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Propidium Iodide Solution Propidium Iodide Solution

Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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421301 2 mL SEK454
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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  4. Sakimoto I, et al. 2006. Cancer Research 66:2287.PubMed
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  9. Beggs KM, et al. 2014. Toxicol Sci. 137:91. PubMed
  10. Ewald SE, et al. 2014. Infect Immun. 82:460. PubMed
  11. Tsou WI, et al. 2014. J Biol Chem. 289:25750. PubMed
  12. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
Product Citations
  1. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  2. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  3. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  4. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
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  6. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  7. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  8. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  9. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
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  11. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  12. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  13. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  14. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  15. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  16. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  17. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  18. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  19. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  20. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  21. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  22. Quintela M, et al. 2023. Br J Cancer. . PubMed
  23. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
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  25. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
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  27. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  28. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  29. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  30. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  31. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  32. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  33. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  34. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  35. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  36. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  37. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  38. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  39. McNeal AS, et al. 2021. Elife. 10:. PubMed
  40. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  41. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  42. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  43. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  44. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  45. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  46. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  47. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  48. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  49. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  50. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  51. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  52. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  53. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  54. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  56. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  57. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  58. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  59. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  60. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  61. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  62. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  63. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  64. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  65. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  66. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  67. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  68. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  69. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  70. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  71. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  72. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  73. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  74. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  75. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  76. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  77. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  78. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  82. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  83. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  84. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  85. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  86. Wang J, et al. 2022. J Clin Invest. :. PubMed
  87. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  88. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  89. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  90. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  91. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  92. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  93. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  94. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  95. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  96. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  97. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  100. Harro CM, et al. 2020. J Clin Invest. . PubMed
  101. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  102. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  103. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  104. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  105. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  106. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  107. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  108. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  109. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  110. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  111. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  112. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  113. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  114. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  115. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  116. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  117. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  121. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  122. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  123. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  130. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  131. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  132. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  133. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  134. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  135. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  137. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  138. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  140. Vulin M, et al. 2022. Oncogene. :. PubMed
  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  144. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  145. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  146. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  147. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  148. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  149. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  150. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  151. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  152. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  153. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  154. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  155. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  156. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  157. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  158. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  159. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  160. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  161. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  162. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  163. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  164. Quintela M, et al. 2023. Br J Cancer. . PubMed
  165. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  166. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  167. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  168. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  169. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  170. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  171. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  172. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  183. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  184. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  185. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  186. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  187. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  190. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  191. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  192. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  193. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  194. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  200. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  201. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  202. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  203. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  207. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  208. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  214. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  215. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  216. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  217. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  218. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  219. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  220. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  224. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  225. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  226. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  227. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  228. Wang J, et al. 2022. J Clin Invest. :. PubMed
  229. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  230. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  231. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  232. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  233. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  234. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  242. Harro CM, et al. 2020. J Clin Invest. . PubMed
  243. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  244. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  245. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  246. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  247. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  248. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  251. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  252. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  253. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  256. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  257. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  258. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  259. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  263. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  264. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  265. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  272. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  273. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  274. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  275. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  276. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  277. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  279. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  280. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  281. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  282. Vulin M, et al. 2022. Oncogene. :. PubMed
  283. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  284. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed

Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10-08-2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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421301 2 mL SEK454
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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Product Citations
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  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
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  76. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  77. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  78. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
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  99. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
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  116. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
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  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
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  121. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  122. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  123. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  124. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  127. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  128. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  129. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  130. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  131. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  132. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  133. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  134. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
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  136. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
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  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
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  141. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  142. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  143. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  144. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  145. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  146. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  147. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  148. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  149. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  150. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  151. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  152. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  153. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  154. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  155. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  156. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  157. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  158. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  159. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  160. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  161. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  162. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  163. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  164. Quintela M, et al. 2023. Br J Cancer. . PubMed
  165. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  166. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  167. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  168. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  169. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  170. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  171. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  172. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  175. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  176. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  177. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  178. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  179. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  180. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  181. McNeal AS, et al. 2021. Elife. 10:. PubMed
  182. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  183. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  184. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  185. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  186. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  187. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  190. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  191. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  192. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  193. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  194. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  200. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  201. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  202. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  203. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  204. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  205. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  206. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  207. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  208. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  211. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  212. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  213. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  214. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  215. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  216. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  217. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  218. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  219. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  220. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  224. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  225. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  226. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  227. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  228. Wang J, et al. 2022. J Clin Invest. :. PubMed
  229. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  230. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  231. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  232. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  233. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  234. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  242. Harro CM, et al. 2020. J Clin Invest. . PubMed
  243. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  244. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  245. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  246. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  247. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  248. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  251. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  252. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  253. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  254. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  255. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  256. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  257. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  258. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  259. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  263. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  264. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  265. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  266. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  269. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  270. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  271. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  272. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  273. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  274. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  275. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  276. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  277. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  278. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
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Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10-08-2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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