 56(1):207-223.e8. PubMed
  56. Kasuya T, et al. 2023. Sci Rep. 13:1653. PubMed
  57. Zheng X, et al. 2019. PLoS Pathog. 15:e1008036. PubMed
  58. Wei H, et al. 2021. Malar J. 20:89. PubMed
  59. Duan Q, et al. 2021. Front Cell Dev Biol. 9:761193. PubMed
  60. Wang D, et al. 2018. Immunity. 48:659. PubMed
  61. Gupta SS, et al. 2019. Cell Rep. 29:1862. PubMed
  62. Mann M, et al. 2018. Cell Rep. 25:2992. PubMed
  63. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
  64. Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed
  65. Parriott G, et al. 2020. Immunology. 160:280. PubMed
  66. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  67. Zebley CC, et al. 2021. Cell Rep. 37:109796. PubMed
  68. Emgård J, et al. 2018. Immunity. 143:419. PubMed
  69. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  70. Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed
  71. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  72. Kotfis K, et al. 2020. British Journal of Pharmacology. 49(1):66-72. PubMed
  73. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  74. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  75. Pardy RD, et al. 2021. Nat Commun. 12:4051. PubMed
  76. de Lucía Finkel P, et al. 2021. Sci Rep. 11:12233. PubMed
  77. La Rose AM, et al. 2021. Mol Metab. 53:101265. PubMed
  78. Belyaev N, et al. 2010. Nat Immunol. 11:477. PubMed
  79. White C, et al. 2015. J Immunol. 194:697. PubMed
  80. Kruta M, et al. 2021. Cell Stem Cell. :. PubMed
  81. Chen H, et al. 2021. iScience. 24:103387. PubMed
  82. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  83. Dekhtiarenko I, et al. 2016. PLoS Pathog. 12:e1006072. PubMed
  84. Chang P, et al. 2012. J Immunol. 189: 701. PubMed
  85. Wang D, et al. 2022. EMBO Rep. 23:e53691. PubMed
  86. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  87. Bajaña S, et al. 2022. iScience. 25:103732. PubMed
  88. Sun Y, et al. 2020. J Immunol. 205:2649. PubMed
  89. Dhayade S, et al. 2020. Nutrients. 12:. PubMed
  90. Magee JA, et al. 2021. Stem Cell Reports. 16:20. PubMed
  91. Gaya M et al. 2018. Cell. 172(3):517-533 . PubMed
  92. Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed
  93. Hidalgo San Jose L, et al. 2020. Cell Rep. 30:69. PubMed
  94. Lu Y, et al. 2018. Cancer Cell. 33:1048. PubMed
  95. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  96. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
RRID
AB_1937252 (BioLegend Cat. No. 135009)
AB_1937251 (BioLegend Cat. No. 135010)

Antigen Details

Structure
Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution

Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells

Function
T cell and immature B cell proliferation and development
Ligand/Receptor
IL-7
Cell Type
B cells, T cells, Thymocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.

Gene ID
16197 View all products for this Gene ID
UniProt
View information about CD127 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD127 Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-mouse CD127 (IL-7Rα) (Maxpar® Ready) A7R34 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 510™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 711™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 785™ anti-mouse CD127 (IL-7Rα) A7R34 FC
APC/Cyanine7 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 650™ anti-mouse CD127 (IL-7Rα) A7R34 FC
TotalSeq™-A0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
TotalSeq™-C0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
Ultra-LEAF™ Purified anti-mouse CD127 (IL-7Rα) A7R34 FC,IP,WB,Block,IHC,ICC
TotalSeq™-B0198 anti-mouse CD127 (IL-7Rα) A7R34 PG
Purified anti-mouse CD127 (IL-7Rα) A7R34 FC,IP,WB,IHC,ICC
FITC anti-mouse CD127 (IL-7Rα) A7R34 FC
PE anti-mouse CD127 (IL-7Rα) A7R34 FC
APC anti-mouse CD127 (IL-7Rα) A7R34 FC
PE/Cyanine7 anti-mouse CD127 (IL-7Rα) A7R34 FC
PE/Cyanine5 anti-mouse CD127 (IL-7Rα) A7R34 FC
Alexa Fluor® 488 anti-mouse CD127 (IL-7Rα) A7R34 FC
Alexa Fluor® 647 anti-mouse CD127 (IL-7Rα) A7R34 FC
PerCP/Cyanine5.5 anti-mouse CD127 (IL-7Rα) A7R34 FC
Biotin anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 421™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 605™ anti-mouse CD127 (IL-7Rα) A7R34 FC
PerCP/Fire™ 780 anti-mouse CD127 (IL-7Rα) A7R34 FC
Brilliant Violet 750™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Spark PLUS B488™ anti-mouse CD127 (IL-7Rα) A7R34 FC
Spark UV™ 387 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark YG™ 581 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark YG™ 593 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Spark NIR™ 685 anti-mouse CD127 (IL-7Rα) (Flexi-Fluor™) A7R34 FC
Go To Top Version: 1    Revision Date: 11-30-2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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