Loading...

APC/Cyanine7 anti-mouse CD3 Antibody APC/Cyanine7 anti-mouse CD3 Antibody

Pricing & Availability
Clone
17A2 (See other available formats)
Regulatory Status
RUO
Other Names
T cell antigen receptor complex, T3
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
17A2_APCCyanine7_CD3_Antibody_031919_updated.png
C57BL/6 splenocytes were stained with CD45R/B220 FITC and CD3 (clone 17A2) APC/Cyanine7 (left) or Rat IgG2b, κ APC/Cyanine7 isotype control (right).
  • 17A2_APCCyanine7_CD3_Antibody_031919_updated.png
    C57BL/6 splenocytes were stained with CD45R/B220 FITC and CD3 (clone 17A2) APC/Cyanine7 (left) or Rat IgG2b, κ APC/Cyanine7 isotype control (right).
Compare all formats See APC/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
100222 100 µg SEK2033
Check Availability


Need larger quantities of this item?
Request Bulk Quote
100221 25 µg SEK882
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD3, also known as T3, is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 is composed of CD3ε, δ, γ and ζ chains. It forms a TCR complex by associating with TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
γδTCR-positive T-T hybridoma D1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported application (for relevant formats) include: spatial biology (IBEX)1,2.

Application References
  1. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  2. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Chung Y, et al. 2014. J Vis Exp. 89: 51660. PubMed
  2. Wu Y, et al. 2021. Immunity. 54:2595. PubMed
  3. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  4. Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed
  5. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  6. Lin G, et al. 2022. Int J Immunopathol Pharmacol. 36:3946320221117933. PubMed
  7. Lee SH, et al. 2023. Nutrients. 15: . PubMed
  8. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  9. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  10. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  11. Abu Hejleh AP, et al. 2023. Int J Tryptophan Res. 16:11786469231153111. PubMed
  12. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  13. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  14. Tao X, et al. 2022. J Exp Med. 219:. PubMed
  15. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  16. Jeon Y, et al. 2022. Cancers (Basel). 14:. PubMed
  17. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  18. Swan SL, et al. 2023. Front Immunol. 14:1085547. PubMed
  19. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  20. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  21. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  22. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  23. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  24. Pelletier A, et al. 2023. EMBO Rep. 24:e56156. PubMed
  25. Tong L, et al. 2023. Sci Adv. 9:eade5041. PubMed
  26. Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed
  27. Zhang J, et al. 2023. Theranostics. 13:2226. PubMed
  28. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  29. van Os BW, et al. 2023. Front Cardiovasc Med. 10:1171764. PubMed
  30. Mackel JJ, et al. 2022. Front Cell Infect Microbiol. 12:974175. PubMed
  31. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  32. Marco Barros R, et al. 2016. Cell. 167: 203-218. PubMed
  33. Shimizu K, et al. 2020. Molecular Cell. 77(5):937-950.e6.. PubMed
  34. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  35. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  36. Israelow B, et al. 2020. bioRxiv. . PubMed
  37. Ferrere G, et al. 2021. JCI Insight. 6:. PubMed
  38. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
  39. Durgeau A, et al. 2018. Nat Commun. 9:5097. PubMed
  40. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  41. Turner JA, et al. 2020. Immunity. 53:1202. PubMed
  42. Chen S, et al. 2022. Cancer Discov. :. PubMed
  43. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  44. Zhou Y, et al. 2016. Acta Pharmacol Sin. 10.1038/aps.2016.102. PubMed
  45. Haertel E, et al. 2018. Eur J Immunol. 48:1001. PubMed
  46. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  47. Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
  48. Diao L, et al. 2022. iScience. 25:105511. PubMed
  49. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  50. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  51. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  52. Tirado-Gonzalez I, et al. 2021. Cancer Discov. 11:2924. PubMed
  53. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  54. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  55. Mathews J, et al. 2014. PLoS One. 9:97707. PubMed
  56. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  57. Shi L, et al. 2021. Immunity. . PubMed
  58. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  59. Chung H, et al. 2021. Immune Netw. 21:e28. PubMed
  60. Spees A, et al. 2014. Infect Immun . 82:1692. PubMed
  61. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  62. Super M, et al. 2021. Nat Biomed Eng. Online ahead of print. PubMed
  63. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  64. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  65. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  66. Wei JL, et al. 2021. J Immunother Cancer. 9: . PubMed
  67. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  68. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  69. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  70. Pandey V, et al. 2021. eLife. 0.416666666666667. PubMed
  71. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  72. Xue L, et al. 2021. BMC Cancer. 21:1134. PubMed
  73. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  74. Adane B, et al. 2019. Cell Rep. 27:238. PubMed
  75. Rashidi M, et al. 2019. J Immunol. 203:736. PubMed
  76. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  77. Liu X, et al. 2022. Nat Cancer. :. PubMed
  78. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  79. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  80. Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed
  81. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  82. Alameh MG, et al. 2021. Immunity. 54:2877. PubMed
  83. Voss M, et al. 2015. Am J Physiol Lung Cell Mol Physiol. 309: L188 - L195. PubMed
  84. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  85. Lang V, et al. 2021. Elife. 10:. PubMed
  86. Zhu W, et al. 2019. FASEB J. 33:5208. PubMed
  87. Jandke A, et al. 2020. Nat Commun. 3.075694444. PubMed
  88. Fischer FA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  89. Robles-Oteiza C, et al. 2021. Dis Model Mech. 14:. PubMed
  90. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  91. Revathikumar P, et al. 2018. PLoS One. 13:e0193210. PubMed
  92. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  93. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  94. Miyauchi E, et al. 2020. Nature. 585:102. PubMed
  95. Sanchez HN, et al. 2020. Nat Commun. 0.5. PubMed
  96. Teater M, et al. 2018. Nat Commun. 9:222. PubMed
  97. Draijer C, et al. 2018. Sci Rep. 8:5105. PubMed
  98. Yin S et al. 2019. Cancer cell. 35(2):283-296 . PubMed
  99. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  100. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  101. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  102. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  103. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  104. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  105. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  106. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  107. Jie Z, et al. 2014. J Immunol. 192:3289. PubMed
  108. Dokoshi T, et al. 2020. Cell Rep. 30:61. PubMed
  109. Szodoray P, et al. 2021. Cell Reports. 36(6):109525. PubMed
  110. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  111. Rouse MD, et al. 2020. Front Microbiol. 11:414. PubMed
  112. Katzmarski N, et al. 2021. Nat Immunol. 22:1382. PubMed
  113. Wen J, et al. 2015. J Pharmacol Sci. 128: 116-124. PubMed
  114. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  115. Sharma R, et al. 2021. J Neuroinflammation. 72:18. PubMed
  116. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  117. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  118. Li C, et al. 2021. Chem Biol Drug Des. 97:1151. PubMed
  119. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  120. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  121. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  122. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  123. Nakazawa S, et al. 2020. Sci Rep. 10:14559. PubMed
  124. Chung Y, et al. 2014. J Vis Exp. 89: 51660. PubMed
  125. Wu Y, et al. 2021. Immunity. 54:2595. PubMed
  126. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  127. Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed
  128. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  129. Lin G, et al. 2022. Int J Immunopathol Pharmacol. 36:3946320221117933. PubMed
  130. Lee SH, et al. 2023. Nutrients. 15: . PubMed
  131. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  132. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  133. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  134. Abu Hejleh AP, et al. 2023. Int J Tryptophan Res. 16:11786469231153111. PubMed
  135. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  136. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  137. Tao X, et al. 2022. J Exp Med. 219:. PubMed
  138. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  139. Jeon Y, et al. 2022. Cancers (Basel). 14:. PubMed
  140. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  141. Swan SL, et al. 2023. Front Immunol. 14:1085547. PubMed
  142. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  143. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  144. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  145. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  146. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  147. Pelletier A, et al. 2023. EMBO Rep. 24:e56156. PubMed
  148. Tong L, et al. 2023. Sci Adv. 9:eade5041. PubMed
  149. Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed
  150. Zhang J, et al. 2023. Theranostics. 13:2226. PubMed
  151. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  152. van Os BW, et al. 2023. Front Cardiovasc Med. 10:1171764. PubMed
  153. Mackel JJ, et al. 2022. Front Cell Infect Microbiol. 12:974175. PubMed
  154. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  155. Marco Barros R, et al. 2016. Cell. 167: 203-218. PubMed
  156. Shimizu K, et al. 2020. Molecular Cell. 77(5):937-950.e6.. PubMed
  157. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  158. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  159. Israelow B, et al. 2020. bioRxiv. . PubMed
  160. Ferrere G, et al. 2021. JCI Insight. 6:. PubMed
  161. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
  162. Durgeau A, et al. 2018. Nat Commun. 9:5097. PubMed
  163. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  164. Turner JA, et al. 2020. Immunity. 53:1202. PubMed
  165. Chen S, et al. 2022. Cancer Discov. :. PubMed
  166. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  167. Zhou Y, et al. 2016. Acta Pharmacol Sin. 10.1038/aps.2016.102. PubMed
  168. Haertel E, et al. 2018. Eur J Immunol. 48:1001. PubMed
  169. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  170. Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
  171. Diao L, et al. 2022. iScience. 25:105511. PubMed
  172. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  173. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  174. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  175. Tirado-Gonzalez I, et al. 2021. Cancer Discov. 11:2924. PubMed
  176. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  177. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  178. Mathews J, et al. 2014. PLoS One. 9:97707. PubMed
  179. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  180. Shi L, et al. 2021. Immunity. . PubMed
  181. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  182. Chung H, et al. 2021. Immune Netw. 21:e28. PubMed
  183. Spees A, et al. 2014. Infect Immun . 82:1692. PubMed
  184. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  185. Super M, et al. 2021. Nat Biomed Eng. Online ahead of print. PubMed
  186. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  187. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  188. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  189. Wei JL, et al. 2021. J Immunother Cancer. 9: . PubMed
  190. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  191. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  192. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  193. Pandey V, et al. 2021. eLife. 0.416666666666667. PubMed
  194. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  195. Xue L, et al. 2021. BMC Cancer. 21:1134. PubMed
  196. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  197. Adane B, et al. 2019. Cell Rep. 27:238. PubMed
  198. Rashidi M, et al. 2019. J Immunol. 203:736. PubMed
  199. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  200. Liu X, et al. 2022. Nat Cancer. :. PubMed
  201. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  202. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  203. Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed
  204. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  205. Alameh MG, et al. 2021. Immunity. 54:2877. PubMed
  206. Voss M, et al. 2015. Am J Physiol Lung Cell Mol Physiol. 309: L188 - L195. PubMed
  207. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  208. Lang V, et al. 2021. Elife. 10:. PubMed
  209. Zhu W, et al. 2019. FASEB J. 33:5208. PubMed
  210. Jandke A, et al. 2020. Nat Commun. 3.075694444. PubMed
  211. Fischer FA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  212. Robles-Oteiza C, et al. 2021. Dis Model Mech. 14:. PubMed
  213. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  214. Revathikumar P, et al. 2018. PLoS One. 13:e0193210. PubMed
  215. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  216. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  217. Miyauchi E, et al. 2020. Nature. 585:102. PubMed
  218. Sanchez HN, et al. 2020. Nat Commun. 0.5. PubMed
  219. Teater M, et al. 2018. Nat Commun. 9:222. PubMed
  220. Draijer C, et al. 2018. Sci Rep. 8:5105. PubMed
  221. Yin S et al. 2019. Cancer cell. 35(2):283-296 . PubMed
  222. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  223. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  224. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  225. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  226. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  227. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  228. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  229. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  230. Jie Z, et al. 2014. J Immunol. 192:3289. PubMed
  231. Dokoshi T, et al. 2020. Cell Rep. 30:61. PubMed
  232. Szodoray P, et al. 2021. Cell Reports. 36(6):109525. PubMed
  233. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  234. Rouse MD, et al. 2020. Front Microbiol. 11:414. PubMed
  235. Katzmarski N, et al. 2021. Nat Immunol. 22:1382. PubMed
  236. Wen J, et al. 2015. J Pharmacol Sci. 128: 116-124. PubMed
  237. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  238. Sharma R, et al. 2021. J Neuroinflammation. 72:18. PubMed
  239. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  240. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  241. Li C, et al. 2021. Chem Biol Drug Des. 97:1151. PubMed
  242. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  243. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  244. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  245. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  246. Nakazawa S, et al. 2020. Sci Rep. 10:14559. PubMed
RRID
AB_2242784 (BioLegend Cat. No. 100222)
AB_2057374 (BioLegend Cat. No. 100221)

Antigen Details

Structure
Ig superfamily, CD3/TCR, 20 kD
Distribution

Thymocytes (differentiation dependent), mature T cells, NK-T cells

Function
Antigen recognition, TCR signal transduction, T cell activation
Ligand/Receptor
Peptide antigen/MHC-complex
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Davis MM. 1990. Annu. Rev. Biochem. 59:475.
3. Weiss A, et al. 1994. Cell 76:263.

Gene ID
12502 View all products for this Gene ID
UniProt
View information about CD3 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD3 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 711™ anti-mouse CD3 17A2 FC
Biotin anti-mouse CD3 17A2 FC,IHC-F
PE/Dazzle™ 594 anti-mouse CD3 17A2 FC
APC/Fire™ 750 anti-mouse CD3 17A2 FC
Brilliant Violet 750™ anti-mouse CD3 17A2 FC
TotalSeq™-A0182 anti-mouse CD3 17A2 PG
TotalSeq™-B0182 anti-mouse CD3 17A2 PG
Spark Blue™ 550 anti-mouse CD3 17A2 FC
Spark NIR™ 685 anti-mouse CD3 17A2 FC
TotalSeq™-C0182 anti-mouse CD3 17A2 PG
APC/Fire™ 810 anti-mouse CD3 17A2 FC
PE/Fire™ 640 anti-mouse CD3 17A2 FC
Spark YG™ 570 anti-mouse CD3 17A2 IHC-F
PE/Fire™ 700 anti-mouse CD3 17A2 FC
Test 17A2 5 17A2
FITC anti-mouse CD3 17A2 FC
PE anti-mouse CD3 17A2 FC
Purified anti-mouse CD3 17A2 FC,IHC-F,IP,ICC
Alexa Fluor® 647 anti-mouse CD3 17A2 FC,IHC-F,3D IHC,SB
Alexa Fluor® 488 anti-mouse CD3 17A2 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse CD3 17A2 FC
Alexa Fluor® 700 anti-mouse CD3 17A2 FC
PerCP/Cyanine5.5 anti-mouse CD3 17A2 FC
PE/Cyanine7 anti-mouse CD3 17A2 FC
APC/Cyanine7 anti-mouse CD3 17A2 FC
Brilliant Violet 421™ anti-mouse CD3 17A2 FC,ICC
Brilliant Violet 570™ anti-mouse CD3 17A2 FC
Brilliant Violet 650™ anti-mouse CD3 17A2 FC
Brilliant Violet 785™ anti-mouse CD3 17A2 FC
Brilliant Violet 510™ anti-mouse CD3 17A2 FC
APC anti-mouse CD3 17A2 FC
Ultra-LEAF™ Purified anti-mouse CD3 17A2 FC,IHC-F,IP,ICC
Brilliant Violet 605™ anti-mouse CD3 17A2 FC
Alexa Fluor® 594 anti-mouse CD3 17A2 IHC-F,FC,3D IHC,SB
PE/Cyanine5 anti-mouse CD3 17A2 FC
Spark Blue™ 574 anti-mouse CD3 Antibody 17A2 FC
Spark Violet™ 423 anti-mouse CD3 17A2 FC
PE/Fire™ 810 anti-mouse CD3 17A2 FC
Spark Red™ 718 anti-mouse CD3 17A2 FC
Spark UV™ 387 anti-mouse CD3 17A2 FC
PerCP/Fire™ 780 anti-mouse CD3 Antibody 17A2 FC
PerCP anti-mouse CD3 Antibody 17A2 FC
Spark YG™ 581 anti-mouse CD3 (Flexi-Fluor™) 17A2 FC
Spark YG™ 593 anti-mouse CD3 (Flexi-Fluor™) Antibody 17A2 FC
Spark PLUS B488™ anti-mouse CD3 17A2 FC
Go To Top Version: 3    Revision Date: 03-19-2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
17A2 (See other available formats)
Regulatory Status
RUO
Other Names
T cell antigen receptor complex, T3
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
17A2_APCCyanine7_CD3_Antibody_031919_updated.png
C57BL/6 splenocytes were stained with CD45R/B220 FITC and CD3 (clone 17A2) APC/Cyanine7 (left) or Rat IgG2b, κ APC/Cyanine7 isotype control (right).
  • 17A2_APCCyanine7_CD3_Antibody_031919_updated.png
    C57BL/6 splenocytes were stained with CD45R/B220 FITC and CD3 (clone 17A2) APC/Cyanine7 (left) or Rat IgG2b, κ APC/Cyanine7 isotype control (right).
Compare all formats See APC/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
100222 100 µg SEK2033
Check Availability


Need larger quantities of this item?
Request Bulk Quote
100221 25 µg SEK882
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD3, also known as T3, is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 is composed of CD3ε, δ, γ and ζ chains. It forms a TCR complex by associating with TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
γδTCR-positive T-T hybridoma D1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported application (for relevant formats) include: spatial biology (IBEX)1,2.

Application References
  1. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  2. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Chung Y, et al. 2014. J Vis Exp. 89: 51660. PubMed
  2. Wu Y, et al. 2021. Immunity. 54:2595. PubMed
  3. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  4. Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed
  5. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  6. Lin G, et al. 2022. Int J Immunopathol Pharmacol. 36:3946320221117933. PubMed
  7. Lee SH, et al. 2023. Nutrients. 15: . PubMed
  8. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  9. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  10. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  11. Abu Hejleh AP, et al. 2023. Int J Tryptophan Res. 16:11786469231153111. PubMed
  12. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  13. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  14. Tao X, et al. 2022. J Exp Med. 219:. PubMed
  15. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  16. Jeon Y, et al. 2022. Cancers (Basel). 14:. PubMed
  17. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  18. Swan SL, et al. 2023. Front Immunol. 14:1085547. PubMed
  19. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  20. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  21. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  22. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  23. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  24. Pelletier A, et al. 2023. EMBO Rep. 24:e56156. PubMed
  25. Tong L, et al. 2023. Sci Adv. 9:eade5041. PubMed
  26. Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed
  27. Zhang J, et al. 2023. Theranostics. 13:2226. PubMed
  28. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  29. van Os BW, et al. 2023. Front Cardiovasc Med. 10:1171764. PubMed
  30. Mackel JJ, et al. 2022. Front Cell Infect Microbiol. 12:974175. PubMed
  31. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  32. Marco Barros R, et al. 2016. Cell. 167: 203-218. PubMed
  33. Shimizu K, et al. 2020. Molecular Cell. 77(5):937-950.e6.. PubMed
  34. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  35. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  36. Israelow B, et al. 2020. bioRxiv. . PubMed
  37. Ferrere G, et al. 2021. JCI Insight. 6:. PubMed
  38. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
  39. Durgeau A, et al. 2018. Nat Commun. 9:5097. PubMed
  40. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  41. Turner JA, et al. 2020. Immunity. 53:1202. PubMed
  42. Chen S, et al. 2022. Cancer Discov. :. PubMed
  43. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  44. Zhou Y, et al. 2016. Acta Pharmacol Sin. 10.1038/aps.2016.102. PubMed
  45. Haertel E, et al. 2018. Eur J Immunol. 48:1001. PubMed
  46. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  47. Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
  48. Diao L, et al. 2022. iScience. 25:105511. PubMed
  49. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  50. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  51. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  52. Tirado-Gonzalez I, et al. 2021. Cancer Discov. 11:2924. PubMed
  53. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  54. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  55. Mathews J, et al. 2014. PLoS One. 9:97707. PubMed
  56. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  57. Shi L, et al. 2021. Immunity. . PubMed
  58. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  59. Chung H, et al. 2021. Immune Netw. 21:e28. PubMed
  60. Spees A, et al. 2014. Infect Immun . 82:1692. PubMed
  61. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  62. Super M, et al. 2021. Nat Biomed Eng. Online ahead of print. PubMed
  63. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  64. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  65. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  66. Wei JL, et al. 2021. J Immunother Cancer. 9: . PubMed
  67. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  68. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  69. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  70. Pandey V, et al. 2021. eLife. 0.416666666666667. PubMed
  71. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  72. Xue L, et al. 2021. BMC Cancer. 21:1134. PubMed
  73. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  74. Adane B, et al. 2019. Cell Rep. 27:238. PubMed
  75. Rashidi M, et al. 2019. J Immunol. 203:736. PubMed
  76. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  77. Liu X, et al. 2022. Nat Cancer. :. PubMed
  78. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  79. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  80. Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed
  81. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  82. Alameh MG, et al. 2021. Immunity. 54:2877. PubMed
  83. Voss M, et al. 2015. Am J Physiol Lung Cell Mol Physiol. 309: L188 - L195. PubMed
  84. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  85. Lang V, et al. 2021. Elife. 10:. PubMed
  86. Zhu W, et al. 2019. FASEB J. 33:5208. PubMed
  87. Jandke A, et al. 2020. Nat Commun. 3.075694444. PubMed
  88. Fischer FA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  89. Robles-Oteiza C, et al. 2021. Dis Model Mech. 14:. PubMed
  90. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  91. Revathikumar P, et al. 2018. PLoS One. 13:e0193210. PubMed
  92. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  93. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  94. Miyauchi E, et al. 2020. Nature. 585:102. PubMed
  95. Sanchez HN, et al. 2020. Nat Commun. 0.5. PubMed
  96. Teater M, et al. 2018. Nat Commun. 9:222. PubMed
  97. Draijer C, et al. 2018. Sci Rep. 8:5105. PubMed
  98. Yin S et al. 2019. Cancer cell. 35(2):283-296 . PubMed
  99. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  100. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  101. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  102. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  103. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  104. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  105. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  106. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  107. Jie Z, et al. 2014. J Immunol. 192:3289. PubMed
  108. Dokoshi T, et al. 2020. Cell Rep. 30:61. PubMed
  109. Szodoray P, et al. 2021. Cell Reports. 36(6):109525. PubMed
  110. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  111. Rouse MD, et al. 2020. Front Microbiol. 11:414. PubMed
  112. Katzmarski N, et al. 2021. Nat Immunol. 22:1382. PubMed
  113. Wen J, et al. 2015. J Pharmacol Sci. 128: 116-124. PubMed
  114. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  115. Sharma R, et al. 2021. J Neuroinflammation. 72:18. PubMed
  116. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  117. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  118. Li C, et al. 2021. Chem Biol Drug Des. 97:1151. PubMed
  119. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  120. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  121. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  122. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  123. Nakazawa S, et al. 2020. Sci Rep. 10:14559. PubMed
  124. Chung Y, et al. 2014. J Vis Exp. 89: 51660. PubMed
  125. Wu Y, et al. 2021. Immunity. 54:2595. PubMed
  126. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  127. Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed
  128. Backlund C, et al. 2022. Proc Natl Acad Sci U S A. 119:e2204078119. PubMed
  129. Lin G, et al. 2022. Int J Immunopathol Pharmacol. 36:3946320221117933. PubMed
  130. Lee SH, et al. 2023. Nutrients. 15: . PubMed
  131. Zhang B, et al. 2023. Signal Transduct Target Ther. 8:28. PubMed
  132. Meng S, et al. 2023. Stem Cell Investig. 10:2. PubMed
  133. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  134. Abu Hejleh AP, et al. 2023. Int J Tryptophan Res. 16:11786469231153111. PubMed
  135. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  136. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  137. Tao X, et al. 2022. J Exp Med. 219:. PubMed
  138. Chen R, et al. 2022. J Mol Cell Biol. 14:. PubMed
  139. Jeon Y, et al. 2022. Cancers (Basel). 14:. PubMed
  140. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  141. Swan SL, et al. 2023. Front Immunol. 14:1085547. PubMed
  142. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  143. Wang YC, et al. 2023. J Exp Med. 220:. PubMed
  144. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  145. Cheng MI, et al. 2023. Nat Immunol. 24:780. PubMed
  146. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  147. Pelletier A, et al. 2023. EMBO Rep. 24:e56156. PubMed
  148. Tong L, et al. 2023. Sci Adv. 9:eade5041. PubMed
  149. Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed
  150. Zhang J, et al. 2023. Theranostics. 13:2226. PubMed
  151. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  152. van Os BW, et al. 2023. Front Cardiovasc Med. 10:1171764. PubMed
  153. Mackel JJ, et al. 2022. Front Cell Infect Microbiol. 12:974175. PubMed
  154. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  155. Marco Barros R, et al. 2016. Cell. 167: 203-218. PubMed
  156. Shimizu K, et al. 2020. Molecular Cell. 77(5):937-950.e6.. PubMed
  157. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  158. Alissafi T, et al. 2018. J Clin Invest. 128:3840. PubMed
  159. Israelow B, et al. 2020. bioRxiv. . PubMed
  160. Ferrere G, et al. 2021. JCI Insight. 6:. PubMed
  161. Silver AC, et al. 2018. Heliyon. 4:e00579. PubMed
  162. Durgeau A, et al. 2018. Nat Commun. 9:5097. PubMed
  163. Marques RM, et al. 2021. Cell Death Differ. 28:3140. PubMed
  164. Turner JA, et al. 2020. Immunity. 53:1202. PubMed
  165. Chen S, et al. 2022. Cancer Discov. :. PubMed
  166. Coleby R, et al. 2021. Clin Exp Rheumatol. :39. PubMed
  167. Zhou Y, et al. 2016. Acta Pharmacol Sin. 10.1038/aps.2016.102. PubMed
  168. Haertel E, et al. 2018. Eur J Immunol. 48:1001. PubMed
  169. Choi H et al. 2019. Cell Rep. 27(3):806-819 . PubMed
  170. Tordesillas L, et al. 2018. Nat Commun. 9:5238. PubMed
  171. Diao L, et al. 2022. iScience. 25:105511. PubMed
  172. Ma C, et al. 2021. Signal Transduct Target Ther. 6:353. PubMed
  173. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  174. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  175. Tirado-Gonzalez I, et al. 2021. Cancer Discov. 11:2924. PubMed
  176. Herman JD, et al. 2021. Nat Commun. 12:6853. PubMed
  177. Tilstam PV, et al. 2021. J Clin Invest. 131:. PubMed
  178. Mathews J, et al. 2014. PLoS One. 9:97707. PubMed
  179. Rafiq S, et al. 2018. Nat Biotechnol. 36:847. PubMed
  180. Shi L, et al. 2021. Immunity. . PubMed
  181. Inoue D, et al. 2021. Nat Genet. 53:707. PubMed
  182. Chung H, et al. 2021. Immune Netw. 21:e28. PubMed
  183. Spees A, et al. 2014. Infect Immun . 82:1692. PubMed
  184. Yoshimi A, et al. 2019. Nature. 574:273. PubMed
  185. Super M, et al. 2021. Nat Biomed Eng. Online ahead of print. PubMed
  186. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  187. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  188. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  189. Wei JL, et al. 2021. J Immunother Cancer. 9: . PubMed
  190. Han JP, et al. 2022. Sci Adv. 8:eabj6901. PubMed
  191. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  192. Zhang B, et al. 2021. Nat Biomed Eng. 5:1288. PubMed
  193. Pandey V, et al. 2021. eLife. 0.416666666666667. PubMed
  194. Katsinas N, et al. 2022. J Clin Med. 11:. PubMed
  195. Xue L, et al. 2021. BMC Cancer. 21:1134. PubMed
  196. Schadt L, et al. 2020. Cell Reports. 29(5):1236-1248.e7.. PubMed
  197. Adane B, et al. 2019. Cell Rep. 27:238. PubMed
  198. Rashidi M, et al. 2019. J Immunol. 203:736. PubMed
  199. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  200. Liu X, et al. 2022. Nat Cancer. :. PubMed
  201. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  202. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  203. Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed
  204. Rohner L, et al. 2020. Sci Rep. 0.570833333. PubMed
  205. Alameh MG, et al. 2021. Immunity. 54:2877. PubMed
  206. Voss M, et al. 2015. Am J Physiol Lung Cell Mol Physiol. 309: L188 - L195. PubMed
  207. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  208. Lang V, et al. 2021. Elife. 10:. PubMed
  209. Zhu W, et al. 2019. FASEB J. 33:5208. PubMed
  210. Jandke A, et al. 2020. Nat Commun. 3.075694444. PubMed
  211. Fischer FA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  212. Robles-Oteiza C, et al. 2021. Dis Model Mech. 14:. PubMed
  213. Li J, et al. 2022. Nat Commun. 13:4032. PubMed
  214. Revathikumar P, et al. 2018. PLoS One. 13:e0193210. PubMed
  215. Zhang S, et al. 2022. Nat Commun. 13:4744. PubMed
  216. Kwok T, et al. 2022. Front Aging. 3:838943. PubMed
  217. Miyauchi E, et al. 2020. Nature. 585:102. PubMed
  218. Sanchez HN, et al. 2020. Nat Commun. 0.5. PubMed
  219. Teater M, et al. 2018. Nat Commun. 9:222. PubMed
  220. Draijer C, et al. 2018. Sci Rep. 8:5105. PubMed
  221. Yin S et al. 2019. Cancer cell. 35(2):283-296 . PubMed
  222. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  223. Dhar P, et al. 2021. Commun Biol. 4:905. PubMed
  224. Do-Thi VA, et al. 2021. Cancers (Basel). 13:. PubMed
  225. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  226. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  227. Bagati A, et al. 2020. Cancer Cell. 39(1):54-67.e9. PubMed
  228. Israelow B, et al. 2020. J Exp Med. 217:00:00. PubMed
  229. Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed
  230. Jie Z, et al. 2014. J Immunol. 192:3289. PubMed
  231. Dokoshi T, et al. 2020. Cell Rep. 30:61. PubMed
  232. Szodoray P, et al. 2021. Cell Reports. 36(6):109525. PubMed
  233. Chao JL, et al. 2021. Cell Rep Med. 2:100399. PubMed
  234. Rouse MD, et al. 2020. Front Microbiol. 11:414. PubMed
  235. Katzmarski N, et al. 2021. Nat Immunol. 22:1382. PubMed
  236. Wen J, et al. 2015. J Pharmacol Sci. 128: 116-124. PubMed
  237. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  238. Sharma R, et al. 2021. J Neuroinflammation. 72:18. PubMed
  239. Siolas D, et al. 2021. Cell Reports. 36:109578. PubMed
  240. Hildreth AD, et al. 2020. STAR Protoc. 1:100113. PubMed
  241. Li C, et al. 2021. Chem Biol Drug Des. 97:1151. PubMed
  242. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  243. Kojima T, et al. 2016. Sci Rep. 6:36457. PubMed
  244. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  245. Rodrigues KA, et al. 2021. Sci Adv. 7:eabj6538. PubMed
  246. Nakazawa S, et al. 2020. Sci Rep. 10:14559. PubMed
RRID
AB_2242784 (BioLegend Cat. No. 100222)
AB_2057374 (BioLegend Cat. No. 100221)

Antigen Details

Structure
Ig superfamily, CD3/TCR, 20 kD
Distribution

Thymocytes (differentiation dependent), mature T cells, NK-T cells

Function
Antigen recognition, TCR signal transduction, T cell activation
Ligand/Receptor
Peptide antigen/MHC-complex
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Davis MM. 1990. Annu. Rev. Biochem. 59:475.
3. Weiss A, et al. 1994. Cell 76:263.

Gene ID
12502 View all products for this Gene ID
UniProt
View information about CD3 on UniProt.org

Other Formats

View All CD3 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 711™ anti-mouse CD3 17A2 FC
Biotin anti-mouse CD3 17A2 FC,IHC-F
PE/Dazzle™ 594 anti-mouse CD3 17A2 FC
APC/Fire™ 750 anti-mouse CD3 17A2 FC
Brilliant Violet 750™ anti-mouse CD3 17A2 FC
TotalSeq™-A0182 anti-mouse CD3 17A2 PG
TotalSeq™-B0182 anti-mouse CD3 17A2 PG
Spark Blue™ 550 anti-mouse CD3 17A2 FC
Spark NIR™ 685 anti-mouse CD3 17A2 FC
TotalSeq™-C0182 anti-mouse CD3 17A2 PG
APC/Fire™ 810 anti-mouse CD3 17A2 FC
PE/Fire™ 640 anti-mouse CD3 17A2 FC
Spark YG™ 570 anti-mouse CD3 17A2 IHC-F
PE/Fire™ 700 anti-mouse CD3 17A2 FC
Test 17A2 5 17A2
FITC anti-mouse CD3 17A2 FC
PE anti-mouse CD3 17A2 FC
Purified anti-mouse CD3 17A2 FC,IHC-F,IP,ICC
Alexa Fluor® 647 anti-mouse CD3 17A2 FC,IHC-F,3D IHC,SB
Alexa Fluor® 488 anti-mouse CD3 17A2 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse CD3 17A2 FC
Alexa Fluor® 700 anti-mouse CD3 17A2 FC
PerCP/Cyanine5.5 anti-mouse CD3 17A2 FC
PE/Cyanine7 anti-mouse CD3 17A2 FC
APC/Cyanine7 anti-mouse CD3 17A2 FC
Brilliant Violet 421™ anti-mouse CD3 17A2 FC,ICC
Brilliant Violet 570™ anti-mouse CD3 17A2 FC
Brilliant Violet 650™ anti-mouse CD3 17A2 FC
Brilliant Violet 785™ anti-mouse CD3 17A2 FC
Brilliant Violet 510™ anti-mouse CD3 17A2 FC
APC anti-mouse CD3 17A2 FC
Ultra-LEAF™ Purified anti-mouse CD3 17A2 FC,IHC-F,IP,ICC
Brilliant Violet 605™ anti-mouse CD3 17A2 FC
Alexa Fluor® 594 anti-mouse CD3 17A2 IHC-F,FC,3D IHC,SB
PE/Cyanine5 anti-mouse CD3 17A2 FC
Spark Blue™ 574 anti-mouse CD3 Antibody 17A2 FC
Spark Violet™ 423 anti-mouse CD3 17A2 FC
PE/Fire™ 810 anti-mouse CD3 17A2 FC
Spark Red™ 718 anti-mouse CD3 17A2 FC
Spark UV™ 387 anti-mouse CD3 17A2 FC
PerCP/Fire™ 780 anti-mouse CD3 Antibody 17A2 FC
PerCP anti-mouse CD3 Antibody 17A2 FC
Spark YG™ 581 anti-mouse CD3 (Flexi-Fluor™) 17A2 FC
Spark YG™ 593 anti-mouse CD3 (Flexi-Fluor™) Antibody 17A2 FC
Spark PLUS B488™ anti-mouse CD3 17A2 FC
Go To Top Version: 3    Revision Date: 03-19-2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account